Uso del software educativo de números fraccionarios en el desarrollo del razonamiento lógico matemático

El trabajo realizado en esta investigación es acerca de la utilización de un software educativo en el bloque de números fraccionarios para desarrollar el razonamiento lógico matemático de los estudiantes. Este software se ha realizado para incorporarlo en la escuela de educación básica José María Urbina del recinto Playa Seca, parroquia Manuel de J. Calle, cantón La Troncal. El mismo que presenta contenidos del bloque # 3 de Números fraccionarios, en el que se ha diseñado actividades tales como: Los contenidos principales, ejemplos explicativos, ejercicios prácticos, videos demostrativos y actividades para que los estudiantes practique de forma interactiva todo con respecto a fracciones. Esta herramienta que sirve como fuente de motivación para los estudiantes, lo que les facilita comprender y fortalecer su razonamiento lógico matemático sobre estos temas, además los docentes acceden a esta tecnología que les sirve como recurso didáctico que pueden utilizarlo para desarrollar sus actividades académicas de una forma innovadora en sus clases. El objetivo principal de la realización de este proyecto es dar a conocer nuevas formas de enseñanza-aprendizaje, que los docentes conozcan nuevas formas de impartir conocimientos utilizando los recursos tecnológicos

Investigations of low-frequency noise of GaN based heterostructure field-effect transistors

NRC publication: Ye

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field