Change of the ice rheology with climatic transitions – implication on ice flow modelling and dating of the EPICA Dome C core

International audienceThe study of the distribution of the crystallographic orientations (the fabric) along ice cores supplies information on the past and current ice flows of ice-sheets. Beside the usually observed formation of a vertical single maximum fabric, the EPICA Dome Concordia ice core (EDC) shows an abrupt and unexpected strenghtening of its fabric during termination II around 1750 m depth. Such strengthenings were already observed for sites located on an ice-sheet. This suggests that horizontal shear could occur along the EDC core. Moreover, the change in the fabric leads to a modification of the viscosity between neighbouring ice layers. Through the use of an anisotropic ice flow model, we quantify the change in viscosity and investigate its implication on ice flow and dating

Change in ice rheology during climate variations – implications for ice flow modelling and dating of the EPICA Dome C core

The study of the distribution of crystallographic orientations (i.e., the fabric) along ice cores provides information on past and current ice flow in ice-sheets. Besides the usually observed formation of a vertical single maximum fabric, the EPICA Dome C ice core (EDC) shows an abrupt and unexpected strengthening of its fabric during termination II around 1750 m depth. Such strengthening has already been observed for sites located on an ice-sheet flank. This suggests that horizontal shear could occur along the EDC core. Moreover, the change in the fabric leads to a modification of the effective viscosity between neighbouring ice layers. Through the use of an anisotropic ice flow model, we quantify the change in effective viscosity and investigate its implication for ice flow and dating

Decreased sAβPPβ, Aβ38, and Aβ40 Cerebrospinal Fluid Levels in Frontotemporal Dementia.

International audienceTo improve the etiological diagnosis of neurodegenerative dementias like Alzheimer's disease (AD) or frontotemporal dementia (FTD), we evaluated the value of individual and combined measurements of the following relevant cerebrospinal fluid (CSF) biomarkers: Tau, 181p-Tau, Aβ38, Aβ40, Aβ42, sAβPPα, and sAβPPβ. This study conducted in two centers included patients with FTD (n = 34), AD (n = 52), as well as a control group of persons without dementia (CTRL, n = 42). Identical clinical criteria and pre-analytical conditions were used while CSF biomarkers were measured using commercial single and multiplex quantitative immunoassays. Thorough statistical analyses, including ROC curves, logistic regressions, and decision trees, were performed. We validated in AD the specific increase of p-Tau levels and the decrease of Aβ42 levels, two biological hallmarks of this disease. Tau concentrations were highest in AD and intermediate in FTD when compared to CTRL. The most interesting results were obtained by focusing on amyloid biomarkers as we found out in FTD a significant decrease of sAβPPβ, Aβ38, and Aβ40 levels. Aβ38 in particular was the most useful biomarker to differentiate FTD subjects from the CTRL population. Combining p-Tau and Aβ38 led us to correctly classifying FTD patients with sensitivity at 85% and specificity at 82%. Significant changes in amyloid biomarkers, particularly for Aβ38, are therefore seen in FTD. This could be quite useful for diagnosis purposes and it might provide additional evidence on the interrelationship between Tau and AβPP biology which understanding is essential to progress towards optimal therapeutic and diagnostic approaches of dementia

A first constraint on basal melt-water production of the Greenland ice sheet

PROMICE is funded by the Geological Survey of Denmark and Greenland (GEUS) and the Danish Ministry of Climate, Energy and Utilities under the Danish Cooperation for Environment in the Arctic (DANCEA), and is conducted in collaboration with DTU Space (Technical University of Denmark) and Asiaq, Greenland.The Greenland ice sheet has been one of the largest sources of sea-level rise since the early 2000s. However, basal melt has not been included explicitly in assessments of ice-sheet mass loss so far. Here, we present the first estimate of the total and regional basal melt produced by the ice sheet and the recent change in basal melt through time. We find that the ice sheet’s present basal melt production is 21.4 +4.4/−4.0 Gt per year, and that melt generated by basal friction is responsible for about half of this volume. We estimate that basal melting has increased by 2.9 ± 5.2 Gt during the first decade of the 2000s. As the Arctic warms, we anticipate that basal melt will continue to increase due to faster ice flow and more surface melting thus compounding current mass loss trends, enhancing solid ice discharge, and modifying fjord circulation.Publisher PDFPeer reviewe

The effects of auditory enrichment on zebrafish behavior and physiology

Environmental enrichment is widely used to improve welfare and behavioral performance of animal species. It ensures housing of laboratory animals in environments with space and complexity that enable the expression of their normal behavioral repertoire. Auditory enrichment by exposure to classical music decreases abnormal behaviors and endocrine stress responses in humans, non-humans primates, and rodents. However, little is known about the role of auditory enrichment in laboratory zebrafish. Given the growing importance of zebrafish for neuroscience research, such studies become critical. To examine whether auditory enrichment by classical music can affect fish behavior and physiology, we exposed adult zebrafish to 2 h of Vivaldi’s music (65–75 dB) twice daily, for 15 days. Overall, zebrafish exposed to such auditory stimuli were less anxious in the novel tank test and less active, calmer in the light-dark test, also affecting zebrafish physiological (immune) biomarkers, decreasing peripheral levels of pro-inflammatory cytokines and increasing the activity of some CNS genes, without overt effects on whole-body cortisol levels. In summary, we report that twice-daily exposure to continuous musical sounds may provide benefits over the ongoing 50–55 dB background noise of equipment in the laboratory setting. Overall, our results support utilizing auditory enrichment in laboratory zebrafish to reduce stress and improve welfare in this experimental aquatic organism

Sensitivity of basal conditions in an inverse model : Vestfonna ice cap, Nordaustlandet/Svalbard

Peer reviewe

Treatment outcome of new pulmonary tuberculosis in Guangzhou, China 1993–2002: a register-based cohort study

<p>Abstract</p> <p>Background</p> <p>Completion of treatment for tuberculosis (TB) is of utmost priority for TB control programs. The aims of this study were to evaluate the treatment outcome of TB cases registered in Guangzhou during the period 1993–2002, and to identify factors associated with treatment success.</p> <p>Methods</p> <p>Two (of eight) districts in Guangzhou were selected randomly as objects of study and their surveillance database was analyzed to assess the treatment outcome and identify factors associated with treatment success for TB cases registered in Guangzhou. Six treatment outcome criteria were assessed based on guidelines set by the World Health Organization (WHO). Logistic regression was used to estimate risk factors for treatment outcome.</p> <p>Results</p> <p>A total of 6743 pulmonary tuberculosis cases (4903 males, 1840 females) were included in this study. The treatment success rate (including cured and complete treatment) was 88% (95%CI 87%–89%). One hundred and eight-six (2.8%) patients died and 401 (5.9%) patients defaulted treatment. In multivariate analysis, treatment success was found to be associated with young age, lack of cavitation and compliance with treatment.</p> <p>Conclusion</p> <p>The total treatment success rate in the current study was similar to the WHO target for all smear positive cases, while the failure rate and the default rate in 2002 were slightly higher. Good care of elderly patients, early diagnosis of cavitation and compliance with treatment could improve the success rate of TB treatment.</p

The stability of present-day Antarctic grounding lines – Part 2: Onset of irreversible retreat of Amundsen Sea glaciers under current climate on centennial timescales cannot be excluded

Observations of ocean-driven grounding-line retreat in the Amundsen Sea Embayment in Antarctica raise the question of an imminent collapse of the West Antarctic Ice Sheet. Here we analyse the committed evolution of Antarctic grounding lines under the present-day climate. To this aim, we first calibrate a sub-shelf melt parameterization, which is derived from an ocean box model, with observed and modelled melt sensitivities to ocean temperature changes, making it suitable for present-day simulations and future sea level projections. Using the new calibration, we run an ensemble of historical simulations from 1850 to 2015 with a state-of-the-art ice sheet model to create model instances of possible present-day ice sheet configurations. Then, we extend the simulations for another 10 000 years to investigate their evolution under constant present-day climate forcing and bathymetry. We test for reversibility of grounding-line movement in the case that large-scale retreat occurs. In the Amundsen Sea Embayment we find irreversible retreat of the Thwaites Glacier for all our parameter combinations and irreversible retreat of the Pine Island Glacier for some admissible parameter combinations. Importantly, an irreversible collapse in the Amundsen Sea Embayment sector is initiated at the earliest between 300 and 500 years in our simulations and is not inevitable yet – as also shown in our companion paper (Part 1, Hill et al., 2023). In other words, the region has not tipped yet. With the assumption of constant present-day climate, the collapse evolves on millennial timescales, with a maximum rate of 0.9 mm a−1 sea-level-equivalent ice volume loss. The contribution to sea level by 2300 is limited to 8 cm with a maximum rate of 0.4 mm a−1 sea-level-equivalent ice volume loss. Furthermore, when allowing ice shelves to regrow to their present geometry, we find that large-scale grounding-line retreat into marine basins upstream of the Filchner–Ronne Ice Shelf and the western Siple Coast is reversible. Other grounding lines remain close to their current positions in all configurations under present-day climate

Enhanced basal lubrication and the contribution of the Greenland ice sheet to future sea-level rise

We assess the effect of enhanced basal sliding on the flow and mass budget of the Greenland ice sheet, using a newly developed parameterization of the relation between meltwater runoff and ice flow. A wide range of observations suggest that water generated by melt at the surface of the ice sheet reaches its bed by both fracture and drainage through moulins. Once at the bed, this water is likely to affect lubrication, although current observations are insufficient to determine whether changes in subglacial hydraulics will limit the potential for the speedup of flow. An uncertainty analysis based on our best-fit parameterization admits both possibilities: continuously increasing or bounded lubrication. We apply the parameterization to four higher-order ice-sheet models in a series of experiments forced by changes in both lubrication and surface mass budget and determine the additional mass loss brought about by lubrication in comparison with experiments forced only by changes in surface mass balance. We use forcing from a regional climate model, itself forced by output from the European Centre Hamburg Model (ECHAM5) global climate model run under scenario A1B. Although changes in lubrication generate widespread effects on the flow and form of the ice sheet, they do not affect substantial net mass loss; increase in the ice sheet’s contribution to sea-level rise from basal lubrication is projected by all models to be no more than 5% of the contribution from surface mass budget forcing alone