Assessment of coronary slow flow and its implications

Background: CAG is seen as the gold standard for the diagnosis of epicardial coronary artery disease. The clinical significance of coronary microvascular dysfunction has not been given much attention as epicardial coronary artery disease. Coronary slow flow phenomenon is another independent entity which is less studied and treatment plan and prognosis are not yet established. The objective of this study was to provide better understanding about the presence and pathophysiologic significance of coronary slow flow phenomena in patients undergoing coronary angiography (CAG) for various indications by corrected TIMI frame count (CFTC) in vessels without any flow limiting disease.Methods: We measured CTFC in patients enrolled for CAG. We compared CTFC among different presentations and in different arteries. We also compared coronary slow flow phenomenon to normal flow in coronaries and its correlation to risk factorsResults: We found that coronary flow was significantly slower in non-infarct related arteries (NIRA) in the setting of ST segment elevation myocardial infraction (STEMI) and non-ST segment elevation myocardial infraction (NSTEMI) with no obstructive epicardial lesion as compared to coronary flow in absence of acute myocardial infraction (AMI). Significant slow flow was present in NIRA in STEMI compared to NSTEMI. Similarly slow flow was noted in unstable angina compared to chronic stable angina patients. Predominantly involved vessel was left anterior descending artery (LAD).Conclusions: Coronary flow was slower in NIRA in the setting of STEMI and NSTEMI with no obstructive epicardial lesion as compared to coronary flow in absence of AMI

Second-order topological superconductor via noncollinear magnetic texture

We put forth a theoretical framework for engineering a two-dimensional (2D) second-order topological superconductor (SOTSC) by utilizing a heterostructure: incorporating noncollinear magnetic textures between an s-wave superconductor and a 2D quantum spin Hall insulator. It stabilizes the higher order topological superconducting phase, resulting in Majorana corner modes (MCMs) at four corners of a 2D domain. The calculated non-zero quadrupole moment characterizes the bulk topology. Subsequently, through a unitary transformation, an effective low-energy Hamiltonian reveals the effects of magnetic textures, resulting in an effective in-plane Zeeman field and spin-orbit coupling. This approach provides a qualitative depiction of the topological phase, substantiated by numerical validation within exact real-space model. Analytically calculated effective pairings in the bulk illuminate the microscopic behavior of the SOTSC. The comprehension of MCM emergence is aided by a low-energy edge theory, which is attributed to the interplay between effective pairings of (px + py )-type and (px + ipy )-type. Our extensive study paves the way for practically attaining the SOTSC phase by integrating noncollinear magnetic textures

Zaciskające zapalenie osierdzia imitujące ciężką restenozę zastawki mitralnej u chorego po leczeniu chirurgicznym choroby reumatycznej serca

Pericardial constriction is a rare, but well documented complication following cardiac surgery. It has been reported following coronary artery bypass grafting (CABG), cardiac surgery for congenital heart diseases and very rarely following closed mitral commissurotomy. We hereby report a case of chronic constrictive pericarditis following closed mitral commissurotomy mimicking mitral restenosis with refractory heart failure

Human protein reference database—2006 update

Human Protein Reference Database (HPRD) () was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

Peer reviewe

Reconstruction of signal amplitudes in the CMS electromagnetic calorimeter in the presence of overlapping proton-proton interactions

A template fitting technique for reconstructing the amplitude of signals produced by the lead tungstate crystals of the CMS electromagnetic calorimeter is described. This novel approach is designed to suppress the contribution to the signal of the increased number of out-of-time interactions per beam crossing following the reduction of the accelerator bunch spacing from 50 to 25 ns at the start of Run 2 of the LHC. Execution of the algorithm is sufficiently fast for it to be employed in the CMS high-level trigger. It is also used in the offline event reconstruction. Results obtained from simulations and from Run 2 collision data (2015-2018) demonstrate a substantial improvement in the energy resolution of the calorimeter over a range of energies extending from a few GeV to several tens of GeV.Peer reviewe

Observation of the Production of Three Massive Gauge Bosons at root s=13 TeV

The first observation is reported of the combined production of three massive gauge bosons (VVV with V = W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis is based on a data sample recorded by the CMS experiment at the CERN LHC corresponding to an integrated luminosity of 137 fb(-1). The searches for individualWWW, WWZ, WZZ, and ZZZ production are performed in final states with three, four, five, and six leptons (electrons or muons), or with two same-sign leptons plus one or two jets. The observed (expected) significance of the combinedVVV production signal is 5.7 (5.9) standard deviations and the corresponding measured cross section relative to the standard model prediction is 1.02(-0.23)(+0.26). The significances of the individual WWW and WWZ production are 3.3 and 3.4 standard deviations, respectively. Measured production cross sections for the individual triboson processes are also reported