Some Observations of Perceptually Impaired Children in Two Approaches to Reading

Reading is one problem facing children having perceptual lags in their development. Some children may reveal clinical evidence of brain injury while others merely show uneven developmental patterns on psychological tests. These children cannot respond to the usual methods of instruction presented during their early school experiences. The regular educational materials and methods are inappropriate for them and must be adapted to meet more primitive learning needs

The Effects of Sorority Recruitment on Self-Esteem

Mental health issues among college students are of increasing concern to administrators (Kitzrow, 2003). Self-esteem is a concept central to mental health (Kittleson, 1989) and can be linked to the social situations found in college settings, especially those that deal with rejection (Caunt, 2003; Eisenberger & Lieberman, 2004; Steffenhagen & Burns, 1987). Sorority recruitment is a process that can include rejection (National Panhellenic Conference, n.d.) and, thus, may negatively affect self-esteem. The purpose of this study was to determine how the sorority recruitment experience affects the self-esteem of participants. First, we explored whether self-esteem differed between two groups of potential members (PMs): those who completed recruitment (persistent PMs) and those who withdrew from the recruitment process (withdrawn PMs). Second, we examined how self-esteem differed at the start and the end of recruitment within these groups of PMs. Results revealed significant differences between groups and suggested a relationship between recruitment and self-esteem

Reduction of Injection-Related Risk Behaviors After Emergency Implementation of a Syringe Services Program During an HIV Outbreak

Objective: To describe injection-related HIV risk behaviors preimplementation and postimplementation of an emergency syringe services program (SSP) in Scott County, Indiana, after an HIV outbreak among persons who inject drugs (PWID). Design: Mixed methods retrospective pre–post intervention analysis. Methods: We analyzed routine SSP program data collected at first and most recent visit among clients with ≥2 visits, ≥7 days apart from April 4 to August 30, 2015, to quantify changes in injection-related risk behaviors. We also analyzed qualitative data collected from 56 PWID recruited in Scott County to understand factors contributing to these behaviors. Results: SSP clients included in our analysis (n = 148, 62% of all SSP clients) reported significant (P < 0.001) reductions over a median 10 weeks (range 1–23) in syringe sharing to inject (18%–2%) and divide drugs (19%–4%), sharing other injection equipment (eg, cookers) (24%–5%), and number of uses of the same syringe [2 (interquartile range: 1–4) to 1 (interquartile range: 1–1)]. Qualitative study participants described access to sterile syringes and safer injection education through the SSP, as explanatory factors for these reductions. Injection frequency findings were mixed, but overall suggested no change. The number of syringes returned by SSP clients increased from 0 at first visit to median 57. All qualitative study participants reported using sharps containers provided by the SSP. Conclusions: Analyses of an SSP program and in-depth qualitative interview data showed rapid reduction of injection-related HIV risk behaviors among PWID post-SSP implementation. Sterile syringe access as part of comprehensive HIV prevention is an important tool to control and prevent HIV outbreaks

CONSTRAINT BASED ANALYSIS OF DATABASE UPDATE PROPAGATION

Semantic and object-oriented data models provide convenient constructs for the specification of objects, relationships, and operations. The vehicle of representation is a collection of abstractions which parallel the means by which humans prefer to organize complex enterprises. These constructs inherently permit focus on one object, relationship, or operation at a time. Propagation, as a semantic construct, provides the extension of existing modeling capabilities by providing a mechanism for the specification of the update semantics between database objects. Through the analysis of constraints and the propagated actions necessary to maintain them, we attempt to do the following: 1) incorporate additional semantics into the database schema in the form of database propagation rules, 2) in the context of constraints and propagation rules, provide a model independent paradigm for determining if schemata are correct, and 3) provide a vehicle fur the explicit specification of update actions during database schema design

Apolipoprotein AV: Gene expression, physiological role in lipid metabolism and clinical relevance

The apolipoprotein APOA5 gene, a member of the gene cluster on chromosome 11q23 that includes APOA1, APOC3 and APOA4, has gained considerable interest as it encodes ApoAV, a key determinant of circulating levels of potentially atherogenic triglyceride-rich lipoproteins (TRL). Indeed, strong associations between genetic variants of the APOA5 gene sequence and elevated triglyceride (TG) levels have been established. This apolipoprotein may potentiate lipolysis of TRL through facilitation of lipoprotein interaction with lipoprotein lipase. In addition, ApoAV may enhance clearance of remnant lipoproteins by mediating their interaction with the LDL receptor-related protein (LRP)1. The implication of ApoAV in intravascular TRL metabolism is further supported by studies that have demonstrated upregulation of APOA5 gene expression by nuclear receptors (PPAR alpha, FXR and HNF4 alpha) and hormones (thyroxine) involved in hypotriglyceridemic pathways. APOA4 expression may equally be modulated by nutritional status and, more specifically, by stimulation of lipogenesis through transcriptional regulation mediated by insulin and SREBP-1c. However, despite the fact that studies in mice have clearly revealed that plasma levels of ApoAV are inversely correlated with plasma TG levels, the relationship between ApoAV and metabolism of TRL remains controversial in man. Indeed, positive correlations between ApoAV and TG levels have recently been observed in patients with hypertriglyceridemia and Type 2 diabetes. The question as to whether ApoAV is a key determinant of TG levels in humans therefore remains conjectural

Association of the tumour necrosis factor alpha -308 but not the interleukin 10 -627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis

BACKGROUND AND AIMS Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Abnormalities in immune regulation and genetic associations suggest that PSC is an immune mediated disease. Several polymorphisms within the tumour necrosis factor α (TNF-α) and interleukin 10 (IL-10) promoter genes have been described which influence expression of these cytokines. This study examines the possible association between polymorphisms at the −308 and −627 positions in the TNF-α and IL-10 promoter genes, respectively, and susceptibility to PSC. METHODS TNF-α −308 genotypes were studied by polymerase chain reaction (PCR) in 160 PSC patients from Norway and the UK compared with 145 ethnically matched controls. IL-10 −627 genotypes were studied by PCR in 90 PSC patients compared with 84 ethnically matched controls. RESULTS A total of 16% of Norwegian PSC patients and 12% of British PSC patients were homozygous for the TNF2 allele compared with 3% and 6% of respective controls. The TNF2 allele was present in 60% of PSC patients versus 30% of controls (ORcombined data=3.2 (95% confidence intervals (CI) 1.8–4.5); pcorr=10−5). The association between the TNF2 allele and susceptibility to PSC was independent of the presence of concurrent inflammatory bowel disease (IBD) in the PSC patients; 61% of PSC patients without IBD had TNF2 compared with 30% of controls (ORcombined data=3.2 (95% CI 1.2–9.0); pcorr=0.006 ). There was no difference in the −627 IL-10 polymorphism distributions between patients and controls in either population. The increase in TNF2 allele in PSC patients only occurs in the presence of DRB1*0301 (DR3) and B8. In the combined population data, DRB1*0301 showed a stronger association with susceptibility to PSC than both the TNF2 and B8 alleles (ORcombined data=3.8, pcorr=10−6 v ORcombined data=3.2, pcorr=10−5 vORcombined data =3.41, pcorr=10−4, respectively). CONCLUSIONS This study identified a significant association between possession of the TNF2 allele, a G→A substitution at position −308 in the TNF-α promoter, and susceptibility to PSC. This association was secondary to the association of PSC with the A1-B8-DRB1*0301-DQA1*0501-DQB1*0201 haplotype. No association was found between the IL-10 −627 promoter polymorphism and PSC

Teacher agency in the selection of literary texts

This is the final version. Available from Routledge via the DOI in this record. The nature of English as a school subject – and particularly English literature – is a longstanding issue of debate for practitioners and researchers internationally. One dimension of this concerns the forces that shape the diet of literary texts that students are fed. In this study, we draw on the ecological model of agency to interrogate the factors which influence how teachers choose literary texts for whole class teaching. Dimensions of agency are used as lenses to reveal the complex ways in which values and beliefs, structures of authority, material resources, and identities shape the selection of books, plays and poetry that are taught in English. By looking across these dimensions, we identify important questions which contribute to the debate: who should have agency to choose the texts taught; how does teacher agency influence students’ experiences of English literature; how far should we expect these experiences to be standardised?United Kingdom Literacy Associatio

Teaching Key Stage 3 literature:The challenges of accountability, gender and diversity

This article presents the results of a study, conducted in parts of Wales and southwest England, focusing on what literature is being taught to learners aged 11–14 years. By exploring this area, we gain insight into influences on teacher choices and the challenges faced by teachers. Our research, which included a survey of over 170 teachers as well as teacher interviews, provides a snapshot of young people's experiences studying literature in the early secondary years (Key Stage 3). The results show that while some schools provide variety and diversity in their choice of texts and authors, the majority provide a limited diet of literature with texts mainly from male writers, with male protagonists. Girls are rarely the main focus. Nor do the majority of children study literature written by or about those from black and minority ethnic backgrounds, highlighting a lack of diversity. Literature teaching at Key Stage 3 is increasingly influenced by the demands of GCSE and exam accountability. We hope the study can act as a catalyst for discussion about what ought to be the purpose and focus of literature study in England, Wales and beyond