Center of pressure displacements in individual swith Down syndrome during a bipedal position

Objetivo:Valorar el equilibrio de adultos con síndrome de Down a través del estudio del desplazamiento del centro depresiones. Método: Estudio transversal de casos y controles. Doce sujetos con síndrome de Down y 12 sin síndrome de Down formaron parte del estudio. Todos los participantes realizaron 2 pruebas sobre plataforma dinamométrica: i)estática con ojos abiertos y ii) estática con ojos cerrados. Las señales del centro de presiones fueron analizadas en el dominio temporal. Se utilizaron contrastes no paramétricos para el análisis estadístico de los datos Resultados:Los resultados mostraron diferencias significativas entre- grupos en las variables rango ante-roposterior, fuerza anteroposterior y fuerzamedio-lateral(p<0.05). Las comparaciones intragrupos mostraron peores resultados en las pruebas con ojos cerrados en ambos grupos. Conclusión:En el presente trabajo las personas con síndrome de Down presentaron un control del equilibrio mermado al compararlo con sujetos sin síndrome de Down. Los datos obtenidos no son concluyentes para determinar cuál de los sistemas involucrados en el control del equilibrio es el responsable de estos resultados.Objective: To evaluate body balance of adults with Down syndrome based on the analysis of their centre of pressure behaviour. Method: Cross-sectional case control-study. Twelve individuals with Down syndrome and twelve without Down syndrome took part in the study. All the participants were tested under two conditions on a force plate: i) static with eyes open and ii) static with eyes closed. Centre of pressure signals were analyzed in time domain. Non-parametric contrasts were used for statistical analysis. Results: Statistical differences between groups were found in anteroposterior range, anterior-posterior force and medio-lateral force (p < 0.05). Within-groups comparisons showed poorer results in eyes closed conditions for both groups. Conclusion: Individuals with Down syndrome involved in the present study showed deficits in balance control when compared with people without Down syndrome. The obtained data are not conclusive. The participation of the different systems which control balance in people with Down syndrome remains unknownObjetivo: Avaliar o equilíbrio de adultos com síndrome de Down através do estudo do desprendimento do centro de pressão. Método: Estudo transversal de caso e controlos. Doze sujeitos com SD e 12 sem Síndrome de Down fizeram parte do estudo. Todos os participantes realizaram 2 provas sobre plataforma dinamométrica: i) estática com olhos abertos e ii) estática com olhos fechados. Os sinais dos centros de pressões foram analisados em domínio temporal. Foram utilizados testes não paramétricos para a análise estatística dos dados. Resultados: Os resultados mostraram diferenc¸ as significativas entre grupos nas variáveis de intervalo ântero-posterior, forc¸ a ântero-posterior e forc¸ a médio-lateral (p < 0.05). As comparac¸ ões intragrupos mostram piores resultados nas provas de equilíbrio com olhos fechados para ambos os grupos. Conclusão: No presente estudo, as pessoas com Síndrome de Down apresentaram um controlo de equilíbrio diminuído em comparac¸ ão a sujeitos sem Síndrome de Down. Os dados obtidos não são conclusivos paradeterminar qualdos sistemas envolvidosno controlodo equilíbrio é responsávelpor estes resultado

Incidencia del ejercicio físico y el entrenamiento vibratorio sobre la amplitud de movimiento de mujeres con fibromialgia

ResumenObjetivoEn la presente investigación hemos planteado como objetivos principales, por un lado, valorar el efecto del ejercicio físico y el entrenamiento vibratorio sobre la amplitud de movimiento en mujeres con fibromialgia (FM) y, por otro, determinar si existe alguna relación entre dicha variable y el dolor y la rigidez.MétodoLa muestra estuvo constituida por un total de cuarenta y seis mujeres (edad: 58,2±8,5 años; peso: 72,1±9,6kg; altura: 156,9±6,1cm) diagnosticadas con FM. Los participantes fueron divididos aleatoriamente en tres grupos: ejercicio físico y entrenamiento vibratorio (WBV + EJ; n=15); ejercicio físico sin vibraciones (EJ; n=15) y un grupo control (GC; n=16). Los grupos WBV + EJ y EJ realizaron dos sesiones semanales de ejercicio físico durante 8 semanas. Además, los integrantes de WBV + EJ realizaron 3 sesiones semanales de entrenamiento vibratorio (30Hz, 4mm). Las pruebas de evaluación incluyeron el test de sit and reach (variable principal), la valoración del número de tender points (TP) y una escala analógica visual (VAS) para determinar la rigidez.ResultadosLos resultados derivados del análisis intra e intergrupo no mostraron diferencias significativas en la rigidez o el número de TP, si bien, la prueba de sit and reach mostró una mejora estadísticamente significativa en WBV + EJ (58%; p<0,05). El análisis correlacional mostró una relación inversa (r =-0,55; p<0,05) entre el sit and reach y el número de TP.ConclusiónComo conclusión, podemos indicar que los datos obtenidos en la presente investigación han mostrado los efectos significativos del entrenamiento vibratorio sobre la amplitud de movimiento en mujeres con FM, aunque el número de TP o la rigidez no se vieron afectados en ningún caso.AbstractObjectiveThe main aim of this investigation was twofold: first to evaluate the effects of exercise and whole body vibration training on flexibility in women with fibromyalgia (FM) and determine whether these improvements are related to symptom severity (stiffness and bodily pain).MethodForty-six women (mean±sd, age: 58.2±8.5 years; weight: 72.1±9.6kg; height: 156.9±6.1cm) with FM were randomized into one of three groups: exercise and whole body vibration (WBV) training group (WBV + EX; n=15), exercise training group (EX), and usual-care control group (CG). WBV + EX and EX groups carried out two sessions per week of exercise training for 8 weeks. In addition, WBV + EX group performed 3 vibration-training (30Hz, 4mm) sessions per week. Outcome assessed included sit and reach test (primary outcome), tender points (TP) evaluation, and a visual analog scale (VAS) was used to determine the stiffness level.ResultsResults showed no statistical intra and intergroup differences in stiffness or the number of TP. However, a significant increment in the sit and reach performance was observed in WBV + EX (58%; p<0.05). Moreover, correlation analysis showed an inverse and significant relationship (r=-0.55; p<0.05) between sit and reach and number of TP in WBV+EX group.ConclusionIn conclusion, exercise and WBV seems to be effective on flexibility in women with FM. However, the number of TP and stiffness was not modified after the interventio

Solar Intranetwork Magnetic Elements: bipolar flux appearance

The current study aims to quantify characteristic features of bipolar flux appearance of solar intranetwork (IN) magnetic elements. To attack such a problem, we use the Narrow-band Filter Imager (NFI) magnetograms from the Solar Optical Telescope (SOT) on board \emph{Hinode}; these data are from quiet and an enhanced network areas. Cluster emergence of mixed polarities and IN ephemeral regions (ERs) are the most conspicuous forms of bipolar flux appearance within the network. Each of the clusters is characterized by a few well-developed ERs that are partially or fully co-aligned in magnetic axis orientation. On average, the sampled IN ERs have total maximum unsigned flux of several 10^{17} Mx, separation of 3-4 arcsec, and a lifetime of 10-15 minutes. The smallest IN ERs have a maximum unsigned flux of several 10^{16} Mx, separations less than 1 arcsec, and lifetimes as short as 5 minutes. Most IN ERs exhibit a rotation of their magnetic axis of more than 10 degrees during flux emergence. Peculiar flux appearance, e.g., bipole shrinkage followed by growth or the reverse, is not unusual. A few examples show repeated shrinkage-growth or growth-shrinkage, like magnetic floats in the dynamic photosphere. The observed bipolar behavior seems to carry rich information on magneto-convection in the sub-photospheric layer.Comment: 26 pages, 14 figure

Dense carbon monoliths for supercapacitors with outstanding volumetric capacitances

A commercially available dense carbon monolith (CM) and four carbon monoliths obtained from it have been studied as electrochemical capacitor electrodes in a two-electrode cell. CM has: (i) very high density (1.17 g cm−3), (ii) high electrical conductivity (9.3 S cm−1), (iii) well-compacted and interconnected carbon spheres, (iv) homogeneous microporous structure and (v) apparent BET surface area of 957 m2g−1. It presents interesting electrochemical behaviors (e.g., excellent gravimetric capacitance and outstanding volumetric capacitance). The textural characteristics of CM (porosity and surface chemistry) have been modified by means of different treatments. The electrochemical performances of the starting and treated monoliths have been analyzed as a function of their porous textures and surface chemistry, both on gravimetric and volumetric basis. The monoliths present high specific and volumetric capacitances (292 F g−1 and 342 F cm−3), high energy densities (38 Wh kg−1 and 44 Wh L−1), and high power densities (176 W kg−1 and 183 W L−1). The specific and volumetric capacitances, especially the volumetric capacitance, are the highest ever reported for carbon monoliths. The high values are achieved due to a suitable combination of density, electrical conductivity, porosity and oxygen surface content.Financial support from projects MAT2011-25198, MP1004 and PROMETEO/2009/047 is gratefully acknowledged. V.B. thanks MINECO for R&C contract

A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn’s disease

Abstract: Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we performed a cross-disease meta-analysis including GWAS data from 5,734 SSc patients, 4,588 CD patients and 14,568 controls of European origin. We identified 4 new loci shared between SSc and CD, IL12RB2, IRF1/SLC22A5, STAT3 and an intergenic locus at 6p21.31. Pleiotropic variants within these loci showed opposite allelic effects in the two analysed diseases and all of them showed a significant effect on gene expression. In addition, an enrichment in the IL-12 family and type I interferon signaling pathways was observed among the set of SSc-CD common genetic risk loci. In conclusion, through the first cross-disease meta-analysis of SSc and CD, we identified genetic variants with pleiotropic effects on two clinically distinct immune-mediated disorders. The fact that all these pleiotropic SNPs have opposite allelic effects in SSc and CD reveals the complexity of the molecular mechanisms by which polymorphisms affect diseases

Search for the Zγ decay mode of new high-mass resonances in pp collisions at √s = 13 TeV with the ATLAS detector

This letter presents a search for narrow, high-mass resonances in the Zγ final state with the Z boson decaying into a pair of electrons or muons. The √s = 13 TeV pp collision data were recorded by the ATLAS detector at the CERN Large Hadron Collider and have an integrated luminosity of 140 fb−1. The data are found to be in agreement with the Standard Model background expectation. Upper limits are set on the resonance production cross section times the decay branching ratio into Zγ. For spin-0 resonances produced via gluon–gluon fusion, the observed limits at 95% confidence level vary between 65.5 fb and 0.6 fb, while for spin-2 resonances produced via gluon–gluon fusion (or quark–antiquark initial states) limits vary between 77.4 (76.1) fb and 0.6 (0.5) fb, for the mass range from 220 GeV to 3400 GeV