La escalera de ojo abierto del Palacio Di Majo en Nápoles entre geometría y equilibrio

The staircases represent one of the most impressive architectural expressions of the building. Many authors presented a great deal of research over the years on this matter intending to understand how they are designed and laid out. This paper is concerned with a particular structural type of masonry staircase, known as stair with open well or roman staircase. It aims to demonstrate that in masonry-vaulted staircases, the close relationship between the shape and static behavior is particularly evident, and geometry and construction are essential for their stability. The authors have proved this statement by studying Palazzo Di Majo’s open-well staircase in Naples, whose main structure consists of tuff vaults. The first part of the article is substantially descriptive and presents an in-depth description of the geometric and architectural features of the stair. The second part explains all the aspects concerning the equilibrium of this kind of stairways, within Heyman’s theory of masonry.  Las escaleras representan una de las más imponentes expresiones arquitectónicas del edificio. Varios autores han presentado muchas publicaciones a lo largo de los años sobre este tema para entender cómo han sido diseñadas y cómo se sostienen. Este trabajo se trata sobre un tipo específico de escalera de albañilería, conocida como escalera “de ojo abierto” o “a la romana”. El objetivo es demostrar que en las escaleras con bóvedas de fábrica existe una estrecha relación entre la forma y su comportamiento estático. La geometría y la construcción son imprescindibles para su estabilidad. Los autores han demostrado esta tesis estudiando la escalera de ojo abierto del Palacio Di Majo en Nápoles, cuya estructura principal está constituida por bóvedas de toba. La primera parte del artículo presenta una descripción detallada de las características geométricas y arquitectónicas de la escalera. La segunda parte, explica el equilibrio de estas escaleras a partir de la teoría del equilibrio de estructuras de fábrica de Heyman

The open-well staircase of Palazzo Di Majo in Naples between geometry and equilibrium | La escalera de ojo abierto del Palacio Di Majo en Nápoles entre geometría y equilibrio

The staircases represent one of the most impressive architectural expressions of the building. Many authors presented a great deal of research over the years on this matter intending to understand how they are designed and laid out. This paper is concerned with a particular structural type of masonry staircase, known as stair with open well or roman staircase. It aims to demonstrate that in masonry-vaulted staircases, the close relationship between the shape and static behavior is particularly evident, and geometry and construction are essential for their stability. The authors have proved this statement by studying Palazzo Di Majo’s open-well staircase in Naples, whose main structure consists of tuff vaults. The first part of the article is substantially descriptive and presents an in-depth description of the geometric and architectural features of the stair. The second part explains all the aspects concerning the equilibrium of this kind of stairways, within Heyman’s theory of masonry

The majolica dome of Santa Maria della Sanità in Naples. Geometric configuration analysis and stability studies | La cúpula de mayólica de Santa Maria della Sanità en Nápoles. Configuración geométrica y estudios de estabilidad

This article deals with the survey and representation of the dome of Santa Maria della Sanità in Naples (Italy). The survey led to a geometric analysis of the spatial configuration of the dome, the drawing of its majolica decoration and its structural behavior. The overall objectives of this research can be briefly outlined as follows. First, the study focuses on defining the correct geometry of the dome obtained through accurate surveys. Finally, the study performs a simplified structural analysis of the compound dome-buttress system set within the theoretical framework of the Limit Analysis through the graphical statics

Correlation analysis between foveal avascular zone and near peripheral retinal hypoperfusion in multiple sclerosis: a wide field optical coherence tomography angiography study

The identification of non-invasive biomarkers to investigate and monitor retinal structural and vascular changes in multiple sclerosis (MS) represents an interesting source of debate. Until now optical coherence tomography angiography (OCTA) evaluated the foveal avascular zone (FAZ) and areas of retinal non-perfusion only in the macular region in MS patients. It could be interesting to identify possible biomarkers, useful in assessing the ischemic areas also in the near peripheral retina, since FAZ enlargement and the areas of peripheral retinal non-perfusions share common pathogenic processes. In this cross-sectional study, we investigated the correlation between the FAZ area and retinal vessel density (VD) in the near peripheral retina by new wide-field optical coherence tomography angiography (OCTA) in patients affected by relapsing-remitting multiple sclerosis (RR-MS). Moreover, we compared the FAZ area and the VD of superficial and deep capillary plexuses in the fovea region and in the near peripheral retina (6.4 x 6.4 mm) between RR-MS patients and healthy controls by means of a Solix full-range OCTA. Last, we also detected the changes in structural OCT parameters (ganglion cell complex and retinal nerve fiber layer). Thirty-three eyes of 33 RR-MS patients and 35 eyes of 35 healthy controls were enrolled. RR-MS patients showed a lower VD in the superficial capillary plexus and a significant increase in the FAZ area compared with controls. The deep capillary plexus revealed a reduced VD although not statistically significant in patients with respect to controls. In the patients' group, the FAZ area showed significantly negative correlations with VD of superficial capillary plexuses in the foveal and whole region, while the FAZ area did not negatively correlate with the VD of the deep capillary plexus. The significant correlations among OCTA parameters could demonstrate the FAZ area as a possible biomarker for assessing the perfusion status in the near peripheral retina, useful in RR-MS management. These findings could confirm the role of vascular dysfunction in the pathogenetic mechanisms of MS

Zoledronic acid in metastatic chondrosarcoma and advanced sacrum chordoma: two case reports

<p>Abstract</p> <p>Introduction</p> <p>Chondrosarcomas and chordomas are usually chemoresistant bone tumors and may have a poor prognosis when advanced. They are usually associated with worsening pain difficult to control.</p> <p>Patients and Methods</p> <p>Zoledronic acid was used in a 63-year-old man with metastatic chondrosarcoma and in a 66-year-old woman with a diagnosis of sacrum chordoma both reporting severe pain related to tumor.</p> <p>Results</p> <p>In the first case, zoledronic acid was able to maintain pain control despite disease progression following chemotherapy, in the other case, zoledronic acid only produced significant clinical benefit.</p> <p>Conclusion</p> <p>Control of pain associated with bone tumors such as chondrosarcoma and chondroma may significantly improve from use of zoledronic acid, independently from tumor response to other treatments. Evaluation on larger series are needed to confirm the clinical effect of this bisphosphonate on such tumors.</p

Guidelines in the management of obstructing cancer of the left colon : consensus conference of the world society of emergency surgery (WSES) and peritoneum and surgery (PnS) society

Peer reviewe

A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma

In the present study we investigated the feasibility and effectiveness of a new biweekly schedule of fotemustine (FTM) in patients with recurrent glioblastoma, after at least one previous treatment. The primary endpoint was progression-free survival at 6 months; secondary objectives were clinical response, overall survival, disease-free survival, and toxicity. Forty patients (median age 52.8 years; median Karnofsky Performance Status at progression 90) underwent second-line chemotherapy with FTM. Selected patients were previously treated with a standard radiotherapy course with concomitant temozolomide (TMZ). After tumor relapse or progression proven by magnetic resonance imaging (MRI), all patients underwent chemotherapy with FTM, given intravenously at dose of 80 mg/m2 every 2 weeks for five consecutive administrations (induction phase), and then every 3 weeks at 100 mg/m2 as maintenance. A total of 329 infusions were administered; the median number of cycles administered was 8. All patients completed the induction phase, and 29 patients received at least one maintenance infusion. Response to treatment was assessed using MacDonald criteria. One complete response [2.5%, 95% confidence interval (CI): 0–10%], 9 partial responses (22.5%, 95% CI: 15–37%), and 16 stable diseases (40%, 95% CI: 32–51%) were observed. Median time to progression was 6.7 months (95% CI: 3.9–9.1 months). Progression-free survival at 6 months was 61%. Median survival from beginning of FTM chemotherapy was 11.1 months. The schedule was generally well tolerated; the main toxicities were hematologic (grade 3 thrombocytopenia in two cases). To the best of our knowledge, this is the first report specifically dealing with the use of a biweekly induction schedule of FTM. The study demonstrates that FTM has therapeutic efficacy as single-drug second-line chemotherapy with a favorable safety profile