2,628 research outputs found
Evidence for intron length conservation in a set of mammalian genes associated with embryonic development
<p>Abstract</p> <p>Background</p> <p>We carried out an analysis of intron length conservation across a diverse group of nineteen mammalian species. Motivated by recent research suggesting a role for time delays associated with intron transcription in gene expression oscillations required for early embryonic patterning, we searched for examples of genes that showed the most extreme conservation of total intron content in mammals.</p> <p>Results</p> <p>Gene sets annotated as being involved in pattern specification in the early embryo or containing the homeobox DNA-binding domain, were significantly enriched among genes with highly conserved intron content. We used ancestral sequences reconstructed with probabilistic models that account for insertion and deletion mutations to distinguish insertion and deletion events on lineages leading to human and mouse from their last common ancestor. Using a randomization procedure, we show that genes containing the homeobox domain show less change in intron content than expected, given the number of insertion and deletion events within their introns.</p> <p>Conclusions</p> <p>Our results suggest selection for gene expression precision or the existence of additional development-associated genes for which transcriptional delay is functionally significant.</p
Searches for B0(s)âJ/ÏppË and B+âJ/ÏppËÏ+ decays
The results of searches for B0(s)âJ/Ï ppÂŻ and B + â J/Ï p pÂŻ Ï+ decays are reported. The analysis is based on a data sample, corresponding to an integrated luminosity of 1.0 fbâ1 of pp collisions, collected with the LHCb detector. An excess with 2.8 Ï significance is seen for the decay B0sâJ/Ï ppÂŻ and an upper limit on the branching fraction is set at the 90 % confidence level: B(B0sâJ/Ï ppÂŻ) < 4.8 Ă 10â6, which is the first such limit. No significant signals are seen for B0 â J/Ï ppÂŻ and B+ â J/Ï ppÂŻ Ï + decays, for which the corresponding limits are set: B(B0âJ/Ï ppÂŻ) < 5.2 Ă 10â7, which significantly improves the existing limit; and B(B+âJ/Ï ppÂŻÏ+) < 5.0 Ă 10â7, which is the first limit on this branching fraction
Study of DJ meson decays to D+Ïâ, D0Ï+ and Dâ+Ïâ final states in pp collisions
A study of D+Ïâ, D0Ï+ and Dâ+Ïâ final states is performed using pp collision data, corresponding to an integrated luminosity of 1.0 fbâ1, collected at a centre-of-mass energy of 7 TeV with the LHCb detector. The D1(2420)0 resonance is observed in the Dâ+Ïâ final state and the Dâ2(2460) resonance is observed in the D+Ïâ, D0Ï+ and Dâ+Ïâ final states. For both resonances, their properties and spin-parity assignments are obtained. In addition, two natural parity and two unnatural parity resonances are observed in the mass region between 2500 and 2800 MeV. Further structures in the region around 3000 MeV are observed in all the Dâ+Ïâ, D+Ïâ and D0Ï+ final states
Observation of the decay
The decay is observed for the first
time, using proton-proton collisions collected with the LHCb detector
corresponding to an integrated luminosity of 3fb. A signal yield of
decays is reported with a significance of 6.2 standard deviations.
The ratio of the branching fraction of \B_c \rightarrow J/\psi K^+ K^- \pi^+
decays to that of decays is measured to be
, where the first uncertainty is statistical and the
second is systematic.Comment: 18 pages, 2 figure
Study of B0(s)âK0Sh+hâČâ decays with first observation of B0sâK0SK±Ïâ and B0sâK0SÏ+Ïâ
A search for charmless three-body decays of B 0 and B0s mesons with a K0S meson in the final state is performed using the pp collision data, corresponding to an integrated luminosity of 1.0 fbâ1, collected at a centre-of-mass energy of 7 TeV recorded by the LHCb experiment. Branching fractions of the B0(s)âK0Sh+hâČâ decay modes (h (âČ) = Ï, K), relative to the well measured B0âK0SÏ+Ïâ decay, are obtained. First observation of the decay modes B0sâK0SK±Ïâ and B0sâK0SÏ+Ïâ and confirmation of the decay B0âK0SK±Ïâ are reported. The following relative branching fraction measurements or limits are obtained B(B0âK0SK±Ïâ)B(B0âK0SÏ+Ïâ)=0.128±0.017(stat.)±0.009(syst.), B(B0âK0SK+Kâ)B(B0âK0SÏ+Ïâ)=0.385±0.031(stat.)±0.023(syst.), B(B0sâK0SÏ+Ïâ)B(B0âK0SÏ+Ïâ)=0.29±0.06(stat.)±0.03(syst.)±0.02(fs/fd), B(B0sâK0SK±Ïâ)B(B0âK0SÏ+Ïâ)=1.48±0.12(stat.)±0.08(syst.)±0.12(fs/fd)B(B0sâK0SK+Kâ)B(B0âK0SÏ+Ïâ)â[0.004;0.068]at90%CL
Precision measurement of violation in decays
The time-dependent asymmetry in decays is
measured using collision data, corresponding to an integrated luminosity
of fb, collected with the LHCb detector at centre-of-mass energies
of and TeV. In a sample of 96 000 decays, the
-violating phase is measured, as well as the decay widths
and of the light and heavy mass eigenstates of the
system. The values obtained are rad, ps, andps, where the first uncertainty is
statistical and the second systematic. These are the most precise single
measurements of those quantities to date. A combined analysis with decays gives rad. All
measurements are in agreement with the Standard Model predictions. For the
first time the phase is measured independently for each polarisation
state of the system and shows no evidence for polarisation
dependence.Comment: 6 figure
Model-independent search for CP violation in D0âKâK+ÏâÏ+ and D0âÏâÏ+Ï+Ïâ decays
A search for CP violation in the phase-space structures of D0 and View the MathML source decays to the final states KâK+ÏâÏ+ and ÏâÏ+Ï+Ïâ is presented. The search is carried out with a data set corresponding to an integrated luminosity of 1.0 fbâ1 collected in 2011 by the LHCb experiment in pp collisions at a centre-of-mass energy of 7 TeV. For the KâK+ÏâÏ+ final state, the four-body phase space is divided into 32 bins, each bin with approximately 1800 decays. The p-value under the hypothesis of no CP violation is 9.1%, and in no bin is a CP asymmetry greater than 6.5% observed. The phase space of the ÏâÏ+Ï+Ïâ final state is partitioned into 128 bins, each bin with approximately 2500 decays. The p-value under the hypothesis of no CP violation is 41%, and in no bin is a CP asymmetry greater than 5.5% observed. All results are consistent with the hypothesis of no CP violation at the current sensitivity
Observation of the decay B+câBÂșsÏ+
The result of a search for the decay B+câBÂșsÏ+ is presented, using the BÂșsâDs-Ï+ and BÂșsâJ/ÏÏ channels. The analysis is based on a data sample of pp collisions collected with the LHCb detector, corresponding to an integrated luminosity of 1ââfb-1 taken at a center-of-mass energy of 7 TeV, and 2ââfb-1 taken at 8 TeV. The decay B+câBÂșsÏ+ is observed with significance in excess of 5 standard deviations independently in both decay channels. The measured product of the ratio of cross sections and branching fraction is [Ï(Bc+)/Ï(BÂșs)]ĂB(Bc+âBÂșsÏ+)=[2.37±0.31â(stat)±0.11â(syst)-0.13+0.17(ÏBc+)]Ă10-3, in the pseudorapidity range 2<η(B)<5, where the first uncertainty is statistical, the second is systematic, and the third is due to the uncertainty on the Bc+ lifetime. This is the first observation of a B meson decaying to another B meson via the weak interaction
- âŠ