Práticas pedagógicas com tecnologias

O artigo aborda a experiência das bolsistas Adler Peggy Lima Aleixo e Lívia Lopes de Carvalho, em atividades do Projeto de Extensão de Ação Contínua Cátedra Unesco de Educação a Distância, do Departamento de Métodos e Técnicas da Faculdade de Educação (MTC/FE)

Hiperplasia Epitelial Focal / Focal epithelial hyperplasia

A hiperplasia epitelial focal é uma doença  rara, que afeta crianças adultos de diversas idades. Esta relacionada ao PAPILOMAVIRUS HUMANO (HPV) No qual o tipo 13 e 32 estao relacionado. Este artigo relata o caso de um paciente que chegou a Faculdade Metropolita de Manaus, com lesões multiplas, e bem caracteristica com a “pedra de calçamento”. Bem localizada nos labios superior e inferior

Copy number alterations associated with clinical features in an underrepresented population with breast cancer

As the most incident tumor among women worldwide, breast cancer is a heterogeneous disease. Tremendous efforts have been made to understand how tumor characteristics as histological type, molecular subtype, and tumor microenvironment collectively influence disease diagnosis to treatment, which impact outcomes. Differences between populations and environmental and cultural factors have impacts on the origin and evolution of the disease, as well as the therapeutic challenges that arise due to these factors. We, then, compared copy number variations (CNVs) in mucinous and nonmucinous luminal breast tumors from a Brazilian cohort to investigate major CNV imbalances in mucinous tumors versus non‐mucinous luminal tumors, taking into account their clinical and pathological features.48 breast tumor samples and 48 matched control blood samples from Brazilian women were assessed for CNVs by chromosome microarray. Logistic regression and random forest models were used in order to assess CNVs in chromosomal regions from tumors.CNVs that were identified in chromosomes 1, 5, 8, 17, 19, and 21 classify tumors according to their histological type, ethnicity, disease stage, and familial history.Copy number alterations described in this study provide a better understanding of the landscape of genomic aberrations in mucinous breast cancers that are associated with clinical features.77FAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulo2013/25683-3; 2015/18830-

Risk factors associated with death in Brazilian children with severe dengue: a case-control study

Objective: The purpose of this case-control study was to evaluate risk factors associated with death in children with severe dengue. Methods: The clinical condition of hospitalized patients with severe dengue who died (cases, n = 18) was compared with that of hospitalized patients with severe dengue who survived (controls, n = 77). The inclusion criteria for this study were age under 13 years; hospital admission in São Luis, northeastern Brazil; and laboratory-confirmed diagnosis of dengue. Results: Severe bleeding (hemoptysis), a defining criterion for dengue severity, was the factor most strongly associated with death in our study. We also found that epistaxis and persistent vomiting, both included as warning signs in the World Health Organization (WHO) classification of dengue, were strongly associated with death. No significant association was observed between any of the laboratory findings and death. Conclusions: The finding that epistaxis and persistent vomiting were also associated with death in children with severe dengue was unexpected and deserves to be explored in future studies. Because intensive care units are often limited in resource-poor settings, any information that can help to distinguish patients with severe dengue with a higher risk to progress to death may be crucial

Doença inflamatória pélvica: fisiopatologia, investigação diagnóstica e manejo terapêutico / Pelvic inflammatory disease: pathophysiology, diagnostic research and therapeutic management

A Doença Inflamatória Pélvica (DIP) é caracterizada pela inflamação do trato genital superior causada, na maioria das vezes, pela Neisseria gonorrhoeae e Chlamydia trachomatis. A afecção decorre da ascensão dos microrganismos do sistema genital inferior em direção ao útero, tubas uterinas e/ou ovários. De modo geral, a DIP gonocócica cursa com maior gravidade em relação aos demais agentes etiológicos causadores da afecção. Em contrapartida, a DIP causada pela C. trachomatis ocorre com maior frequência e costuma cursar com sintomatologia discreta e inespecífica, porém, assim como a DIP por N. gonorrhoeae, essa também pode causar danos significativos ao trato genital. O diagnóstico dessa afecção é predominantemente clínico e deve ser aventado diante de mulheres jovens com idade entre 15 a 25 anos, sexualmente ativas e que possuem múltiplos parceiros sexuais, queixando-se de dor abdominal ou pélvica. Quanto ao tratamento, deve ser instituído de maneira empírica quando houver suspeita clínico-epidemiológica compatível com a DIP, a fim de mitigar possíveis complicações a longo prazo, como taxas de gravidez ectópica e infertilidade por fator tubário

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis