Experiencias de aprendizaje en las competencias matemáticas de los estudiantes de secundaria de una institución educativa de Huancayo, 2023

El estudio tuvo como objetivo determinar la influencia de las experiencias de aprendizaje en el desarrollo de las competencias matemáticas de los estudiantes de una institución de Huancayo, 2023. El trabajo estuvo fundamentado en la teoría del aprendizaje experiencial donde la motivación brindada al estudiante de su contexto tiene un papel importante, fue de tipo experimental realizado en 31 estudiantes de educación secundaria donde se aplicó una prueba de matemáticas para medir el nivel de competencias de los estudiantes. Como resultados se obtuvieron que un 0.0% de los estudiantes después del experimento se encuentran en el nivel de inicio y que un 74.2% tienen el nivel de logro esperado cuando en un inicio se encontró un 3.2% de los estudiantes. Se obtuvo en el estudio un z = -4,878 con p-valor de 0,000 en la prueba de Wilcoxon concluyendo que las experiencias de aprendizaje influyen en el desarrollo de las competencias matemática

Linking endangerment databases and descriptive linguistics: An assessment of the use of terms relating to language endangerment in grammars

The world harbours a diversity of some 6,500 mutually unintelligible languages. As has been increasingly observed by linguists, many minority languages are becoming endangered and will be lost forever if not documented. The increased urgency has led to the development of several global endangerment databases and a more fine-grained understanding of the language endangerment progression as well as its possible reversal. In the present paper, we explore the terminological correlates of this development as found in the descriptive linguistic literature, using a corpus of over 10,000 digitized grammatical descriptions. Comparing this with existing endangerment databases, we find that simply counting terms related to endangerment does signal endangerment, but the degree of endangerment is more difficult to assess from grammatical descriptions. The label endangered seems to be an umbrella term that covers different situations ranging from moribund languages with less than ten speakers to minority languages with several thousand speakers. For many languages considered endangered in existing databases, explicit terms to this effect cannot be found in their descriptions. The discrepancy is due to incompleteness of the searchterm set, gaps in the literature, and projected rather than observed information in the databases. Our explorations illustrate the potential for database curation assisted by computational searches both to maintain accuracy of the databases and to investigate assumed language endangerment. Future work includes a larger cloud of search terms, usage of term frequencies, and prescreening of descriptive literature for the existence of a relevant section. From the perspective of descriptive linguistics, this study calls for a more careful correlation between the language endangerment indexes, as developed in the global endangerment databases, and the treatment of the endangerment status of individual languages in descriptive grammars.National Foreign Language Resource Cente

Planeamiento estratégico para el sistema de empresas financieras 2016-2025

La presente tesis desarrolla el plan estratégico del sector de empresas financieras peruano, sector que se considera muy potente para el desarrollo del sistema financiero nacional, ya que sus servicios están orientados a atender al sector socio económico menos desarrollado y con una cultura financiera en proceso de formación. La metodología empleada se basó en la revisión bibliográfica, así como publicaciones de actualidad, artículos académicos, bases de datos de interés nacional, mediante las cuales se pudo formar un criterio de análisis para el presente documento. Para llevar a cabo el plan estratégico se utilizó la estructura definida por D’Alessio (2015) en su libro El proceso estratégico: un enfoque de gerencia. El presente plan estratégico se desarrolla en base a los siguientes temas: (a) situación general del sistema de empresas financieras, (b) planteamiento de la visión, misión, valores y código de ética; (c) análisis externo, (d) análisis interno, (e) intereses del sector de empresas financieras peruanas y objetivos de largo plazo; (f) proceso estratégico, (g) implementación estratégica, (h) evaluación estratégica, (i) análisis de la competitividad del sector bancario peruano. El presente plan estratégico han sido definidas 11 estrategias y 4 objetivos de largo plazo, los cuales desarrollan diversas áreas de aprovechamiento del sector de empresas financieras en el Perú; con lo cual se espera potenciar su crecimiento y ayudar al desarrollo de los mercados financieros que conforman los niveles socio económicos C, D y E mediante la educación financiera, una mayor penetración de mercado y desarrollo de productos innovadores apoyados de las nuevas tecnologíasThis thesis develops the strategic plan of Peruvian financial corporate sector, a sector that is considered very powerful for the development of the domestic financial system because its services are aimed at addressing the socio-economic sector, less developed and a financial culture in the process of training. The methodology used was based on the literature review and current publications, academic articles, databases of national interest, through which could form a criterion of analysis for this document. To carry out the strategic plan the structure defined by Professor Fernando A. Dalessio Ipinza in his book The strategic process, a management approach was used. This strategic plan is developed based on the following topics: (a) General situation System of Financial Enterprises; (B) The approach of the vision, mission, values and code of ethics; (C) External analysis; (D) Internal analysis; (E) Interest Peruvian financial companies and long-term objectives sector; (F) Strategic Process; (G) strategic implementation; (H) Strategic Assessment; (I) Analysis of the Peruvian banking sector's competitiveness. This strategic plan have been defined 11 strategies and 4 long-term goals, which develop various areas of use in the sector of financial companies in Peru, which is expected to boost growth and help develop financial markets that make levels C, D and E socioeconomic, through financial education, greater market penetration and development of innovative products supported by new technologiesTesi

Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism

[Objective] To evaluate the taxonomic composition of the gut microbiome in gout patients with and without tophi formation, and predict bacterial functions that might have an impact on urate metabolism.[Methods] Hypervariable V3–V4 regions of the bacterial 16S rRNA gene from fecal samples of gout patients with and without tophi (n = 33 and n = 25, respectively) were sequenced and compared to fecal samples from 53 healthy controls. We explored predictive functional profiles using bioinformatics in order to identify differences in taxonomy and metabolic pathways. [Results] We identified a microbiome characterized by the lowest richness and a higher abundance of Phascolarctobacterium, Bacteroides, Akkermansia, and Ruminococcus_gnavus_group genera in patients with gout without tophi when compared to controls. The Proteobacteria phylum and the Escherichia-Shigella genus were more abundant in patients with tophaceous gout than in controls. Fold change analysis detected nine genera enriched in healthy controls compared to gout groups (Bifidobacterium, Butyricicoccus, Oscillobacter, Ruminococcaceae_UCG_010, Lachnospiraceae_ND2007_group, Haemophilus, Ruminococcus_1, Clostridium_sensu_stricto_1, and Ruminococcaceae_UGC_013). We found that the core microbiota of both gout groups shared Bacteroides caccae, Bacteroides stercoris ATCC 43183, and Bacteroides coprocola DSM 17136. These bacteria might perform functions linked to one-carbon metabolism, nucleotide binding, amino acid biosynthesis, and purine biosynthesis. Finally, we observed differences in key bacterial enzymes involved in urate synthesis, degradation, and elimination. [Conclusion] Our findings revealed that taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism.This study was supported by the Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra” and the Grant INF-2016-01-269675 from the Consejo Nacional de Ciencia y Tecnología (CONACYT)

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue

The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria. The CD4(+) T cell response to pneumococcus is increasingly recognised as an important mediator of immunity that protects against invasive disease, with data suggesting a critical role for Th17 cells in mucosal clearance. By assessing CD4 T cell proliferative responses we demonstrate age-related sequestration of Th1 and Th17 CD4(+) T cells reactive to pneumococcal protein antigens within mucosal lymphoid tissue. CD25(hi) T cell depletion and utilisation of pneumococcal specific MHCII tetramers revealed the presence of antigen specific Tregs that utilised CTLA-4 and PDL-1 surface molecules to suppress these responses. The balance between mucosal effector and regulatory CD4(+) T cell immunity is likely to be critical to pneumococcal commensalism and the prevention of unwanted pathology associated with carriage. However, if dysregulated, such responses may render the host more susceptible to invasive pneumococcal infection and adversely affect the successful implementation of both polysaccharide-conjugate and novel protein-based pneumococcal vaccines

Associations Between the Modified Food Standard Agency Nutrient Profiling System Dietary Index and Cardiovascular Risk Factors in an Elderly Population

Background: Helping consumers to improve the nutritional quality of their diet is a key public health action to prevent cardiovascular diseases (CVDs). The modified version of the Food Standard Agency Nutrient Profiling System Dietary Index (FSAm-NPS DI) underpinning the Nutri-Score front-of-pack label has been used in public health strategies to address the deleterious consequences of poor diets. This study aimed to assess the association between the FSAm-NPS DI and some CVD risk factors including body mass index (BMI), waist circumference, plasma glucose levels, triglyceride levels, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, and diastolic and systolic blood pressure. Materials and Methods: Dietary intake was assessed at baseline and after 1 year of follow-up using a 143-item validated semi-quantitative food-frequency questionnaire. Dietary indices based on FSAm-NPS applied at an individual level were computed to characterize the diet quality of 5,921 participants aged 55-75 years with overweight/obesity and metabolic syndrome from the PREDIMED-plus cohort. Associations between the FSAm-NPS DI and CVD risk factors were assessed using linear regression models. Results: Compared to participants with a higher nutritional quality of diet (measured by a lower FSAm-NPS DI at baseline or a decrease in FSAm-NPS DI after 1 year), those participants with a lower nutritional quality of diet (higher FSAm-NPS DI or an increase in score) showed a significant increase in the levels of plasma glucose, triglycerides, diastolic blood pressure, BMI, and waist circumference (beta coefficient [95% confidence interval]; P for trend) (1.67 [0.43, 2.90]; <0.001; 6.27 [2.46, 10.09]; <0.001; 0.56 [0.08, 1.05]; 0.001; 0.51 [0.41, 0.60]; <0.001; 1.19 [0.89, 1.50]; <0.001, respectively). No significant associations in relation to changes in HDL and LDL-cholesterol nor with systolic blood pressure were shown. Conclusion: This prospective cohort study suggests that the consumption of food items with a higher FSAm-NPS DI is associated with increased levels of several major risk factors for CVD including adiposity, fasting plasma glucose, triglycerides, and diastolic blood pressure. However, results must be cautiously interpreted because no significant prospective associations were identified for critical CVD risk factors, such as HDL and LDL-cholesterol, and systolic blood pressure

Associations Between the Modified Food Standard Agency Nutrient Profiling System Dietary Index and Cardiovascular Risk Factors in an Elderly Population

BackgroundHelping consumers to improve the nutritional quality of their diet is a key public health action to prevent cardiovascular diseases (CVDs). The modified version of the Food Standard Agency Nutrient Profiling System Dietary Index (FSAm-NPS DI) underpinning the Nutri-Score front-of-pack label has been used in public health strategies to address the deleterious consequences of poor diets. This study aimed to assess the association between the FSAm-NPS DI and some CVD risk factors including body mass index (BMI), waist circumference, plasma glucose levels, triglyceride levels, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, and diastolic and systolic blood pressure.Materials and MethodsDietary intake was assessed at baseline and after 1 year of follow-up using a 143-item validated semi-quantitative food-frequency questionnaire. Dietary indices based on FSAm-NPS applied at an individual level were computed to characterize the diet quality of 5,921 participants aged 55–75 years with overweight/obesity and metabolic syndrome from the PREDIMED-plus cohort. Associations between the FSAm-NPS DI and CVD risk factors were assessed using linear regression models.ResultsCompared to participants with a higher nutritional quality of diet (measured by a lower FSAm-NPS DI at baseline or a decrease in FSAm-NPS DI after 1 year), those participants with a lower nutritional quality of diet (higher FSAm-NPS DI or an increase in score) showed a significant increase in the levels of plasma glucose, triglycerides, diastolic blood pressure, BMI, and waist circumference (β coefficient [95% confidence interval]; P for trend) (1.67 [0.43, 2.90]; &lt;0.001; 6.27 [2.46, 10.09]; &lt;0.001; 0.56 [0.08, 1.05]; 0.001; 0.51 [0.41, 0.60]; &lt;0.001; 1.19 [0.89, 1.50]; &lt;0.001, respectively). No significant associations in relation to changes in HDL and LDL-cholesterol nor with systolic blood pressure were shown.ConclusionThis prospective cohort study suggests that the consumption of food items with a higher FSAm-NPS DI is associated with increased levels of several major risk factors for CVD including adiposity, fasting plasma glucose, triglycerides, and diastolic blood pressure. However, results must be cautiously interpreted because no significant prospective associations were identified for critical CVD risk factors, such as HDL and LDL-cholesterol, and systolic blood pressure

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia

Phagocytosis and inflammation within the lungs is crucial for host defense during bacterial pneumonia. Triggering receptor expressed on myeloid cells (TREM)-2 was proposed to negatively regulate TLR-mediated responses and enhance phagocytosis by macrophages, but the role of TREM-2 in respiratory tract infections is unknown. Here, we established the presence of TREM-2 on alveolar macrophages (AM) and explored the function of TREM-2 in the innate immune response to pneumococcal infection in vivo. Unexpectedly, we found Trem-2(-/-) AM to display augmented bacterial phagocytosis in vitro and in vivo compared to WT AM. Mechanistically, we detected that in the absence of TREM-2, pulmonary macrophages selectively produced elevated complement component 1q (C1q) levels. We found that these increased C1q levels depended on peroxisome proliferator-activated receptor-δ (PPAR-δ) activity and were responsible for the enhanced phagocytosis of bacteria. Upon infection with S. pneumoniae, Trem-2(-/-) mice exhibited an augmented bacterial clearance from lungs, decreased bacteremia and improved survival compared to their WT counterparts. This work is the first to disclose a role for TREM-2 in clinically relevant respiratory tract infections and demonstrates a previously unknown link between TREM-2 and opsonin production within the lungs

Engineered Superinfective Pf Phage Prevents Dissemination of Pseudomonas aeruginosa in a Mouse Burn Model

ABSTRACT Pf is a filamentous bacteriophage integrated in the chromosome of most clinical isolates of Pseudomonas aeruginosa. Under stress conditions, mutations occurring in the Pf genome result in the emergence of superinfective variants of Pf (SI-Pf) that are capable of circumventing phage immunity; therefore, SI-Pf can even infect Pf-lysogenized P. aeruginosa. Here, we identified specific mutations located between the repressor and the excisionase genes of Pf4 phage in the P. aeruginosa PAO1 strain that resulted in the emergence of SI-Pf. Based on these findings, we genetically engineered an SI-Pf (eSI-Pf) and tested it as a phage therapy tool for the treatment of life-threatening burn wound infections caused by PAO1. In validation experiments, eSI-Pf was able to infect PAO1 grown in a lawn as well as biofilms formed in vitro on polystyrene. eSI-Pf also infected PAO1 present in burned skin wounds on mice but was not capable of maintaining a sustained reduction in bacterial burden beyond 24 h. Despite not lowering bacterial burden in burned skin tissue, eSI-Pf treatment completely abolished the capability of P. aeruginosa to disseminate from the burn site to internal organs. Over the course of 10 days, this resulted in bacterial clearance and survival of all treated mice. We subsequently determined that eSI-Pf induced a small-colony variant of P. aeruginosa that was unable to disseminate systemically. This attenuated phenotype was due to profound changes in virulence determinant production and altered physiology. Our results suggest that eSI-Pf has potential as a phage therapy against highly recalcitrant antimicrobial-resistant P. aeruginosa infections of burn wounds. IMPORTANCE Pseudomonas aeruginosa is a major cause of burn-related infections. It is also the most likely bacterial infection to advance to sepsis and result in burn-linked death. Frequently, P. aeruginosa strains isolated from burn patients display a multidrug-resistant phenotype necessitating the development of new therapeutic strategies and prophylactic treatments. In this context, phage therapy using lytic phages has demonstrated exciting potential in the control P. aeruginosa infection. However, lytic phages can present a set of drawbacks during phage therapy, including the induction of bacterial resistance and limited bacteria-phage interactions in vivo. Here, we propose an alternative approach to interfere with P. aeruginosa pathogenesis in a burn infection model, i.e., by using an engineered superinfective filamentous phage. Our study demonstrates that treatment with the engineered Pf phage can prevent sepsis and death in a burn mouse model