Samuelson´s full duality and the use of directed acyclical graphs

To date, mixed demand systems have been all but ignored in empirical work. A possible reason for the scarcity of such applications is that one needs to know a priori which prices and quantities are endogenous in the mixed demand system. By using a directed acyclical graph (DAG), causal relationships among price and quantity variables are identified giving rise to a causally identified mixed demand system. A statistical comparison is made of the traditional Rotterdam model, a synthetic demand system, which subsumes the traditional Rotterdam model, and a Rotterdam mixed demand system identified through the use of a DAG. In this analysis, the respective demand systems consist of five products: steak, ground beef, beef roasts, pork, and chicken.directed acyclic graphs, mixed demand systems

SAMUELSON'S FULL DUALITY AND THE USE OF DIRECTED ACYCLICAL GRAPHS: THE BIRTH OF CAUSALLY IDENTIFIED DEMAND SYSTEMS

To date, mixed demand systems have been all but ignored in empirical work. A possible reason for the scarcity of such applications is that one needs to know a priori which prices and quantities are endogenous in the mixed demand system. By using a directed acyclical graph (DAG), causal relationships among price and quantity variables are identified giving rise to a causally identified demand system (CIDS). A statistical comparison is made of the traditional Rotterdam model with a Rotterdam mixed demand system identified through the use of a DAG. In this analysis, the respective Rotterdam demand systems consist of five products: steak, ground beef, roast beef, pork, and chicken.Demand and Price Analysis,

An Optoelectronic Adaptive Resonance Unit

The authors demonstrate a hardware implementation of the adaptive resonance theory ART 1 neural network architecture. The optoelectronic ART1 unit, is a novel application of an old device. This device-the 4-f or Van der Lugt correlator-has historically been used as a fast pattern classifier. Usually the correlation operation is employed as a matched filter, so that a maximum correlation peak corresponds to a well-matched pattern. The device described also uses the large peaks, but takes specific advantage of the fact that a zero-shift correlation is mathematically equivalent to a two-dimensional inner product. The authors describe a promising method for emulating an ART1 unit in optics. They review ART1 from an algorithmic point of view, which shows that inner products are a critical part of ART1. They then discuss its implementation, and show some experimental results. The device works by performing the most computationally intensive parts of the algorithm in optical hardware, and thus offers a suitable marriage of the strengths of electronics and optics

A Neural Architecture for Unsupervised Learning with Shift, Scale and Rotation Invariance, Efficient Software Simulation Heuristics, and Optoelectronic Implementation

A simple modification of the adaptive resonance theory (ART) neural network allows shift, scale and rotation invariant learning. The authors point out that this can be accomplished as a neural architecture by modifying the standard ART with hardwired interconnects that perform a Fourier-Mellin transform, and show how to modify the heuristics for efficient simulation of ART architectures to accomplish the additional innovation. Finally, they discuss the implementation of this in optoelectronic hardware, using a modification of the Van der Lugt optical correlato

An Optoelectronic Implementation of the Adaptive Resonance Neural Network

A solution to the problem of implementation of the adaptive resonance theory (ART) of neural networks that uses an optical correlator which allows the large body of correlator research to be leveraged in the implementation of ART is presented. The implementation takes advantage of the fact that one ART-based architecture, known as ART1, can be broken into several parts, some of which are better to implement in parallel. The control structure of ART, often regarded as its most complex part, is actually not very time consuming and can be done in electronics. The bottom-up and top-down gated pathways, however, are very time consuming to simulate and are difficult to implement directly in electronics due to the high number of interconnections. In addition to the design, the authors present experiments with a laboratory prototype to illustrate its feasibility and to discuss implementation details that arise in practice. This device can potentially outperform alternative implementations of ART1 by as much as two to three orders of magnitude in problems requiring especially large input field

Class dynamics of development: a methodological note

This article argues that class relations are constitutive of developmental processes and central to understanding inequality within and between countries. In doing so it illustrates and explains the diversity of the actually existing forms of class relations, and the ways in which they interplay with other social relations such as gender and ethnicity. This is part of a wider project to re- vitalise class analysis in the study of development problems and experiences

Global Patterns and Controls of Nutrient Immobilization On Decomposing Cellulose In Riverine Ecosystems

Microbes play a critical role in plant litter decomposition and influence the fate of carbon in rivers and riparian zones. When decomposing low-nutrient plant litter, microbes acquire nitrogen (N) and phosphorus (P) from the environment (i.e., nutrient immobilization), and this process is potentially sensitive to nutrient loading and changing climate. Nonetheless, environmental controls on immobilization are poorly understood because rates are also influenced by plant litter chemistry, which is coupled to the same environmental factors. Here we used a standardized, low-nutrient organic matter substrate (cotton strips) to quantify nutrient immobilization at 100 paired stream and riparian sites representing 11 biomes worldwide. Immobilization rates varied by three orders of magnitude, were greater in rivers than riparian zones, and were strongly correlated to decomposition rates. In rivers, P immobilization rates were controlled by surface water phosphate concentrations, but N immobilization rates were not related to inorganic N. The N:P of immobilized nutrients was tightly constrained to a molar ratio of 10:1 despite wide variation in surface water N:P. Immobilization rates were temperature-dependent in riparian zones but not related to temperature in rivers. However, in rivers nutrient supply ultimately controlled whether microbes could achieve the maximum expected decomposition rate at a given temperature

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice