Role of the Hereditary Thrombophilic Abnormalities in Retinal Vein Occlusions

Purpose: The aim of our study was to evaluate the relation between hereditary thrombophilic factors leading to coagulation disorders and retinal vein occlusion (RVO). Material and Methods: A total of 45 consecutive patients with RVO group and 42 healty subjects (Control group) were enrolled. The mean follow-up period was 15.2 +/- 5.5 months. The following investigations were performed in both groups: Factor V Leiden (FVL), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) enzyme mutations, antithrombin III, protein C and S activities, fibrinogen, factor VII and VIII levels, D-dimer, activated partial thromboplastin time and prothrombin time/INR, complete blood count, ESR and blood biochemistry. Results: Factor V leiden heterozygote mutation was found in four (9%) patients in RVO and one (2.4%) in Control groups. Homozygote FVL mutation and PT G20210A mutation were not found in neither of the groups. In the RVO group, 26 patients (57.8%) had MTHFR C677T heterozygote mutation and four (8.9%) had homozygote mutation. In the Control group 14 (33.3%) patients had MTHFR C677T heterozygote mutation and four (9.5%) had homozygote mutation. There was a significant difference in MTHFR C677T genotype distribution between the 2 groups (p = 0,032). The serum triglyceride, glucose, fibrinogen and ESR levels were significantly higher in patients compared to the controls Conclusion: We believe that, in addition to all related systemic and ophthalmological investigations, hematological screening tests to detect hypercoagulation should be performed while investigating the etiology in patients with RVO

Retinal Ven Tıkanıklıklarında Herediter Trombofilinin Rolü

Çalışmamızda retina ven tıkanıklıkları (RVT) ile koagülasyon bozukluklarına yol açan herediter trombofili faktörleri arasındaki ilişkiyi incelemeyi amaçladık. Materyal ve Metod: Çalışmamıza 45 hasta RVT grubu olarak, 42 sağlıklı olgu kontrol grubu olarak dahil edildi. Takip süresi ortalama 15.2±5.5 aydı. Her 2 grupta Faktör V Leiden (FVL), protrombin G20210A ve metilentetrahidrofolat redüktaz (MTHFR) enzim mutasyonu, antitrombin III, protein C ve S aktivitesi, fibrinojen, faktör VII ve VIII seviyeleri, Ddimer, aktive parsiel tromboplastin zamanı, protrombin zamanı/INR, CBC, ESR ve tam kan biyokimyası incelemeleri yapıldı. Bulgular: RVT grubunda 4 (%9), kontrol grubunda ise 1 (%2.4) olguda FVL heterozigot mutasyonu tespit edildi. Her 2 grupta da homozigot FVL mutasyonu ve PT G20210A mutasyonu tespit edilmedi. RVT grubunda 26 (%57.8) hastada heterozigot, 4 olguda (%8.9) homozigot MTHFR C677T mutasyonu tespit edildi. Kontrol grubunda ise 14 (%33.3) olguda heterozigot ve 4(%9.5) olguda ise homozigot MTHFR C677T mutasyonu vardı. Gruplar arasında MTHFR C677T mutasyonu açısından istatistiksel olarak anlamlı fark vardı (p=0,032). RVT grubunda serum trigliserid, glukoz , fibrinojen ve ESR seviyeleri kontrol grubuna göre belirgin olarak yüksek bulundu. Sonuç: RVT olan hastaların etyolojisini araştırırken tüm ilişkili sistemik ve oftalmolojik muayenenin yanısıra hiperkoagülasyon değerlendirmesi için hematolojik testlerin yapılması gerektiğini düşünmekteyizThe aim of our study was to evaluate the relation between hereditary thrombophilic factors leading to coagulation disorders and retinal vein occlusion (RVO). Material and Methods: A total of 45 consecutive patients with RVO group and 42 healty subjects (Control group) were enrolled. The mean follow-up period was 15.2±5.5 months. The following investigations were performed in both groups: Factor V Leiden (FVL), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) enzyme mutations, antithrombin III, protein C and S activities, fibrinogen, factor VII and VIII levels, D-dimer, activated partial thromboplastin time and prothrombin time/INR, complete blood count, ESR and blood biochemistry. Results: Factor V leiden heterozygote mutation was found in four (9%) patients in RVO and one (2.4%) in Control groups. Homozygote FVL mutation and PT G20210A mutation were not found in neither of the groups. In the RVO group, 26 patients (57.8%) had MTHFR C677T heterozygote mutation and four (8.9%) had homozygote mutation. In the Control group 14 (33.3%) patients had MTHFR C677T heterozygote mutation and four (9.5%) had homozygote mutation. There was a significant difference in MTHFR C677T genotype distribution between the 2 groups (p=0,032). The serum triglyceride, glucose, fibrinogen and ESR levels were significantly higher in patients compared to the controls Conclusion: We believe that, in addition to all related systemic and ophthalmological investigations, hematological screening tests to detect hypercoagulation should be performed while investigating the etiology in patients with RV

Gebelik ve Laktasyon Döneminde Ruhsal Bozukluklar ve Tedavisi

Ruhsal hastalıklar kadınlarda sıklıkla 18-45 yaşları arasındaki reprodüktif dönemde ortaya çıkmaktadır. Dolayısıyla gebelik ve postpartum dönem pek çok kadın için anksiyete bozukluğu, depresyon, yeme bozukluğu ve psikoz gibi ruhsal hastalıklara yatkınlığın arttığı bir dönem olabilmektedir. Bu yazıda gebelik ve laktasyon döneminde ruhsal bozukluklar ve tedavi seçenekleri güncel tedavi kılavuzları ışığında gözden geçirilmiştir. Gebelikte psikofarmakolojik tedavinin yararları ve riskleri dikkate alınmalı, teratojenite ve laktasyon riski göz önünde bulundurulmalıdır.  Gebelik ve laktasyon döneminde en düşük etkin dozda ve mümkünse tek ilaç kullanılmalıdır ve fetüs/bebek yakından izlenmelidir.Anahtar kelimeler: Gebelik ve laktasyon, ruhsal bozukluklar, tedavi, ilaç kullanımı, teratojenit

Aetiological factors and clinical findings in anterior uveitis

AMAÇ: Ön üveit tanısıyla takip ettiğimiz hastalarda etyolojik ve klinik özelliklerin incelenmesi. YÖNTEM: Kliniğimiz Üvea-immunoloji biriminde Ocak 1987-Aralık 2001 tarihleri arasında takibe alınmış olan tüm ön üveitli hastaların hikayeleri alınıp, bütün sistemik ve göz muayeneleri ile ön üveite yönelik gerekli laboratuar çalışmaları yapıldı. BULGULAR: Behçet hastalığı hariç tüm ön üveit hastaları etyolojik açıdan incelendiklerinde en sık görülen grubun Fuch's heterokromik üveiti (%10,74), ikinci sıklıkta ise seronegatif spondiloartropatiler (%10,07) ve daha sonra HLA-B27 pozitif üveitler (%7,38) olduğu görüldü. Doksan üç hastada (%62,42) ise etyolojik bir neden bulunamadı. Hastalarda ön segment bulguları açısından 105 hastada (%66,45) ön kamara reaksiyonu en sık bulgu olarak karşımıza çıkarken keratik presipitatlar 96 hastada (%60,75) ikinci sıklıkta görüldü. TARTIŞMA: Üveit çoğunlukla etyolojik açıdan ileri tetkiklerin yapılmasını gerektiren, bununla beraber sıklıkla bir nedenin bulunamadığı, göz komplikasyonlannın sık görüldüğü bir grup hastalıktır.PURPOSE: To evaluate the etiologic factors and clinical findings of patients with anterior uveitis. METHOD: Patients with anterior uveitis who were admitted and followed in the Uvea-immunology department of our clinic between January 1987 and December 2001 were included in this study. All their medical history was obtained and their ophthalmological and systemic examinations were performed in detail. Laboratory research necessary for the diagnosis of anterior uveitis was performed. RESULTS: When anterior uveitis, except for BehÇet's disease, was evaluated according to the etiological factors, Fuch's heterochromic uveitis was found to be the most common of all (10,74%), which was followed by seronegative spondylartropathies (10,07%) and uveitis with HLA-B27 followed the latter (7,38%). No etiological factor could be found in 93 patients (62,42%). When anterior segment examination findings were evaluated, tyndal was found to be the most common (66.45%) and the second was keratic precipitates (60.75%). CONCLUSION: Uveitis is mostly associated with ocular complications and requires more detailed clinical and laboratory examinations, although the etiological factor can not be found in some groups

Antibacterial Activity of Citrus limon Peel Essential Oil and Argania spinosa Oil Against Fish Pathogenic Bacteria

The main objective of the study was the identification of antibacterial activity of lemon (Citrus limon L.) peel essential oil and argan (Argania spinosa L.) oil against fish pathogenic bacteria. Antibacterial activity was determined against six different fish pathogens (Yersinia ruckeri, Aeromonas hydrophila, Listonella anguillarum, Edwarsiella tarda, Citrobacter freundii and Lactococcus garvieae). Essential oil derived from lemon peel and argan oil were applied against the bacteria using the disc diffusion and micro dilution method under in vitro conditions. The disc diffusion results indicated that essential oil of naturally C. limon peel and argan oil significantly inhibited the growth of Y. ruckeri, A. hydrophila, L. anguillarum and C. freundii. Our results suggested that the use of lemon peel essential oil and argan oil induced a stronger antibacterial effect

Correlation between 18F-FDG Positron-Emission Tomography 18F-FDG Uptake Levels at Diagnosis and Histopathologic and Immunohistochemical Factors in Patients with Breast Cancer

WOS: 000382992100004PubMed ID: 28331746Objective: In this study, we aimed to determine the correlation between pretreatment-staging 18F-FDG total body positron-emission tomography/computed tomography (PET/CT) maximum standardized uptake value (SUVmax) levels and histopathologic and immunohistochemical predictive and prognostic factors in patients with breast cancer. Materials and Methods: One hundred thirty-nine women with breast cancer who were treated between 2009 and 2015 at our hospital and who had pretreatment-staging PET/CT were included in the study. SUVmax levels and histopathologic and immunohistochemical results were compared. Results: The median age was 48 years (range, 29-79 years). The mean tumor diameter was 33.4 mm (range, 7-120 mm). The histology was invasive ductal carcinoma in 80.6% of the patients. In the univariate analysis, SUVmax levels were significantly higher in patients with invasive ductal carcinoma; in patients with a maximum tumor diameter more than 2 cm; patients who were estrogen, progesterone, and combined hormone receptor-negative, triple-negative patients, and in tumors with higher grades (p<0.05). In HER2-positive patients, SUVmax levels were higher even if it was not statistically significant. There was no correlation between lymph node metastases and pathologic stage. In multivariate analysis, tumor diameter was an independent factor. Conclusion: SUVmax levels are correlated with known histopathologic and immunohistochemical prognostic factors. PET/CT could be useful in preoperative evaluation of patients with breast cancer to predict biologic characteristics of tumors and prognosis

Neck and Wrist Circumferences Propose a Reliable Approach to Qualify Obesity and Insulin Resistance

Objective of this study is to evaluate the association of neck circumference and wrist circumference with traditional abdominal and general obesity measurement parameters, insulin resistance, insulin resistance-related factors such as blood lipids, fasting glucose, insulin concentration and adiponectin, in order to predict their values as obesity measurement parameters. Eighty six female and 20 male subjects between 18-75 years of age were included in the study. Body weight, height, waist, hip, neck and wrist circumferences were measured. Body mass index and waist-to-hip ratio were calculated. Laboratory parameters such as fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, insulin and adiponectin were measured after 12 hours of overnight fasting. Low density lipoprotein cholesterol and the insulin resistance index (HOMA-IR) were calculated. Neck circumference showed positive correlation with age, weight, body mass index, waist and hip circumferences, waist to hip ratio, wrist circumference, insulin, HOMA-IR and negative correlation with adiponectin and high density lipoprotein cholesterol in females and positive correlation with weight, body mass index, waist and hip circumferences, waist to hip ratio and negative correlation with adiponectin in males. Wrist circumference showed positive correlation with weight, body mass index, neck, waist and hip circumferences, waist to hip ratio, insulin, HOMA-IR and negative correlation with adiponectin, high density lipoprotein cholesterol in females. No correlation was found in male subjects. Neck circumference can be a reliable obesity and insulin resistance parameter in both genders. Wrist circumference requires further investigation for the classification of its possible position in obesity evaluation. [Med-Science 2014; 3(1.000): 1013-25