143 research outputs found

    Utopismo y guerra justa: La invasión de Irak en 2003

    Full text link
    This article examines one of the major foreign policy disasters of recent times: the American invasion of Iraq in 2003. It explores American policy in terms of the utopian attempt to create a perfect society in Iraq based on the American model. It will locate origins for American policy in Thomas More’s text and argue that, 500 years after the original publication, utopianism plays a vital role in global politics. American neoconservatism originates in two waves of reaction against the authoritarian utopianism of the revolutionary left, the first one in the 1930s and the second one –that founded neoconservatism proper – in the 1960s. Turning to standard American imagery, the neoconservatives concluded that moral renewal was the only way to return to the utopian vision of America’s founding fathers. It was thought that moral renewal within the USA could be encouraged by a strong foreign policy. The paper concludes is that utopias cannot be established through external forceEste artículo examina uno de los principales desastres de política exterior de los últimos tiempos: la invasión estadounidense de Irak en 2003. Explora la política estadounidense en términos del intento utópico de crear una sociedad perfecta en Iraq, basada en el modelo estadounidense. Localiza los orígenes de la política americana en el texto de Tomás Moro y argumenta que, 500 años después de la publicación original, el utopismo juega un papel vital en la política global. El neoconservadurismo estadounidense se origina en dos oleadas de reacción contra el utopismo autoritario de la izquierda revolucionaria: el primero en la década de 1930 y el segundo –que fundó el neoconservadurismo propiamente dicho– en los años sesenta. Pasando a la imaginación colectiva norteamericana, concluyeron que la renovación moral era la única forma de regresar a la visión utópica de los padres fundadores de los Estados Unidos. Se pensó que la renovación moral dentro de los EE. UU. podría ser alentada por una política exterior fuerte. La conclusión es que las utopías no se pueden establecer a través de la fuerza extern

    The Importance of Cosmology in Culture: Contexts and Consequences

    Get PDF
    Scientific cosmology is the study of the universe through astronomy and physics. However, cosmology also has a significant cultural impact. People construct anthropological cosmologies (notions about the way the world works), drawing in scientific theories in order to construct models for activities in disciplines, such as politics and psychology. In addition, the arts (literature, film and painting, for example) comment on cosmological ideas and use them to develop plot lines and content. This chapter illustrates examples of such work, arguing that scientific cosmology should be understood as a significant cultural influence

    Retinoids and the breast cancer cell cycle

    Full text link

    Editorial—Culture and Cosmos : The Marriage of Astronomy and Culture, Volume 21

    Get PDF
    This volume of Culture and Cosmos draws together a selection of papers delivered at the 24th annual conference of the European Society for Astronomy in Culture (SEAC). The conference, titled \u27The Marriage of Astronomy and Culture: Theory and Method in the Study of Cultural Astronomy\u27, occurred between the 12th and the 16th September 2016 and was held at The Bath Literary and Scientific Institution (BRLSI), which has been hosting research endeavours since it foundation in 1824. SEAC 2016 combined history with the latest in twenty-first century developments and, for the very first time, was webcast to SEAC members who could not attend, in addition to students of the MA in Cultural Astronomy and Astrology at the Sophia Centre University of Wales Trinity Saint David. The papers in this volume are organized around archaeology, ethnography, and images. These are available to download at http://www.cultureandcosmos.org/issues/vol21.php. Other papers from this conference appear in issue 3.2 (2017) of the Journal of Skyscape Archaeology

    Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs

    Get PDF
    Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Spliceosomes remove introns from primary gene transcripts. They assemble de novo on each intron through a series of steps that involve the incorporation of five snRNP particles and multiple non-snRNP proteins. In mammals, all the intermediate complexes have been characterized on one transcript (MINX), with the exception of the very first, complex E. We have purified this complex by two independent procedures using antibodies to either U1-A or PRPF40A proteins, which are known to associate at an early stage of assembly. We demonstrate that the purified complexes are functional in splicing using commitment assays. These complexes contain components expected to be in the E complex and a number of previously unrecognized factors, including survival of motor neurons (SMN) and proteins of the SMN-associated complex. Depletion of the SMN complex proteins from nuclear extracts inhibits formation of the E complex and causes non-productive complexes to accumulate. This suggests that the SMN complex stabilizes the association of U1 and U2 snRNPs with pre-mRNA. In addition, the antibody to PRPF40A precipitated U2 snRNPs from nuclear extracts, indicating that PRPF40A associates with U2 snRNPs

    Differential diagnosis of illness in travelers arriving from sierra Leone, Liberia, or guinea: A cross-sectional study from the Geosentinel surveillance network

    Get PDF
    Background: The largest-ever outbreak of Ebola virus disease (EVD), ongoing in West Africa since late 2013, has led to export of cases to Europe and North America. Clinicians encountering ill travelers arriving from countries with widespread Ebola virus transmission must be aware of alternate diagnoses associated with fever and other nonspecific symptoms. Objective: To define the spectrum of illness observed in persons returning from areas of West Africa where EVD transmission has been widespread. Design: Descriptive, using GeoSentinel records. Setting: 57 travel or tropical medicine clinics in 25 countries. Patients: 805 ill returned travelers and new mmigrants from Sierra Leone, Liberia, or Guinea seen between September 2009 and August 2014. Measurements: Frequencies of demographic and travelrelated characteristics and illnesses reported. Results: The most common specific diagnosis among 770 nonimmigrant travelers was malaria (n = 310 [40.3%]), with Plasmodium falciparum or severe malaria in 267 (86%) and non–P. falciparum malaria in 43 (14%). Acute diarrhea was the second most common diagnosis among nonimmigrant travelers (n= 95 [12.3%]). Such common diagnoses as upper respiratory tract infection, urinary tract infection, and influenza-like illness occurred in only 26, 9, and 7 returning travelers, respectively. Few instances of typhoid fever (n = 8), acute HIV infection (n = 5), and dengue (n = 2) were encountered. Limitation: Surveillance data collected by specialist clinics may not be representative of all ill returned travelers. Conclusion: Although EVD may currently drive clinical evaluation of ill travelers arriving from Sierra Leone, Liberia, and Guinea, clinicians must be aware of other more common, potentially fatal diseases. Malaria remains a common diagnosis among travelers seen at GeoSentinel sites. Prompt exclusion of malaria and other life-threatening conditions is critical to limiting morbidity and mortality

    Reflections on the Formation and Growth of the SURE Network: a National Disciplinary Network to Enhance Undergraduate Research in the Sciences

    Get PDF
    The Science Undergraduate Research Experience (SURE) Network is an academic network comprised of nine Higher Education Institutions (HEI) in Ireland that seeks to enhance the profile of, and practices in, undergraduate research in the Sciences within the Technological Higher Education Sector. This paper presents the reflections of the network\u27s leaders on the formation and growth of the network over the period from 2015, just prior to its establishment, to 2020 when the network hosted its seventh undergraduate research conference, published its second undergraduate journal issue, and initiated a coordinated community of practice in response to the Covid-19 crisis. The paper presents the motivations of the leaders for establishing and joining the SURE network, their interpretation of how involvement in the network enhances practice in their own HEI, their reflections on how their own personal development was enhanced, their interpretation of the factors that have contributed to the success of the network, and the direction in which they see the network going in the future. The collective reflections of the leaders of the SURE Network, as presented in this paper, provide importance guidance for those seeking to establish similar academic networks, both in the area of undergraduate research and elsewhere

    Beyond Paradigms in Cultural Astronomy. Proceedings of the 27th SEAC conference held together with the EAA

    Get PDF
    Proceedings of the 27th SEAC conference held together with the EAA.-- Editors: A. César González-García, Roslyn M. Frank, Lionel D. Sims, Michael A. Rappenglück, Georg Zotti, Juan A. Belmonte, Ivan Šprajc.Cultural Astronomy is the endeavour to understand the role of the sky in past and present societies, and how these societies incorporated the sky into their culture. This broad ranging discipline is closely related to archaeology when investigating material remains of the past. Cultural Astronomy also explores the role of the heavens from the perspectives of the anthropological sciences. In recent decades the discipline has been concerned with methodological and theoretical issues. This volume offers chapters based on presentations at the 27th SEAC meeting held in Bern (2019). These chapters provide a vivid image of front-line research in diverse areas, from Roman light and shadow effects to highlight power, to Maya city organization, Etruscan temple orientation or the ontology of the sky.Peer reviewe

    Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

    Get PDF
    We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10−5. We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10−17; including ADGC data, meta P = 5.0 × 10−21) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10−14; including ADGC data, meta P = 1.2 × 10−16) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10−4; including ADGC data, meta P = 8.6 × 10−9), CD33 (GERAD+, P = 2.2 × 10−4; including ADGC data, meta P = 1.6 × 10−9) and EPHA1 (GERAD+, P = 3.4 × 10−4; including ADGC data, meta P = 6.0 × 10−10)
    corecore