Higher Quality at Lower Cost: Community Health Worker Interventions in the Health Care Innovation Awards

Background: Published evidence regarding cost savings, reduced utilization, and improved quality associated with employing community health workers (CHWs) is largely lacking. This paper presents findings from the Centers for Medicare & Medicaid Services Health Care Innovation Awards (HCIA), with a focus on six diverse programs that employ CHWs. We examine outcomes associated with programs incorporating CHWs into care teams for a broad age range of patients with various health issues such as cancer, asthma, and complex conditions. Methods: This mixed-methods study used data from claims and site visits to assess the effectiveness of CHW programs. In difference-in-differences analyses of Medicare fee-for-service and Medicaid claims, we compared utilization and spending for beneficiaries participating in each CHW program with propensity score matched non-participant beneficiaries for baseline (2010 – 2012) and post-intervention (2013 – 2016). We adjusted for geographic area, prior utilization, and clinical and sociodemographic characteristics. We assessed changes in care quality through beneficiary focus groups and interviews with program leadership and staff. Results: Five of the six programs saw a significant reduction in utilization and/or spending relative to a comparison group, and all programs had positive qualitative findings regarding quality of care. In three of the six programs, the adjusted total cost of care was significantly reduced (-$143 to -$2,044 per beneficiary quarter). We hypothesize that some reductions in spending can be attributed to CHWs’ provision of enhanced access outside of regular clinic hours, which facilitated patient adherence to evidence-based treatment pathways and averted unnecessary ED visits and hospitalizations. Culturally competent CHW encounters engaged patients in health care decisions, generated confidence in their decisions, encouraged adherence to treatment pathways, and mitigated social barriers to care. Conclusions: Programs were associated with improved quality and reductions in health care utilization and spending up to $20,000 per patient over the three-year period. Findings suggest a strong business case for the use of CHWs as part of interdisciplinary teams as CHW programs can provide a significant return on investment for payers. Reimbursement policies that do not account for the services of non-clinical staff such as CHWs impede the sustainability and spread of these interventions, despite mounting evidence of CHWs’ effectiveness. Organizations looking to integrate CHWs into care delivery may conduct feasibility assessments of available workforce and the capacity for clinical oversight, physician buy-in, and funding sustainability. Established programs could be leveraged for mentorship

A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria

To broadly explore mitochondrial structure and function as well as the communication of mitochondria with other cellular pathways, we constructed a quantitative, high-density genetic interaction map (the MITO-MAP) in Saccharomyces cerevisiae. The MITO-MAP provides a comprehensive view of mitochondrial function including insights into the activity of uncharacterized mitochondrial proteins and the functional connection between mitochondria and the ER. The MITO-MAP also reveals a large inner membrane–associated complex, which we term MitOS for mitochondrial organizing structure, comprised of Fcj1/Mitofilin, a conserved inner membrane protein, and five additional components. MitOS physically and functionally interacts with both outer and inner membrane components and localizes to extended structures that wrap around the inner membrane. We show that MitOS acts in concert with ATP synthase dimers to organize the inner membrane and promote normal mitochondrial morphology. We propose that MitOS acts as a conserved mitochondrial skeletal structure that differentiates regions of the inner membrane to establish the normal internal architecture of mitochondria