166 research outputs found
Spectroscopy of Isolated Prebiotic Nucleobases
We use multiphoton ionization and double resonance spectroscopy to study the excited state dynamics of biologically relevant molecules as well as prebiotic nucleobases, isolated in the gas phase. Molecules that are biologically relevant to life today tend to exhibit short excited state lifetimes compared to similar but non-biologically relevant analogs. The mechanism is internal conversion, which may help protect the biologically active molecules from UV damage. This process is governed by conical intersections that depend very strongly on molecular structure. Therefore we have studied purines and pyrimidines with systematic variations of structure, including substitutions, tautomeric forms, and cluster structures that represent different base pair binding motifs. These structural variations also include possible alternate base pairs that may shed light on prebiotic chemistry. With this in mind we have begun to probe the ultrafast dynamics of molecules that exhibit very short excited states and search for evidence of internal conversions
The Grizzly, March 5, 2009
Memorable Performance Depicts Life of Anne Frank âą Batter Up! Baseball Hopes for Home Run Season âą Cheapest Trip to Italy âą Young Invincibles Shun Medical Care âą Black in History: Tribute to Debbie Allen âą Money, Sex, Faith, Health and a True Happiness Formula? âą Finding Inspiration on the Back of Your Dove Chocolate Wrapper âą Opinions: Updike\u27s Death Calls for a Greater Appreciation for His Life âą Senior Leatherman Hurdles Into Eighth and Final Season at UChttps://digitalcommons.ursinus.edu/grizzlynews/1782/thumbnail.jp
The Grizzly, September 11, 2008
Republican National Convention Rallies Supporters âą Studies Show Half of College Students Contemplate Suicide âą Start of New Now on View Art Film Festival âą Science, Strife and Speculation of Hurricane Season \u2708 âą UC Senior Implements First Ever Bike Share Program âą Cinematic Guild Brings Creative Filmography to Campus âą Introducing Cassandra Aguilar âą The Grizzly Catches Up with Dean Nolan âą Celebrating Herencia Latina Fall Events âą Molly Maguire\u27s: A Bit O\u27 Irish Spirit âą UC Women\u27s Soccer Fights for Another Strong Season âą Football\u27s New Motto: No Interceptions, No Exceptionshttps://digitalcommons.ursinus.edu/grizzlynews/1767/thumbnail.jp
The Grizzly, October 30, 2008
Sounds of NYC Poet Tracie Morris âą Plan to Vote? UC Students Take Note: Polling Location Change âą Business Management Students Assist Charitable Causes âą Colin Powell Publicly Endorses Obama âą Young and Engaged: Planning for Life Beyond UC Years âą Hingston of Philadelphia Speaks at UC âą Faculty Spotlight on Philosophy Professor Kelly Sorensen âą More from Students Studying Abroad: UC in Germany âą Opinions: We Will Overcome: Positive Psychology in America; Logical Reason Behind Refusal to Vote; Controversy for the Republicans âą Football Quarterback Nick Dye Great Leader for Young Team âą Kelly Hosier: Sole, Shy Senior on UC Women\u27s Volleyball Teamhttps://digitalcommons.ursinus.edu/grizzlynews/1773/thumbnail.jp
Early Neolithic wine of Georgia in the South Caucasus
Chemical analyses of ancient organic compounds absorbed into the pottery fabrics from sites in Georgia in the South Caucasus region, dating to the early Neolithic period (ca. 6,000-5,000 BC), provide the earliest biomolecular archaeological evidence for grape wine and viniculture from the Near East, at ca. 6,000-5,800 BC. The chemical findings are corroborated by climatic and environmental reconstruction, together with archaeobotanical evidence, including grape pollen, starch, and epidermal remains associated with a jar of similar type and date. The very large-capacity jars, some of the earliest pottery made in the Near East, probably served as combination fermentation, aging, and serving vessels. They are the most numerous pottery type at many sites comprising the so-called "Shulaveri-Shomutepe Culture" of the Neolithic period, which extends into western Azerbaijan and northern Armenia. The discovery of early sixth millennium BC grape wine in this region is crucial to the later history of wine in Europe and the rest of the world
Implicit Review Instrument to Evaluate Quality of Care Delivered by Physicians to Children in Emergency Departments
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144238/1/hesr12800_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144238/2/hesr12800.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144238/3/hesr12800-sup-0001-AppendixSA1.pd
Risk Factors for and Prediction of Post-Intubation Hypotension in Critically Ill Adults: A Multicenter Prospective Cohort Study
OBJECTIVE: Hypotension following endotracheal intubation in the ICU is associated with poor outcomes. There is no formal prediction tool to help estimate the onset of this hemodynamic compromise. Our objective was to derive and validate a prediction model for immediate hypotension following endotracheal intubation.
METHODS: A multicenter, prospective, cohort study enrolling 934 adults who underwent endotracheal intubation across 16 medical/surgical ICUs in the United States from July 2015-January 2017 was conducted to derive and validate a prediction model for immediate hypotension following endotracheal intubation. We defined hypotension as: 1) mean arterial pressure \u3c 65 mmHg; 2) systolic blood pressure \u3c 80 mmHg and/or decrease in systolic blood pressure of 40% from baseline; 3) or the initiation or increase in any vasopressor in the 30 minutes following endotracheal intubation.
RESULTS: Post-intubation hypotension developed in 344 (36.8%) patients. In the full cohort, 11 variables were independently associated with hypotension: increasing illness severity; increasing age; sepsis diagnosis; endotracheal intubation in the setting of cardiac arrest, mean arterial pressure \u3c 65 mmHg, and acute respiratory failure; diuretic use 24 hours preceding endotracheal intubation; decreasing systolic blood pressure from 130 mmHg; catecholamine and phenylephrine use immediately prior to endotracheal intubation; and use of etomidate during endotracheal intubation. A model excluding unstable patientsâ pre-intubation (those receiving catecholamine vasopressors and/or who were intubated in the setting of cardiac arrest) was also developed and included the above variables with the exception of sepsis and etomidate. In the full cohort, the 11 variable model had a C-statistic of 0.75 (95% CI 0.72, 0.78). In the stable cohort, the 7 variable model C-statistic was 0.71 (95% CI 0.67, 0.75). In both cohorts, a clinical risk score was developed stratifying patientsâ risk of hypotension.
CONCLUSIONS: A novel multivariable risk score predicted post-intubation hypotension with accuracy in both unstable and stable critically ill patients.
STUDY REGISTRATION: Clinicaltrials.gov identifier: NCT02508948 and Registered Report Identifier: RR2-10.2196/11101
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
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