The age, origin and emplacement of the Tsiknias Ophiolite, Tinos, Greece

The Tsiknias Ophiolite, exposed at the highest structural levels of Tinos, Greece, represents a thrust sheet of Tethyan oceanic crust and upper mantle emplaced onto the Attic‐Cycladic Massif. We present new field observations and a new geological map of Tinos, integrated with petrology, THERMOCALC phase diagram modelling, U–Pb geochronology and whole rock geochemistry, resulting in a tectono‐thermal model that describes the formation and emplacement of the Tsiknias Ophiolite and newly identified underlying metamorphic sole. The ophiolite comprises a succession of partially dismembered and structurally repeated ultramafic and gabbroic rocks that represent the Moho Transition Zone. A plagiogranite dated by U‐Pb zircon at 161.9 ± 2.8 Ma, reveals that the Tsiknias Ophiolite formed in a supra‐subduction zone setting, comparable to the “East‐Vardar Ophiolites”, and was intruded by gabbros at 144.4 ± 5.6 Ma. Strongly sheared metamorphic sole rocks show a condensed and inverted metamorphic gradient, from partially anatectic amphibolites at P–T conditions of ca. 8.5 kbar 850‐600 °C, down‐structural section to greenschist‐facies oceanic metasediments over ~250 m. Leucosomes generated by partial melting of the uppermost sole amphibolite, yielded a U–Pb zircon protolith age of ca. 190 Ma and a high‐grade metamorphic‐anatectic age of 74.0 ± 3.5 Ma associated with ophiolite emplacement. The Tsiknias Ophiolite was therefore obducted ~90 Myrs after it formed during initiation of a NE‐dipping intra‐oceanic subduction zone to the northeast of the Cyclades that coincides with Africa's plate motion changing from transcurrent to convergent. Continued subduction resulted in high‐pressure metamorphism of the Cycladic continental margin ~25 Myrs later

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an acylguanidine that was developed following a whole-cell screen with compounds known to hit high-value targets in human cells. MMV688533 displays fast parasite clearance in vitro and is not cross-resistant with known antimalarials. In a P. falciparum NSG mouse model, MMV688533 displays a long-lasting pharmacokinetic profile and excellent safety. Selection studies reveal a low propensity for resistance, with modest loss of potency mediated by point mutations in PfACG1 and PfEHD. These proteins are implicated in intracellular trafficking, lipid utilization, and endocytosis, suggesting interference with these pathways as a potential mode of action. This preclinical candidate may offer the potential for a single low-dose cure for malaria

L'occupation du Néolithique moyen II de Champ Lamet 3 à Pont-du-Château (Puy-de-Dôme, Auvergne)

National audienc

Symmetric Multimodal Mapping of Ex Vivo Cardiac Microstructure of Large Mammalian Whole Hearts for Volumetric Comparison of Myofiber Orientation Estimated from Diffusion MRI and MicroCT

Description of the cardiac myofiber architecture in pathological or even physiological conditions is essential for image-based modeling in electrophysiology or mechanical studies. While diffusion tensor imaging (DTI) is one of the best modalities to capture myofiber orientation of large mammalian hearts, validations of putative myofiber’s main orientation from DTI in whole hearts of large mammals is limited. First we design an experimental protocol for sheep (N = 1) and human (N = 1) whole hearts that combine a standardized sample preparation with high-resolution diffusion MRI at 600 µm3 using low angular resolution (6 directions) followed by a tissue air-drying approach coupled with X-ray imaging at 42 µm3. Secondly, we propose a standardized post-processing pipeline for symmetric multimodal mapping allowing the comparison of myofiber orientation computed from DTI and structure tensor imaging (STI), respectively. We then identified region-of-interest (ROI) exhibiting small or sharp spatial variations in myofiber orientation and compared the putative myofiber orientation for both methods. In conclusion, we show a good correspondence of structural features between the two imaging modalities and identify new unexpected and complex cardiomyocytes organization such as oscillating patterns or clear separation of opposing fiber-bundles

La nécropole Bronze ancien de Gerzat, Chantemerle (Puy-de-Dôme)

Au lieu-dit « Chantemerle », sur la commune de Gerzat (Puy-de-Dôme), un ensemble funéraire composé de six enclos circulaires, d'un enclos ovale et de 72 tombes contenant les restes de 83 individus a été fouillé préventivement durant le printemps et l'été 2001. Il couvre une surface d'environ 6 000 m2. Les perspectives d'étude sont très favorables dans la mesure où l'on peut estimer que la fouille a touché la majeure partie de la nécropole au vu de la densité et de la répartition des tombes. L’aménagement des 72 tombes varie du simple contenant à parois rigides (coffres) à des constructions complexes comportant à la fois un dallage aménagé sur le fond de la fosse, un contenant à parois rigides (coffre), un blocage massif (calage du coffre) et un système de signalisation de surface composé d'un ou plusieurs blocs de basalte. L'élément structurant de cet ensemble semble résider dans la position et l'orientation des individus inhumés qui reposent, le plus souvent, la tête tournée vers le sud. Au-delà de ce constat, le choix du mode d'inhumation (fosse aménagée, contenant rigide ou souple, pleine terre, association de mobilier) ne laisse rien au hasard. La combinaison des différents critères descriptifs (anthropologiques, architecturaux, dépôts mobiles) a montré des cas récurrents d'associations. Il a été possible de dégager des axes et des groupes structurants au plan spatial qui ont pu être confrontés aux données de la chronométrie fournies par les radiodatations et l'étude du mobilier céramique et métallique essentiellement. Ainsi, au terme d'une publication minutieuse des constats et arguments, c'est l'histoire globale de cette nécropole, avec ses modalités de recrutement et le statut des individus, qui est mise en évidence. Cet ensemble sépulcral revêt un caractère exceptionnel par des contours connus, une trame d'organisation spatiale, une longue durée d'utilisation, le nombre et la nature variée des sépultures, une bonne conservation globale des restes osseux, un mobilier particulier. Son étude ouvre de nouvelles perspectives dans l'approche des pratiques funéraires et dans la perception de l'organisation sociale et des courants culturels qui ont marqué cette communauté du centre de la France. Son intérêt dépasse les frontières nationales et place la nécropole de Gerzat Chantemerle parmi les sites de référence européens du Bronze ancien

Copy Book Art

In his introduction to this unconventional catalogue - which is also a Copy Art book composed of images and texts by 58 artists -, Huemer reflects on the development of photocopy as an art medium, and outlines his reasons for choosing the Maerz gallery as exhibition site. Biographical notes. Circa 223 bibl. ref

L’établissement de Pratz le Curtillet: Un domaine mérovingien dans les hautes terres jurassiennes (fin VIe-VIIe siècle)

National audienceAmong the earliest habitats of the early Middle Ages studied in Franche-Comté, the Pratz le Curtillet a settlement sets itself apart by its location in the Jura highlands, renowned for its remoteness and inhospitable landscapes. On the Lizon plateau, the scope of the archaeological work explored on the 16 hectares and the quality of the remains still constitute an exceptional complex today. An imposing 16m by 13m stone building flanked by an annex forms the residential part of the estate, while sheltering fodder and livestock, while the second building houses a forge. Domestic and artisanal equipment provide ample documentation on the living conditions of this small community of high status due to its involvement in the iron economy. Studies undertaken at different scales in a territory where one of the earliest monastic communities in Gaule is located, not far from a route crossing the massif, contribute to setting precious milestones for this period.Parmi les tout premiers habitats du haut Moyen Âge étudiés en Franche-Comté, l’établissement de Pratz le Curtillet se distingue par son implantation dans les hautes terres jurassiennes, longtemps réputées comme reculées et inhospitalières. L’envergure des travaux archéologiques sur les 16 hectares explorés du plateau du Lizon et la qualité des vestiges font aujourd’hui encore exception. Un imposant édifice en pierre de 16 m sur 13 flanqué d’une annexe constitue la partie résidentielle du domaine, tout en abritant fourrage et bétail, alors que le second bâtiment accueille une forge. Les équipements domestiques et artisanaux livrent une ample documentation sur les conditions de vie de cette petite communauté de statut élevé, lié à son implication dans l’économie du fer. Les études engagées à différentes échelles dans un territoire où s’installe une communauté monastique parmi les plus précoces de Gaule, non loin d’un itinéraire de franchissement du massif, contribuent à poser de précieux jalons pour cette période

Characterization of the Septal Discontinuity in Ex-Vivo Human Hearts Using Diffusion Tensor Imaging: The Potential Structural Determinism Played by Fiber Orientation in Clinical Phenotype of Laminopathy Patients

A key component of the cardiac conduction system is the atrioventricular (AV) node where the His bundle (HB) divides into the right (RBB) and left (LBB) bundles branches. The RBB is connected to the right ventricle (RV) via the moderator band (MB)