A higher quantum bound for the V\'ertesi-Bene-Bell-inequality and the role of POVMs regarding its threshold detection efficiency

Recently, V\'{e}rtesi and Bene [Phys. Rev. A. {\bf 82}, 062115 (2010)] derived a two-qubit Bell inequality, $I_{CH3}$, which they show to be maximally violated only when more general positive operator valued measures (POVMs) are used instead of the usual von Neumann measurements. Here we consider a general parametrization for the three-element-POVM involved in the Bell test and obtain a higher quantum bound for the $I_{CH3}$-inequality. With a higher quantum bound for $I_{CH3}$, we investigate if there is an experimental setup that can be used for observing that POVMs give higher violations in Bell tests based on this inequality. We analyze the maximum errors supported by the inequality to identify a source of entangled photons that can be used for the test. Then, we study if POVMs are also relevant in the more realistic case that partially entangled states are used in the experiment. Finally, we investigate which are the required efficiencies of the $I_{CH3}$-inequality, and the type of measurements involved, for closing the detection loophole. We obtain that POVMs allow for the lowest threshold detection efficiency, and that it is comparable to the minimal (in the case of two-qubits) required detection efficiency of the Clauser-Horne-Bell-inequality.Comment: 11 Pages, 16 Figure

MethOds and tools for comprehensive impact Assessment of the CCAM solutions for passengers and goods. D1.1: CCAM solutions review and gaps

Review of the state-of-the-art on Cooperative, Connected and Automated mobility use cases, scenarios, business models, Key Performance Indicators, impact evaluation methods, technologies, and user needs (for organisations & citizens)

Cooperative, Connected and Automated Mobility - primary and secondary data

This report presents materials to collect information on the impacts of autonomous vehicles through a series of engagement activities with citizens and organisations in 8 European countries. The materials include: 1) questionnaires about current travel behaviour and attitudes and levels of awareness and intentions towards autonomous vehicles. 2) materials used in the co-creation of use cases and business models for autonomous vehicles for passenger and freight transport 3) material used in focus groups exploring impacts of autonomous vehicles 4) topic guides for in-depth interviews with organisations 5) questionnaires assessing the experience of participants in a real-world demonstration of autonomous vehicles 6) virtual reality scenarios of autonomous cars and buses and related questionnaires and focus groups topic guides 7) a large-scale online survey The report also details secondary data used to supplement the modelling of the inter-relationships between different types of impacts of autonomous vehicles

TOI-150: A transiting hot Jupiter in the TESS southern CVZ

We report the detection of a hot Jupiter ($M_{p}=1.75_{-0.17}^{+0.14}\ M_{J}$,$R_{p}=1.38\pm0.04\ R_{J}$) orbiting a middle-aged star ($\log g=4.152^{+0.030}_{-0.043}$) in the Transiting Exoplanet Survey Satellite (TESS) southern continuous viewing zone ($\beta=-79.59^{\circ}$). We confirm the planetary nature of the candidate TOI-150.01 using radial velocity observations from the APOGEE-2 South spectrograph and the Carnegie Planet Finder Spectrograph, ground-based photometric observations from the robotic Three-hundred MilliMeter Telescope at Las Campanas Observatory, and Gaia distance estimates. Large-scale spectroscopic surveys, such as APOGEE/APOGEE-2, now have sufficient radial velocity precision to directly confirm the signature of giant exoplanets, making such data sets valuable tools in the TESS era. Continual monitoring of TOI-150 by TESS can reveal additional planets and subsequent observations can provide insights into planetary system architectures involving a hot Jupiter around a star about halfway through its main-sequence life.Comment: 13 pages, 3 figures, 2 tables, accepted to ApJ

ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis, chemoresistance and metastasis. While eliminating this subpopulation of cells would theoretically result in tumor eradication, PaCSCs are extremely plastic and can successfully adapt to targeted therapies. In this study, we demonstrate that PaCSCs increase expression of interferon-stimulated gene 15 (ISG15) and protein ISGylation, which are essential for maintaining their metabolic plasticity. CRISPR-mediated ISG15 genomic editing reduces overall ISGylation, impairing PaCSCs self-renewal and their in vivo tumorigenic capacity. At the molecular level, ISG15 loss results in decreased mitochondrial ISGylation concomitant with increased accumulation of dysfunctional mitochondria, reduced oxidative phosphorylation (OXPHOS) and impaired mitophagy. Importantly, disruption in mitochondrial metabolism affects PaCSC metabolic plasticity, making them susceptible to prolonged inhibition with metformin in vivo. Thus, ISGylation is critical for optimal and efficient OXPHOS by ensuring the recycling of dysfunctional mitochondria, and when absent, a dysregulation in mitophagy occurs that negatively impacts PaCSC stemness

Food security through translational biology between wheat and rice

Wheat and rice are the most important food crops in agriculture providing around 50% of all calories consumed in the human diet. While both are C3 species, the evolution and domestication of wheat and rice occurred in very different environments, resulting in diverse anatomical and metabolic adaptation. This review focuses on the current understanding of their adaptation in an agronomic context. The similarities and differences between wheat and rice are discussed, focusing on traits related to phenology, photosynthesis, assimilate partitioning, and lodging resistance, these being the main abiotic drivers of yield expression in most agro‐ecosystems. Currently, there are significant knowledge gaps in the major biological processes that account not only for differential adaption among cultivars within each species, but even between the two species. By addressing what is known as well as where gaps exist in a comparative context, this review aims to highlight translational research approaches that could provide insights into the genetic improvement of both crops

A walk in the PARC:developing and implementing 21st century chemical risk assessment in Europe

Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety