49 research outputs found
Alimentos funcionales para cerdos al destete
- Author
- Publication venue
- 'Universidad Nacional Autonoma de Mexico'
- Publication date
- 01/01/2006
- Field of study
A functional food is a compound that, being or not a nutrient, has a positive effect on one or several functions in the organism, producing well-being in the animal. The following compounds are considered functional foods: prebiotics, probiotics, symbiotics, antioxidants, secondary products of plant metabolism, structural lipids, polyunsaturated fatty acids, fat metabolism byproducts, bioactive peptides, fi ber, vitamins and minerals. Prebiotics, probiotics and symbiotics are modifi ers of the intestinal microfl ora increasing mainly lactobacilli and bifi dobacteria populations and reducing pathogenic bacteria. Lactobacilli and bifi - dobacteria use oligosaccharides and fructo-oligosaccharides arriving at the colon, producing fatty acids and freeing minerals to be absorbed and utilized by the host. Prebiotics are partially-digestible oligosaccharides; probiotics are microorganisms (mainly lactobacilli and bifi dobacteria); and symbiotics are a mixture of probiotics and prebiotics. During the weaning period, piglets face dramatic changes in feeding management and environment, affecting feed intake and, at the same time, affecting digestive functions resulting in lower growth and higher incidence of disease, mainly diarrhea. Functional food may be an alternative to reduce the effects of weaning on growth performance and health of piglets, to diminish or to avoid gastrointestinal problems during weaning, preventing the proliferation of pathogenic bacteria, and improving digestive functions. All these may help to withdraw antibiotics from piglet feed
Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study
- Author
- Agresta Ferdinando
- Ajawin Pawel
- Al Amri Nadiah
- al-Najami Issam
- AlAamer Ohood
- Alconchel Felipe
- Alghamdi Abdulrahman
- Alharthi Qasem
- Alhazmi Ahmad
- Ali Mazin
- Ali Mujahid
- Almalki Abdulrahman
- Alselaim Nahar
- Alshamrani Abdullah
- Alsherif Omar
- Alsofyani Fahad
- Alsufyani Ahmed
- Althobaiti Shabab
- AlThomali Musab
- Altinel Yuksel
- Alturkistani Abdullah
- Andriola Valeria
- André Ana
- Angelico Roberta
- Angrisani Marco
- Anoldo Pietro
- Anselmo Alessandro
- Antonacci Nicola
- Argenio Giulio
- Arredondo Gerardo
- Avila Mercado Octavio
- Awad Selmy
- Azfar Mohammad
- Bacchiocchi Giulia
- Bagaglini Giulia
- Baili Efstratia
- Balciscueta Izaskun
- Balciscueta Zutoia
- Bandin Alfonso
- Barcenas Francisco Javier Quezada
- Baroffio Paolo
- Bavikatte Akshay
- Bechstein Wolf
- Bekele Kebebe
- Bellanova Giovanni
- Bellato Vittoria
- Bellido Juan
- Bellini Maria Irene
- Benli Sami
- Benzoni Enrico
- Blanco-Antona Francisco
- Bonavina Luigi
- Bondurri Andrea
- Bouhuwaish Ahmad
- Bozbiyik Osman
- Brady Richard
- Brillantino Antonio
- Brisinda Giuseppe
- Buonomi Oreste Claudio
- Cabrera Vargas Luis Felipe
- Calderón Duque Teresa
- Calini Giacomo
- Calussi Marco
- Campagnaro Tommaso
- Campanelli Michela
- Cardamone Eugenia
- Caruso Riccardo
- Castaldi Antonio
- Catarci Marco
- Celentano Valerio
- Cerdán Carlos
- Chacón Carlos Petrola
- Charalabopoulos Alexandros
- Chessa Antonella
- Chiappetta Sonja
- Chiarello Maria Michela
- Cillara Nicola
- Colombo Francesco
- Colucci Gianluca
- Colás-Ruiz Enrique
- Conti Luigi
- Cordera Fernando
- Cornejo Isabel
- Costanzi Andrea
- Creavin Ben
- Curella Luciano
- Das Andre
- Daskalakis Theodoros
- Davies Justin
- de Andrés-Asenjo Beatriz
- De Campos Tercio
- de Guzmán Aragón Sara Ortiz
- de las Casas Sara Gortázar
- De Luca Alessandro
- De Luca Giuseppe Massimiliano
- De Lucia Chiara
- De Nobili Giovanni
- De Rosa Michele
- de San Ildefonso Pereira Alberto
- De Simone Belinda
- Delis Spiros
- Delko Tarik
- Delogu Daniele
- Di Giovanni Silvia
- Di Martino Marcello
- Di Marzo Francesco
- Di Saverio Salomone
- Diaz-Elizondo Jose Antonio
- Dominguez Casandra
- Dorovinis Panagiotis
- Douka Eleftheria
- Dudi-Venkata Nagendra
- Dziakova Jana
- Díaz Carlos Javier Gómez
- D’Antonio Dario
- Elhadi Muhammed
- Elia Rossella
- Erdas Enrico
- Esposito Giuseppe
- Faisal Alsulaimani
- Fajardo Roosevelt
- Falco Nicolò
- Faro Carmelo Lo
- Feituri Nura
- Ferrara Francesco
- Ferrario Luca
- Ferronetti Antonio
- Fidoshev Iliya
- Foianini Esteban
- Folliero Cristina
- Formisano Giampaolo
- Francone Elisa
- Frazzetta Giuseppe
- Frontali Alice
- Fuentes Sara
- Fung Chia Chi
- Fung Tak Lit Derek
- Galiffa Giampaolo
- Gallo Gaetano
- García Domínguez Melody
- García Orozco Víctor Hugo
- Gazia Carlo
- Gentilli Sergio
- Ghedan Soliman
- Gica Corina
- Gica Nicolae
- Giordano Luca
- Giordano Marco
- Giuliani Antonio
- Goh Brian
- González Tomás Elosua
- Graham Victoria
- Gravante Gianpiero
- Grossi Ugo
- Guaitoli Eleonora
- Guerci Claudio
- Hamid Amal
- Hernández Palmas Oscar Isaac
- Herrera-Almario Gabriel
- Iacobone Maurizio
- Ielpo Benedetto
- Ioannidis Argyrios
- Ioannidis Orestis
- Iossa Angelo
- Iqbal Atif
- Irkorucu Oktay
- Isernia Roberta Maria
- Izzo Giuliano
- Jamiri Al-Radjid
- Jennifer Chiu Hiu Fung
- Jiménez Carneros Virginia
- Jovanovic Branislav
- Jovanovic Jelena Pejanovic
- Julio Abba
- Junaid Sofi
- Kampouroglou Georgios
- Katta Venkateswara Rao
- Keller Deborah
- Kenington Cleo
- Khalid Ahmad
- Khan Farhan
- Khan Mansoor
- Koh Peng Soon
- Koëter Tijmen
- Krivan Sylvia
- Kumar Akshay
- Kuvvetli Adnan
- Kykalos Stylianos
- laharwal Asim
- Lammel-Lindemann Jan
- Lancellotti Francesco
- Laterza Ernesto
- Lemma Maria
- Leppäniemi Ari
- Liakakos Theodore
- Liarakos Athanasios
- Licardie Eugenio
- Linardoutsos Dimitrios
- Lisi Giorgio
- Litta Francesco
- Lolli Maria Giulia
- Lucchi Andrea
- Luglio Gaetano
- Lui Rashid
- Luvisetto Federico
- Machain Vega Gustavo Miguel
- Machairas Nikolaos
- Madrid Fausto
- Maggi Giulia
- Major Piotr
- Malet Marcelo Viola
- Manigrasso Michele
- Maraska Fatlum
- Marinis Athanasios
- Marino Fabio
- Marino Marco Vito
- Marsanic Patrizia
- Martin-Martin Gonzalo
- Martinez-Mier Gustavo
- Martini Francesco
- Martín del Olmo Juan Carlos
- Martínez Iñaki
- Maruccia Michele
- Materazzo Marco
- Matías-García Belén
- Mehraj Asif
- Mendoza-Moreno Fernando
- Merlini David
- Merlini David Alessio
- Mihailescu Andrei
- Milito Pamela
- Milone Marco
- Minaya-Bravo Ana
- Mitul Ashrarur Rahman
- Moletta Lucia
- Montes-Manrique Mario
- Montuori Mauro
- Mora-Guzmán Ismael
- Morales Emilio
- Morales-Conde Salvador
- Moreno Villamizar María Daniela
- Moro-Valdezate David
- Muhammad Ali Syed
- Munoz-Flores Fernando
- Nacion Aeris Jane
- Nardi Matteo
- Nari Gustavo
- Necchi Giovanni Sammy
- Negoi Ionut
- Neri Ignacio
- Nespoli Luca
- Neves Fernanda
- Nicolaescu Diana Cristiana
- Nicolás López Tatiana
- Nigri Giuseppe
- Nikaj Herald
- Nájar Alfonso
- Nájar-Castañeda Pedro Alfonso
- Olivier James
- Ordoñez Juliana María
- Orengia Adam
- Ortega Torrecilla Nuria
- Ortega Irene
- Oumar Toure Alpha
- Ovalle-Chao Christian
- Pagano Gianluca
- Palini Gian Marco
- Panaccio Paolo
- Paniagua-García-Señoráns Marta
- Paola Menna Maria
- Papadopoulos Georgios
- Papagni Vincenzo
- Paranjape Charudutt
- Pardo Fernando
- Pareja-Ciuro Felipe
- Parreira Jose Gustavo
- Pata Francesco
- Pattacini Gianmaria Casoni
- Pecchini Francesca
- Pecorelli Nicolò
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- Pellicciaro Marco
- Pellino Gianluca
- Peltrini Roberto
- Pera Miguel
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- Petagna Lorenzo
- Peter Mark
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- Picciariello Arcangelo
- Piccoli Micaela
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- Pio Luca
- Pisanu Adolfo
- Podda Mauro
- Police Andrea
- Popowich Daniel
- Porcu Alberto
- Prieto Mikel
- Prieto Paola
- Pérez-Bertólez Sonia
- Pérez-Sánchez Luis Eduardo
- Qahtani Fahad
- Rachkov Viktor
- Ramos-De la Medina Antonio
- Rashid Arshad
- Rattan Rishi
- Raza Muhammad Asif
- Reinke Caroline
- Reyes Jeryl Anne Silvia
- Ricciardi Edoardo
- Rocca Aldo
- Rodas Edgar
- Rodrigues Pablo
- Rodriguez-Lopez Mario
- Roldan Amaia Martínez
- Romano Angela
- Romic Ivan
- Ros Emilio Peña
- Rosa Fausto
- Roscio Francesco
- Rosso Edoardo
- Rottoli Matteo
- Rubio Ainhoa Valle
- Russello Domenico
- Rutegård Martin
- Sahnan Kapil
- Saladino Edoardo
- Salamea Juan
- Salas Joanne
- Salinas Javier
- Saliu Fatmir
- Salö Martin
- San Roman Igor Alberdi
- Sanz Guadarrama Oscar
- Sartori Alberto
- Sasia Diego
- Scaringi Stefano
- Schlottmann Francisco
- Sensi Bruno
- Serio Francesca
- Serradilla-Martín Mario
- Shaat Mohamed
- Shalaby Mostafa
- Sica Giuseppe
- Silveri Massimiliano
- Silvestri Francesca Maria
- Singhal Rishi
- Sinibaldi Giovanni
- Siragusa Leandro
- Smart Neil
- Smith Adrian
- Smith-Singares Eduardo
- Sosa Valentina
- Spampinato Marcello Giuseppe
- Sretenovic Aleksandar
- Stavrou Habil Gregor
- Stubbs Ben
- Sánchez-Guillén Luis
- Taglietti Lucio
- Tallon-Aguilar Luis
- Tamini Nicolò
- Tarasconi Antonio
- Tayar Serkan
- Tejos Rodrigo
- Testa Valentina
- Thomas Charlotte
- Thway Min Myat
- Tolonen Matti
- Tomajer Valentina
- Tonini Valeria
- Torre Michele
- Trelles Nelson
- Treviño Figueroa Adriana Michelle
- Tromba Antonella
- Tropeano Francesca Paola
- Turrado-Rodriguez Victor
- Tutino Roberta
- Tzivanakis Alexios
- Ugon Gustavo Armand
- Valles-Guerra Orestes
- van Ramshorst Gabrielle
- Vanni Gianluca
- Varela Cristopher
- Vaterlini Elisa Maria
- Veroux Massimiliano
- Vertaldi Sara
- Vicente Rodríguez Irune
- Vigorita Vincenzo
- Vinci Danilo
- Viola Marcelo
- Visag-Castillo Victor
- Voglino Valerio
- Voon Kelvin
- Weckmann Lujan Sergio Alberto
- Weerasekera Mihiri
- Younis Muhammad Umar
- Yánez Carlos
- Zalla Tiku
- Zigiotto Daniele
- Zuchini Andres Mendoza
- Zuluaga Mauricio
- Zuolo Michele
- Çetinkünar Süleyman
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak.
Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study.
Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM.
Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide
Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
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- Bakhshiansohi Hamed
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- Barbone Lucia
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- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
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- Barrett Matthew
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- Basegmez Suzan
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- Bauer Julia
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- de Trocóniz Jorge F.
- De Visscher Simon
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- Deisher Amanda
- Deiters Konrad
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- Del Re Daniele
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- Yilmaz Yetkin
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- Yohay Rachel
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- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zumerle Gianni
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2011
- Field of study
A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- Barišić Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos Catalá
- Bawa Ashvind
- Bawa Sayesha
- Bayhan Hüseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
- Benamar Safia
- Bence Matthew
- Benshetrit Guy
- Bensoltane Khadidja
- Bergkvist David Julià
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- Valadez Tania Abigail Cueto
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- Valeanu Liana
- Valioulis Ioannis
- Valladares Sergio Chávez
- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- Velázquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- Vilaró Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study (vol 46, pg 2021, 2022)
- Author
- Abdullah Alshamrani
- Abdullah Alturkistani
- Abdulrahman Alghamdi
- Abdulrahman Almalki
- Adam Orengia
- Adnan Kuvvetli
- Adolfo Pisanu
- Adrian Smith
- Adriana Michelle Treviño Figueroa
- Aeris Jane Nacion
- Ahmad Alhazmi
- Ahmad Bouhuwaish
- Ahmad Khalid
- Ahmed Alsufyani
- Ainhoa Valle Rubio
- Akshay Bavikatte
- Akshay Kumar
- Al-Radjid Jamiri
- Alberto de San Ildefonso Pereira
- Alberto Porcu
- Alberto Sartori
- Aldo Rocca
- Aleksandar Sretenovic
- Alessandro Anselmo
- Alessandro De Luca
- Alexandros Charalabopoulos
- Alexios Tzivanakis
- Alfonso Bandin
- Alfonso Nájar
- Alice Frontali
- Alsulaimani Faisal
- Amaia Martínez Roldan
- Amal Hamid
- Ana André
- Ana Minaya-Bravo
- Andre Das
- Andrea Bondurri
- Andrea Costanzi
- Andrea Lucchi
- Andrea Police
- Andrei Mihailescu
- Andres Mendoza Zuchini
- Angela Romano
- Angelo Iossa
- Antonella Chessa
- Antonella Tromba
- Antonio Brillantino
- Antonio Castaldi
- Antonio Ferronetti
- Antonio Giuliani
- Antonio Ramos-De la Medina
- Antonio Tarasconi
- Arcangelo Picciariello
- Argyrios Ioannidis
- Ari Leppäniemi
- Arshad Rashid
- Ashrarur Rahman Mitul
- Asif Mehraj
- Asim Laharwal
- Athanasios Liarakos
- Athanasios Marinis
- Atif Iqbal
- Beatriz de Andrés-Asenjo
- Belinda De Simone
- Belén Matías-García
- Ben Creavin
- Ben Stubbs
- Branislav Jovanovic
- Brian Goh
- Bruno Sensi
- Carlo Gazia
- Carlos Cerdán
- Carlos Javier Gómez Díaz
- Carlos Petrola Chacón
- Carlos Yánez
- Carmelo Lo Faro
- Caroline Reinke
- Casandra Dominguez
- Charlotte Thomas
- Charudutt Paranjape
- Chia Chi Fung
- Chiara De Lucia
- Chiu Hiu Fung Jennifer
- Christian Ovalle-Chao
- Claudio Guerci
- Cleo Kenington
- Corina Gica
- Cristina Folliero
- Cristopher Varela
- Daniel Popowich
- Daniele Delogu
- Daniele Zigiotto
- Danilo Vinci
- Dario D'Antonio
- David Alessio Merlini
- David Merlini
- David Moro-Valdezate
- Deborah Keller
- Di Martino Marcello
- Di Saverio Salomone
- Diana Cristiana Nicolaescu
- Diego Sasia
- Dimitrios Linardoutsos
- Domenico Russello
- Edgar Rodas
- Edoardo Ricciardi
- Edoardo Rosso
- Edoardo Saladino
- Eduardo Smith-Singares
- Efstratia Baili
- Eleftheria Douka
- Eleonora Guaitoli
- Elisa Francone
- Elisa Maria Vaterlini
- Elisa Sefora Pierobon
- Emilio Morales
- Emilio Peña Ros
- Enrico Benzoni
- Enrico Erdas
- Enrico Pinotti
- Enrique Colás-Ruiz
- Ernesto Laterza
- Esteban Foianini
- Eugenia Cardamone
- Eugenio Licardie
- Fabio Marino
- Fahad Alsofyani
- Fahad Qahtani
- Farhan Khan
- Fatlum Maraska
- Fatmir Saliu
- Fausto Madrid
- Fausto Rosa
- Federico Luvisetto
- Felipe Alconchel
- Felipe Pareja-Ciuro
- Ferdinando Agresta
- Fernanda Neves
- Fernando Cordera
- Fernando Mendoza-Moreno
- Fernando Munoz-Flores
- Fernando Pardo
- Francesca Maria Silvestri
- Francesca Paola Tropeano
- Francesca Pecchini
- Francesca Serio
- Francesco Colombo
- Francesco Di Marzo
- Francesco Ferrara
- Francesco Lancellotti
- Francesco Litta
- Francesco Martini
- Francesco Roscio
- Francisco Blanco-Antona
- Francisco Javier Quezada Barcenas
- Francisco Schlottmann
- Gabriel Herrera-Almario
- Gabrielle van Ramshorst
- Gaetano Gallo
- Gaetano Luglio
- Georgios Kampouroglou
- Georgios Papadopoulos
- Gerardo Arredondo
- Giacomo Calini
- Giampaolo Formisano
- Giampaolo Galiffa
- Gian Marco Palini
- Gianluca Colucci
- Gianluca Pagano
- Gianluca Vanni
- Gianluca. ACIE Appy Study Collaborative Abba Julio
- Gianmaria Casoni Pattacini
- Gianpiero Gravante
- Giorgio Lisi
- Giovanni Bellanova
- Giovanni De Nobili
- Giovanni Sammy Necchi
- Giovanni Sinibaldi
- Giulia Bacchiocchi
- Giulia Bagaglini
- Giulia Maggi
- Giuliano Izzo
- Giulio Argenio
- Giuseppe Brisinda
- Giuseppe Esposito
- Giuseppe Frazzetta
- Giuseppe Massimiliano De Luca
- Giuseppe Nigri
- Giuseppe Sica
- Gonzalo Martin-Martin
- Gustavo Armand Ugon
- Gustavo Martinez-Mier
- Gustavo Miguel Machain Vega
- Gustavo Nari
- Habil Gregor Stavrou
- Herald Nikaj
- Ielpo Benedetto
- Ignacio Neri
- Igor Alberdi San Roman
- Iliya Fidoshev
- Ionut Negoi
- Irene Ortega
- Irune Vicente Rodríguez
- Isabel Cornejo
- Ismael Mora-Guzmán
- Issam Al-Najami
- Ivan Romic
- Izaskun Balciscueta
- Iñaki Martínez
- James Olivier
- Jan Lammel-Lindemann
- Jana Dziakova
- Javier Salinas
- Jelena Pejanovic Jovanovic
- Jeryl Anne Silvia Reyes
- Joanne Salas
- Jose Antonio Diaz-Elizondo
- Jose Gustavo Parreira
- Juan Bellido
- Juan Carlos Martín Del Olmo
- Juan Salamea
- Juliana María Ordoñez
- Justin Davies
- Kapil Sahnan
- Kebebe Bekele
- Kelvin Voon
- Leandro Siragusa
- Lorenzo Petagna
- Luca Ferrario
- Luca Giordano
- Luca Nespoli
- Luca Pio
- Lucia Moletta
- Luciano Curella
- Lucio Taglietti
- Luigi Bonavina
- Luigi Conti
- Luis Eduardo Pérez-Sánchez
- Luis Felipe Cabrera Vargas
- Luis Sánchez-Guillén
- Luis Tallon-Aguilar
- Mansoor Khan
- Marcello Giuseppe Spampinato
- Marcelo Viola
- Marcelo Viola Malet
- Marco Angrisani
- Marco Calussi
- Marco Catarci
- Marco Giordano
- Marco Materazzo
- Marco Milone
- Marco Pellicciaro
- Marco Vito Marino
- Maria Giulia Lolli
- Maria Irene Bellini
- Maria Lemma
- Maria Michela Chiarello
- Mario Montes-Manrique
- Mario Rodriguez-Lopez
- Mario Serradilla-Martín
- Mark Peter
- Marta Paniagua-García-Señoráns
- Martin Rutegård
- Martin Salö
- María Daniela Moreno Villamizar
- Massimiliano Silveri
- Massimiliano Veroux
- Matteo Nardi
- Matteo Rottoli
- Matti Tolonen
- Mauricio Pedraza Ciro
- Mauricio Zuluaga
- Maurizio Iacobone
- Mauro Montuori
- Mazin Ali
- Melody García Domínguez
- Menna Maria Paola
- Micaela Piccoli
- Michela Campanelli
- Michele De Rosa
- Michele Manigrasso
- Michele Maruccia
- Michele Torre
- Michele Zuolo
- Miguel Pera
- Mihiri Weerasekera
- Mikel Prieto
- Min Myat Thway
- Mohamed Shaat
- Mohammad Azfar
- Mostafa Shalaby
- Muhammad Asif Raza
- Muhammad Umar Younis
- Muhammed Elhadi
- Mujahid Ali
- Musab AlThomali
- Nadiah Al Amri
- Nagendra Dudi-Venkata
- Nahar Alselaim
- Neil Smart
- Nelson Trelles
- Niccolo Petrucciani
- Nicola Antonacci
- Nicola Cillara
- Nicolae Gica
- Nicolò Falco
- Nicolò Pecorelli
- Nicolò Tamini
- Nikolaos Machairas
- Nura Feituri
- Nuria Ortega Torrecilla
- Octavio Avila Mercado
- Ohood AlAamer
- Oktay Irkorucu
- Omar Alsherif
- Oreste Claudio Buonomo
- Orestes Valles-Guerra
- Orestis Ioannidis
- Oscar Isaac Hernández Palmas
- Oscar Sanz Guadarrama
- Osman Bozbiyik
- Pablo Rodrigues
- Pamela Milito
- Panagiotis Dorovinis
- Paola Prieto
- Paolo Baroffio
- Paolo Panaccio
- Pata Francesco
- Patrizia Marsanic
- Pawel Ajawin
- Pedro Alfonso Nájar-Castañeda
- Pellino
- Peng Soon Koh
- Pietro Anoldo
- Piotr Major
- Podda Mauro
- Qasem Alharthi
- Rashid Lui
- Riccardo Caruso
- Richard Brady
- Rishi Rattan
- Rishi Singhal
- Roberta Angelico
- Roberta Maria Isernia
- Roberta Tutino
- Roberto Peltrini
- Rodrigo Tejos
- Roosevelt Fajardo
- Rossella Elia
- Salvador Morales-Conde
- Sami Benli
- Sara Fuentes
- Sara Gortázar de Las Casas
- Sara Ortiz de Guzmán Aragón
- Sara Vertaldi
- Selmy Awad
- Sergio Alberto Weckmann Lujan
- Sergio Gentilli
- Serkan Tayar
- Shabab Althobaiti
- Silvia Di Giovanni
- Sofi Junaid
- Soliman Ghedan
- Sonia Pérez-Bertólez
- Sonja Chiappetta
- Spiros Delis
- Stefano Scaringi
- Stylianos Kykalos
- Syed Muhammad Ali
- Sylvia Krivan
- Süleyman Çetinkünar
- Tak Lit Derek Fung
- Tarik Delko
- Tatiana Nicolás López
- Tercio De Campos
- Teresa Calderón Duque
- Teresa Perra
- Theodore Liakakos
- Theodoros Daskalakis
- Tijmen Koëter
- Tiku Zalla
- Tommaso Campagnaro
- Tomás Elosua González
- Toure Alpha Oumar
- Ugo Grossi
- Valentina Sosa
- Valentina Testa
- Valentina Tomajer
- Valeria Andriola
- Valeria Tonini
- Valerio Celentano
- Valerio Voglino
- Venkateswara Rao Katta
- Victor Turrado-Rodriguez
- Victor Visag-Castillo
- Victoria Graham
- Viktor Rachkov
- Vincenzo Papagni
- Vincenzo Vigorita
- Virginia Jiménez Carneros
- Vittoria Bellato
- Víctor Hugo García Orozco
- Wolf Bechstein
- Yuksel Altinel
- Zutoia Balciscueta
- Publication venue
- place:One new Yok Plaza, suite 4600, New York, NY, United States
- Publication date
- 01/01/2022
- Field of study
N/
Recommended from our members
Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
- Author
- Abbasciano Isabella
- Abrantes Catarina
- Accarino Simone
- Adler Sharon
- Adoberg Annika
- Afsari Rouzbeh
- Ahmad Syeda
- Ahmed Jafar
- Ahn Wooin
- Ajayi Bamidele
- Aksamit Dariusz
- Al Chalabi Saif
- Alamartine Eric
- Alchi Bassam
- Ali Mohammad
- Aliotta Roberta
- Almaani Salem
- Almeida Catarina
- Almeida Edgar
- Alpers Charles E
- Alvarez Francisco de la Prada
- Alves Patricia
- Annese Francesca
- Appel Gerald
- Arduan Alberto Ortiz
- Arena Maria
- Arevalo Marta Calvo
- Arfaania Dariush
- Arias Carlos
- Aristoy Emma Calatayud
- Asakiene Egle
- Ashley Sarah
- Assefi Ali
- Atenza Alba
- Auerbach Asta
- Augustyniak-Bartosik Hanna
- Avella Monroy
- Ayling-Smith Jonathan
- Ayoub Isabelle
- Ayvazyan Christine
- Baccaro Rocco
- Bailey Asha
- Baker Bruce
- Balamuthusamy Saravanan
- Ballarin Jose
- Barata Rui
- Barbic Jerko
- Barisic Dunja
- Barratt Jonathan
- Barreto Jose Carlos de Jesus
- Barrios Clara
- Belingheri Mirco
- Benesova Anna
- Bernabeu Ana Avila
- Bernhardt Wanja
- Bhadra Shamik
- Biancone Luigi
- Bieler Stewart
- Blanchard Anne
- Boaglio Elena
- Bolignano Davide
- Bomback Andrew
- Bonilla Gustavo Andres Useche
- Bordoli Monica
- Bose Bhadran
- Boudville Neil
- Brandon Donald
- Brown Karen
- Broyet Christian
- Bucknall Thomas
- Buffet Alexandre
- Bumblyte' Inga Arune
- Burdese Manuel
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- Burguet Laure
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- Busch Martin
- Cakiroglu Figen
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- Canetta Pietro
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- Carbonell Juan
- Cardoso Filipa
- Carro Clara Garcia
- Carroll Robert
- Carron Pierre-Louis
- Carullo Nazareno
- Cassia Matthias
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- Castillo Belen Vizcaino
- Catucci Davide
- Cavalli Andrea
- Chae Dong-Wan
- Chakera Aron
- Chan Anthony Ting Pong
- Chan Doris
- Chan Gary Chi Wang
- Chan Lai Wan
- Chang Jae Hyun
- Chang Ming-Shan
- Chapman Fiona
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- Chaudhry Asghar
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- Chen Hsin-Yu
- Chen Hung-Chun
- Chen Hung-Yuan
- Chenine Leila
- Cheung Chee Kay
- Cheung Siu Fai
- Chiche-Jourde Noemie
- Chiu Hsien-Fu
- Chiu Ian
- Chiu Yen-Ling
- Chiu Yi-Wen
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- Chou Kang-Ju
- Chowdhury Paramit
- Chowdhury Pradip
- Chrysochou Constantina
- Chukwu Chukwuma
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- Chung Wookyung
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- Clement Nisha
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- Kwella Bogna
- Kwella Norbert
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- Wyndham Roger
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- Yang Ju-Yeh
- Yeap Chii
- Yim Ka Fai
- Yong Kenneth
- Yoo Tae-Hyun
- Yoon Songuk
- Yu Tung-Min
- Yue Tak Tai Andrew
- Zakari Michel
- Zakauskiene Urte
- Zaoui Philippe
- Zbrzezniak Justyna
- Zielinska Dorota
- Zizzi Carlotta Federica
- Publication venue
- Publication date
- 01/11/2023
- Field of study
BackgroundSparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.MethodsPROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.FindingsBetween Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.InterpretationOver 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function
Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial
- Author
- Aaron Fearday
- Abdallah Geara
- Adam Morris
- Adriana Fernandes
- Adriana Sierra Ochoa
- Aejin Kim
- Agata Winiarska
- Aine Maire De Bhailis
- Ajay Dhaygude
- Alastair Gillies
- Alba Atenza
- Alberto Ortiz Arduan
- Alejandro Soria Villen
- Alessia Fornoni
- Alex Mercer PhD g
- Alexandre Buffet
- Alexandre Karras
- Alfred Rodriguez
- Ali Assefi
- Allister Williams
- Allyson Medina
- Alvaro Vaz
- Alvita Vickiene
- Amanda Hall
- Amanda Mather
- Amanda Siriwardana
- Amar Mahdi
- Amy Henderson
- Amy Hudson
- An Vanacker
- Ana Avila Bernabeu
- Ana Carolina Figueiredo
- Ana Cortesão Costa
- Ana Farinha
- Ana Marta Gomes
- Ana Messias
- Ana Natario
- Ana Perez de Jose
- Ana Savuk
- Ana Vilar Gimeno
- Andrea Cavalli
- Andrea Solazzo
- Andrew Bomback
- Andrew Henderson
- Andrew McNally
- Angel Forcen
- Angel Sevillano
- Angus Ritchie
- Angus Turnbull
- Anna Benesova
- Anna Jander
- Anna Ricchiuto
- Anne Blanchard
- Anne-Elisabeth Heng
- Annegret Koch
- Annette Girardet
- Annie Reynolds
- Annika Adoberg
- Anoushka Krishnan
- Anthony Ting Pong Chan
- Antolina Moreno
- Antonio Galan Serrano
- Aparna Padiyar
- Archana Gautam
- Arksarapuk Jittirat
- Arnold Silva
- Aron Chakera
- Artashes Patrikyan
- Arun Gopu
- Arunima Jain
- Arvind Ponnusamy
- Asghar Chaudhry
- Asha Bailey
- Ashik Hayat
- Ashraf Mikhail
- Asta Auerbach
- Asta Stankuviene
- Aurore Labat
- Bamidele Ajayi
- Bang-Gee Hsu
- Barbara Greco
- Bart Maes
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- Prof Jai Radhakrishnan MD c
- Prof Jonathan Barratt PhD e
- Prof Vlado Perkovic MD b ofor the PROTECT Investigators† Author links open overlay panelEric Alarmartine
- Przemyslaw Miarka
- Rachel Jones
- Radko Komers MD f
- Radu Jacob
- Raffi Minasian
- Rajan Patel
- Rajdeep Gadh
- Ramachandra Patak
- Ranjit Dhelaria
- Rathika Krishnasamy
- Rathika Krishnasamy
- Raul Fernandez Prado
- Richard Lafayette
- Rishi Pruthi
- Ritesh Raichoudhury
- Robert Carroll
- Robert Davidson
- Robert Haws
- Robert Malecki
- Roberta Aliotta
- Rocco Baccaro
- Roderick Comunale
- Roderick Comunale
- Roger Wyndham
- Rouzbeh Afsari
- Roxane Gaisset
- Rui Barata
- Sadia Jahan
- Saif Al Chalabi
- Salem Almaani
- Salia Virxinia Pol Heres
- Sam Daneshvari
- Samir Parikh
- Sandra Karanovic
- Sang-Kyung Jo
- Sapna Shah
- Sara Fernandes
- Sara Goncalves
- Sara Ombelet
- Sara Vigano
- Sarah Ashley Ford Sightler
- Sarah Lawman
- Sarah Quinn
- Sarah Roxburgh
- Saravanan Balamuthusamy
- Se Joong Kim
- Sebahat Sat
- Secundino Cigarran Guldris
- Selena Longhi
- Serena Ponti
- Seung Hyeok Han
- SeWon Oh
- Shamik Bhadra
- Shang-Feng Tsai
- Shang-Jyh Hwang
- Sharon Adler
- Shaundeep Sen
- Sheng Kuo
- Shih-Hsiang Ou
- Shih-Ping Hsu
- Shilpanjali Jesudason
- Sian Griffin
- Siddhartha Kattamanchi
- Silja Sanden
- Silvia Malvica
- Simon Mucha
- Simon Roger
- Simone Accarino
- Simone Kulka
- Siu Fai Cheung
- Smeeta Sinha
- Sofia Jorge
- Sofie Jamar
- Songuk Yoon
- Sradha Kotwal
- Sreedhar Mandayam
- Stacy Martinez
- Stefan Weiner
- Stefanie Stangenberg
- Stefano Costanzi
- Stephan Christian Werth
- Stephane Burtey
- Stephane Roueff
- Stephen McDonald
- Stewart Bieler BA a
- Sui Kon
- Suneel Udani
- Sunggyun Kim
- Susan Crail
- Susan Wan
- Suzanne Forbes
- Sven Heinrichs
- Sydney Chi Wai Tang
- Syeda Ahmad
- Sze Ho Sunny Wong
- Szu-Yu Pan
- Sónia Silva
- Tae-Hyun Yoo
- Tak Tai Andrew Yue
- Tamara Malek Marin
- Tania Salehi
- Teresa Furtado
- Theodoros Kasimatis
- Thida Maung Maung Myint
- Thilo Krueger
- Thomas Bucknall
- Thomas Malfait
- Thomas Powell
- Thomas Weinreich
- Thu Nguyen
- Tiane Dai
- Toby Coates
- Tomasz Stompor
- Tung-Min Yu
- Tze Goh
- Tzung-Yo Ho
- Ulrich Kunzendorf
- Ulysses Diva PhD f
- Unnikrishnan Pillai
- Unnikrishnan Pillai
- Ursula Verdalles Guzman
- Urte Zakauskiene
- Usha Peri
- Valentin Mayet
- Valérie de Précigout
- Veronica Viramontes
- Victor Fernandez
- Victoria Campbell
- Victoria Campbell
- Vidu Wijeratne
- Viet Nguyen
- Viet Nguyen
- Vittoria Esposito
- Vladmir Tesar
- Wai Lim
- Wai Ping Law
- Wan-Chuan Tsai
- Wanja Bernhardt
- Wenceslao Adrian Aguilera Morales
- William Paxton
- William Rote PhD f
- Wim Lemahieu
- Wladyslaw Sulowicz
- Wooin Ahn
- Wookyung Chung
- Xavier Warling
- Yahsou Delmas
- Yan Li
- Yelena Drexler
- Yen-Ling Chiu
- Yeong Hoon Kim
- Yi-Wen Chiu
- Yick Hei Wong
- Yonatan Peleg
- Young Rim Song
- YoungYoul Hyun
- Yu-Sen Peng
- Yunmi Kim
- Yusuf Eqbal
- Yusuf Eqbal
- Yvonne Shen
- Zivka Dika
- Zoltan Endre
- Zvonimir Sitas
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin and angiotensin receptor antagonist being examined in an ongoing phase 3 trial in adults with IgA nephropathy. We report the prespecified interim analysis of the primary proteinuria efficacy endpoint, and safety. Methods: PROTECT is an international, randomised, double-blind, active-controlled study, being conducted in 134 clinical practice sites in 18 countries. The study examines sparsentan versus irbesartan in adults (aged ≥18 years) with biopsy-proven IgA nephropathy and proteinuria of 1·0 g/day or higher despite maximised renin-angiotensin system inhibitor treatment for at least 12 weeks. Participants were randomly assigned in a 1:1 ratio to receive sparsentan 400 mg once daily or irbesartan 300 mg once daily, stratified by estimated glomerular filtration rate at screening (30 to 1·75 g/day). The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, assessed using mixed model repeated measures. Treatment-emergent adverse events (TEAEs) were safety endpoints. All endpoints were examined in all participants who received at least one dose of randomised treatment. The study is ongoing and is registered with ClinicalTrials.gov, NCT03762850. Findings: Between Dec 20, 2018, and May 26, 2021, 404 participants were randomly assigned to sparsentan (n=202) or irbesartan (n=202) and received treatment. At week 36, the geometric least squares mean percent change from baseline in urine protein-creatinine ratio was statistically significantly greater in the sparsentan group (-49·8%) than the irbesartan group (-15·1%), resulting in a between-group relative reduction of 41% (least squares mean ratio=0·59; 95% CI 0·51-0·69; p<0·0001). TEAEs with sparsentan were similar to irbesartan. There were no cases of severe oedema, heart failure, hepatotoxicity, or oedema-related discontinuations. Bodyweight changes from baseline were not different between the sparsentan and irbesartan groups. Interpretation: Once-daily treatment with sparsentan produced meaningful reduction in proteinuria compared with irbesartan in adults with IgA nephropathy. Safety of sparsentan was similar to irbesartan. Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term nephroprotective potential of sparsentan. Funding: Travere Therapeutics
First Sagittarius A* Event Horizon Telescope Results. I. The Shadow of the Supermassive Black Hole in the Center of the Milky Way
- Author
- Agurto Claudio
- Akiyama Kazunori
- Alberdi Antxon
- Alef Walter
- Algaba Juan Carlos
- Allardi Alexander
- Amestica Rodrigo
- Anantua Richard
- Araneda Juan Pablo
- Arriagada Oriel
- Asada Keiichi
- Azulay Rebecca
- Bach Uwe
- Baczko Anne-Kathrin
- Ball David
- Baloković Mislav
- Barrett John
- Bauböck Michi
- Bella Noemi La
- Benson Bradford A.
- Berghuis Jennie L.
- Bertarini Alessandra
- Berthold Ryan
- Bintley Dan
- Blackburn Lindy
- Blanchard Jay
- Blundell Raymond
- Bouman Katherine L.
- Bower Geoffrey C.
- Boyce Hope
- Bremer Michael
- Brinkerink Christiaan D.
- Brissenden Roger
- Britzen Silke
- Broderick Avery E.
- Broguiere Dominique
- Bronzwaer Thomas
- Brown Ken
- Bustamante Sandra
- Byun Do-Young
- Cantzler Michael
- Carlstrom John E.
- Caro Patricio
- Castillo-Domínguez Edgar
- Ceccobello Chiara
- Chael Andrew
- Chan Chi-kwan
- Chan Tin Lok
- Chang Chih-Cheng
- Chang Dominic O.
- Chang Shu-Hao
- Chang Song-Chu
- Chatterjee Koushik
- Chatterjee Shami
- Chen Chung-Chen
- Chen Ming-Tang
- Chen Yongjun
- Cheng Xiaopeng
- Chilson Ryan
- Cho Ilje
- Christian Pierre
- Chuter Tim C
- Ciechanowicz Miroslaw
- Colin-Beltran Edgar
- Conroy Nicholas S.
- Conway John E.
- Cordes James M.
- Coulson Iain M.
- Crawford Thomas M.
- Crew Geoffrey B.
- Crowley Joseph
- Cruz-Osorio Alejandro
- Cui Yuzhu
- Cárdenas Mauricio
- Davelaar Jordy
- Deane Roger
- Degenaar Nathalie
- Dempsey Jessica
- Desvignes Gregory
- Dexter Jason
- Dhruv Vedant
- Doeleman Sheperd S.
- Dornbusch Sven
- Dougal Sean
- Durán Carlos A.
- Dzib Sergio A.
- Eatough Ralph P.
- Emami Razieh
- Event Horizon Telescope Collaboration
- Everett Wendeline B.
- Faber Aaron
- Falcke Heino
- Farah Joseph
- Fish Vincent L.
- Fomalont Ed
- Ford H. Alyson
- Forster Karl
- Fraga-Encinas Raquel
- Freeman William T.
- Friberg Per
- Fromm Christian M.
- Fuchs Miriam M.
- Fuentes Antonio
- Fuentes Santiago Navarro
- Gale David M.
- Galison Peter
- Gammie Charles F.
- García Roberto
- Geertsema Gertie
- Gentaz Olivier
- Georgiev Boris
- Goddi Ciriaco
- Gold Roman
- González Edouard
- Graham Dave
- Gu Minfeng
- Gueth Frédéric
- Gurwell Mark
- Gómez José L.
- Gómez-Ruiz Arturo I.
- Hada Kazuhiro
- Haggard Daryl
- Halverson Nils W.
- Han Chih-Chiang
- Han Kuo-Chang
- Hasegawa Yutaka
- Haworth Kari
- Hecht Michael H.
- Hernández-Rebollar José Luis
- Herrera Cristian
- Herrero-Illana Ruben
- Hesper Ronald
- Heumann Dirk
- Heyminck Stefan
- Hirota Akihiko
- Ho Luis C.
- Ho Paul
- Hoge James
- Honma Mareki
- Hostler Schimpf Shelbi R.
- Howie Ryan E.
- Huang Chih-Wei L.
- Huang Lei
- Huang Yau-De
- Hughes David H.
- Ikeda Shiro
- Impellizzeri C.M.Violette
- Inoue Makoto
- Issaoun Sara
- James David J.
- Jannuzi Buell T.
- Janssen Michael
- Jeter Britton
- Jiang Homin
- Jiang Wu
- Jiménez-Rosales Alejandra
- Jinchi Hao
- John David
- Johnson Michael D.
- Jorstad Svetlana
- Joshi Abhishek V.
- Jung Taehyun
- Karami Mansour
- Karuppusamy Ramesh
- Kawashima Tomohisa
- Keating Garrett K.
- Kettenis Mark
- Kim Dong-Jin
- Kim Jae-Young
- Kim Jongsoo
- Kim Junhan
- Kimura Kimihiro
- Kino Motoki
- Klein Thomas
- Koay Jun Yi
- Koch Patrick M.
- Kocherlakota Prashant
- Kofuji Yutaro
- Koyama Shoko
- Kramer Carsten
- Kramer Michael
- Krichbaum Thomas P.
- Kubo Derek
- Kuo Cheng-Yu
- Kuroda John
- Kwon Caleb
- Lacasse Richard
- Laing Robert
- Lauer Tod R.
- Laurentis Mariafelicia De
- Lee Daeyoung
- Lee Sang-Sung
- Leitch Erik M.
- Leung Po Kin
- Levis Aviad
- Li Chao-Te
- Li Zhiyuan
- Lico Rocco
- Lin Lupin C.-C.
- Lindahl Greg
- Lindqvist Michael
- Lisakov Mikhail
- Liu Ching-Tang
- Liu Jun
- Liu Kuan-Yu
- Liu Kuo
- Liuzzo Elisabetta
- Lo Wen-Ping
- Lobanov Andrei P.
- Loinard Laurent
- Lonsdale Colin J.
- Lu Li-Ming
- Lu Ru-Sen
- Mac-Auliffe Felipe
- Mao Jirong
- Marchili Nicola
- Markoff Sera
- Marrone Daniel P.
- Marscher Alan P.
- Martin-Cocher Pierre
- Martí-Vidal Iván
- Matsushita Satoki
- Matthews Lynn D.
- Matulonis Callie
- Maute John K
- Medeiros Lia
- Menten Karl M.
- Messias Hugo
- Meyer-Zhao Zheng
- Michalik Daniel
- Mizuno Izumi
- Mizuno Yosuke
- Montaña Alfredo
- Montenegro-Montes Francisco
- Montgomerie William
- Moran James M.
- Moreno Nolasco Marcos Emir
- Moriyama Kotaro
- Moscibrodzka Monika
- Muders Dirk
- Mus Alejandro
- Musoke Gibwa
- Myserlis Ioannis
- Müller Cornelia
- Nadolski Andrew
- Nagai Hiroshi
- Nagar Neil M.
- Nakamura Masanori
- Narayan Ramesh
- Narayanan Gopal
- Natarajan Iniyan
- Nathanail Antonios
- Neilsen Joey
- Neri Roberto
- Ni Chunchong
- Nishioka Hiroaki
- Norton Timothy J.
- Noutsos Aristeidis
- Nowak Michael A.
- Nystrom George
- Ogawa Hideo
- Oh Junghwan
- Okino Hiroki
- Olivares Héctor
- Olivares Rodrigo
- Ortiz-León Gisela N.
- Oshiro Peter
- Oyama Tomoaki
- Palumbo Daniel CM
- Paraschos Georgios Filippos
- Park Jongho
- Parra Rodrigo
- Parsons Harriet
- Patel Nimesh
- Pen Ue-Li
- Pesce Dominic W.
- Phillips Neil M.
- Piétu Vincent
- Plambeck Richard
- Poirier Michael
- PopStefanija Aleksandar
- Porth Oliver
- Pradel Nicolas
- Prather Ben
- Preciado-López Jorge A.
- Psaltis Dimitrios
- Pu Hung-Yi
- Pérez-Beaupuits Juan Pablo
- Pötzl Felix M.
- Qiu Richard
- Raffin Philippe A.
- Rahlin Alexandra S.
- Ramakrishnan Venkatessh
- Ramírez Jorge
- Rao Ramprasad
- Rawlings Mark G.
- Raymond Alexander W.
- Ressler Sean
- Reynolds Mark
- Rezzolla Luciano
- Ricarte Angelo
- Ripperda Bart
- Rodríguez-Montoya Iván
- Roelofs Freek
- Rogers Alan
- Romero-Cañizales Cristina
- Ros Eduardo
- Roshanineshat Arash
- Rottmann Helge
- Roy Alan L.
- Ruiz Ignacio
- Ruszczyk Chet
- Rygl Kazi L.J.
- Saez-Madain Alejandro F.
- Santana Jorge
- Sasada Mahito
- Satapathy Kaushik
- Savolainen Tuomas
- Schloerb F. Peter
- Schonfeld Jonathan
- Schuster Karl-Friedrich
- Shao Lijing
- Shaw Paul
- Shen Zhiqiang
- Shirkey Leslie E.
- Silva Kevin M.
- Small Des
- Snow William
- Sohn Bong Won
- SooHoo Jason
- Souccar Kamal
- Sousa Don
- Sridharan T.K.
- Stahm William
- Stark Anthony A.
- Sun He
- Sánchez Salvador
- Sánchez-Argüelles David
- Sánchez-Portal Miguel
- Tazaki Fumie
- Test John
- Tetarenko Alexandra J.
- Tiede Paul
- Tilanus Remo P.J.
- Titus Michael
- Torne Pablo
- Torstensson Karl
- Traianou Efthalia
- Trent Tyler
- Trippe Sascha
- Turk Matthew
- van Bemmel Ilse
- van Langevelde Huib Jan
- van Rossum Daniel R.
- Venegas Paulina
- Vos Jesse
- Wagner Jan
- Walther Craig
- Ward-Thompson Derek
- Wardle John
- Wei Ta-Shun
- Weintroub Jonathan
- Wex Norbert
- Wharton Robert
- White Chris
- Wieching Gundolf
- Wielgus Maciek
- Wiik Kaj
- Wijnands Rudy
- Witzel Gunther
- Wondrak Michael F.
- Wong George N.
- Wouterloot Jan G.A.
- Wu Qingwen
- Yamaguchi Paul
- Yoon Doosoo
- Young André
- Young Ken
- Younsi Ziri
- Yu (于威) Wei
- Yu Chen-Yu
- Yuan Feng
- Yuan Ye-Fei
- Zeballos Milagros
- Zensus J. Anton
- Zhang Shuo
- Zhao Guang-Yao
- Zhao Shan-Shan
- Özel Feryal
- Publication venue
- ASTROPHYSICAL JOURNAL LETTERS
- Publication date
- 01/01/2022
- Field of study
Abstract
We present the first Event Horizon Telescope (EHT) observations of Sagittarius A* (Sgr A*), the Galactic center source associated with a supermassive black hole. These observations were conducted in 2017 using a global interferometric array of eight telescopes operating at a wavelength of λ = 1.3 mm. The EHT data resolve a compact emission region with intrahour variability. A variety of imaging and modeling analyses all support an image that is dominated by a bright, thick ring with a diameter of 51.8 ± 2.3 μas (68% credible interval). The ring has modest azimuthal brightness asymmetry and a comparatively dim interior. Using a large suite of numerical simulations, we demonstrate that the EHT images of Sgr A* are consistent with the expected appearance of a Kerr black hole with mass ∼4 × 106
M
⊙, which is inferred to exist at this location based on previous infrared observations of individual stellar orbits, as well as maser proper-motion studies. Our model comparisons disfavor scenarios where the black hole is viewed at high inclination (i > 50°), as well as nonspinning black holes and those with retrograde accretion disks. Our results provide direct evidence for the presence of a supermassive black hole at the center of the Milky Way, and for the first time we connect the predictions from dynamical measurements of stellar orbits on scales of 103–105 gravitational radii to event-horizon-scale images and variability. Furthermore, a comparison with the EHT results for the supermassive black hole M87* shows consistency with the predictions of general relativity spanning over three orders of magnitude in central mass.</jats:p
Global attitudes in the management of acute appendicitis during COVID-19 pandemic: ACIE Appy Study
- Author
- Adam Orengia
- Aditya Chowdary
- Aditya Kulkarni
- Adnan Kuvvetli
- Adolfo Navarro
- Adolfo Pisanu
- Adrian Smith
- Adriana Cavero Ibiricu
- Aeris Jane D Nacion
- Ahmad Alhazmi
- Ahmad Alsaleh
- Ahmad Elmabri
- Ahmet Rencuzogullari
- Aingeru Sarriugarte Lasarte
- Ainhoa Valle Rubio
- Ajaz Wani
- Akshay Bavikatte
- Akshay Kumar
- Al-Radjid Jamiri
- Alain Michel Alvarado Padilla
- Alban Cacurri
- Alberto de San Ildefonso
- Alberto Porcu
- Alberto Sartori
- Aldo Rocca
- Alejandro Becaria
- Alejandro Paz Yáñez
- Alejandro Solís-Peña
- Aleksandar Sretenović
- Alessandro De Luca
- Alex Boddy
- Alex Urbistondo
- Alexandros Charalabopoulos
- Alexios Tzivanakis
- Alfonso Amendola
- Alfonso Bandin
- Alfonso Najar
- Alfredo Ramirez-Gutierrez de Velasco
- Ali Cihat Yildirim
- Alice Frontali
- Alpha Oumar Toure
- Alvaro García-Granero
- Amaia Martínez Roldan
- Amaia Sanz Larrainzar
- Amila Sanjiva Ratnayake
- Ana Gonzales-Ganso
- Ana M Minaya-Bravo
- Ana María Gonzalez-Ganso
- Andre Das
- Andrea Bondurri
- Andrea Costanzi
- Andrea Lucchi
- Andrea Mazzari
- Andrea Musig
- Andrea Peloso
- Andrea Piano
- Andrea Police
- Andrei Mihailescu
- Andrés Pouy
- Angela Romano
- Angelo Iossa
- Anna Carmen Leonetti
- Anna Guariniello
- Anna Isaac
- Anna Pia Delli Bovi
- Antonella Chessa
- Antonella Tromba
- Antonino Tornambè
- Antonio Brillantino
- Antonio Caira
- Antonio Castaldi
- Antonio Ferronetti
- Antonio Giuliani
- Antonio Prestera
- Antonio Ramos-De la Medina
- Antonio Tarasconi
- Antonio Álvarez Martínez
- Arcangelo Picciariello
- Argyrios Ioannidis
- Ari Leppäniemi
- Arshad Khan
- Arshad Rashid
- Arteaga Luis Eduardo Pérez-Sánchez
- Ashok Mittal
- Ashrarur Rahman Mitul
- Asif Mehraj
- Asim Laharwal
- Asnel Dorismé
- Athanasios Marinis
- Atif Iqbal
- Augusto Moncada
- Bartolomeo Braccio
- Basim Alkhafaji
- Beatriz de Andrés Asenjo
- Beatriz Martin-Perez
- Belinda Sánchez Pérez
- Ben Creavin
- Benedetto Calì
- Benedetto Ielpo
- Beniamino Pascotto
- Benjamin Stubbs
- Benjamin Zavala Retes
- Branislav Jovanovic
- Brian K P Goh
- Brian Kp Goh
- Bruno Sensi
- Carlo Biddau
- Carlo Gazia
- Carlo Vallicelli
- Carlos Alberto Fagundes
- Carlos Cerdán Santacruz
- Carlos Chirico
- Carlos Javier Gómez
- Carlos Petrola
- Carlos Sánchez Rodriguez
- Carlos Yánez Benítez
- Carmelisa Dammaro
- Carmelo Lo Faro
- Caroline Reinke
- Casandra Dominguez Paez
- Catalina Oliva
- Charlotte Thomas
- Charudutt Paranjape
- Chi Fung Chia
- Chi Kwan Kong
- Chiara De Lucia
- Christian Ovalle Chao
- Claudio Arcudi
- Claudio Guerci
- Clement Chia
- Cristiano Parise
- Cristina Folliero
- Cristopher Varela
- Dalya M Ferguson
- Daniel Camacho
- Daniel Popowich
- Daniel Souza Lima
- Daniela Rega
- Daniele Delogu
- Daniele Zigiotto
- Danilo Vinci
- Dario D'Antonio
- Dario Parini
- David Alessio Merlini
- David DE Zimmerman
- David Moro-Valdezate
- Davide Pertile
- Deborah Maria Giusti
- Deborah S Keller
- Delko Tarik
- Denis Kalivaçi
- Dennis Mazingi
- Diana Gabriela Maldonado-Pintado
- Diego Sasia
- Dimitrios Linardoutsos
- Dixon Osilli
- Domenico Murrone
- Domenico Russello
- Edgar Rodas
- Edisson Alberto Acuña Roa
- Edoardo Ricciardi
- Edoardo Rosso
- Edoardo Saladino
- Eduardo Flores-Villalba
- Eduardo Ruiz Ajs
- Eduardo Smith-Singares
- Efstratia Baili
- Efstratios Kouroumpas
- Eirini Bourmpouteli
- Eleftheria Douka
- Elena Martin-Perez
- Eleonora Guaitoli
- Elgun Samadov
- Elisa Francone
- Elisa Vaterlini
- Emilio Morales
- Emilio Peña
- Eneko Del Pozo Andres
- Enhao Zhao
- Enrico Benzoni
- Enrico Erdas
- Enrico Pinotti
- Enrique Colás-Ruiz
- Erman Aytac
- Ernesto Laterza
- Ervis Agastra
- Esteban Foianini
- Esteban Moscoso
- Estefania Laviano
- Ester Marra
- Eugenia Cardamone
- Eugenio Licardie
- Eustratia Mpaili
- Eva Pinna
- Eva Pueyo
- Evaristo Varo
- Fabian Martín Navarro
- Fabio Marino
- Fabio Medas
- Fabio Romano
- Fatlum Maraska
- Fatmir Saliu
- Fausto Madrid
- Fausto Rosa
- Federica Mastella
- Federico Gheza
- Federico Luvisetto
- Felipe Alconchel
- Felipe Monge Vieira
- Felipe Pareja
- Ferdinando Agresta
- Fernanda Luna
- Fernando Bonilla
- Fernando Burdió
- Fernando Cordera
- Fernando Mendoza-Moreno
- Fernando Muñoz Flores
- Fernando Pardo Aranda
- Fiona Taylor
- Flavia L Ramos
- Flavio Fernandes
- Francesca Paola Tropeano
- Francesco Balestra
- Francesco Bianco
- Francesco Ceci
- Francesco Colombo
- Francesco Di Marzo
- Francesco Ferrara
- Francesco Lancellotti
- Francesco Lazzarin
- Francesco Litta
- Francesco Martini
- Francesco Palmieri
- Francesco Pata
- Francesco Pizza
- Francesco Roscio
- Francesco Virdis
- Francisco Blanco Antona
- Francisco Cervantes Ramírez
- Francisco Miguel Fernandez
- Francisco Oliver Llinares
- Francisco Quezada
- Francisco Schlottmann
- Gabriel Herrera-Almario
- Gabriel Massaferro
- Gabriele Bislenghi
- Gabrielle van Ramshorst
- Gaetano Gallo
- Gaetano Gallo
- Gaetano Luglio
- Georgios Bointas
- Georgios Kampouroglou
- Georgios Papadopoulos
- Gerardo Arredondo Manrique
- Giacomo Calini
- Giacomo Nastri
- Giampaolo Formisano
- Giampaolo Galiffa
- Gian Marco Palini
- Gianluca Colucci
- Gianluca Pagano
- Gianluca Pellino
- Gianluca Pellino
- Gianluca Vanni
- Gianmaria Casoni Pattacini
- Gianpiero Gravante
- Gianpiero Gravante
- Gilda De Paola
- Giorgio Lisi
- Giovanna Partida
- Giovanni Bellanova
- Giovanni De Nobili
- Giovanni Sammy Necchi
- Giovanni Sinibaldi
- Giovanni Tebala
- Giulia Bagaglini
- Giuliano Izzo
- Giulio Argenio
- Giuseppe Brisinda
- Giuseppe Candilio
- Giuseppe Di Grezia
- Giuseppe Esposito
- Giuseppe Faillace
- Giuseppe Frazzetta
- Giuseppe La Gumina
- Giuseppe Massimiliano de Luca
- Giuseppe Nigri
- Giuseppe Romeo
- Gloria Chocarro Amatriaín
- Gloria Ortega
- Gonzalo Martin-Martin
- Gregor A Stavrou
- Gunadi
- Gustavo Armand Ugon
- Gustavo Machain
- Gustavo Marcucci
- Gustavo Martínez-Mier
- Gustavo Miguel Machain
- Gustavo Nari
- Hamada Fathy
- Hamilto
- Haydée Calvo
- Hazem Ahmed
- Hazem Faraj
- Hector Nava
- Hector Ordas Macias
- Herald Nikaj
- Heriberto Solano
- Huma Ahmed Khan
- Humberto Sánchez Alarcón
- Husam Ebied
- Iacopo Giani
- Ibabe Villalabeitia Ateca
- Ignacio Neri
- Igor Alberdi San Roman
- Iliya Fidoshev
- Ionut Negoi
- Irene Ortega
- Irina Bernescu
- Iris Shari Russo
- Irune Vincente Rodríguez
- Irving Palomares
- Isaac Baltazar
- Isabel Jaén Torrejimeno
- Isabel María Cornejo Jurado
- Isabella Reccia
- Ishtiyaq Hussain
- Ismael Brito Toledo
- Ismael Mora-Guzmán
- Iulia Dogaru
- Ivan Romic
- Izaskun Balciscueta
- Iñaki Martinez Rodriguez
- J Cleo Kenington
- Jackison Sagolsem
- Jae Y Jang
- James Olivier
- Jan Lammel-Lindemann
- Jana Dziakova
- Javier Ismael Roldán Villavicencio
- Javier Salinas
- Jelena Pejanovic
- Jeny Rincón Pérez
- Jeryl AsReyes
- Jesus Antonio Medina Luque
- Jesus Silva
- Joanna Mak
- Joanne Salas Rodriguez
- Johnn Henry Herrera Kok
- Jon Krook
- Jose Antonio Diaz-Elizondo
- Jose Castell
- Jose Gustavo Parreira
- Jose Mauro Silva Rodrigues
- José Eduardo García-Flores
- José María Jover Navalón
- José Pereira
- José Tomas Castell Gómez
- Jovanovic
- Juan Bellido Luque
- Juan Carlos Martín Del Olmo
- Juan Carlos Salamea
- Juan Francisco Coronel Olivier
- Juan Luis Blas Laina
- Juliana Maria Ordoñez
- Julieta Gutierrez
- Julio Abba
- Junaid Ahmad Sofi
- Kapil Sahnan
- Kashaf Sherafgan
- Katsuhiko Yanaga
- Ken Min Chin
- Kevin Beatson
- Laharwal Asim
- Laura Alvarez
- Leandro Siragusa
- Lee Farber
- Lester Ong
- Liarakos Athanasios
- Lorena García-Bruña
- Luca De Martino
- Luca Ferrario
- Luca Giordano
- Luca Gordini
- Luca Pio
- Luca Ponchietti
- Lucia Moletta
- Luciano Curella
- Luciano Poggi
- Lucio Taglietti
- Luigi Bonavina
- Luigi Conti
- Luigi Goffredi
- Luis Angel Garcia Ruiz
- Luis Barrionuevo
- Luis Enrique Fregoso
- Luis F Cabrera
- Luis G Rodriguez
- Luis Grande
- Luis Gregorio Osoria
- Luis Javier Kantun Gonzalez
- Luis Sánchez-Guillén
- Luis Tallon-Aguilar
- Luis Tresierra
- Luisa Giavarini
- Mahmoud Hasabelnabi
- Maja Odovic
- Mamoru Uemura
- Mansoor Khan
- Manuel Artiles-Armas
- Mara David
- Marcello Di Martino
- Marcello Giuseppe Spampinato
- Marcelo A F Ribeiro
- Marcelo Viola
- Marco Angrisani
- Marco Calussi
- Marco Cannistrà
- Marco Catarci
- Marco Cereda
- Marco Conte
- Marco Giordano
- Marco Pellicciaro
- Marco Vito Marino
- Maria E Vaterlini
- Maria Irene Bellini
- Maria Lemma
- Maria Michela Chiarello
- Maria Nicola
- Maria Victoria Diago
- Mario Arrigo
- Mario Caneda Mejia
- Mario Montes Manrique
- Mario Rodriguez-Lopez
- Mario Serradilla-Martín
- Mario Zambrano Lara
- Marisa Martínez
- Mark Bagnall
- Mark Peter
- Marta Cañón Lara
- Marta Jimenez Gomez
- Marta Paniagua-Garcia-Señorans
- Marta Perez Gonzalez
- Martin Rutegård
- Martin Salö
- Marzia Franceschilli
- María F Jiménez
- María Giulia Lolli
- Massimiliano Silveri
- Massimiliano Veroux
- Massimo Pezzulo
- Matteo Nardi
- Matteo Rottoli
- Matti Tolonen
- Mauricio Pedraza Ciro
- Mauricio Zuluagua
- Maurizio Cannavò
- Maurizio Cervellera
- Maurizio Iacobone
- Mauro Montuori
- Mauro Podda
- Mauro Podda
- Melody García Domínguez
- Meltem Bingol-Kologlu
- Mian Tahir
- Michael Lim
- Michael Sj Wilson
- Michael Wilson
- Michela Campanelli
- Michele Bisaccia
- Michele De Rosa
- Michele Maruccia
- Michele Paterno
- Michele Pisano
- Michele Torre
- Michele Treviño
- Michele Zuolo
- Miguel A Hernandez Bartolome
- Miguel Farina
- Miguel Pera
- Miguel Prieto Calvo
- Milagros Sotelo
- Min Myat Thway
- Mohamed Hassan
- Mohamed Salah Eldin Hassan
- Mohammad Azfar
- Mohammad Bouhuwaish
- Mohammad Taha
- Mohammad Zaieem
- Mohammed Korkoman
- Montserrat Guraieb
- Mostafa Shalaby
- Muhammad Asif Raza
- Muhammad Umar Younis
- Muhammed Elhadi
- Mujahid Zulfiqar Ali
- Nadeem Quazi
- Nagendra N Dudi-Venkata
- Nahar Alselaim
- Natasha Loria
- Nathalie Villan Ramírez
- Nay Win Than
- Neil Smart
- Nelson Trelles
- Nicanor Pinto
- Niccolo Petrucciani
- Niccolò Allievi
- Nicholas Syn
- Nicola Antonacci
- Nicola Cillara
- Nicolae Gica
- Nicolaescu Diana Cristiana
- Nicolás Nicolás
- Nicolò Falco
- Nicolò Pecorelli
- Nicolò Tamini
- Nikolaos Andreas Dallas
- Nikolaos Machairas
- Noelia Brito
- Nura Ahmed Fieturi
- Nuria Ortega
- Octavio AvilaMercado
- Oktay Irkorucu
- Omar Alsherif
- Orestes Valles
- Orestis Ioannidis
- Oscar Hernández Palmas
- Oscar Isaac Hernandez Palmas
- Oscar Sanz Guadarrama
- Osman Bozbiyik
- Pablo Omelanczuk
- Pablo Ottolino
- Pablo Rodrigues
- Pablo Ruiz
- Paola Campenni
- Paola Chiarade
- Paola Prieto Olivares
- Paolo Baroffio
- Paolo Baroffio
- Pascal Wintringer
- Pasquale Di Fronzo
- Pasquale Talento
- Pasqualino Favoriti
- Patricia Mifsut
- Patricia Sendino
- Patrizia Marsanic
- Pawel Ajawin
- Paúl Andrade
- Pedro Abadía-Barnó
- Pedro Alfonso Najar Castañeda
- Pedro Omar Sillas Arevalos
- Pedro Palazón Bellver
- Peng Soon Koh
- Petry Souza
- Piotr Major
- Rajandeep Singh Bali
- Rakesh Mohan Khattar
- Rashid Lui
- Renato Bessa Melo
- Reza Ebrahiminia
- Ricardo Azar
- Ricardo López Murga
- Riccardo Caruso
- Riccardo Pirolo
- Richard Brady
- Richard Justin Davies
- Rishi Dholakia
- Rishi Rattan
- Rishi Singhal
- Robert Lim
- Roberta Angelico
- Roberta Maria Isernia
- Roberta Tutino
- Roberto Faccincani
- Roberto Peltrini
- Rocío Carrera-Ceron
- Rodrigo Tejos
- Rohit Kashyap
- Roosevelt Fajardo
- Rosa Lozito
- Royer Madariaga Pareja
- Sabrina Garbarino
- Salomone Di Saverio
- Salomone Di Saverio
- Salvador Morales-Conde
- Sami Benli
- Sami Mansour
- Samir Flores
- Samuel Limon Suarez
- Santiago Lopez Ben
- Sara Fuentes
- Sara Ingallinella
- Sara Napetti
- Sara Ortiz de Guzmán
- Selmy Awad
- Sergio A Weckmann Luján
- Sergio Gentilli
- Sergio Grimaldi
- Sergio Olivares Pizarro
- Serkan Tayar
- Shakeeb Nabi
- Shannon M Chan
- Sheikh Junaid
- Sidney Rojas
- Silvana Monetti
- Silvia García
- Silvia Salvans
- Silvia Tenconi
- Simon Shaw
- Simone Santoni
- Sofia Andrea Parra
- Sofía Cárdenas
- Sonia Pérez-Bertólez
- Sonja Chiappetta
- Sophie Dessureault
- Spiros Delis
- Stefano Amore Bonapasta
- Stefano Rausei
- Stefano Scaringi
- Sundeep Keswani
- Syed Muhammad Ali
- Süleyman Cetinkunar
- Tak Lit Derek Fung
- Tariq Rawashdeh
- Tatiana Nicolás López
- Tercio De Campos
- Teresa Calderon Duque
- Teresa Perra
- Theodore Liakakos
- Theodoros Daskalakis
- Theodoros Liakakos
- Thomas Barnes
- Tijmen Koëter
- Tiku Zalla
- Tommaso Campagnaro
- Tommy Brown
- Tomás E González
- Tomás Elosua
- Topi Luoto
- Touré Alpha Oumar
- Ugo Giustizieri
- Ugo Grossi
- Umberto Bracale
- Uriel Rivas
- Valentina Ferri
- Valentina Sosa
- Valentina Testa
- Valeria Andriola
- Valeria Tonini
- Valeria Tonini
- Valerio Balassone
- Valerio Celentano
- Valerio Progno
- Vanessa Carroni
- Varun Raju
- Venera Cavallaro
- Venkateswara Rao Katta
- Veronica De Simone
- Vicent Primo Romaguera
- Vicente Simó
- Victor Hugo García Orozco
- Victor Luraschi
- Victor Rachkov
- Victor Turrado-L
- Victor Visag-Castillo
- Victoria Dowling
- Victoria Graham
- Vincenzo Papagni
- Vincenzo Vigorita
- Vinicius Cordeiro Fonseca
- Virginia Jimenez Carneros
- Vittoria Bellato
- Walyson Gonçalves
- William F Powers
- William Grigg
- Wolf O Bechstein
- Ye Xin Koh
- Yu Bing Lim
- Yuksel Altinel
- Zoran Golubović
- Zutoia Balciscueta
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis.
Methods: The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons globally regarding the management of patients with acute appendicitis during the pandemic. Questions were divided into baseline information, hospital organization and screening, personal protective equipment, management and surgical approach, and patient presentation before versus during the pandemic.
Results: Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There was variation in screening indications and modality used, with chest X-ray plus molecular testing (PCR) being the commonest (19\ub78 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6\ub76 and 2\ub74 per cent respectively before, but 23\ub77 and 5\ub73 per cent, during the pandemic (both P < 0\ub7001). One-third changed their approach from laparoscopic to open surgery owing to the popular (but evidence-lacking) advice from expert groups during the initial phase of the pandemic. No agreement on how to filter surgical smoke plume during laparoscopy was identified. There was an overall reduction in the number of patients admitted with appendicitis and one-third felt that patients who did present had more severe appendicitis than they usually observe.
Conclusion: Conservative management of mild appendicitis has been possible during the pandemic. The fact that some surgeons switched to open appendicectomy may reflect the poor guidelines that emanated in the early phase of SARS-CoV-2
First Sagittarius A* Event Horizon Telescope results. I. The shadow of the supermassive black hole in the center of the Milky Way
- Author
- Agurto Claudio
- Akiyama Kazunori
- Alberdi Antxon
- Alef Walter
- Algaba Juan Carlos
- Allardi Alexander
- Amestica Rodrigo
- Anantua Richard
- Araneda Juan Pablo
- Arriagada Oriel
- Asada Keiichi
- Azulay Rebecca
- Bach Uwe
- Baczko Anne-Kathrin
- Ball David
- Baloković Mislav
- Barrett John
- Bauböck Michi
- Bella Noemi La
- Benson Bradford A.
- Berghuis Jennie L.
- Bertarini Alessandra
- Berthold Ryan
- Bintley Dan
- Blackburn Lindy
- Blanchard Jay
- Blundell Raymond
- Bouman Katherine L.
- Bower Geoffrey C.
- Boyce Hope
- Bremer Michael
- Brinkerink Christiaan D.
- Brissenden Roger
- Britzen Silke
- Broderick Avery E.
- Broguiere Dominique
- Bronzwaer Thomas
- Brown Ken
- Bustamante Sandra
- Byun Do-Young
- Cantzler Michael
- Carlstrom John E.
- Caro Patricio
- Castillo-Domínguez Edgar
- Ceccobello Chiara
- Chael Andrew
- Chan Chi-kwan
- Chan Tin Lok
- Chang Chih-Cheng
- Chang Dominic O.
- Chang Shu-Hao
- Chang Song-Chu
- Chatterjee Koushik
- Chatterjee Shami
- Chen (陈永军) Yongjun
- Chen Chung-Chen
- Chen Ming-Tang
- Cheng Xiaopeng
- Chilson Ryan
- Cho Ilje
- Christian Pierre
- Chuter Tim C.
- Ciechanowicz Miroslaw
- Colin-Beltran Edgar
- Conroy Nicholas S.
- Conway John E.
- Cordes James M.
- Coulson Iain M.
- Crawford Thomas M.
- Crew Geoffrey B.
- Crowley Joseph
- Cruz-Osorio Alejandro
- Cui Yuzhu
- Cárdenas Mauricio
- Davelaar Jordy
- De Laurentis Mariafelicia
- Deane Roger
- Degenaar Nathalie
- Dempsey Jessica
- Desvignes Gregory
- Dexter Jason
- Dhruv Vedant
- Doeleman Sheperd S.
- Dornbusch Sven
- Dougal Sean
- Durán Carlos A.
- Dzib Sergio A.
- Eatough Ralph P.
- Emami Razieh
- Everett Wendeline B.
- Faber Aaron
- Falcke Heino
- Farah Joseph
- Fish Vincent L.
- Fomalont Ed
- Ford H. Alyson
- Forster Karl
- Fraga-Encinas Raquel
- Freeman William T.
- Friberg Per
- Fromm Christian M.
- Fuchs Miriam M.
- Fuentes Antonio
- Fuentes Santiago Navarro
- Gale David M.
- Galison Peter
- Gammie Charles F.
- García Roberto
- Geertsema Gertie
- Gentaz Olivier
- Georgiev Boris
- Goddi Ciriaco
- Gold Roman
- González Edouard
- Graham Dave
- Gu (顾敏峰) Minfeng
- Gueth Frédéric
- Gurwell Mark
- Gómez José L.
- Gómez-Ruiz Arturo I.
- Hada Kazuhiro
- Haggard Daryl
- Halverson Nils W.
- Han Chih-Chiang
- Han Kuo-Chang
- Hasegawa Yutaka
- Haworth Kari
- Hecht Michael H.
- Hernández-Rebollar José Luis
- Herrera Cristian
- Herrero-Illana Ruben
- Hesper Ronald
- Heumann Dirk
- Heyminck Stefan
- Hirota Akihiko
- Ho (何子山) Luis C.
- Ho Paul
- Hoge James
- Honma Mareki
- Howie Ryan E.
- Huang (黄磊) Lei
- Huang Chih-Wei L.
- Huang Yau-De
- Hughes David H.
- Ikeda Shiro
- Impellizzeri C. M. Violette
- Inoue Makoto
- Issaoun Sara
- James David J.
- Jannuzi Buell T.
- Janssen Michael
- Jeter Britton
- Jiang (江悟) Wu
- Jiang Homin
- Jiménez-Rosales Alejandra
- Jinchi Hao
- John David
- Johnson Michael D.
- Jorstad Svetlana
- Joshi Abhishek V.
- Jung Taehyun
- Karami Mansour
- Karuppusamy Ramesh
- Kawashima Tomohisa
- Keating Garrett K.
- Kettenis Mark
- Kim Dong-Jin
- Kim Jae-Young
- Kim Jongsoo
- Kim Junhan
- Kimura Kimihiro
- Kino Motoki
- Klein Thomas
- Koay Jun Yi
- Koch Patrick M.
- Kocherlakota Prashant
- Kofuji Yutaro
- Koyama Shoko
- Kramer Carsten
- Kramer Michael
- Krichbaum Thomas P.
- Kubo Derek
- Kuo Cheng-Yu
- Kuroda John
- Kwon Caleb
- Lacasse Richard
- Laing Robert
- Lauer Tod R.
- Lee Daeyoung
- Lee Sang-Sung
- Leitch Erik M.
- Leung Po Kin
- Levis Aviad
- Li (李志远) Zhiyuan
- Li Chao-Te
- Lico Rocco
- Lin Lupin C.-C.
- Lindahl Greg
- Lindqvist Michael
- Lisakov Mikhail
- Liu Ching-Tang
- Liu Jun
- Liu Kuan-Yu
- Liu Kuo
- Liuzzo Elisabetta
- Lo Wen-Ping
- Lobanov Andrei P.
- Loinard Laurent
- Lonsdale Colin J.
- Lu (路如森) Ru-Sen
- Lu Li-Ming
- Mac-Auliffe Felipe
- Mao (毛基荣) Jirong
- Marchili Nicola
- Markoff Sera
- Marrone Daniel P.
- Marscher Alan P.
- Martin-Cocher Pierre
- Martí-Vidal Iván
- Matsushita Satoki
- Matthews Lynn D.
- Matulonis Callie
- Maute John K.
- Medeiros Lia
- Menten Karl M.
- Messias Hugo
- Meyer-Zhao Zheng
- Michalik Daniel
- Mizuno Izumi
- Mizuno Yosuke
- Montaña Alfredo
- Montenegro-Montes Francisco
- Montgomerie William
- Moran James M.
- Moriyama Kotaro
- Moscibrodzka Monika
- Muders Dirk
- Mus Alejandro
- Musoke Gibwa
- Myserlis Ioannis
- Müller Cornelia
- Nadolski Andrew
- Nagai Hiroshi
- Nagar Neil M.
- Nakamura Masanori
- Narayan Ramesh
- Narayanan Gopal
- Natarajan Iniyan
- Nathanail Antonios
- Neilsen Joey
- Neri Roberto
- Ni Chunchong
- Nishioka Hiroaki
- Nolasco Marcos Emir Moreno
- Norton Timothy J.
- Noutsos Aristeidis
- Nowak Michael A.
- Nystrom George
- Ogawa Hideo
- Oh Junghwan
- Okino Hiroki
- Olivares Héctor
- Olivares Rodrigo
- Ortiz-León Gisela N.
- Oshiro Peter
- Oyama Tomoaki
- Palumbo Daniel C. M.
- Paraschos Georgios Filippos
- Park Jongho
- Parra Rodrigo
- Parsons Harriet
- Patel Nimesh
- Pen Ue-Li
- Pesce Dominic W.
- Phillips Neil M.
- Piétu Vincent
- Plambeck Richard
- Poirier Michael
- PopStefanija Aleksandar
- Porth Oliver
- Pradel Nicolas
- Prather Ben
- Preciado-López Jorge A.
- Psaltis Dimitrios
- Pu Hung-Yi
- Pérez-Beaupuits Juan Pablo
- Pötzl Felix M.
- Qiu Richard
- Raffin Philippe A.
- Rahlin Alexandra S.
- Ramakrishnan Venkatessh
- Ramírez Jorge
- Rao Ramprasad
- Rawlings Mark G.
- Raymond Alexander W.
- Ressler Sean
- Reynolds Mark
- Rezzolla Luciano
- Ricarte Angelo
- Ripperda Bart
- Rodríguez-Montoya Iván
- Roelofs Freek
- Rogers Alan
- Romero-Cañizales Cristina
- Ros Eduardo
- Roshanineshat Arash
- Rottmann Helge
- Roy Alan L.
- Ruiz Ignacio
- Ruszczyk Chet
- Rygl Kazi L. J.
- Saez-Madain Alejandro F.
- Santana Jorge
- Sasada Mahito
- Satapathy Kaushik
- Savolainen Tuomas
- Schimpf Shelbi R. Hostler
- Schloerb F. Peter
- Schonfeld Jonathan
- Schuster Karl-Friedrich
- Shao Lijing
- Shaw Paul
- Shen (沈志强) Zhiqiang
- Shirkey Jr. Leslie E.
- Silva Kevin M.
- Small Des
- Snow William
- Sohn Bong Won
- SooHoo Jason
- Souccar Kamal
- Sousa Don
- Sridharan T. K.
- Stahm William
- Stark Anthony A.
- Sun He
- Sánchez Salvador
- Sánchez-Argüelles David
- Sánchez-Portal Miguel
- Tazaki Fumie
- Test John
- Tetarenko Alexandra J.
- Tiede Paul
- Tilanus Remo P. J.
- Titus Michael
- Torne Pablo
- Torstensson Karl
- Traianou Efthalia
- Trent Tyler
- Trippe Sascha
- Turk Matthew
- van Bemmel Ilse
- van Langevelde Huib Jan
- van Rossum Daniel R.
- Venegas Paulina
- Vos Jesse
- Wagner Jan
- Walther Craig
- Ward-Thompson Derek
- Wardle John
- Wei Ta-Shun
- Weintroub Jonathan
- Wex Norbert
- Wharton Robert
- White Chris
- Wieching Gundolf
- Wielgus Maciek
- Wiik Kaj
- Wijnands Rudy
- Witzel Gunther
- Wondrak Michael F.
- Wong George N.
- Wouterloot Jan G. A.
- Wu (吴庆文) Qingwen
- Yamaguchi Paul
- Yoon Doosoo
- Young André
- Young Ken
- Younsi Ziri
- Yu Chen-Yu
- Yu Wei
- Yuan (袁业飞) Ye-Fei
- Yuan (袁峰) Feng
- Zeballos Milagros
- Zensus J. Anton
- Zhang Shuo
- Zhao Guang-Yao
- Zhao Shan-Shan
- Özel Feryal
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/05/2022
- Field of study
We present the first Event Horizon Telescope (EHT) observations of Sagittarius A* (Sgr A*), the Galactic center source associated with a supermassive black hole. These observations were conducted in 2017 using a global interferometric array of eight telescopes operating at a wavelength of λ = 1.3 mm. The EHT data resolve a compact emission region with intrahour variability. A variety of imaging and modeling analyses all support an image that is dominated by a bright, thick ring with a diameter of 51.8 ± 2.3 μas (68% credible interval). The ring has modest azimuthal brightness asymmetry and a comparatively dim interior. Using a large suite of numerical simulations, we demonstrate that the EHT images of Sgr A* are consistent with the expected appearance of a Kerr black hole with mass ∼4 × 106 M⊙, which is inferred to exist at this location based on previous infrared observations of individual stellar orbits, as well as maser proper-motion studies. Our model comparisons disfavor scenarios where the black hole is viewed at high inclination (i > 50°), as well as nonspinning black holes and those with retrograde accretion disks. Our results provide direct evidence for the presence of a supermassive black hole at the center of the Milky Way, and for the first time we connect the predictions from dynamical measurements of stellar orbits on scales of 103–105 gravitational radii to event-horizon-scale images and variability. Furthermore, a comparison with the EHT results for the supermassive black hole M87* shows consistency with the predictions of general relativity spanning over three orders of magnitude in central mass.http://iopscience.iop.org/2041-8205Physic