10 research outputs found
Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis
- Author
- AI Othman
- Alexandra Benachi
- B Gondos
- C Gautier
- CE Hoei-Hansen
- Delphine Moison
- DJ Macleod
- G Livera
- Gabriel Livera
- Gabriele Matilionyte
- H Kabuto
- H Leridon
- H Tinwell
- H Wartenberg
- IA Olesen
- J Auger
- J Merlet
- J Merlet
- J Peretz
- J Vilela
- Jean-Philippe Antignac
- JG Teeguarden
- Joël R Drevet
- K Kobayashi
- K Pauls
- K Pauls
- Karen Kilcoyne
- KL Howdeshell
- KM Main
- L Evtouchenko
- L Lecerf
- LN Vandenberg
- LN Vandenberg
- LN Vandenberg
- M Ben Maamar
- M Miao
- M Poulain
- M Tanaka
- M Welsh
- MA Brieno-Enriquez
- Marie-Justine Guerquin
- MI Churchwell
- MZ Lacroix
- N Chevalier
- NE Skakkebaek
- NE Skakkebaek
- NE Skakkebaek
- P Allard
- P Fenichel
- P Jin
- P Naik
- P Urriola-Munoz
- PA Fowler
- PA Hunt
- Q Wang
- R Habert
- R Habert
- R Habert
- R Lambrot
- R Lambrot
- R Olaso
- R Thuillier
- René Habert
- RM Sharpe
- RM Sharpe
- Rod Mitchell
- RR Gerona
- RT Mitchell
- RT Mitchell
- RT Mitchell
- RW Tyl
- S Eladak
- S Lee
- S Salian
- S Tayama
- S van den Driesche
- S van den Driesche
- S Watanabe
- Soria Eladak
- Stéphanie Pozzi-Gaudin
- Sébastien Messiaen
- T Aoki
- T Fujimoto
- T Fukuda
- T N'Tumba-Byn
- Thierry N’Tumba-Byn
- TJ Murray
- TL Gaskell
- V Rouiller-Fabre
- V Rouiller-Fabre
- V Rouiller-Fabre
- Virginie Rouiller-Fabre
- W Xi
- XF Zhang
- Y Deceuninck
- Y Deceuninck
- Y Ikezuki
- YJ Li
- Yoann Deceuninck
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 31/01/2018
- Field of study
<div><p>Background</p><p>Using an organotypic culture system termed human Fetal Testis Assay (hFeTA) we previously showed that 0.01 μM BPA decreases basal, but not LH-stimulated, testosterone secreted by the first trimester human fetal testis. The present study was conducted to determine the potential for a long-term antiandrogenic effect of BPA using a xenograft model, and also to study the effect of BPA on germ cell development using both the hFETA and xenograft models.</p><p>Methods</p><p>Using the hFeTA system, first trimester testes were cultured for 3 days with 0.01 to 10 μM BPA. For xenografts, adult castrate male nude mice were injected with hCG and grafted with first trimester testes. Host mice received 10 μM BPA (~ 500 μg/kg/day) in their drinking water for 5 weeks. Plasma levels of total and unconjugated BPA were 0.10 μM and 0.038 μM respectively. Mice grafted with second trimester testes received 0.5 and 50 μg/kg/day BPA by oral gavage for 5 weeks.</p><p>Results</p><p>With first trimester human testes, using the hFeTA model, 10 μM BPA increased germ cell apoptosis. In xenografts, germ cell density was also reduced by BPA exposure. Importantly, BPA exposure significantly decreased the percentage of germ cells expressing the pluripotency marker AP-2γ, whilst the percentage of those expressing the pre-spermatogonial marker MAGE-A4 significantly increased. BPA exposure did not affect hCG-stimulated androgen production in first and second trimester xenografts as evaluated by both plasma testosterone level and seminal vesicle weight in host mice.</p><p>Conclusions</p><p>Exposure to BPA at environmentally relevant concentrations impairs germ cell development in first trimester human fetal testis, whilst gonadotrophin-stimulated testosterone production was unaffected in both first and second trimester testis. Studies using first trimester human fetal testis demonstrate the complementarity of the FeTA and xenograft models for determining the respective short-term and long term effects of environmental exposures.</p></div
Spectral profiles of commercial omega-3 supplements: an exploratory analysis by ATR-FTIR and 1H NMR
- Author
- A Bratu
- A Nordøy
- A Rohman
- A Ruiz-Aracama
- A Simopoulos
- AR Medina
- B Nieva-Echevarría
- CB Dias
- CE Tyl
- DJA Jenkins
- GC Zittelli
- HE Krokan
- JA Kralovec
- JB Hansen
- JM Leite
- KC Maki
- LD Lawson
- M Aursand
- M Aursand
- M Plans
- MA Lopez-Toledano
- MA Lopez-Toledano
- MS Dhanoa
- R Popescu
- R Sacchi
- RB Derner
- S Boustani
- S Huerta-Yépez
- S Punia
- S Yoshida
- T Igarashi
- TL Vestland
- V Shapaval
- Y Ando
- Z Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties
- Author
- A Aguirre
- A Croquelois
- AJ Engler
- AK Zupanska
- AM Smits
- C Jopling
- CE Weidgang
- CJ Hatcher
- EA Blaber
- ER Porrello
- F Louis
- G Blin
- H Kang
- I Arnaoutova
- I Vlachos
- KA Gerbin
- KU Hong
- L Yuge
- LA Cubano
- M Mizutani
- M Pucéat
- M Tanaka
- ML Bakker
- MTX Nguyen
- P Menasché
- R Bolli
- R Edgar
- R Jha
- RR Makkar
- S Sharma
- S Versari
- S Zhang
- SC Lin
- TF Plageman
- TI Fuentes
- TI Fuentes
- TJ Kim
- TYL Le
- VE Meyers
- Z Chen
- ZQ Dai
- ZY Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and Mouse Fetal Leydig Cell Function
- Author
- A Bouskine
- A Lehraiki
- A Lehraiki
- Alexandra Benachi
- AM Soto
- BT Akingbemi
- CE Talsness
- Charlotte Lecureuil
- CS Mazur
- D Nakamura
- Delphine Moison
- DF Swaab
- DM Kristensen
- EP Murono
- F Chauvigne
- G Angenard
- G Delbes
- G Delbes
- G Livera
- G Livera
- Gabriel Livera
- GG Kuiper
- H Leridon
- HM Scott
- J Lassurguere
- J Mendiola
- J Merlet
- J Toppari
- J Toppari
- JA Taylor
- JD Meeker
- JG Teeguarden
- Joel R. Drevet
- K Bay
- K Kobayashi
- KL Howdeshell
- KM Main
- L Evtouchenko
- L Gaspari
- L Lecerf
- L Ye
- Laëtitia Lesage
- LN Vandenberg
- LN Vandenberg
- LN Vandenberg
- M Miao
- M Tanaka
- M Welsh
- Marlène Lacroix
- MZ Lacroix
- MZ Lacroix
- N Chevalier
- NE Skakkebaek
- NJ Cabaton
- P Fenichel
- R Habert
- R Habert
- R Habert
- R Ivell
- R Lambrot
- R Lambrot
- R Lambrot
- R Olaso
- R Thuillier
- René Frydman
- René Habert
- RM Sharpe
- RW Tyl
- RW Tyl
- S Dupont
- S Salian
- S Takayanagi
- S van den Driesche
- Sophie M. Prud’homme
- Stéphanie Pozzi-Gaudin
- T Galloway
- T Hanaoka
- Thierry N’Tumba-Byn
- TJ Murray
- TL Gaskell
- V Muczynski
- Virginie Rouiller-Fabre
- X Zhang
- Y Ikezuki
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Examining the associations of autonomy and directive support given and received with relationship satisfaction in the context of goals that romantic partners have for one another
- Author
- A Aron
- A Aron
- A Nadler
- A Nadler
- A Nadler
- A Nadler
- AA Gorin
- BC Feeney
- BE Solstad
- BN Uchino
- CE Rusbult
- CN Markey
- EL Deci
- EL Deci
- EL Deci
- F Guay
- GA Mageau
- GA Mageau
- J Reeve
- JG La Guardia
- K Brenning
- KM Hanna
- LG Pelletier
- M Demir
- MD Hammond
- N Bolger
- N Carbonneau
- N Carbonneau
- N Gillet
- NC Overall
- Noémie Carbonneau
- R Koestner
- R Koestner
- R Koestner
- Richard Koestner
- RL Kahn
- RL Piferi
- RM Ryan
- RM Ryan
- S Chua
- S Cohen
- Samuel Rochette
- SC Duncan
- SL Brown
- SL Brown
- SS Hendrick
- TA Powers
- Tamas Martos
- TK Inagaki
- TK Inagaki
- TYL Cheng
- Viola Sallay
- VS Helgeson
- YA Momtaz
- YU Girme
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Comparison of Infrared Spectroscopy and Nuclear Magnetic Resonance Techniques in Tandem with Multivariable Selection for Rapid Determination of ω-3 Polyunsaturated Fatty Acids in Fish Oil
- Author
- A Flåtten
- AOAC Method 963.22
- BG Osborne
- C Song
- C Wang
- CE Tyl
- CL Jensen
- D Cozzolino
- D Cozzolino
- D Wu
- D Wu
- D Wu
- D Wu
- D Wu
- Da-Wen Sun
- Di Wu
- EF Olsen
- F Marini
- Fang Cao
- G ElMasry
- G Kaur
- H Azizian
- H Nemets
- HA Martens
- IAA Shaikh
- IM Berquin
- Institute of Medicine National Academy of Science
- JG Martins
- JM Curtis
- K Rennie
- K Yurko-Mauro
- M Bousquet
- M Huan
- M Wolters
- MC Morris
- MCU Araujo
- MD Guillen
- MD Guillén
- MJ Rivero
- O Papadopoulou
- P Guesnet
- PC Calder
- PC Williams
- R Sacchi
- RM Balabin
- RM Balabin
- S Masoum
- SA Schønberg
- SA Wright
- T Igarashi
- T Kimiya
- V Centner
- Xiaojing Chen
- XJ Chen
- Y Endo
- Y Miyake
- Yanhui Jiang
- Yong He
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sexual EDC-ucation: What we Have Learned About Endocrine-Disrupting Chemicals and Reproduction
- Author
- A Ben Slima
- A Burdorf
- A Colciago
- A Gemmill
- A Janesick
- A Mouritsen
- A. Holley
- AJJM Lemos
- AK Goetz
- AK Goetz
- AM Calafat
- AM Mandl
- AM Soto
- AN Garcia
- AP Arnold
- AP Arnold
- AR Zota
- AW Sullivan
- B Eskenazi
- B Eskenazi
- B Lauby-Secretan
- B Weinberger
- BA Jones
- BC Ryan
- BE Lee
- BJ Everitt
- BJ Wojtyniak
- BK Petroff
- BM Nugent
- C Chevrier
- C Dombret
- C Philippat
- C Taxvig
- C. A. Gerson
- C. E. Mac Cionnaith
- CA Snijder
- CA Snijder
- CC Cheung
- CE Roselli
- CH Phoenix
- CJ Marsit
- CL Portigal
- CY Chen
- D Capela
- D Crews
- D deCatanzaro
- DA Dewsbury
- DB Barr
- DB Martinez-Arguelles
- DJ Barker
- DK Sarkar
- DK Sarkar
- E Durmaz
- E Govarts
- E Kornberg
- EF Rissman
- EM Hull
- EP Hines
- ES Webber
- EU Directive
- FA Beach
- FA Beach
- FA Beach
- FH Bronson
- FS Vom Saal
- FS von Saal
- FZ Stanczyk
- G Lahr
- GC Harris
- GC Kennedy
- H Frederiksen
- H Fromme
- HB Patisaul
- I Al-Saleh
- J Bakker
- J Burgdorf
- J Jurewicz
- J Terkel
- JA Cummings
- JD Blaustein
- JD Meeker
- JG Pfaus
- JG Pfaus
- JJ Stern
- JM Greally
- JP Lomenick
- JW Everett
- K Konishi
- K Tawara
- KV Pernoncini
- L Huang
- L Monje
- L Naulé
- LH Clark
- LM Kow
- LM Kow
- LM Kow
- M Bialy
- M Kamishima
- M Picot
- M Uzumcu
- M Vafeiadi
- M Willadsen
- M Wöhr
- MA Sanchez-Garrido
- MB Kjærstad
- MD Anway
- ME Freeman
- MK McClintock
- MK McClintock
- MR Bell
- MS Erskine
- MS Wolff
- MS Wolff
- N Ranjit
- NO Costa
- NT Adler
- O Faass
- P Pocar
- P Södersten
- PC Huang
- PN Goodfellow
- R Bergonzi
- R Dallaire
- R Gillette
- R Gillette
- R Hart
- R Takai
- R Wang
- RJ Blandau
- RL Meisel
- RM Steinberg
- RV Chester
- RW Tyl
- RW Tyl
- S Edmonds
- S Gill
- S Sathyanarayana
- SA Ferguson
- SE Abdelgadir
- SM Dickerson
- SM Ho
- SQ Chen
- T Liu
- TR Chakraborty
- U Hass
- US Environmental Protection Agency
- V Migeot
- V Padmanabhan
- VY Topper
- W Völkel
- WH Nah
- X Wang
- X Xu
- XB Xu
- Y Ding
- Y Suzuki
- Y Suzuki
- Z Zuo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Phenolic Compounds in Wheat Kernels: Genetic and Genomic Studies of Biosynthesis and Regulations
- Author
- A Bhargava
- A Blanco
- A Brandolini
- A Mpofu
- A Pasqualone
- A Pasqualone
- A Pasqualone
- A Peragine
- A Sacco
- A Serpen
- A Žofajová
- AM Leonardis de
- AP Dias
- AP Dias
- AS Sivam
- B Craven-Bartle
- B Laddomada
- B Laddomada
- B Laddomada
- B Stumpf
- B Zhang
- BHJ Juurlink
- C Dubos
- C Dubos
- C Fares
- C Li
- CE Tyl
- CF Verdu
- CG Rizzello
- CM Liyana-Pathirana
- CM Rommens
- CO Qualset
- D Chagné
- D Heimler
- D Ma
- D Martini
- D Nigro
- D Wang
- DH Rhodes
- DV Bustos
- DW Hatcher
- E Allen
- E Graf
- EK Khlestkina
- EK Khlestkina
- ESM Abdel-Aal
- ESM Abdel-Aal
- F Brouns
- F Cardona
- F Taranto
- F Vazquez
- F Yang
- FJ Zeller
- FM Sonbol
- FS Hosseinian
- G Dinelli
- GF Heine
- H Du
- H Jin
- H Jin
- H Kikuzaki
- H Liu
- H Wu
- HM Mu
- HO Iwakawa
- I Hichri
- I Lempereur
- I Nicoletti
- IC Vélez-Bermúdez
- J Lachman
- J Liu
- J Luo
- J Mol
- J Preston
- J Prohens
- J Qiu
- J Wang
- J Zhang
- JD McKeehen
- JR Widhalm
- JT Oberlerchner
- K Drankham
- K Katina
- K Kazan
- K Kyung-Hee
- K Matsui
- K Sevgi
- KE Schwinn
- KK Adom
- KO Vollmer
- L Bourne
- L Bravo
- L Gauthier
- L Jin
- L Li
- L Yu
- LC Bourne
- M Blandino
- M Bunzel
- M Hiemori
- M Maccaferri
- M Mohammadi
- M Plazas
- M Salmenkallio-Marttila
- M Shahid
- M Shamloo
- M Varga
- M Whent
- M Zhou
- M Zhou
- MA Okot-Kotber
- MF Andreasen
- ML Parker
- MN Laus
- MW Li
- N Li
- N Mateo Anson
- NM Edwards
- O Lukow
- OY Shoeva
- OY Shoeva
- OY Tereschenko
- P Vitaglione
- P Wang
- PR Shewry
- PR Shewry
- Q Liu
- R Fernandez-Orozco
- R Santiago
- R Vanholme
- RJ Metzger
- RS Payyavula
- RT Furbank
- S Böhmdorfer
- S Fornalé
- S Fornalé
- S Hemdane
- S Itagaki
- S Kock De
- S Ragaee
- S Ramos
- S Siebenhandl
- S Zhang
- SC Thomasset
- SG Cai
- SL Dwivedi
- SN Syed Jaafar
- SZ El-Basyouni
- T Agarwal
- T Vogt
- TA Geissman
- TA Holton
- V Atanasova-Penichon
- V Buresova
- V Menga
- VL Singleton
- W Jiang
- W Li
- W Li
- W Xu
- WB Griffin
- Y Deng
- Y Hemery
- Y Hemery
- YA Zhang
- YZ Qin
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Whole wheat grains are an important source of bioactive components,
particularly of phenolic acids and flavonoids. Due to the health-promoting effects of
these phenolics, nowadays, the increase of their content in mature kernels is of great
interest and a potential target for wheat breeding programs. The biogenesis of phenolics
occurs through the general phenylpropanoid pathway, which is ubiquitous in
plant cell walls and leads to the synthesis of secondary metabolites that are involved
in plant defence and structural support. This chapter reviews the current knowledge
in phenylpropanoid chemistry, and the genetic and molecular basis for the biosynthesis
of phenolic acids and anthocyanins in wheat grains. Also, advances in assessing
genetic variation in the content and composition of these components in wheat
germplasm are reviewed, including the effects of different environmental conditions
on their accumulation in mature kernels. The recent, ongoing genomic studies are
reviewed providing updates on quantitative trait loci and genes involved in the synthesis
and accumulation of phenolics in wheat kernels. Finally, the promise and
limitations of breeding programs to potentially develop wheat cultivars rich in phenolic
components are discussed
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
- Abe R
- Abe S
- Abel L
- Abel L
- Abernathy C
- Abraham R
- Abraheem A
- Abu Alragheb BO
- Abulail JA
- Acklery A
- Acosta-Herrera M
- Adachi T
- Adachi Y
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agravante K
- Agrawal A
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar SEV
- Aguilar-Salinas CA
- Aguilera-Albesa S
- Agüero D
- Ahmad HF
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Ahram M
- Ai M
- Ain Q
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Ani A
- Al-Ja’afreh MM
- Al-Kadash A
- Al-Kasasbeh MM
- Al-Moasseb H
- Al-Muftah W
- Al-Sarraj Y
- Alamer LM
- Alasdair F
- Alawneh FM
- Alawneh LM
- Albaiceta GM
- Albano G
- Albillos A
- Albrecht W
- Aldridge J
- Alexander P
- Alfonso J
- Alhousani TN
- Ali A
- Ali HH
- Ali IAM
- Ali S
- Aliberti S
- ALjalamdeh M
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen M
- Allen S
- Allen U
- Allibone S
- Allison KS
- Allouzy SK
- Ally SM
- Almadana V
- Almaden-Boyle C
- Almoguera B
- Alpuche-Aranda C
- AlRawashdeh TJ
- Alsafadi DB
- Alshaer W
- Alsoub FS
- Altabaibeh A
- Alvarez N
- Alvaro A
- Alzuraiqi MR
- Amamio M
- Aman NF
- Amin V
- Amiya S
- Ampuero J
- Anan R
- Anastasescu E
- Andersen S
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andrade V
- Andreou P
- Andreu-Bernabeu Á
- Andrew A
- Andrew B
- Andrew G
- Andrews J
- Andrews S
- Andrews SJ
- Angelini C
- Ansari AI
- Antcliffe D
- Antoine P
- Antony S
- Anumakonda V
- Anwer M
- Anzai T
- Apetri E
- Aquino M
- Aquino-Gálvez A
- Arai D
- Arakelyan A
- Arana-Arri E
- Arana-Arri E
- Arango C
- Aravindan L
- Arbane G
- Archer K
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armistead J
- Armstrong D
- Armstrong J
- Armstrong L
- Armstrong R
- Arning N
- Arnoldo S
- Arnott A
- Arora J
- Arora M
- Arranz MJ
- Arranz MJ
- Arribas-Rodriguez E
- Artiga M-J
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ashby K
- Ashok SR
- Ashraf S
- Ashton L
- Asimakopoulos A
- Aslibekyan S
- Asselta R
- Astin-Chamberlain R
- Atayeva N
- Athanasiou L
- Atkinson EG
- Attwood B
- Atwal I
- Augustin M
- Auld D
- Auld F
- Austin K
- Austin P
- Auton A
- Avetyan D
- Awano N
- Awasthi S
- Ayers A
- Ayo NI
- Ayuso C
- Aziz F
- Aziz N
- Azuma M
- Azuure C
- Azzolini E
- Baba R
- Baba T
- Bacher P
- Badal B
- Badalamenti S
- Baddeley A
- Badia JR
- Badji RM
- Bafitis V
- Bahmer T
- Baikady RR
- Bailey L
- Baillie JK
- Baines D
- Baines K
- Baird T
- Baird Y
- Baker M
- Bakthavatsalam D
- Balaconis MK
- Baldini M
- Balla D
- Bals R
- Bamford A
- Bamford A
- Bamford P
- Banach D
- Banales JM
- Banasik K
- Banasik K
- Bancroft H
- Band G
- Bandera A
- Bandla N
- Bani younis FM
- Bano S
- Baptista D
- Baptista-Rosas RC
- Barber R
- Barberena-Jonas C
- Barberis L
- Barclay C
- Barclay L
- Barker J
- Barker M
- Barnes KC
- Barnes N
- Barnetche JM
- Barr J
- Barreda-Sánchez M
- Barreira A
- Barretina J
- Barretina J
- Barrett F
- Barron A
- Barrow E
- Barry P
- Bartley S
- Barton J
- Barton-Forbes M
- Baruah R
- Baselli G
- Bashyal A
- Basikolo C
- Bastion V
- Bates H
- Bates M
- Battle C
- Bauchmuller K
- Baxter N
- Baxter-Dore S
- Baya N
- Bayo L-A
- Beadle J
- Bean S
- Bearss E
- Beasley A
- Beaumont K
- Beavis S
- Bedini JL
- Beech E
- Beech V
- Beekes M
- Beer S
- Beesley K
- Beger SD
- Begg C
- Beguin Y
- Behan T
- Behzad P
- Beileke S
- Beith C
- Bekbossynova M
- Belagodu Z
- Belfield H
- Belhassen-Garcia M
- Bell D
- Bell G
- Bell J
- Bell M
- Bell S
- Bellamy M
- Bellani G
- Bellelli G
- Bellinghausen C
- Bellini A
- Bellwood R
- Below JE
- Bemand T
- Benham L
- Benkenstein S
- Bennett S
- Bentley D
- Bentley M
- Benyon S
- Beppu S
- Beranova E
- Bercades G
- Bergan J
- Berger MM
- Bernardo D
- Bernier FP
- Betschel S
- Bettini LR
- Bevan E
- Bewley J
- Bezerra JF
- Bezerra MAC
- Bhatia N
- Bhatterjee R
- Bhuie P
- Bhutta MJ
- Bi R
- Bianco C
- Bibi F
- Biddle J
- Biggs CM
- Biggs H
- Binatti E
- Binnie A
- Biondi A
- Birch J
- Birch J
- Birch S
- Birchall K
- Birchall K
- Bircham S
- Bird S
- Birkinshaw I
- Biros D
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- Tanaka A
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- Yasui Y
- Yates B
- Yatomi M
- Ye C
- Yermakovich D
- Yeung RSM
- Yi X
- Yonekawa A
- Yoo S
- Yoon K
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Young M
- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
- Zamikula J
- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
- Zitter L
- Zoller H
- Zongo O
- Zorloni C
- Zuñiga-Pacheco P
- Zárate RN
- Zúñiga-Ramos J
- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
- Angus B
- Annis A
- Antcliffe D
- Antinori A
- Antoni MD
- Anumakonda V
- Anwar M
- Anzai T
- Apetri E
- Arai D
- Arana E
- Arbane G
- Archer K
- Arciero E
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armstrong J
- Armstrong JA
- Armstrong L
- Armstrong R
- Arning N
- Arnold S
- Arora J
- Artuso R
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ascolillo S
- Ashish A
- Ashley E
- Ashraf S
- Ashraf S
- Ashton L
- Ashworth M
- Asiimwe IG
- Aslibekyan S
- Asselta R
- Atanasovska B
- Atkinson D
- Atkinson EG
- Attwood B
- Aucella F
- Augustin M
- Auld D
- Auld F
- Austin K
- Austin P
- Auton A
- Auton A
- Avendano-Ortiz J
- Awano N
- Ayers A
- Azarzar S
- Aziz F
- Azuma M
- Azuure C
- Azzolini E
- Baba R
- Baba T
- Bach B
- Bacher P
- Bachetti T
- Badalamenti S
- Badia JR
- Badji RM
- Bahmer T
- Baikady RR
- Baillie JK
- Baillie JK
- Baillie JK
- Baillie JK
- Baines B
- Baines D
- Baines K
- Baird T
- Baird Y
- Bakshi S
- Bakthavatsalam D
- Balaconis MK
- Baldassarri M
- Baldini M
- Ball CA
- Bals R
- Baltzell AH
- Bamford A
- Bamford P
- Banach D
- Banagan J
- Banales JM
- Bancroft H
- Band G
- Bandera A
- Bandini M
- Bandla N
- Bano S
- Baptista D
- Barada O
- Baras A
- Baratti S
- Barber R
- Barbieri C
- Barbieri C
- Barbour A
- Barclay L
- Barclay WS
- Barda B
- Bargagli E
- Bari S
- Barker J
- Barlow G
- Barlow SL
- Barnass S
- Barnes KC
- Baroni S
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- Barreira A
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- Barrett KMS
- Barrett N
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- Bartels M
- Bartley S
- Baruah R
- Baselli G
- Bashyal A
- Basikolo C
- Bassetti M
- Bassford C
- Basso MEF
- Bastion V
- Basude S
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- Bates M
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- Baya N
- Bayo L-A
- Beadle J
- Beadsworth M
- Beale R
- Bean S
- Beaumont K
- Beavis S
- Beck A
- Beckmann ND
- Beech E
- Beech V
- Beekes M
- Beesley K
- Begg C
- Beguin Y
- Behan T
- Beith CM
- Belagodu Z
- Belbin GM
- Belfield H
- Belhaj Y
- Beligni G
- Belisle A
- Bell D
- Bell G
- Bell M
- Bellamy M
- Belli MA
- Bellinghausen C
- Bellini A
- Bellwood R
- Below JE
- Bemand T
- Benetti E
- Benham L
- Bennet D
- Bennett S
- Bentley M
- Benyon S
- Beppu S
- Beranova E
- Bercades G
- Bergan J
- Bergantini L
- Berger MM
- Bergomi M
- Bergomi P
- Berkowitz N
- Bernardo D
- Bernasconi A
- Bernatoniene J
- Berridge J
- Bertrand A
- Best N
- Bettini LR
- Beudel M
- Bevan E
- Bewley J
- Bhardwaj N
- Bhatia N
- Bhatterjee R
- Bhuie P
- Bi R
- Bianchi F
- Bianco C
- Bibert S
- Bibert S
- Bibi F
- Biddle J
- Biesecker L
- Biggs H
- Biondi A
- Birch J
- Birch J
- Birch S
- Birchall K
- Birchall K
- Bird S
- Birkinshaw I
- Birney E
- Birt M
- Biscarini F
- Black E
- Black K
- Blackledge B
- Blackledge B
- Blackman H
- Blakemore H
- Blanco-Grau A
- Blasi F
- Blay N
- Blay N
- Blow S
- Blunt M
- Boada M
- Board S
- Bocciardi R
- Bocciolone M
- Bochud M
- Bochud P-Y
- Bochud PY
- Bochud PY
- Bochud PY
- Bociek A
- Boer C
- Boezen M
- Bogaard HJ
- Bogaert D
- Boillat N
- Boillat-Blanco N
- Bokhari M
- Bolton M
- Bolton R
- Bolze A
- Bombace S
- Bomers M
- Bonfanti P
- Bonner S
- Bonta PI
- Booker L
- Booth L
- Booth S
- Borislavova B
- Borra C
- Bos L
- Bosari S
- Bosio G
- Bosse Y
- Botello A
- Bothma P
- Botta G
- Botta M
- Boua PR
- Bouab M
- Bough L
- Boughton AP
- Boujemla B
- Bouras K
- Boutros P
- Bouysran Y
- Bowes A
- Bowles R
- Boyle P
- Boyle R
- Boz C
- Bradford Y
- Bradley C
- Bradley P
- Bradley-Potts J
- Bradshaw Z
- Brady A
- Brady M
- Brady R
- Brahier T
- Brandwood C
- Branney D
- Brantwood C
- Brassard N
- Braun A
- Braun N
- Brayne A
- Brealey D
- Brealey D
- Breen G
- Bremmer P
- Brennan B
- Brenner B
- Brenner T
- Bretherick AD
- Brett M
- Brett S
- Brickell K
- Bridgett V
- Brimfield L
- Brinkworth E
- Briton K
- Brittain-Long R
- Britvan B
- Bromley M
- Brooke H
- Brooks S
- Brouwer MC
- Brown A
- Brown A
- Brown A
- Brown CW
- Brown E
- Brown J
- Bruce M
- Brunak S
- Bruno R
- Brunton M
- Brusco A
- Bruttini M
- Bryant J
- Bryant S
- Bryant S
- Buckley C
- Buckley S
- Bugiani M
- Bujanda L
- Bulik CM
- Bulle E
- Bullock K
- Bulteel N
- Bunni L
- Burda D
- Burden T
- Burn I
- Burnett C
- Burns K
- Burt K
- Burtenshaw A
- Burtenshaw A
- Burton M
- Busani S
- Busson A
- Bussotti M
- Bustamante C
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- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease