193 research outputs found
Does hepatocellular carcinoma in non-alcoholic steatohepatitis exist in cirrhotic and non-cirrhotic patients?
Non-alcoholic steatohepatitis (NASH) has been associated with hepatocellular carcinoma (HCC) often arising in histologically advanced disease when steatohepatitis is not active (cryptogenic cirrhosis). Our objective was to characterize patients with HCC and active, histologically defined steatohepatitis. Among 394 patients with HCC detected by ultrasound imaging over 8 years and staged by the Barcelona Clinic Liver Cancer (BCLC) criteria, we identified 7 cases (1.7%) with HCC occurring in the setting of active biopsy-proven NASH. All were negative for other liver diseases such as hepatitis C, hepatitis B, autoimmune hepatitis, Wilson disease, and hemochromatosis. The patients (4 males and 3 females, age 63 ± 13 years) were either overweight (4) or obese (3); 57% were diabetic and 28.5% had dyslipidemia. Cirrhosis was present in 6 of 7 patients, but 1 patient had well-differentiated HCC in the setting of NASH without cirrhosis (fibrosis stage 1) based on repeated liver biopsies, the absence of portal hypertension by clinical and radiographic evaluations and by direct surgical inspection. Among the cirrhotic patients, 71.4% were clinically staged as Child A and 14.2% as Child B. Tumor size ranged from 1.0 to 5.2 cm and 5 of 7 patients were classified as early stage; 46% of all nodules were hyper-echoic and 57% were <3 cm. HCC was well differentiated in 1/6 and moderately differentiated in 5/6. Alpha-fetoprotein was <100 ng/mL in all patients. HCC in patients with active steatohepatitis is often multifocal, may precede clinically advanced disease and occurs without diagnostic levels of alpha-fetoprotein. Importantly, HCC may occur in NASH in the absence of cirrhosis. More aggressive screening of NASH patients may be warranted
Cosmological Constant, Gauge Hierarchy and Warped Geometry
It is suggested that the mechanism responsible for the resolution of the
gauge hierarchy problem within the warped geometry framework can be generalized
to provide a new explanation of the extremely tiny vacuum energy density rho_V
suggested by recent observations. We illustrate the mechanism with some 5D
examples in which the true vacuum energy is assumed to vanish, and rho_V is
associated with a false vacuum energy such that rho_V^{1/4} ~ TeV^2/M_{Pl} ~
10^{-3} eV, where M_{Pl} denotes the reduced Planck mass. We also consider a
quintessence-like solution to the dark energy problem.Comment: 10 pages, LaTeX, 2 figures, section on quantum corrections added,
version to appear in Phys. Rev.
Stringent Constraints on Cosmological Neutrino-Antineutrino Asymmetries from Synchronized Flavor Transformation
We assess a mechanism which can transform neutrino-antineutrino asymmetries
between flavors in the early universe, and confirm that such transformation is
unavoidable in the near bi-maximal framework emerging for the neutrino mixing
matrix. We show that the process is a standard Mikheyev-Smirnov-Wolfenstein
flavor transformation dictated by a synchronization of momentum states. We also
show that flavor ``equilibration'' is a special feature of maximal mixing, and
carefully examine new constraints placed on neutrino asymmetries. In
particular, the big bang nucleosynthesis limit on electron neutrino degeneracy
xi_e < 0.04 does not apply directly to all flavors, yet confirmation of the
large-mixing-angle solution to the solar neutrino problem will eliminate the
possibility of degenerate big bang nucleosynthesis.Comment: 11 pages, 6 figures; minor changes to match PRD versio
An Assessment of the Use of Chimpanzees in Hepatitis C Research Past, Present and Future: 1. Validity of the Chimpanzee Model
The USA is the only significant user of chimpanzees in biomedical research in the world, since many countries have banned or limited the practice due to substantial ethical, economic and scientific concerns. Advocates of chimpanzee use cite hepatitis C research as a major reason for its necessity and continuation, in spite of supporting evidence that is scant and often anecdotal. This paper examines the scientific and ethical issues surrounding chimpanzee hepatitis C research, and concludes that claims of the necessity of chimpanzees in historical and future hepatitis C research are exaggerated and unjustifiable, respectively. The chimpanzee model has several major scientific, ethical, economic and practical caveats. It has made a relatively negligible contribution to knowledge of, and tangible progress against, the hepatitis C virus compared to non-chimpanzee research, and must be considered scientifically redundant, given the array of alternative methods of inquiry now available. The continuation of chimpanzee use in hepatitis C research adversely affects scientific progress, as well as chimpanzees and humans in need of treatment. Unfounded claims of its necessity should not discourage changes in public policy regarding the use of chimpanzees in US laboratories
Toward an internally consistent astronomical distance scale
Accurate astronomical distance determination is crucial for all fields in
astrophysics, from Galactic to cosmological scales. Despite, or perhaps because
of, significant efforts to determine accurate distances, using a wide range of
methods, tracers, and techniques, an internally consistent astronomical
distance framework has not yet been established. We review current efforts to
homogenize the Local Group's distance framework, with particular emphasis on
the potential of RR Lyrae stars as distance indicators, and attempt to extend
this in an internally consistent manner to cosmological distances. Calibration
based on Type Ia supernovae and distance determinations based on gravitational
lensing represent particularly promising approaches. We provide a positive
outlook to improvements to the status quo expected from future surveys,
missions, and facilities. Astronomical distance determination has clearly
reached maturity and near-consistency.Comment: Review article, 59 pages (4 figures); Space Science Reviews, in press
(chapter 8 of a special collection resulting from the May 2016 ISSI-BJ
workshop on Astronomical Distance Determination in the Space Age
Born-Infeld Type Phantom Model in the Plane
In this paper, we investigate the dynamics of Born-Infeld(B-I) phantom model
in the plane, which is defined by the equation of state
parameter for the dark energy and its derivative with respect to (the
logarithm of the scale factor ). We find the scalar field equation of motion
in plane, and show mathematically the property of attractor
solutions which correspond to , , which avoid
the "Big rip" problem and meets the current observations well.Comment: 6 pages, 3 figures, some references adde
QCD ghost f(T)-gravity model
Within the framework of modified teleparallel gravity, we reconstruct a f(T)
model corresponding to the QCD ghost dark energy scenario. For a spatially flat
FRW universe containing only the pressureless matter, we obtain the time
evolution of the torsion scalar T (or the Hubble parameter). Then, we calculate
the effective torsion equation of state parameter of the QCD ghost f(T)-gravity
model as well as the deceleration parameter of the universe. Furthermore, we
fit the model parameters by using the latest observational data including
SNeIa, CMB and BAO data. We also check the viability of our model using a
cosmographic analysis approach. Moreover, we investigate the validity of the
generalized second law (GSL) of gravitational thermodynamics for our model.
Finally, we point out the growth rate of matter density perturbation. We
conclude that in QCD ghost f(T)-gravity model, the universe begins a matter
dominated phase and approaches a de Sitter regime at late times, as expected.
Also this model is consistent with current data, passes the cosmographic test,
satisfies the GSL and fits the data of the growth factor well as the LCDM
model.Comment: 19 pages, 9 figures, 2 tables. arXiv admin note: substantial text
overlap with arXiv:1111.726
On Phantom Thermodynamics
The thermodynamic properties of dark energy fluids described by an equation
of state parameter are rediscussed in the context of FRW type
geometries. Contrarily to previous claims, it is argued here that the phantom
regime is not physically possible since that both the temperature
and the entropy of every physical fluids must be always positive definite. This
means that one cannot appeal to negative temperature in order to save the
phantom dark energy hypothesis as has been recently done in the literature.
Such a result remains true as long as the chemical potential is zero. However,
if the phantom fluid is endowed with a non-null chemical potential, the phantom
field hypothesis becomes thermodynamically consistent, that is, there are
macroscopic equilibrium states with and in the course of the
Universe expansion. Further, the negative value of the chemical potential
resulting from the entropy constraint () suggests a bosonic massless
nature to the phantom particles.Comment: 14 pages, no figures, text revise
Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays
Average charged multiplicities have been measured separately in , and
light quark () events from decays measured in the SLD experiment.
Impact parameters of charged tracks were used to select enriched samples of
and light quark events, and reconstructed charmed mesons were used to select
quark events. We measured the charged multiplicities:
,
, from
which we derived the differences between the total average charged
multiplicities of or quark events and light quark events: and . We compared
these measurements with those at lower center-of-mass energies and with
perturbative QCD predictions. These combined results are in agreement with the
QCD expectations and disfavor the hypothesis of flavor-independent
fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters
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