On the full Boltzmann equations for Leptogenesis

We consider the full Boltzmann equations for standard and soft leptogenesis, instead of the usual integrated Boltzmann equations which assume kinetic equilibrium for all species. Decays and inverse decays may be inefficient for thermalising the heavy-(s)neutrino distribution function, leading to significant deviations from kinetic equilibrium. We analyse the impact of using the full kinetic equations in the case of a previously generated lepton asymmetry, and find that the washout of this initial asymmetry due to the interactions of the right-handed neutrino is larger than when calculated via the integrated equations. We also solve the full Boltzmann equations for soft leptogenesis, where the lepton asymmetry induced by the soft SUSY-breaking terms in sneutrino decays is a purely thermal effect, since at T=0 the asymmetry in leptons cancels the one in sleptons. In this case, we obtain that in the weak washout regime (K ~< 1) the final lepton asymmetry can change up to a factor four with respect to previous estimates.Comment: 34 pages, 6 figures, to be published in JCA

Potential alternative feed sources for ruminant feeding from the biodiesel production chain by-products

This study aimed to evaluate the chemical composition, fractionation of nitrogen compounds and carbohydrates, digestibility parameters, gas production kinetics and ruminal fermentation of fruit seed cakes. The experiment was conducted in a completely randomized design with three fruit seed cakes (treatments) and four replications. The cakes were made of seeds of custard apple (Annona squamosa), soursop (Annona muricata) and passion fruit (Passiflora edulis), which were collected in a biodiesel plant. The passion fruit seed cake presented the highest content of dry matter, neutral detergent fibre crude protein (NDFcp), acid detergent fibre (ADF), lignin and total carbohydrates (P&lt;0.05). The custard apple seed cake presented high proportions of crude protein, condensed tannins and digestible energy (P&lt;0.05). The soursop seed cake presented higher values for ether extract and total digestible nutrients (P&lt;0.05). For potential degradability, the authors detected a difference between the custard apple, soursop and passion fruit seed cakes. The total volume of gases was higher for custard apple and soursop seed cakes. Custard apple seed cake presented higher proportions of in vitro degradation parameters (P&lt;0.05). Thus this cake could provide greater nutrient levels when supplied in ruminant diets, followed by soursop seed cake and passion fruit seed cake. Keywords: alternative food, by-products, ruminant feeding, seed cake, semi-ari

Multidisciplinary Experience In The Selection Of Patients For Tubal Sterilization.

Results of the use of a special protocol for evaluation of patients requiring tubal ligation is presented after applied by a multidisciplinary group. The authors conclude that the use of defined parameters of age, parity, marital union duration, number of children alive and the presence of maternal clinical pathology are useful to identify patients with smaller chances of regret after surgery.27% of reproductive-age women in Brazil have chosen surgical sterilization as their contraceptive method. Most of these women who have undergone tubal sterilization opted for cesarean surgery. However, given the young ages of many of these women, many regret having been sterilized. This paper summarizes the experience of a multidisciplinary group in evaluating women who apply for surgical sterilization at the Department of Tocogynecology, Faculdade de Ciencas Medicas, Universidade Estadual de Campinas in Sao Paulo. Detailed descriptions are presented of the medical and social characteristics of cases seen between June 1988 and July 1989. The authors conclude that the use of the defined parameters of age, parity, marital union duration, number of living children, and the presence of maternal clinical pathology are useful in identifying the patients who are least likely to regret undergoing surgical sterilization.113171572

The Portuguese Third Version of the Copenhagen Psychosocial Questionnaire: Preliminary Validation Studies of the Middle Version among Municipal and Healthcare Workers

A third version of the Copenhagen Psychosocial Questionnaire (COPSOQ III) was developed internationally aiming to respond to new trends in working conditions, theoretical concepts, and international experience. This article aims to present the preliminary validation studies for the Portuguese middle version of COPSOQ III. This is an exploratory cross-sectional study viewing the cross-cultural adaption of COPSOQ III to Portugal, ensuring the contents and face validity and performing field-testing in order to reduce the number of items and to obtain insight into the data structure, through classic test theory and item response theory approaches. The qualitative study encompassed 29 participants and the quantitative one 659 participants from municipalities and healthcare settings. Content analysis suggested that minor re-wording could improve the face validity of items, while a reduced version, with 85 items, shows psychometric stability, achieving good internal consistency in all subscales. The COPSOQ III Portuguese middle version proved to be a valid preliminary version for future validation studies with various populations, able to be used in correlational studies with other dimensions

The Dark Matter Density in the Solar Neighborhood reconsidered

Both the gas flaring and the dip in the rotation curve, which was recently reconfirmed with precise measurements using the VERA VLBI array in Japan, suggest doughnut-like substructure in the dark matter (DM) halo. A global fit to all available data shows that the data are indeed best described by an NFW DM profile complemented by two doughnut-like DM substructures with radii of 4.2 and 12.4 kpc, which coincide with the local dust ring and the Monocerus ring of stars, respectively. Both regions have been suggested as regions with tidal streams from "shredded" satellites. If real, the radial extensions of these nearby ringlike structures enhance the local dark matter density by a factor of four to about 1.3$\pm0.3$ GeV/cm$^3$. It is shown that i) this higher DM density is perfectly consistent with the local gravitational potential determining the surface density and the local matter density (Oort limit), ii) previous determinations of the surface density were biased by the assumption of a smoothly varying DM halo and iii) the s-shaped gas flaring is explained. Such a possible enhancement of the local DM density is of great interest for direct DM searches and would change the directional dependence for indirect DM searches.Comment: 14 pages, 4 figures, extended version, accepted for publication in JCA

Peripheral post-ischemic vascular repair is impaired in a murine model of Alzheimer&#039;s disease

The pathophysiology of sporadic Alzheimer\u27s disease (AD) remains uncertain. Along with brain amyloid-β (Aβ) deposits and neurofibrillary tangles, cerebrovascular dysfunction is increasingly recognized as fundamental to the pathogenesis of AD. Using an experimental model of limb ischemia in transgenic APPPS1 mice, a model of AD (AD mice), we showed that microvascular impairment also extends to the peripheral vasculature in AD. At D70 following femoral ligation, we evidenced a significant decrease in cutaneous blood flow (- 29%, P &lt; 0.001), collateral recruitment (- 24%, P &lt; 0.001), capillary density (- 22%; P &lt; 0.01) and arteriole density (- 28%; P &lt; 0.05) in hind limbs of AD mice compared to control WT littermates. The reactivity of large arteries was not affected in AD mice, as confirmed by unaltered size, and vasoactive responses to pharmacological stimuli of the femoral artery. We identified blood as the only source of Aβ in the hind limb; thus, circulating Aβ is likely responsible for the impairment of peripheral vasculature repair mechanisms. The levels of the majority of pro-angiogenic mediators were not significantly modified in AD mice compared to WT mice, except for TGF-β1 and PlGF-2, both of which are involved in vessel stabilization and decreased in AD mice (P = 0.025 and 0.019, respectively). Importantly, endothelin-1 levels were significantly increased, while those of nitric oxide were decreased in the hind limb of AD mice (P &lt; 0.05). Our results suggest that vascular dysfunction is a systemic disorder in AD mice. Assessment of peripheral vascular function may therefore provide additional tools for early diagnosis and management of AD

Estado neoliberal e juventudes / Neoliberal state and yougster

Este texto propõe analisar a inserção das “juventudes” da classe trabalhadora na sociedade capitalista, compreendendo o capitalismo e a luta de classes como questões fundamentais para definir a identidade destas juventudes na sociedade moderna. Para isso realizou-se pesquisa bibliográfica, destacando autores que debatam o conceito de juventude, Estado e Neoliberalismo, tendo como método de análise o materialismo histórico dialético. Este estudo proporcionou uma maior reflexão acerca da posição da juventude perante as condições de produção capitalista num espaço marcado pelas contradições próprias da luta de classes. Toma o Estado capitalista e o neoliberalismo enquanto instrumentos de perpetuação do Capital em detrimento ao trabalho e essa situação como definidora da condição juvenil, determinando especificidades à parcela trabalhadora das juventudes. Neste sentido, faz-se necessário a ruptura com o capital para que as juventudes da classe trabalhadora possam ter a possibilidade de transformação radical de sua vida

Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media

MgCa and MgGd series of alloys are often reported as promising candidates for biomedical applications. In the present study, cytotoxicity and corrosion behavior of Mg1Ca and Mg10Gd alloys in different electrolytes (NaCl, PBS, MEM) have been investigated in order to make a direct comparison and understand the mechanisms behind their performance. Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) were employed to analyze corrosion processes depending on media composition, whereas X-Ray diffraction (XRD) and scanning electron microscopy (SEM) were used to evaluate crystalline structure, phase composition and surface morphology of the corroded substrates after immersion in the different electrolytes. Moreover, cytotoxicity of the Mg alloys was assessed using the WST-1 reduction and lactate dehydrogenase (LDH) release assays in L929 mouse fibroblasts. The electrochemical results showed that Mg1Ca has a lower degradation rate when compared to Mg10Gd, due to the lower microgalvanic effects and the presence of Ca as an alloying element. Furthermore, the corrosion activity is reduced in MEM, for both alloys, when compared to NaCl and PBS. The cytotoxicity assays revealed that Mg10Gd was cytotoxic in all the conditions tested, while the toxicity of Mg1Ca was low. Overall, these findings show that Mg1Ca alloy presents a higher corrosion resistance and biocompatibility and is a promising material to be used in biomedical implants.This work was financed by Portugal 2020 through European Regional Development Fund (ERDF) in the frame of Operational Competitiveness and Internationalization Programme (POCI), in the scope of the project MAGICOAT POCI-01-0145-FEDER016597/PTDC/CTM-BIO/2170/2014 and in the scope of the project CICECO - Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, financed by national funds through the Portuguese Foundation for Science and Technology/ MCTES. Furthermore, thanks are due to Portuguese Foundation for Science and Technology/MCTES for the financial support through national funds to EPI Unit (UIDB/04750/2020).info:eu-repo/semantics/publishedVersio

Validity of numerical trajectories in the synchronization transition of complex systems

We investigate the relationship between the loss of synchronization and the onset of shadowing breakdown {\it via} unstable dimension variability in complex systems. In the neighborhood of the critical transition to strongly non-hyperbolic behavior, the system undergoes on-off intermittency with respect to the synchronization state. There are potentially severe consequences of these facts on the validity of the computer-generated trajectories obtained from dynamical systems whose synchronization manifolds share the same non-hyperbolic properties.Comment: 4 pages, 4 figure

Disentanglement of the chemical, physical, and biological processes aids the development of quantitative structure-biodegradation relationships for aerobic wastewater treatment

Environmental Biolog