77 research outputs found
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Finite-difference modelling to evaluate seismic P-wave and shear-wave field data
High-resolution reflection seismic methods are an established non-destructive tool for engineering tasks. In the near surface, shear-wave reflection seismic measurements usually offer a higher spatial resolution in the same effective signal frequency spectrum than P-wave data, but data quality varies more strongly.
To discuss the causes of these differences, we investigated a P-wave and a SH-wave seismic reflection profile measured at the same location on the island of Föhr, Germany and applied seismic reflection processing to the field data as well as finite-difference modelling of the seismic wave field. The simulations calculated were adapted to the acquisition field geometry, comprising 2 m receiver distance (1 m for SH wave) and 4 m shot distance along the 1.5 km long P-wave and 800 m long SH-wave profiles. A Ricker wavelet and the use of absorbing frames were first-order model parameters. The petrophysical parameters to populate the structural models down to 400 m depth were taken from borehole data, VSP (vertical seismic profile) measurements and cross-plot relations.
The simulation of the P-wave wave-field was based on interpretation of the P-wave depth section that included a priori information from boreholes and airborne electromagnetics. Velocities for 14 layers in the model were derived from the analysis of five nearby VSPs (vP =1600â2300 m s-1). Synthetic shot data were compared with the field data and seismic sections were created. Major features like direct wave and reflections are imaged. We reproduce the mayor reflectors in the depth section of the field data, e.g. a prominent till layer and several deep reflectors. The SH-wave model was adapted accordingly but only led to minor correlation with the field data and produced a higher signal-to-noise ratio. Therefore, we suggest to consider for future simulations additional features like intrinsic damping, thin layering, or a near-surface weathering layer. These may lead to a better understanding of key parameters determining the data quality of near-surface shear-wave seismic measurements
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Asymmetry of high-velocity lower crust on the South Atlantic rifted margins and implications for the interplay of magmatism and tectonics in continental breakup
High-velocity lower crust (HVLC) and seaward-dipping reflector (SDR) sequences are typical features of volcanic rifted margins. However, the nature and origin of HVLC is under discussion. Here we provide a comprehensive analysis of deep crustal structures in the southern segment of the South Atlantic and an assessment of HVLC along the margins. Two new seismic refraction lines off South America fill a gap in the data coverage and together with five existing velocity models allow for a detailed investigation of the lower crustal properties on both margins. An important finding is the major asymmetry in volumes of HVLC on the conjugate margins. The seismic refraction lines across the South African margin reveal cross-sectional areas of HVLC 4 times larger than at the South American margin, a finding that is opposite to the asymmetric distribution of the flood basalts in the ParanĂĄâEtendeka Large Igneous Province. Also, the position of the HVLC with respect to the SDR sequences varies consistently along both margins. Close to the FalklandâAgulhas Fracture Zone in the south, a small body of HVLC is not accompanied by SDRs. In the central portion of both margins, the HVLC is below the inner SDR wedges while in the northern area, closer to the Rio Grande Rise-Walvis Ridge, large volumes of HVLC extend far seaward of the inner SDRs.
This challenges the concept of a simple extrusive/intrusive relationship between SDR sequences and HVLC, and it provides evidence for formation of the HVLC at different times during the rifting and breakup process. We suggest that the drastically different HVLC volumes are caused by asymmetric rifting in a simple-shear-dominated extension
Fat and SugarâA Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is a common disease in Western society and ranges from steatosis to steatohepatitis to end-stage liver disease such as cirrhosis and hepatocellular carcinoma. The molecular mechanisms that are involved in the progression of steatosis to more severe liver damage in patients are not fully understood. A deeper investigation of NAFLD pathogenesis is possible due to the many different animal models developed recently. In this review, we present a comparative overview of the most common dietary NAFLD rodent models with respect to their metabolic phenotype and morphological manifestation. Moreover, we describe similarities and controversies concerning the effect of NAFLD-inducing diets on mitochondria as well as mitochondria-derived oxidative stress in the progression of NAFLD
Recent glitches detected in the Crab pulsar
From 2000 to 2010, monitoring of radio emission from the Crab pulsar at
Xinjiang Observatory detected a total of nine glitches. The occurrence of
glitches appears to be a random process as described by previous researches. A
persistent change in pulse frequency and pulse frequency derivative after each
glitch was found. There is no obvious correlation between glitch sizes and the
time since last glitch. For these glitches and
span two orders of magnitude. The pulsar suffered the
largest frequency jump ever seen on MJD 53067.1. The size of the glitch is
6.8 Hz, 3.5 times that of the glitch occured in
1989 glitch, with a very large permanent changes in frequency and pulse
frequency derivative and followed by a decay with time constant 21 days.
The braking index presents significant changes. We attribute this variation to
a varying particle wind strength which may be caused by glitch activities. We
discuss the properties of detected glitches in Crab pulsar and compare them
with glitches in the Vela pulsar.Comment: Accepted for publication in Astrophysics & Space Scienc
Sensitizing thermochemotherapy with a PARP1-inhibitor
Cis-diamminedichloroplatinum(II) (cisplatin, cDDP) is an effective chemotherapeutic agent that induces DNA double strand breaks (DSBs), primarily in replicating cells. Generally, such DSBs can be repaired by the classical or backup non-homologous end joining (c-NHEJ/b-NHEJ) or homologous recombination (HR). Therefore, inhibiting these pathways in cancer cells should enhance the efficiency of cDDP treatments. Indeed, inhibition of HR by hyperthermia (HT) sensitizes cancer cells to cDDP and in the Netherlands this combination is a standard treatment option for recurrent cervical cancer after previous radiotherapy. Additionally, cDDP has been demonstrated to disrupt c-NHEJ, which likely further increases the treatment efficacy. However, if one of these pathways is blocked, DSB repair functions can be sustained by the Poly-(ADP-ribose)-polymerase1 (PARP1)-dependent b-NHEJ. Therefore, disabling b-NHEJ should, in principle, further inhibit the repair of cDDP-induced DNA lesions and enhance the toxicity of thermochemotherapy. To explore this hypothesis, we treated a panel of cancer cell lines with HT, cDDP and a PARP1-i and measured various end-point relevant in cancer treatment. Our results demonstrate that PARP1-i does not considerably increase the efficacy of HT combined with standard, commonly used cDDP concentrations. However, in the presence of a PARP1-i, ten-fold lower concentration of cDDP can be used to induce similar cytotoxic effects. PARP1 inhibition may thus permit a substantial lowering of cDDP concentrations without diminishing treatment efficacy, potentially reducing systemic side effects
Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia
Background: Poly-(ADP-ribose)-polymerase1 (PARP1) is involved in repair of DNA single strand breaks. PARP1-inhibitors (PARP1-i) cause an accumulation of DNA double strand breaks, which are generally repaired by homologous recombination (HR). Therefore, cancer cells harboring HR deficiencies are exceptionally sensitive to PARP1-i. For patients with HR-proficient tumors, HR can be temporarily inhibited by hyperthermia, thereby inducing synthetic lethal conditions in every tumor type. Since cisplatin is successfully used combined with hyperthermia (thermochemotherapy), we investigated the effectiveness of combining PARP1-i with thermochemotherapy. Results: The in vitro data demonstrate a decreased in cell survival after addition of PARP1-i to thermochemotherapy, which can be explained by increased DNA damage induction and less DSB repair. These in vitro findings are in line with in vivo model, in which a decreased tumor growth is observed upon addition of PARP1-i. Materials and Methods: Survival of three HR-proficient cell lines after cisplatin, hyperthermia and/or PARP1-i was studied. Cell cycle analyses, quantification of Îł-H2AX foci and apoptotic assays were performed to understand these survival data. The effects of treatments were further evaluated by monitoring tumor responses in an in vivo rat model. Conclusions: Our results in HR-proficient cell lines suggest that PARP1-i combined with thermochemotherapy can be a promising clinical approach for all tumors independent of HR status
Flavor changing Z-decays from scalar interactions at a Giga-Z Linear Collider
The flavor changing decay Z -> d_I \bar{d}_J is investigated with special
emphasis on the b \bar{s} final state. Various models for flavor violation are
considered: two Higgs doublet models (2HDM's), supersymmetry (SUSY) with flavor
violation in the up and down-type squark mass matrices and SUSY with flavor
violation mediated by R-parity-violating interaction. We find that, within the
SUSY scenarios for flavor violation, the branching ratio for the decay Z -> b
\bar{s} can reach 10^{-6} for large \tan\beta values, while the typical size
for this branching ratio in the 2HDM's considered is about two orders of
magnitudes smaller at best. Thus, flavor changing SUSY signatures in radiative
Z decays such as Z -> b \bar{s} may be accessible to future ``Z factories''
such as a Giga-Z version of the TESLA design.Comment: 27 pages, 15 figures, REVTeX4. A new section added and a few minor
corrections were made in the tex
Study of the lineshape of the chi(c1) (3872) state
A study of the lineshape of the chi(c1) (3872) state is made using a data sample corresponding to an integrated luminosity of 3 fb(-1) collected in pp collisions at center-of-mass energies of 7 and 8 TeV with the LHCb detector. Candidate chi(c1)(3872) and psi(2S) mesons from b-hadron decays are selected in the J/psi pi(+)pi(-) decay mode. Describing the lineshape with a Breit-Wigner function, the mass splitting between the chi(c1 )(3872) and psi(2S) states, Delta m, and the width of the chi(c1 )(3872) state, Gamma(Bw), are determined to be (Delta m=185.598 +/- 0.067 +/- 0.068 Mev,)(Gamma BW=1.39 +/- 0.24 +/- 0.10 Mev,) where the first uncertainty is statistical and the second systematic. Using a Flatte-inspired model, the mode and full width at half maximum of the lineshape are determined to be (mode=3871.69+0.00+0.05 MeV.)(FWHM=0.22-0.04+0.13+0.07+0.11-0.06-0.13 MeV, ) An investigation of the analytic structure of the Flatte amplitude reveals a pole structure, which is compatible with a quasibound D-0(D) over bar*(0) state but a quasivirtual state is still allowed at the level of 2 standard deviations
Measurement of the CKM angle in and decays with
A measurement of -violating observables is performed using the decays
and , where the meson is
reconstructed in one of the self-conjugate three-body final states and (commonly denoted ). The decays are analysed in bins of the -decay phase space, leading
to a measurement that is independent of the modelling of the -decay
amplitude. The observables are interpreted in terms of the CKM angle .
Using a data sample corresponding to an integrated luminosity of
collected in proton-proton collisions at centre-of-mass
energies of , , and with the LHCb experiment,
is measured to be . The hadronic
parameters , , , and ,
which are the ratios and strong-phase differences of the suppressed and
favoured decays, are also reported
Detachment tectonics during continental rifting off the west Iberia Atlantic margin: seismic reflection and drilling constraints
Lithospheric extension and thinning leading to complete continental rupture and the formation of rifted margins are among the most fundamental geological processes. The west Iberia Atlantic margin represents a type-example of a non-volcanic rifted margin, and is an ideal site to study the nature of lithospheric extension. It is relatively sediment-starved and exhibits in the Galicia Bank area landward tilted crustal blocks, which are bound by west-dipping normal faults. Seismic time sections image these faults underlain by an apparently undulating and discontinuous bright reflection, the S reflector, terminating further west near the ocean-continent boundary (OCT). This boundary is marked by a mantle outcrop shown by drilling to consist of serpentinised peridotite. Similar observations in the Iberia Abyssal Plain had not been reported until the beginning of this study, except the hypothesis of mantle material at the OCT proved in 1993 by drilling. (orig.)Available from TIB Hannover: RR 1846(37) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDeutsche Forschungsgemeinschaft (DFG), Bonn (Germany)DEGerman
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