Charge disproportionation and Jahn-Teller distortion in LiNiO2 and NaNiO2: A density functional theory study

Density functional theory calculations have been performed on three potential ground-state configurations of LiNiO2 and NaNiO2. These calculations show that, whereas NaNiO2 shows the expected cooperative Jahn-Teller distortion (and therefore a crystal structure with C2/m symmetry), LiNiO2 shows at least two possible crystal structures very close in energy (within 3 meV/f.u.): P21/c and P2/c. Moreover, one of them (P2/c) shows charge disproportionation of the (expected) Ni3+ cations into Ni2+ and Ni4+. We discuss the implications of this complex ground state for the interpretation of the available electron and neutron structure data, its electronic and complex magnetic behaviour

Influence of skew and cross-coupling on flux-weakening performance of permanent-magnet brushless AC machines

A method is proposed for predicting the flux-weakening performance of permanent-magnet (PM) brushless ac machines accounting for skew and d-q axis cross-coupling. The method is based on a d-q-axis flux-linkage model, a hybrid 2-D finite-element (FE)-analytical method being used to predict the d- and q-axis inductances. However, it only requires 2-D FE analysis of the magnetic field distribution over a cross section of the machine. The developed method is used to predict the torque-speed characteristic of an interior PM brushless ac machine with one stator slot-pitch skew. This is compared with predictions from a direct FE analysis of the machine and validated by measurements

PHP61 The Financial Impacts of Pharmacist Intervention in Inpatient Department of a Local Hospital in Taiwan

Morphometric analysis of S. mortenseni. (DOC 44 kb

Nash equilibria in quantum games with generalized two-parameter strategies

In the Eisert protocol for 2 X 2 quantum games [Phys. Rev. Lett. 83, 3077], a number of authors have investigated the features arising from making the strategic space a two-parameter subset of single qubit unitary operators. We argue that the new Nash equilibria and the classical-quantum transitions that occur are simply an artifact of the particular strategy space chosen. By choosing a different, but equally plausible, two-parameter strategic space we show that different Nash equilibria with different classical-quantum transitions can arise. We generalize the two-parameter strategies and also consider these strategies in a multiplayer setting.Comment: 19 pages, 2 eps figure

Carrier dynamics and infrared-active phonons in c-axis oriented RuSr2_2GdCu2_2O8_8 film

The conductivity spectra of c-axis oriented thin RuSr$_2$GdCu$_2$O$_8$ film on SrTiO$_3$ substrate, prepared by pulsed-laser deposition, are obtained from the analysis of the reflectivity spectra over broad frequency range and temperatures between 10 and 300 K. The free charge carriers are found to be strongly overdamped with their scattering rate (1.0 eV at room temperature) exceeding the plasma frequency (0.55 eV). Four phonon lines are identified in the experimental spectra and assigned to the specific oxygen related in-plane polarized vibrations based on the comparison with the results of a lattice dynamics shell model calculations.Comment: 3 pages, 4 figure

Synchronization and Coarsening (without SOC) in a Forest-Fire Model

We study the long-time dynamics of a forest-fire model with deterministic tree growth and instantaneous burning of entire forests by stochastic lightning strikes. Asymptotically the system organizes into a coarsening self-similar mosaic of synchronized patches within which trees regrow and burn simultaneously. We show that the average patch length grows linearly with time as t-->oo. The number density of patches of length L, N(L,t), scales as ^{-2}M(L/), and within a mean-field rate equation description we find that this scaling function decays as e^{-1/x} for x-->0, and as e^{-x} for x-->oo. In one dimension, we develop an event-driven cluster algorithm to study the asymptotic behavior of large systems. Our numerical results are consistent with mean-field predictions for patch coarsening.Comment: 5 pages, 4 figures, 2-column revtex format. To be submitted to PR

Passivity-based nonlinear control of CSTR via asymptotic observers.

International audienceThis work makes use of a passivity-based approach (PBA) and tools from Lyapunov theory to design a nonlinear controller for the asymptotic stabilization of a class of non isothermal Continuous Stirred Tank Reactors (CSTR) around any desired stationary point. The convergence and stability proofs are derived in the port Hamiltonian framework. Asymptotic observers that do not require knowledge of reaction kinetics are also proposed for a system with incomplete state measurement. Numerical simulations are given to illustrate the application of the theoretical results to a CSTR with multiple steady states

A preexisting rare PIK3CA e545k subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling

Combined MEK and CDK4/6 inhibition (MEKi + CDK4i) has shown promising clinical outcomes in patients with NRAS- mutant melanoma. Here, we interrogated longitudinal biopsies from a patient who initially responded to MEKi + CDK4i therapy but subsequently developed resistance. Whole-exome sequencing and functional validation identified an acquired PIK3CA E545K mutation as conferring drug resistance. We demonstrate that PIK3CA E545K preexisted in a rare subpopulation that was missed by both clinical and research testing, but was revealed upon multiregion sampling due to PIK3CA E545K being nonuniformly distributed. This resistant population rapidly expanded after the initiation of MEKi + CDK4i therapy and persisted in all successive samples even after immune checkpoint therapy and distant metastasis. Functional studies identified activated S6K1 as both a key marker and specific therapeutic vulnerability downstream of PIK3CA E545K -induced resistance. These results demonstrate that difficult-to-detect preexisting resistance mutations may exist more often than previously appreciated and also posit S6K1 as a common downstream therapeutic nexus for the MAPK, CDK4/6, and PI3K pathways. SIGNIFICANCE: We report the first characterization of clinical acquired resistance to MEKi + CDK4i, identifying a rare preexisting PIK3CA E545K subpopulation that expands upon therapy and exhibits drug resistance. We suggest that single-region pretreatment biopsy is insufficient to detect rare, spatially segregated drug-resistant subclones. Inhibition of S6K1 is able to resensitize PIK3CA E545K -expressing NRAS-mutant melanoma cells to MEKi + CDK4i. © 2018 AAC

Interaction of CO2 laser-modified nylon with osteoblast cells in relation to wettability

It has been amply demonstrated previously that CO2 lasers hold the ability to surface modify various polymers. In addition, it has been observed that these surface enhancements can augment the biomimetic nature of the laser irradiated materials. This research has employed a CO2 laser marker to produce trench and hatch topographical patterns with peak heights of around 1 μm on the surface of nylon 6,6. The patterns generated have been analysed using white light interferometery, optical microscopy and X-ray photoelectron spectroscopy was employed to determine the surface oxygen content. Contact angle measurements were used to characterize each sample in terms of wettability. Generally, it was seen that as a result of laser processing the contact angle, surface roughness and surface oxygen content increased whilst the apparent polar and total surface energies decreased. The increase in contact angle and reduction in surface energy components was found to be on account of a mixed intermediate state wetting regime owing to the change in roughness due to the induced topographical patterns. To determine the biomimetic nature of the modified and as-received control samples each one was seeded with 2×104 cells/ml normal human osteoblast cells and observed after periods of 24 hours and 4 days using optical microscopy and SEM to determine mean cell cover densities and variations in cell morphology. In addition a haeymocytometer was used to show that the cell count for the laser patterned samples had increased by up to a factor of 1.5 compared to the as-received control sample after 4 days of incubation. Significantly, it was determined that all laser-induced patterns gave rise to better cell response in comparison to the as-received control sample studied due to increased preferential cell growth on those surfaces with increased surface roughness

Large non-Gaussianities in the Effective Field Theory Approach to Single-Field Inflation: the Bispectrum

The methods of effective field theory are used to study generic theories of inflation with a single inflaton field and to perform a general analysis of the associated non-Gaussianities. We investigate the amplitudes and shapes of the various generic three-point correlators, the bispectra, which may be generated by different classes of single-field inflationary models. Besides the well-known results for the DBI-like models and the ghost inflationary theories, we point out that curvature-related interactions may give rise to large non-Gaussianities in the form of bispectra characterized by a flat shape which, quite interestingly, is independently produced by several interaction terms. In a subsequent work, we will perform a similar general analysis for the non-Gaussianities generated by the generic four-point correlator, the trispectrum.Comment: Version matching the one published in JCAP, 2 typos fixed, references added. 30 pages, 20 figure