Flip invariance for domino tilings of three-dimensional regions with two floors

We investigate tilings of cubiculated regions with two simply connected floors by 2 x 1 x 1 bricks. More precisely, we study the flip connected component for such tilings, and provide an algebraic invariant that "almost" characterizes the flip connected components of such regions, in a sense that we discuss in the paper. We also introduce a new local move, the trit, which, together with the flip, connects the space of domino tilings when the two floors are identical.Comment: 33 pages, 34 figures, 2 tables. We updated the reference lis

Domino tilings of three-dimensional regions: flips, trits and twists

In this paper, we consider domino tilings of regions of the form $\mathcal{D} \times [0,n]$, where $\mathcal{D}$ is a simply connected planar region and $n \in \mathbb{N}$. It turns out that, in nontrivial examples, the set of such tilings is not connected by flips, i.e., the local move performed by removing two adjacent dominoes and placing them back in another position. We define an algebraic invariant, the twist, which partially characterizes the connected components by flips of the space of tilings of such a region. Another local move, the trit, consists of removing three adjacent dominoes, no two of them parallel, and placing them back in the only other possible position: performing a trit alters the twist by $\pm 1$. We give a simple combinatorial formula for the twist, as well as an interpretation via knot theory. We prove several results about the twist, such as the fact that it is an integer and that it has additive properties for suitable decompositions of a region.Comment: 38 pages, 17 figures. Most of this material is also covered in the first author's Ph.D. thesis (arXiv:1503.04617

Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicated and severe malaria

Background: The three members of the ring-infected erythrocyte surface antigen (RESA) proteins family share high sequence homologies, which impair the detection and assignment to one or another protein of some pathogenic processes inherent to Plasmodium falciparum malaria. The present study was intended to determine if the antibody and inflammatory responses of children living in a malaria-endemic area varied depending on the RESA-1, RESA-2 or RESA-3 proteins and the severity of the disease, two groups of severe and uncomplicated malaria cases being considered. Methods: Two synthetic peptides representing predicted B cell epitopes were designed per RESA protein, all located outside of the 3' and 5' repetition blocks, in order to allow an antibody detection specific of each member of the family. Recombinant rRESA-1B and rRESA-3B proteins were also engineered. Two groups of Beninese children admitted to hospital in 2009 for either uncomplicated or severe malaria were compared for their plasma levels of IgG specifically recognizing each recombinant RESA protein or synthetic peptide, and for their plasma inflammatory cytokine levels (IFN-gamma, TNF-alpha and IL-10), taking into account host and parasite genetic factors. Results: The absence of IgG cross-reactivity between rRESA proteins and their protein carrier as well as between each RESA peptide and a non-epitopic RESA control peptide validated the use of the engineered recombinant proteins and peptides for the measurement of plasma IgG. Taking into account age, fever duration and parasitaemia, a multiple logistic regression performed on children clustered according to their antibody responses' profiles concluded to an increased risk of severe malaria for P2 (representative of RESA-1) responders (P = 0.007). Increased IL-10 plasma levels were found in children harbouring multiclonal P. falciparum infections on the basis of the T1526G resa2 gene polymorphism (P = 0.004). Conclusions: This study provided novel tools to dissect the seroreactivity against the three members of the RESA protein family and to describe its relation to protection against malaria. It suggested the measurement of plasma antibodies raised against specific peptides to serve as predictive immunologic markers for disease severity. Lastly, it reinforced previous observations linking the T1526G resa2 gene mutation to severe malaria

French political science at a turning point

This paper outlines the origins and institutionalization process of French political science since 1945. It sketches the present state of the discipline, and it analyses recent trends that appear almost as a form of ‘de-institutionalization’. Overall, the discipline is quite well entrenched and is independent in terms of recruitment with its own teaching and research branches. However, political scientists suffer from a relative lack of visibility in the public space in comparison with their colleagues from more prominent disciplines. In many fields French political science remains invisible at the international level, though this may change considerably in the years to come. The main element of uncertainty comes from the ongoing reforms, the redefinition of the partnership between universities, the Instituts d'Etudes Politiques and the CNRS, and the way the autonomy of universities will be implemented

The positive transcriptional elongation factor (P-TEFb) is required for neural crest specification

Regulation of gene expression at the level of transcriptional elongation has been shown to be important in stem cells and tumour cells, but its role in the whole animal is only now being fully explored. Neural crest cells (NCCs) are a multipotent population of cells that migrate during early development from the dorsal neural tube throughout the embryo where they differentiate into a variety of cell types including pigment cells, cranio-facial skeleton and sensory neurons. Specification of NCCs is both spatially and temporally regulated during embryonic development. Here we show that components of the transcriptional elongation regulatory machinery, CDK9 and CYCLINT1 of the P-TEFb complex, are required to regulate neural crest specification. In particular, we show that expression of the proto-oncogene c-Myc and c-Myc responsive genes are affected. Our data suggest that P-TEFb is crucial to drive expression of c-Myc, which acts as a ‘gate-keeper’ for the correct temporal and spatial development of the neural crest

Genome-Wide Association Study Identifies Genetic Loci Associated with Iron Deficiency

The existence of multiple inherited disorders of iron metabolism in man, rodents and other vertebrates suggests genetic contributions to iron deficiency. To identify new genomic locations associated with iron deficiency, a genome-wide association study (GWAS) was performed using DNA collected from white men aged ≥25 y and women ≥50 y in the Hemochromatosis and Iron Overload Screening (HEIRS) Study with serum ferritin (SF) ≤ 12 µg/L (cases) and iron replete controls (SF>100 µg/L in men, SF>50 µg/L in women). Regression analysis was used to examine the association between case-control status (336 cases, 343 controls) and quantitative serum iron measures and 331,060 single nucleotide polymorphism (SNP) genotypes, with replication analyses performed in a sample of 71 cases and 161 controls from a population of white male and female veterans screened at a US Veterans Affairs (VA) medical center. Five SNPs identified in the GWAS met genome-wide statistical significance for association with at least one iron measure, rs2698530 on chr. 2p14; rs3811647 on chr. 3q22, a known SNP in the transferrin (TF) gene region; rs1800562 on chr. 6p22, the C282Y mutation in the HFE gene; rs7787204 on chr. 7p21; and rs987710 on chr. 22q11 (GWAS observed P<1.51×10−7 for all). An association between total iron binding capacity and SNP rs3811647 in the TF gene (GWAS observed P = 7.0×10−9, corrected P = 0.012) was replicated within the VA samples (observed P = 0.012). Associations with the C282Y mutation in the HFE gene also were replicated. The joint analysis of the HEIRS and VA samples revealed strong associations between rs2698530 on chr. 2p14 and iron status outcomes. These results confirm a previously-described TF polymorphism and implicate one potential new locus as a target for gene identification

Historical Everyday Geopolitics on the Chile-Peru Border

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.Geopolitics is increasingly seen by scholars as occurring in everyday spaces and performed by ordinary people. This paper extends this idea to historical work to examine how citizens themselves (re)produce geopolitics at the time of historical events. It does so through a case study of geopolitical tension on the Chile‐Peru border in the 1970s. Through oral histories and newspaper analysis, a historical everyday geopolitics approach reveals how those living in the Chilean border city of Arica played a part in promoting national and border security. This centres the embodied and emotional experiences of those affected by violence and conflict