Thermophysical properties and oxygen transport in (Thx,Pu1-x)O2

Using Molecular Dynamics, this paper investigates the thermophysical properties and oxygen transport of (Thx,Pu1−x)O2 (0 ≤ x ≤ 1) between 300-3500 K. In particular, the superionic transition is investigated and viewed via the thermal dependence of lattice parameter, linear thermal expansion coefficient, enthalpy and specific heat at constant pressure. Oxygen diffusivity and activation enthalpy are also investigated. Below the superionic temperature an increase of oxygen diffusivity for certain compositions of (Thx,Pu1−x)O2 compared to the pure end members is predicted. Oxygen defect formation enthalpies are also examined, as they underpin the superionic transition temperature and the increase in oxygen diffusivity. The increase in oxygen diffusivity for (Thx,Pu1−x)O2 is explained in terms of lower oxygen defect formation enthalpies for (Thx,Pu1−x)O2 than PuO2 and ThO2, while links are drawn between the superionic transition temperature and oxygen Frenkel disorder

'HeART of Stroke (HoS)', a community-based Arts for Health group intervention to support self-confidence and psychological well-being following a stroke: protocol for a randomised controlled feasibility study

Introduction Over 152 000 people in the UK have strokes annually and a third experience residual disability. Low mood also affects a third of stroke survivors; yet psychological support is poor. While Arts for Health interventions have been shown to improve well-being in people with mild-to-moderate depression post-stroke, their role in helping people regain sense of self, well-being and confidence has yet to be evaluated. The main aim of this study is to explore the feasibility of conducting a pragmatic multicentre randomised controlled trial to assess the effectiveness and cost-effectiveness of an Arts for Health group intervention (‘HeART of Stroke’ (HoS)) for stroke survivors. HoS is a 10-session artist-facilitated group intervention held in the community over 14 weeks. It offers a non-judgemental, supportive environment for people to explore sense of self, potentially enhancing well-being and confidence. Methods and analysis Sixty-four people, up to 2 years post-stroke, recruited via secondary care research staff or community stroke/rehabilitation teams in two UK centres will be randomised to either HoS plus usual care or usual care only. Self-reported outcomes, measured at baseline and approximately 5 months postrandomisation, will include stroke-related, well-being, mood, self-esteem, quality of life and process measures. Analyses will focus on estimating key feasibility parameters (eg, rates of recruitment, retention, intervention attendance). We will develop outcome and resource use data collection methods to inform an effectiveness and cost-effectiveness analysis in the future trial. Interviews, with a sample of participants, will explore the acceptability of the intervention and study processes, as well as experiences of the HoS group. Ethics and dissemination National Health Service (NHS), Research and Development and University ethical approvals have been obtained. Two peer-reviewed journal publications are planned plus one service user led publication. Findings will be disseminated at key national conferences, local stakeholder events and via institutional websites.This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-0212-27054)

Verbal and visuospatial deficits in dementia with Lewy bodies

This is the publisher's version, also available electronically from http://www.neurology.org/content/65/8/1232.Objective: To investigate the cognitive decline in dementia with Lewy bodies (DLBs) and characterize the contribution of Lewy bodies (LBs) to cognitive impairment in the presence of concurrent Alzheimer disease (AD). Methods: Cognitive deficits and rates of progression attributable to DLB and AD neuropathology were investigated in three groups of participants from the longitudinal cohort of the Alzheimer Disease Research Center at Washington University with autopsy-confirmed diagnoses of pure DLB (n = 9), mixed DLB/AD (n = 57), and pure AD (n = 66). Factor analysis was used to recover latent constructs in a comprehensive psychometric test battery, analysis of variance was used to test group differences on the observed dimensions, and random effects models were used to test longitudinal rates of cognitive decline. Results: Patients with AD pathology performed worse on the verbal memory dimension. Patients with LB pathology performed worse on the visuospatial dimension. Combined pathology affected visuospatial performance but not verbal memory. The rate of cognitive decline in the DLB, DLB/AD combined, and the pure AD groups was equivalent. Conclusions: The comorbid presence of DLB and AD alters the cognitive presentation of visuospatial deficits in dementia but does not alter dementia progression. Both visuospatial and verbal abilities declined at similar rates across the three patient groups. DLB diagnosis may be improved, particularly when there is comorbid AD, by using domain-specific testing

On the role of the Knudsen layer in rapid granular flows

A combination of molecular-dynamics simulations, theoretical predictions, and previous experiments are used in a two-part study to determine the role of the Knudsen layer in rapid granular flows. First, a robust criterion for the identification of the thickness of the Knudsen layer is established: a rapid deterioration in Navier-Stokes-order prediction of the heat flux is found to occur in the Knudsen layer. For (experimental) systems in which heat flux measurements are not easily obtained, a rule-of-thumb for estimating the Knudsen layer thickness follows, namely that such effects are evident within 2.5 (local) mean free paths of a given boundary. Second, comparisons of simulation and experimental data with Navier-Stokes order theory are used to provide a measure as to when Knudsen layer effects become non-negligible. Specifically, predictions that do not account for the presence of a Knudsen layer appear reliable for Knudsen layers collectively composing up to 20% of the domain, whereas deterioration of such predictions becomes apparent when the domain is fully comprised of the Knudsen layer.Comment: 9 figures, accepted to Journal of Fluid Mechanic

A qualitative study of mothers’ perceptions of weaning and the use of commercial infant food in the United Kingdom

Background: Commercially produced infant food has a different taste profile and nutritional content to homemade baby food and its consumption is now very widespread. This change in early food experience may lead to a reduced dietary variety and a decreased microbial load exposure.Objective: The purpose of this study was to gain insight into parental perceptions of complementary feeding, specifically opinions of commercially produced baby food, using qualitative research methods. Methods: Four focus group discussions took place (n = 24), with mothers of infants aged 4-7 months. Half of participants were first time mothers and a third had experience weaning infants with symptoms of cows' milk allergy. Participants were prompted with questions about complementary feeding and shown several different products to stimulate discussion. Results: Thematic analysis of focus groups indicated that three distinctive groups of mothers exis

Markov-Airy method for electromagnetic fields in layered structures and microsphere-stabilized planar resonators

In this work, a new technique to calculate the behavior of electromagnetic fields in layered structures is presented. Based upon keeping track of reflections throughout the structure, this technique is a special case of the method of moments. Analysis of layered scatterers, waveguides, and resonators is presented for structures possessing rectangular, cylindrical, and spherical symmetry. In rectangular coordinates, exact formulas are presented for calculating the group delay, group delay dispersion, and third-order dispersion upon reflection or transmission. For the first time, exact formulas are derived for calculating the dispersion of a planar waveguide up to third order. The algorithm has been implemented and subsequently validated by testing it against analytic solutions. In the second section of the thesis, a new method of constructing a cavity is demonstrated. A microsphere is placed in between two high-reflecting mirrors. Depending on the separation of the mirrors, the spheres were observed to either lower or raise the lasing threshold. Models of the cavity were developed and agree with observed data. By self-assembling spheres, a laser array is demonstrated

Linking remote imagery of a coronal mass ejection to its in situ signatures at 1 AU

In a case study (June 6-7, 2008) we report on how the internal structure of a coronal mass ejection (CME) at 1 AU can be anticipated from remote observations of white-light images of the heliosphere. Favorable circumstances are the absence of fast equatorial solar wind streams and a low CME velocity which allow us to relate the imaging and in-situ data in a straightforward way. The STEREO-B spacecraft encountered typical signatures of a magnetic flux rope inside an interplanetary CME (ICME) whose axis was inclined at 45 degree to the solar equatorial plane. Various CME direction-finding techniques yield consistent results to within 15 degree. Further, remote images from STEREO-A show that (1) the CME is unambiguously connected to the ICME and can be tracked all the way to 1 AU, (2) the particular arc-like morphology of the CME points to an inclined axis, and (3) the three-part structure of the CME may be plausibly related to the in situ data. This is a first step in predicting both the direction of travel and the internal structure of CMEs from complete remote observations between the Sun and 1 AU, which is one of the main requirements for forecasting the geo-effectiveness of CMEs.Comment: The Astropyhsical Journal Letters (accepted); 4 figure

Production Strategies of Livestock Herders in the Grasslands of Kazakhstan: Implications for the Marketing of Fine Fibres

Goat populations have been rising in Kazakhstan over the past ten years since independence and goats are preferred by farmers trying to restock. Quality of cashmere production is the key to profitable and sustainable sales to world markets for this luxury good. However, Kazakhstan did not develop a cashmere industry in the Soviet period so today goats are sheared rather than combed and little profit is made from cashmere. Goats, as well as sheep and camels are currently multi-purpose animals providing income from sales of animals, cashmere, milk and meat. This will change as the terms of trade change for high quality cashmere and households comb for fine down