Odorant Receptor (Or) genes: polymorphism and divergence in the D. melanogaster and D. pseudoobscura Lineages

Background: In insects, like in most invertebrates, olfaction is the principal sensory modality, which provides animals with essential information for survival and reproduction. Odorant receptors are involved in this response, mediating interactions between an individual and its environment, as well as between individuals of the same or different species. The adaptive importance of odorant receptors renders them good candidates for having their variation shaped by natural selection. Methodology/Principal Findings: We analyzed nucleotide variation in a subset of eight Or genes located on the 3L chromosomal arm of Drosophila melanogaster in a derived population of this species and also in a population of Drosophila pseudoobscura. Some heterogeneity in the silent polymorphism to divergence ratio was detected in the D. melanogaster/D. simulans comparison, with a single gene (Or67b) contributing ~37% to the test statistic. However, no other signals of a very recent selective event were detected at this gene. In contrast, at the speciation timescale, the MK test uncovered the footprint of positive selection driving the evolution of two of the encoded proteins in both D. melanogaster ¿OR65c and OR67a ¿and D. pseudoobscura ¿OR65b1 and OR67c. Conclusions: The powerful polymorphism/divergence approach provided evidence for adaptive evolution at a rather high proportion of the Or genes studied after relatively recent speciation events. It did not provide, however, clear evidence for very recent selective events in either D. melanogaster or D. pseudoobscura

Determinación de la vida de anaquel de sales de ajo, cebolla y pimienta limón en tres tipos de empaque

Las sales condimentadas son susceptibles a la degradación de los atributos que le confieren la calidad, por lo que son importantes los estudios de vida de anaquel. El propósito del estudio fue determinar la vida de anaquel  de sales condimentadas de ajo, cebolla y pimienta limón en tres tipos de empaque (estructuras del tipo bobina y envase PET) por análisis sensorial y bioquímico. Se realizó un estudio experimental pretest y post test con un grupo control. Se analizaron seis muestras para la pimienta limón y dos de sal de ajo y de cebolla por método acelerado para cada empaque. El análisis sensorial fue por la prueba hedónica y los fisicoquímicos por análisis de pH, sal y humedad. Se analizaron por análisis de varianza (ANOVA) determinando que no existe diferencia significativa en los atributos sensoriales de olor y sabor; los datos fisicoquímicos pH, y sal, demuestran que los tres tipos de empaque ofrecen una buena barrera contra estos parámetros. Se analizó el porcentaje de humedad del producto, que es el principal parámetro para determinar la vida de anaquel, por lo que partiendo de la correlación del porcentaje de la humedad y el tiempo, se determinó la cinética de la reacción, su orden el cual fue cero y coeficiente de determinación. Se concluye que el empaque que ofrece la mejor barrera contra la humedad y mantiene la vida de anaquel del producto es el del tipo bobina BEDP

Derecho judicial: el derecho de creación judicial a la luz del siglo XXI

Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à Lei de Direitos Autorais, não disponibilizamos a obra na íntegra.Localização na estante: 34 D431jOrganizado por: Eduardo de Porres Ortiz de Urbina e Jordan C. Sos

Systematic Review of Patient-Reported Outcome Measures for Patients with Exercise-Induced Leg Pain

Background and Objectives: To determine the most commonly used patient-reported outcome measures (PROMs) in exercise-induced leg pain (EILP) and to identify specific PROMs for EILP in order to evaluate their psychometric properties and methodological quality. Materials and Methods: A strategic search was performed in different databases to identify and extract the characteristics of studies based on the use of PROMs in patients with EILP. Specific PROMs were evaluated according to the Terwee et al. and COSMIN criteria. Results: Fifty-six studies were included in the review. The Medial Tibial Stress Syndrome Score (MTSSS), Lower Extremity Functional Scale (LEFS) and Exercise-Induced Leg Pain Questionnaire (EILP-Q) were identified as specific PROMs for EILP. The Visual Analog Scale (VAS) was the most widely used instrument in the assessment of EILP. The methodological quality assessment showed six positive values for the LEFS, four for the MTSSS and three for the EILP-Q for the eight psychometric properties analyzed according to the COSMIN criteria. The evaluation of the nine psychometric properties according to Terwee showed five positive values for the LEFS and MTSSS, and three for the EILP-Q. Conclusions: The overall methodological quality of the PROMs used was low. The VAS was the most widely used instrument in the assessment of EILP, and the LEFS was the highest quality PROM available for EILP, followed by the MTSSS and EILP-Q, respectively.Castillo-Domínguez A, García-Romero JC, Alvero-Cruz JR, Ponce-García T, Benítez-Porres J, Páez-Moguer J. Systematic Review of Patient-Reported Outcome Measures for Patients with Exercise-Induced Leg Pain. Medicina. 2022; 58(7):841. https://doi.org/10.3390/medicina5807084

The development of a concept project unloading complex in a coal terminal in the software solidworks

Разработана компьютерная компоновочная модель разгрузочного комплекса. Произведено моделирование движения машин и узлов, соответствующее технологическим процессам протекающим при работе комплекса.A computer layout model of the unloading complex was designed. Motions of machines and units, corresponding to technological process operates when the complex works were simulated

Angle-resolved photoemission study and first principles calculation of the electronic structure of GaTe

The electronic band structure of GaTe has been calculated by numerical atomic orbitals density-functional theory, in the local density approximation. In addition, the valence-band dispersion along various directions of the GaTe Brillouin zone has been determined experimentally by angle-resolved photoelectron spectroscopy. Along these directions, the calculated valence-band structure is in good concordance with the valence-band dispersion obtained by these measurements. It has been established that GaTe is a direct-gap semiconductor with the band gap located at the Z point, that is, at Brillouin zone border in the direction perpendicular to the layers. The valence-band maximum shows a marked \textit{p}-like behavior, with a pronounced anion contribution. The conduction band minimum arises from states with a comparable \textit{s}- \textit{p}-cation and \textit{p}-anion orbital contribution. Spin-orbit interaction appears to specially alter dispersion and binding energy of states of the topmost valence bands lying at $\Gamma$. By spin-orbit, it is favored hybridization of the topmost \textit{p}$_z$-valence band with deeper and flatter \textit{p$_x$}-\textit{p$_y$} bands and the valence-band minimum at $\Gamma$ is raised towards the Fermi level since it appears to be determined by the shifted up \textit{p$_x$}-\textit{p$_y$} bands.Comment: 7 text pages, 6 eps figures, submitted to PR

Toward the adaptation of component-based architectures by model transformation: behind smart user interfaces

Graphical user interfaces are not always developed for remaining static. There are GUIs with the need of implementing some variability mechanisms. Component-based GUIs are an ideal target for incorporating this kind of operations, because they can adapt their functionality at run-time when their structure is updated by adding or removing components or by modifying the relationships between them. Mashup user interfaces are a good example of this type of GUI, and they allow to combine services through the assembly of graphical components. We intend to adapt component based user interfaces for obtaining smart user interfaces. With this goal, our proposal attempts to adapt abstract component-based architectures by using model transformation. Our aim is to generate at run-time a dynamic model transformation, because the rules describing their behavior are not pre set but are selected from a repository depending on the context. The proposal describes an adaptation schema based on model transformation providing a solution to this dynamic transformation. Context information is processed to select at run-time a rule subset from a repository. Selected rules are used to generate, through a higher-order transformation, the dynamic model transformation. This approach has been tested through a case study which applies different repositories to the same architecture and context. Moreover, a web tool has been developed for validation and demonstration of its applicability. The novelty of our proposal arises from the adaptation schema that creates a non pre-set transformation, which enables the dynamic adaptation of component-based architectures

Toward the adaptation of component-based architectures by model transformation: behind smart user interfaces

Graphical user interfaces are not always developed for remaining static. There are GUIs with the need of implementing some variability mechanisms. Component-based GUIs are an ideal target for incorporating this kind of operations, because they can adapt their functionality at run-time when their structure is updated by adding or removing components or by modifying the relationships between them. Mashup user interfaces are a good example of this type of GUI, and they allow to combine services through the assembly of graphical components. We intend to adapt component based user interfaces for obtaining smart user interfaces. With this goal, our proposal attempts to adapt abstract component-based architectures by using model transformation. Our aim is to generate at run-time a dynamic model transformation, because the rules describing their behavior are not pre set but are selected from a repository depending on the context. The proposal describes an adaptation schema based on model transformation providing a solution to this dynamic transformation. Context information is processed to select at run-time a rule subset from a repository. Selected rules are used to generate, through a higher-order transformation, the dynamic model transformation. This approach has been tested through a case study which applies different repositories to the same architecture and context. Moreover, a web tool has been developed for validation and demonstration of its applicability. The novelty of our proposal arises from the adaptation schema that creates a non pre-set transformation, which enables the dynamic adaptation of component-based architectures

Phase Transitions of BiVO4 under High Pressure and High Temperature

We have studied the occurrence of phase transitions in two polymorphs of BiVO4 under high-pressure and high-temperature conditions by means of X-ray diffraction measurements. The fergusonite polymorph undergoes a phase transition at 1.5(1) GPa and room temperature into a tetragonal scheelite-type structure. The same transition takes place at 523(1) K and ambient pressure. A second phase transition takes place at room temperature under compression at 16(1) GPa. The transition is from the tetragonal scheelite structure to a monoclinic structure (space group P21/c). All observed phase transitions are reversible. The zircon polymorph counterpart also transforms under compression into the scheelite-type structure. In this case, the transitions take place at 4.3(1) GPa and room temperature and at 653(1) K and ambient pressure. The zircon–scheelite transition is nonreversible. The experiments support that the fergusonite–scheelite transformation is a second-order transition and that the zircon–scheelite transformation is a first-order transition. Finally, we have also determined the compressibility and the thermal expansion of the fergusonite, scheelite, and zircon phases