199 research outputs found
Galois sections for abelianized fundamental groups
Given a smooth projective curve of genus at least 2 over a number field
, Grothendieck's Section Conjecture predicts that the canonical projection
from the \'etale fundamental group of onto the absolute Galois group of
has a section if and only if the curve has a rational point. We show that there
exist curves where the above map has a section over each completion of but
not over . In the appendix Victor Flynn gives explicit examples in genus 2.
Our result is a consequence of a more general investigation of the existence
of sections for the projection of the \'etale fundamental group `with
abelianized geometric part' onto the Galois group. We give a criterion for the
existence of sections in arbitrary dimension and over arbitrary perfect fields,
and then study the case of curves over local and global fields more closely. We
also point out the relation to the elementary obstruction of
Colliot-Th\'el\`ene and Sansuc.Comment: This is the published version, except for a characteristic 0
assumption added in Section 5 which was unfortunately omitted there. Thanks
to O. Wittenberg for noticing i
The Spin Structure Function of the Proton and a Test of the Bjorken Sum Rule
New results for the double spin asymmetry and the proton
longitudinal spin structure function are presented. They were
obtained by the COMPASS collaboration using polarised 200 GeV muons scattered
off a longitudinally polarised NH target. The data were collected in 2011
and complement those recorded in 2007 at 160\,GeV, in particular at lower
values of . They improve the statistical precision of by
about a factor of two in the region . A next-to-leading order
QCD fit to the world data is performed. It leads to a new determination
of the quark spin contribution to the nucleon spin, ranging
from 0.26 to 0.36, and to a re-evaluation of the first moment of .
The uncertainty of is mostly due to the large uncertainty in
the present determinations of the gluon helicity distribution. A new evaluation
of the Bjorken sum rule based on the COMPASS results for the non-singlet
structure function yields as ratio of the axial and
vector coupling constants , which validates the sum rule to an accuracy of about
9\%.Comment: 19 pages, 8 figures and table
Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial
IMPORTANCE:
Surgical resection has a potential benefit for patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction.
OBJECTIVE:
To evaluate outcome in patients with limited metastatic disease who receive chemotherapy first and proceed to surgical resection.
DESIGN, SETTING, AND PARTICIPANTS:
The AIO-FLOT3 (Arbeitsgemeinschaft Internistische Onkologie-fluorouracil, leucovorin, oxaliplatin, and docetaxel) trial is a prospective, phase 2 trial of 252 patients with resectable or metastatic gastric or gastroesophageal junction adenocarcinoma. Patients were enrolled from 52 cancer care centers in Germany between February 1, 2009, and January 31, 2010, and stratified to 1 of 3 groups: resectable (arm A), limited metastatic (arm B), or extensive metastatic (arm C). Data cutoff was January 2012, and the analysis was performed in March 2013.
INTERVENTIONS:
Patients in arm A received 4 preoperative cycles of fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) followed by surgery and 4 postoperative cycles. Patients in arm B received at least 4 cycles of neoadjuvant FLOT and proceeded to surgical resection if restaging (using computed tomography and magnetic resonance imaging) showed a chance of margin-free (R0) resection of the primary tumor and at least a macroscopic complete resection of the metastatic lesions. Patients in arm C were offered FLOT chemotherapy and surgery only if required for palliation. Patients received a median (range) of 8 (1-15) cycles of FLOT.
MAIN OUTCOMES AND MEASURES:
The primary end point was overall survival.
RESULTS:
In total, 238 of 252 patients (94.4%) were eligible to participate. The median (range) age of participants was 66 (36-79) years in arm A (n = 51), 63 (28-79) years in arm B (n = 60), and 65 (23-83) years in arm C (n = 127). Patients in arm B (n = 60) had only retroperitoneal lymph node involvement (27 patients [45%]), liver involvement (11 [18.3%]), lung involvement (10 [16.7%]), localized peritoneal involvement (4 [6.7%]), or other (8 [13.3%]) incurable sites. Median overall survival was 22.9 months (95% CI, 16.5 to upper level not achieved) for arm B, compared with 10.7 months (95% CI, 9.1-12.8) for arm C (hazard ratio, 0.37; 95% CI, 0.25-0.55) (P < .001). The response rate for arm B was 60% (complete, 10%; partial, 50%), which is higher than the 43.3% for arm C. In arm B, 36 of 60 patients (60%) proceeded to surgery. The median overall survival was 31.3 months (95% CI, 18.9-upper level not achieved) for patients who proceeded to surgery and 15.9 months (95% CI, 7.1-22.9) for the other patients.
CONCLUSIONS AND RELEVANCE:
Patients with limited metastatic disease who received neoadjuvant chemotherapy and proceeded to surgery showed a favorable survival. The AIO-FLOT3 trial provides a rationale for further randomized clinical trials.
TRIAL REGISTRATION:
clinicaltrials.gov identifier: NCT00849615.info:eu-repo/semantics/publishedVersio
Transverse-momentum-dependent Multiplicities of Charged Hadrons in Muon-Deuteron Deep Inelastic Scattering
A semi-inclusive measurement of charged hadron multiplicities in deep
inelastic muon scattering off an isoscalar target was performed using data
collected by the COMPASS Collaboration at CERN. The following kinematic domain
is covered by the data: photon virtuality (GeV/), invariant
mass of the hadronic system GeV/, Bjorken scaling variable in the
range , fraction of the virtual photon energy carried by the
hadron in the range , square of the hadron transverse momentum
with respect to the virtual photon direction in the range 0.02 (GeV/ (GeV/). The multiplicities are presented as a
function of in three-dimensional bins of , , and
compared to previous semi-inclusive measurements. We explore the
small- region, i.e. (GeV/), where
hadron transverse momenta are expected to arise from non-perturbative effects,
and also the domain of larger , where contributions from
higher-order perturbative QCD are expected to dominate. The multiplicities are
fitted using a single-exponential function at small to study
the dependence of the average transverse momentum on , and . The power-law behaviour of the
multiplicities at large is investigated using various
functional forms. The fits describe the data reasonably well over the full
measured range.Comment: 28 pages, 20 figure
Collins and Sivers asymmetries in muonproduction of pions and kaons off transversely polarised proton
Measurements of the Collins and Sivers asymmetries for charged pions and
charged and neutral kaons produced in semi-inclusive deep-inelastic scattering
of high energy muons off transversely polarised protons are presented. The
results were obtained using all the available COMPASS proton data, which were
taken in the years 2007 and 2010. The Collins asymmetries exhibit in the
valence region a non-zero signal for pions and there are hints of non-zero
signal also for kaons. The Sivers asymmetries are found to be positive for
positive pions and kaons and compatible with zero otherwise.Comment: 15 pages, 13 figures and 1 tabl
Search for exclusive photoproduction of Z(3900) at COMPASS
A search for the exclusive production of the hadron by
virtual photons has been performed in the channel . The data cover the range from 7 GeV to 19 GeV in the
centre-of-mass energy of the photon-nucleon system. The full set of the COMPASS
data set collected with a muon beam between 2002 and 2011 has been used. An
upper limit for the ratio of has been established at the confidence
level of 90%.Comment: 8 pages, 3 figures, 1 tabl
Spin alignment and violation of the OZI rule in exclusive and production in pp collisions
Exclusive production of the isoscalar vector mesons and is
measured with a 190 GeV proton beam impinging on a liquid hydrogen target.
Cross section ratios are determined in three intervals of the Feynman variable
of the fast proton. A significant violation of the OZI rule is found,
confirming earlier findings. Its kinematic dependence on and on the
invariant mass of the system formed by fast proton
and vector meson is discussed in terms of diffractive
production of resonances in competition with central
production. The measurement of the spin density matrix element of
the vector mesons in different selected reference frames provides another
handle to distinguish the contributions of these two major reaction types.
Again, dependences of the alignment on and on are
found. Most of the observations can be traced back to the existence of several
excited baryon states contributing to production which are absent in
the case of the meson. Removing the low-mass resonant
region, the OZI rule is found to be violated by a factor of eight,
independently of .Comment: 23 pages, 13 figures and 5 table
40 GBd 16QAM signaling at 160 Gb/s in a silicon-organic hybrid modulator
We demonstrate for the first time generation of 16-state quadrature amplitude modulation (16QAM) signals at a symbol rate of 40 GBd using silicon-based modulators. Our devices exploit silicon-organic hybrid (SOH) integration, which combines silicon-on-insulator slot waveguides with electro-optic cladding materials to realize highly efficient phase shifters. The devices enable 16QAM signaling and quadrature phase shift keying (QPSK) at symbol rates of 40 GBd and 45 GBd, respectively, leading to line rates of up to 160 Gbit/s on a single wavelength and in a single polarization. This is the highest value demonstrated by a silicon-based device up to now. The energy consumption for 16QAM signaling amounts to less than 120 fJ/bit – one order of magnitude below that of conventional silicon photonic 16QAM modulators
The COMPASS Setup for Physics with Hadron Beams
The main characteristics of the COMPASS experimental setup for physics with
hadron beams are described. This setup was designed to perform exclusive
measurements of processes with several charged and/or neutral particles in the
final state. Making use of a large part of the apparatus that was previously
built for spin structure studies with a muon beam, it also features a new
target system as well as new or upgraded detectors. The hadron setup is able to
operate at the high incident hadron flux available at CERN. It is characterised
by large angular and momentum coverages, large and nearly flat acceptances, and
good two and three-particle mass resolutions. In 2008 and 2009 it was
successfully used with positive and negative hadron beams and with liquid
hydrogen and solid nuclear targets. This article describes the new and upgraded
detectors and auxiliary equipment, outlines the reconstruction procedures used,
and summarises the general performance of the setup.Comment: 91 pages, 101 figures and 7 table
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