Gender Norms and Other Factors Explaining the Gender Gap in Students’ Entrepreneurial Inclination in Spain and Iceland

Young women still have a lower entrepreneurial inclination (EI) than young men in both a Latin society (Spain) and in a Nordic society (Iceland). Our data come from a survey conducted among university students who attended the Complutense University of Madrid and the University of Iceland. After constructing a set of variables and indicators that served as explanatory variables, and after conducting a statistical and regression analysis, this study provides evidence about the determinants of this gender gap in EI. The EI of male students was more sensitive to having higher self-confidence than in the case of female students. In turn, the EI of female students was more sensitive to both positive (enrichment) and negative (conflict) perspectives about the work–family interface than in the case of males. Additionally, the EI of students was positively related with entrepreneurial family antecedents, and with the level of parental income; and it was negatively related with their tolerance for risk. Some cross-cultural differences were also found between the Spanish and Icelandic samples

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA

The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 1.0E-4 sensitivity. This approach was validated with a well-stablished RNA-based nested NGS method. The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-DeepNGS a sensitivity of 92% and specificity of 82%. The clinical impact was studied in a cohort of 129 patients (n = 67 for CML and n = 62 for B-ALL patients). A total of 162 samples (n = 86 CML and n = 76 B-ALL) were studied. Of them, 27 out of 86 harbored mutations (6 in warning and 21 in failure) for CML, and 13 out of 76 (2 diagnostic and 11 relapse samples) did in B-ALL patients. In addition, in four cases were detected mutation despite BCR::ABL1 < 1%. In conclusion, we were able to detect KD ABL1 mutations with a 1.0E-4 sensitivity by NGS using DNA as starting material even in patients with low levels of disease

Soy Niña

Este libro pretende contribuir al reencuentro de la educación con esas finalidades que verdaderamente importan a una niña o un niño: ser feliz, jugar, vivir juntos y (no) aprender. Para ello hemos puesto el arte, nuestras experiencias y el saber acumulado al servicio del disfrute, el cuestionamiento, el análisis crítico y la construcción común de un presente deseable. Un texto colaborativo coordinado por Ignacio Calderón Almendros y realizado por alumnado de Educación y Cambio Social en el Grado en Educación Infantil de la Universidad de Málaga

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Hacia la construcción de una ciudadanía digital: nuevos modelos de participación y empoderamiento a través de Internet

Este trabajo aborda la cuestión de la participación digital de los ciudadanos en las cuestiones públicas como una forma de empoderamiento. Además trata de identificar los factores que favorecen dicha participación. Metodológicamente se han recogido los datos a partir de una encuesta a 1183 usuarios de Internet a los que se ha aplicado un análisis de regresión lineal múltiple. Los resultados muestran que para la mitad de la población existe la percepción de que las prácticas digitales en la Red sí empoderan, aunque con matices y que la ciudadanía confía más en la acción colectiva con los pares que en la utilidad que puedan tener sus acciones respecto a las instituciones públicas. Además se observa una considerable participación ciudadana en los asuntos públicos a través de Internet, especialmente entre aquellos que muestran estar más alfabetizados digitalmente y tienen mayores expectativas respecto a esas acciones

Comunicación interpersonal en la web 2.0 : las relaciones de los jóvenes con desconocidos

Se presentan los resultados de una investigación a propósito de las nuevas formas que adopta la comunicación interpersonal en la web 2.0. El objetivo ha sido abordar la s transformaciones de las comunicaciones interpersonales mediadas por ordenador, en concreto, verificar si la relación con desconocidos es una práctica frecuente; cuál es la percepción de quién es desconocido en la Red y qué confianza suscitan los desconocidos. Se ha trabajado a partir de datos de una encuesta realizada en España a 1121 jóvenes (proyecto I+D+i Referencia CSO2008-01496. Entre otras conclusiones, destaca que más de la mitad (53,1%) de los jóvenes considera el trato con desconocidos como forma normalizada de relación y que los que se relacionan con desconocidos tienen un perfil diferente de aquellos que no lo hacen: entienden las comunicaciones interpersonales como más sinceras, más controlables, más personales. [ABSTRACT]This article presents the results of a research study on the new forms of interpersonal communication that young people establish in the Web 2.0. The general objective is to identify the transformations that have occurred in interpersonal computer-mediated-communication. The particular objectives are: a) to determine whether communication with strangers is a common practice among young people; b) to establish young internet users’ perception of “stranger”; and c) to establish the degree of trust young people place on strangers. Methods. The study (whose reference code is CSO2008-01496) is based on a survey carried out in Spain among 1121 young participants. Results. More than half (53.1%) of young people consider online communication with strangers to be a normal type of social relation; the profile of the internet users who talk to strangers on the internet is different from that of the people who do not talk to strangers online, as this latter group conceives interpersonal communications as more sincere, more controllable and more personal

El uso de la televisión en un contexto multipantallas: viejas prácticas en nuevos medios

Esta colaboración trata de ahondar en la relación entre televisión e Internet, de ir más allá de los meros datos de audiencia e interpretar cuál es el alcance social de todos estos cambios que invo­lucran aspectos que se relacionan con la deslocalización del consumo televisivo, la desestructuración de los contenidos audiovisuales y la superposición de tareas diversas al visionado de la televisión. Presentamos datos que nos permiten profundizar en la cuestión de si Internet se constituye como una alternativa al medio televisivo o si realmente estamos ante una relación complementaria.This paper tries to go into the relation between television and Internet in depth, going beyond to the information provided about the audience and interpreting which are the social implica­tions of all these changes that involve aspects related to the relocation of the television consump­tion, the deconstruction of the audio-visual contents and the overlapping of diverse tasks to the tele­vision viewing. We provide some data that allow us to study the question of if Internet appears as an alternative to the television or if we really are before a complementary relationship.Aquesta col·laboració tracta d'aprofundir en la relació entre televisió i Internet, d'anar més enllà de les meres dades d'audiència i interpretar quin és l'abast social de tots aquests canvis que impliquen aspectes que es relacionen amb la deslocalització del consum televisiu, la desestructuració dels continguts audiovisuals i la superposició de tasques diverses al visionat de la televisió. Presentem dades que ens permeten aprofundir en la qüestió de si Internet es constitueix com una alternativa al mitjà televisiu o si realment estem davant una relació complementària

Memoria de la actuación " Excavación arqueológica en el yacimiento de Albalat (Romangordo, Cáceres). Campaña 2012 "

2 volumes ; 351 p.Resultados de la cuarta campaña de excavación en el yacimiento medieval de Albalat (T.M. Romangordo, Cáceres)Résultats de la 4ème campagne de fouille sur le site médiéval d'Albalat (Romangordo, province de Cáceres, Espagne)

Consenso español sobre el hemangioma infantil.

Infantile haemangiomas are benign tumours produced by the proliferation of endothelial cells of blood vessels, with a high incidence in children under the age of one year (4-10%). It is estimated that 12% of them require treatment. This treatment must be administered according to clinical practice guidelines, expert experience, patient characteristics and parent preferences. The consensus process was performed by using scientific evidence on the diagnosis and treatment of infantile haemangiomas, culled from a systematic review of the literature, together with specialist expert opinions. The recommendations issued were validated by the specialists, who also provided their level of agreement. This document contains recommendations on the classification, associations, complications, diagnosis, treatment, and follow-up of patients with infantile haemangioma. It also includes action algorithms, and addresses multidisciplinary management and referral criteria between the different specialities involved in the clinical management of this type of patient. The recommendations and the diagnostic and therapeutic algorithms of infantile haemangiomas contained in this document are a useful tool for the proper management of these patients