The prognosis of allocentric and egocentric neglect : evidence from clinical scans

We contrasted the neuroanatomical substrates of sub-acute and chronic visuospatial deficits associated with different aspects of unilateral neglect using computed tomography scans acquired as part of routine clinical diagnosis. Voxel-wise statistical analyses were conducted on a group of 160 stroke patients scanned at a sub-acute stage. Lesion-deficit relationships were assessed across the whole brain, separately for grey and white matter. We assessed lesions that were associated with behavioural performance (i) at a sub-acute stage (within 3 months of the stroke) and (ii) at a chronic stage (after 9 months post stroke). Allocentric and egocentric neglect symptoms at the sub-acute stage were associated with lesions to dissociated regions within the frontal lobe, amongst other regions. However the frontal lesions were not associated with neglect at the chronic stage. On the other hand, lesions in the angular gyrus were associated with persistent allocentric neglect. In contrast, lesions within the superior temporal gyrus extending into the supramarginal gyrus, as well as lesions within the basal ganglia and insula, were associated with persistent egocentric neglect. Damage within the temporo-parietal junction was associated with both types of neglect at the sub-acute stage and 9 months later. Furthermore, white matter disconnections resulting from damage along the superior longitudinal fasciculus were associated with both types of neglect and critically related to both sub-acute and chronic deficits. Finally, there was a significant difference in the lesion volume between patients who recovered from neglect and patients with chronic deficits. The findings presented provide evidence that (i) the lesion location and lesion size can be used to successfully predict the outcome of neglect based on clinical CT scans, (ii) lesion location alone can serve as a critical predictor for persistent neglect symptoms, (iii) wide spread lesions are associated with neglect symptoms at the sub-acute stage but only some of these are critical for predicting whether neglect will become a chronic disorder and (iv) the severity of behavioural symptoms can be a useful predictor of recovery in the absence of neuroimaging findings on clinical scans. We discuss the implications for understanding the symptoms of the neglect syndrome, the recovery of function and the use of clinical scans to predict outcome

Influence of delayed on established prognostic factors in endometrial cancer

To evaluate the influence of delayed diagnosis on prognostic factors in endometrial cancer, we conducted a retrospective chart analysis based on the data of 116 postmenopausal patients with FIGO stage I-IV endometrial carcinoma. The interval from the first episode of postmenopausal vaginal bleeding to definitive, histological diagnosis (bleeding interval) was compared with tumor stage and various histomorphologic features in endometrial cancer. The mean bleeding interval was 12.7 ± 17.8 weeks in 74 patients with FIGO stage IA, IB endometrial carcinoma and 35.2 ± 69.3 weeks in 42 patients with stage IC-IV disease (t-test, p: 0.011). FIGO stage IA, IB disease was diagnosed in 23/26 (88%) patients with a bleeding inten

Motor awareness in anosognosia for hemiplegia : experiments at last

“The original publication is available at www.springerlink.com”. Copyright SpringerAnosognosia for hemiplegia (AHP) is the apparent inability to acknowledge contralesional paralysis, typically following right-hemisphere lesions. Here we review studies that regard AHP as a specific deficit of motor awareness and explain its symptoms by employing an established computational model of motor control. These accounts propose that AHP arises from a breakdown in the monitoring of intended and actual movement. First, we critically examine physiological and behavioural experiments, which attempt to provide an account of AHP by verifying the presence or absence of motor intentions. We then review more recent experiments that endeavour to empirically address the hitherto unexplored role of motor intentions and internal representations of movements in AHP patients’ non-veridical (illusory) awareness of movement. Finally, we consider implications of AHP research for clinical practice and the understanding of motor awareness more generally. We conclude that the false experience of movement in AHP may provide insight into what occurs when the mechanism responsible for monitoring and correcting significant discrepancies between predicted and executed actions is impaired. The system seems to continue to operate by deceiving awareness.Peer reviewe