123 research outputs found
Corals in the hottest reefs in the world exhibit symbiont fidelity not flexibility
- Author
- Publication venue
- NSUWorks
- Publication date
- 03/02/2020
- Field of study
Reef-building corals are at risk of extinction from ocean warming. While some corals can enhance their thermal limits by associating with dinoflagellate photosymbionts of superior stress tolerance, the extent to which symbiont communities will reorganize under increased warming pressure remains unclear. Here we show that corals in the hottest reefs in the world in the Persian Gulf maintain associations with the same symbionts across 1.5 years despite extreme seasonal warming and acute heat stress (≥35°C). Persian Gulf corals predominantly associated with Cladocopium (clade C) and most also hosted Symbiodinium (clade A) and/or Durusdinium (clade D). This is in contrast to the neighbouring and milder Oman Sea, where corals associated with Durusdinium and only a minority hosted background levels of Cladocopium. During acute heat stress, the higher prevalence of Symbiodinium and Durusdinium in bleached versus nonbleached Persian Gulf corals indicates that genotypes of these background genera did not confer bleaching resistance. Within symbiont genera, the majority of ITS2 rDNA type profiles were unique to their respective coral species, confirming the existence of host-specific symbiont lineages. Notably, further differentiation among Persian Gulf sites demonstrates that symbiont populations are either isolated or specialized over tens to hundreds of kilometres. Thermal tolerance across coral species was associated with the prevalence of a single ITS2 intragenomic sequence variant (C3gulf), definitive of the Cladocopium thermophilum group. The abundance of C3gulf was highest in bleaching-resistant corals and at warmer sites, potentially indicating a specific symbiont genotype (or set of genotypes) that may play a role in thermal tolerance that warrants further investigation. Together, our findings indicate that co-evolution of host–Symbiodiniaceae partnerships favours fidelity rather than flexibility in extreme environments and under future warming
A many-analysts approach to the relation between religiosity and well-being
- Author
- Aczel Balazs
- Aczel Balazs
- Aditya Yonathan
- Aditya Yonathan
- Alayan Alexandra J.
- Alayan Alexandra J.
- Allen Peter J.
- Allen Peter J.
- Altay Sacha
- Altay Sacha
- Alzahawi Shilaan
- Alzahawi Shilaan
- Amir Yulmaida
- Amir Yulmaida
- Ann Vaughn Leigh
- Ann Vaughn Leigh
- Anthony Francis-Vincent
- Anthony Francis-Vincent
- Atkinson Quentin D.
- Atkinson Quentin D.
- Baimel Adam
- Baimel Adam
- Balkaya-Ince Merve
- Balkaya-Ince Merve
- Balsamo Michela
- Balsamo Michela
- Banker Sachin
- Banker Sachin
- Bartoš František
- Bartoš František
- Becerra Mario
- Becerra Mario
- Beffara Bertrand
- Beffara Bertrand
- Beitner Julia
- Beitner Julia
- Bendixen Theiss
- Bendixen Theiss
- Berkessel Jana B.
- Berkessel Jana B.
- Berniūnas Renatas
- Berniūnas Renatas
- Billet Matthew I.
- Billet Matthew I.
- Billingsley Joseph
- Billingsley Joseph
- Bortolini Tiago
- Bortolini Tiago
- Breitsohl Heiko
- Breitsohl Heiko
- Bret Amélie
- Bret Amélie
- Brown Faith L.
- Brown Faith L.
- Brown Jennifer
- Brown Jennifer
- Brumbaugh Claudia C.
- Brumbaugh Claudia C.
- Buczny Jacek
- Buczny Jacek
- Bulbulia Joseph
- Bulbulia Joseph
- Caballero Saúl
- Caballero Saúl
- Carlucci Leonardo
- Carlucci Leonardo
- Carmichael Cheryl L.
- Carmichael Cheryl L.
- Cattaneo Marco E. G. V.
- Cattaneo Marco E. G. V.
- Charles Sarah J.
- Charles Sarah J.
- Claessens Scott
- Claessens Scott
- Costa Angelo Brandelli
- Costa Angelo Brandelli
- Crone Damien L.
- Crone Damien L.
- Czoschke Stefan
- Czoschke Stefan
- Czymara Christian
- Czymara Christian
- D'Urso E. Damiano
- D'Urso E. Damiano
- Dahlström Örjan
- Dahlström Örjan
- Danielsson Henrik
- Danielsson Henrik
- De Ron Jill
- De Ron Jill
- de Vries Ymkje Anna
- de Vries Ymkje Anna
- Dean Kristy K.
- Dean Kristy K.
- Dik Bryan J.
- Dik Bryan J.
- Disabato David J.
- Disabato David J.
- Doherty Jaclyn K.
- Doherty Jaclyn K.
- Draws Tim
- Draws Tim
- Drouhot Lucas
- Drouhot Lucas
- Dujmovic Marin
- Dujmovic Marin
- Dunham Yarrow
- Dunham Yarrow
- Ebert Tobias
- Ebert Tobias
- Edelsbrunner Peter A.
- Edelsbrunner Peter A.
- Eerland Anita
- Eerland Anita
- Elbaek Christian T.
- Elbaek Christian T.
- Farahmand Hooman
- Farahmand Hooman
- Farahmand Shole
- Farahmand Shole
- Farias Miguel
- Farias Miguel
- Feliccia Abrey A.
- Feliccia Abrey A.
- Fischer Kyle
- Fischer Kyle
- Fischer Ronald
- Fischer Ronald
- Fisher-Thompson Donna
- Fisher-Thompson Donna
- Forsyth Guy A. Lavender
- Forsyth Guy A. Lavender
- Francis Zoë
- Francis Zoë
- Frick Susanne
- Frick Susanne
- Frisch Lisa K.
- Frisch Lisa K.
- Geraldes Diogo
- Geraldes Diogo
- Gerdin Emily
- Gerdin Emily
- Geven Linda
- Geven Linda
- Ghasemi Omid
- Ghasemi Omid
- Gielens Erwin
- Gielens Erwin
- Gligorić Vukašin
- Gligorić Vukašin
- Hagel Kristin
- Hagel Kristin
- Hajdu Nandor
- Hajdu Nandor
- Hamilton Hannah R.
- Hamilton Hannah R.
- Hamzah Imaduddin
- Hamzah Imaduddin
- Hanel Paul H. P.
- Hanel Paul H. P.
- Hawk Christopher E.
- Hawk Christopher E.
- Holding Benjamin C.
- Holding Benjamin C.
- Homman Lina E.
- Homman Lina E.
- Hoogeveen Suzanne
- Hoogeveen Suzanne
- Ingendahl Moritz
- Ingendahl Moritz
- Inkilä Hilla
- Inkilä Hilla
- Inman Mary L.
- Inman Mary L.
- Islam Chris-Gabriel
- Islam Chris-Gabriel
- Isler Ozan
- Isler Ozan
- Izydorczyk David
- Izydorczyk David
- J. Roberts Andrew
- J. Roberts Andrew
- Jaeger Bastian
- Jaeger Bastian
- Johnson Kathryn A.
- Johnson Kathryn A.
- Jong Jonathan
- Jong Jonathan
- K. Himawan Karel
- K. Himawan Karel
- Karl Johannes A.
- Karl Johannes A.
- Kaszubowski Erikson
- Kaszubowski Erikson
- Katz Benjamin A.
- Katz Benjamin A.
- Keefer Lucas A.
- Keefer Lucas A.
- Kelchtermans Stijn
- Kelchtermans Stijn
- Kelly John M.
- Kelly John M.
- Klein Richard A.
- Klein Richard A.
- Kleinberg Bennett
- Kleinberg Bennett
- Knowles Megan L.
- Knowles Megan L.
- Koller Dave
- Koller Dave
- Kołczyńska Marta
- Kołczyńska Marta
- Krasko Julia
- Krasko Julia
- Kritzler Sarah
- Kritzler Sarah
- Krypotos Angelos-Miltiadis
- Krypotos Angelos-Miltiadis
- Kwame Appiah Obed
- Kwame Appiah Obed
- Kyritsis Thanos
- Kyritsis Thanos
- L. Landes Todd
- L. Landes Todd
- Laukenmann Ruben
- Laukenmann Ruben
- Lazar Aryeh
- Lazar Aryeh
- Lehman Barbara J.
- Lehman Barbara J.
- Levy Neil
- Levy Neil
- Lo Ronda F.
- Lo Ronda F.
- Lodder Paul
- Lodder Paul
- Lorenz Jennifer
- Lorenz Jennifer
- Luna Lindsey M. Root
- Luna Lindsey M. Root
- Ly Albert L.
- Ly Albert L.
- Maassen Esther
- Maassen Esther
- Magyar-Russell Gina M.
- Magyar-Russell Gina M.
- Maier Maximilian
- Maier Maximilian
- Marsh Dylan R.
- Marsh Dylan R.
- Martinez N.
- Martinez N.
- Martinie Marcellin
- Martinie Marcellin
- Martoyo Ihan
- Martoyo Ihan
- Mason Susan E.
- Mason Susan E.
- Mauritsen Anne Lundahl
- Mauritsen Anne Lundahl
- McAleer Phil
- McAleer Phil
- McCauley Thomas
- McCauley Thomas
- McCullough Michael
- McCullough Michael
- McKay Ryan
- McKay Ryan
- McMahon Camilla M.
- McMahon Camilla M.
- McNamara Amelia A.
- McNamara Amelia A.
- Means Kira K.
- Means Kira K.
- Mercier Brett
- Mercier Brett
- Mitkidis Panagiotis
- Mitkidis Panagiotis
- Monin Benoît
- Monin Benoît
- Moon Jordan W.
- Moon Jordan W.
- Moreau David
- Moreau David
- Morgan Jonathan
- Morgan Jonathan
- Murphy J.
- Murphy J.
- Muscatt George
- Muscatt George
- Nagy Tamás
- Nagy Tamás
- Nalborczyk Ladislas
- Nalborczyk Ladislas
- Nilsonne Gustav
- Nilsonne Gustav
- Noack Pamina
- Noack Pamina
- Norenzayan Ara
- Norenzayan Ara
- Nuijten Michèle B.
- Nuijten Michèle B.
- Nägel Christof
- Nägel Christof
- Olsson-Collentine Anton
- Olsson-Collentine Anton
- Oviedo Lluis
- Oviedo Lluis
- Panagopoulos Maxinne C.
- Panagopoulos Maxinne C.
- Pavlov Yuri G.
- Pavlov Yuri G.
- Pawelski James O.
- Pawelski James O.
- Pearson Hannah I.
- Pearson Hannah I.
- Pedder Hugo
- Pedder Hugo
- Peetz Hannah K.
- Peetz Hannah K.
- Pinus Michael
- Pinus Michael
- Pirutinsky Steven
- Pirutinsky Steven
- Polito Vince
- Polito Vince
- Porubanova Michaela
- Porubanova Michaela
- Poulin Michael J.
- Poulin Michael J.
- Prenoveau Jason M.
- Prenoveau Jason M.
- Prince Mark A.
- Prince Mark A.
- Protzko John
- Protzko John
- Pryor Campbell
- Pryor Campbell
- Purzycki Benjamin G.
- Purzycki Benjamin G.
- Pütter Julian Quevedo
- Pütter Julian Quevedo
- Qiu Lin
- Qiu Lin
- Rabelo André
- Rabelo André
- Radell Milen L.
- Radell Milen L.
- Ramsay Jonathan E.
- Ramsay Jonathan E.
- Reid Graham
- Reid Graham
- Rosa Anna Dalla
- Rosa Anna Dalla
- Ross Robert M.
- Ross Robert M.
- Roszak Piotr
- Roszak Piotr
- Roy Nirmal
- Roy Nirmal
- Saarelainen Suvi-Maria K.
- Saarelainen Suvi-Maria K.
- Sarafoglou Alexandra
- Sarafoglou Alexandra
- Sasaki Joni Y.
- Sasaki Joni Y.
- Schaumans Catherine
- Schaumans Catherine
- Schivinski Bruno
- Schivinski Bruno
- Schmitt Marcel C.
- Schmitt Marcel C.
- Schnitker Sarah A.
- Schnitker Sarah A.
- Schnuerch Martin
- Schnuerch Martin
- Schreiner Marcel R.
- Schreiner Marcel R.
- Schüttengruber Victoria
- Schüttengruber Victoria
- Sebben Simone
- Sebben Simone
- Segerstrom Suzanne C.
- Segerstrom Suzanne C.
- Seryczyńska Berenika
- Seryczyńska Berenika
- Shjoedt Uffe
- Shjoedt Uffe
- Simsek Müge
- Simsek Müge
- Sleegers Willem W. A.
- Sleegers Willem W. A.
- Smith Eliot R.
- Smith Eliot R.
- Sowden Walter J.
- Sowden Walter J.
- Späth Marion
- Späth Marion
- Spörlein Christoph
- Spörlein Christoph
- Stedden William
- Stedden William
- Stoevenbelt Andrea H.
- Stoevenbelt Andrea H.
- Stuber Simon
- Stuber Simon
- Sulik Justin
- Sulik Justin
- Suwartono Christiany
- Suwartono Christiany
- Syropoulos Stylianos
- Syropoulos Stylianos
- Szaszi Barnabas
- Szaszi Barnabas
- Szecsi Peter
- Szecsi Peter
- Tappin Ben M.
- Tappin Ben M.
- Tay Louis
- Tay Louis
- Thibault Robert T.
- Thibault Robert T.
- Thompson Burt
- Thompson Burt
- Thurn Christian M.
- Thurn Christian M.
- Torralba Josefa
- Torralba Josefa
- Tuthill Shelby D.
- Tuthill Shelby D.
- Ullein Ann-Marie
- Ullein Ann-Marie
- Van Aert Robbie C. M.
- Van Aert Robbie C. M.
- van Assen Marcel A. L. M.
- van Assen Marcel A. L. M.
- Van Cappellen Patty
- Van Cappellen Patty
- van den Akker Olmo R.
- van den Akker Olmo R.
- Van der Cruyssen Ine
- Van der Cruyssen Ine
- Van der Noll Jolanda
- Van der Noll Jolanda
- van Dongen Noah N. N.
- van Dongen Noah N. N.
- van Elk Michiel
- van Elk Michiel
- Van Lissa Caspar J.
- Van Lissa Caspar J.
- van Mulukom Valerie
- van Mulukom Valerie
- van Ravenzwaaij Don
- van Ravenzwaaij Don
- van Zyl Casper J. J.
- van Zyl Casper J. J.
- Verschuere Bruno
- Verschuere Bruno
- Većkalov Bojana
- Većkalov Bojana
- Vianello Michelangelo
- Vianello Michelangelo
- Vilanova Felipe
- Vilanova Felipe
- Vishkin Allon
- Vishkin Allon
- Vogel Vera
- Vogel Vera
- Vogelsmeier Leonie V. D. E.
- Vogelsmeier Leonie V. D. E.
- Wagenmakers Eric-Jan
- Wagenmakers Eric-Jan
- Watanabe Shoko
- Watanabe Shoko
- White Cindel J. M.
- White Cindel J. M.
- Wiebels Kristina
- Wiebels Kristina
- Wiechert Sera
- Wiechert Sera
- Willett Zachary Z.
- Willett Zachary Z.
- Witkowiak Maciej
- Witkowiak Maciej
- Witvliet Charlotte V. O.
- Witvliet Charlotte V. O.
- Wiwad Dylan
- Wiwad Dylan
- Wuyts Robin
- Wuyts Robin
- Xygalatas Dimitris
- Xygalatas Dimitris
- Yang Xin
- Yang Xin
- Yeo Darren J.
- Yeo Darren J.
- Yilmaz Onurcan
- Yilmaz Onurcan
- Zarzeczna Natalia
- Zarzeczna Natalia
- Zhao Yitong
- Zhao Yitong
- Zijlmans Josjan
- Zijlmans Josjan
- Łowicki Paweł
- Łowicki Paweł
- Publication venue
- Taylor & Francis
- Publication date
- 01/01/2022
- Field of study
The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N=10,535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β=0.120). For the second research question, this was the case for 65% of the teams (median reported β=0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates
A Many-analysts Approach to the Relation Between Religiosity and Well-being
- Author
- Aczel Balazs
- Aditya Yonathan
- Alayan Alexandra J.
- Allen Peter J.
- Altay Sacha
- Alzahawi Shilaan
- Amir Yulmaida
- Anthony Francis-Vincen
- Atkinson Quentin D.
- Baimel Adam
- Balkaya-Ince Merve
- Balsamo Michela
- Banker Sachin
- Bartoš František
- Becerra Mario
- Beffara Bertrand
- Beitner Julia
- Bendixen Theiss
- Berkessel Jana B.
- Berniūnas Renatas
- Billet Matthew I.
- Billingsley Joseph
- Bortolini Tiago
- Breitsohl Heiko
- Bret Amélie
- Brown Faith L.
- Brown Jennifer
- Brumbaugh Claudia C.
- Buczny Jacek
- Bulbulia Joseph
- Caballero Saúl
- Carlucci Leonardo
- Carmichael Cheryl L.
- Cattaneo Marco E. G. V.
- Charles Sarah J.
- Claessens Scott
- Costa Angelo Brandelli
- Crone Damien L.
- Czoschke Stefan
- Czymara Christian
- D\u27Urso E. Damiano
- Dahlström Örjan
- Danielsson Henrik
- De Ron Jill
- de Vries Ymkje Anna
- Dean Kristy K.
- Dik Bryan J.
- Disabato David J.
- Doherty Jaclyn K.
- Draws Tim
- Drouhot Lucas
- Dujmovic Marin
- Dunham Yarrow
- Ebert Tobias
- Edelsbrunner Peter A.
- Eerland Anita
- Elbaek Christian T.
- Farahmand Hooman
- Farahmand Shole
- Farias Miguel
- Feliccia Abrey A.
- Fischer Kyle
- Fischer Ronald
- Fisher-Thompson Donna
- Francis Zoë
- Frick Susanne
- Frisch Lisa K.
- Geraldes Diogo
- Gerdin Emily
- Geven Linda
- Ghasemi Omid
- Gielens Erwin
- Gligorić Vukašin
- Hagel Kristin
- Hajdu Nandor
- Hamilton Hannah R.
- Hamzah Imaduddin
- Hanel Paul H. P.
- Hawk Christopher E.
- Himawan Karel K.
- Holding Benjamin C.
- Homman Lina E.
- Hoogeveen Suzanne
- Ingendahl Moritz
- Inkilä Hilla
- Inman Mary L.
- Islam Chris-Gabriel
- Isler Ozan
- Izydorczyk David
- Jaeger Bastian
- Johnson Kathryn A.
- Jong Jonathan
- Karl Johannes A.
- Kaszubowski Erikson
- Katz Benjamin A.
- Keefer Lucas A.
- Kelchtermans Stijn
- Kelly John M.
- Klein Richard A.
- Kleinberg Bennett
- Knowles Megan L.
- Koller Dave
- Kołczyńska Marta
- Krasko Julia
- Kritzler Sarah
- Krypotos Angelos-Miltiadis
- Kwame Appiah Obed
- Kyritsis Thanos
- Landes Todd L.
- Laukenmann Ruben
- Lavender Forsyth Guy A.
- Lazar Aryeh
- Lehman Barbara J.
- Levy Neil
- Lo Ronda F.
- Lodder Paul
- Lorenz Jennifer
- Lundahl Mauritsen Anne
- Ly Albert L.
- Maassen Esther
- Magyar-Russell Gina M.
- Maier Maximilian
- Marsh Dylan R.
- Martinez Nuria
- Martinie Marcellin
- Martoyo Ihan
- Mason Susan E.
- McAleer Phil
- McCauley Thomas
- McCullough Michael
- McKay Ryan
- McMahon Camilla M.
- McNamara Amelia A.
- Means Kira K.
- Mercier Brett
- Mitkidis Panagiotis
- Monin Benoît
- Moon Jordan W.
- Moreau David
- Morgan Jonathan
- Murphy James
- Muscatt George
- Nagy Tamás
- Nalborczyk Ladislas
- Nilsonne Gustav
- Noack Pamina
- Norenzayan Ara
- Nuijten Michèle B.
- Nägel Christof
- Olsson-Collentine Anton
- Oviedo Lluis
- Panagopoulos Maxinne C.
- Pavlov Yuri G.
- Pawelski James O.
- Pearson Hannah I.
- Pedder Hugo
- Peetz Hannah K.
- Pinus Michael
- Pirutinsky Steven
- Polito Vince
- Porubanova Michaela
- Poulin Michael J.
- Prenoveau Jason M.
- Prince Mark A.
- Protzko John
- Pryor Campbell
- Purzycki Benjamin G.
- Pütter Julian Quevedo
- Qiu Lin
- Rabelo André
- Radell Milen L.
- Ramsay Jonathan E.
- Reid Graham
- Roberts Andrew J.
- Root Luna Lindsey M.
- Rosa Anna Dalla
- Ross Robert M.
- Roszak Piotr
- Roy Nirmal
- Saarelainen Suvi-Maria K.
- Sarafoglou Alexandra
- Sasaki Joni Y.
- Schaumans Catherine
- Schivinski Bruno
- Schmitt Marcel C.
- Schnitker Sarah A.
- Schnuerch Martin
- Schreiner Marcel R.
- Schüttengruber Victoria
- Sebben Simone
- Segerstrom Suzanne C.
- Seryczyńska Berenika
- Shjoedt Uffe
- Simsek Müge
- Sleegers Willem W. A.
- Smith Eliot R.
- Sowden Walter J.
- Späth Marion
- Spörlein Christoph
- Stedden William
- Stoevenbelt Andrea H.
- Stuber Simon
- Sulik Justin
- Suwartono Christiany
- Syropoulos Stylianos
- Szaszi Barnabas
- Szecsi Peter
- Tappin Ben M.
- Tay Louis
- Thibault Robert T.
- Thompson Burt
- Thurn Christian M.
- Torralba Josefa
- Tuthill Shelby D.
- Ullein Ann-Marie
- Van Aert Robbie C. M.
- van Assen Marcel A. L. M.
- Van Cappellen Patty
- van den Akker Olmo R.
- Van der Cruyssen Ine
- Van der Noll Jolanda
- van Dongen Noah N. N.
- van Elk Michiel
- Van Lissa Caspar J.
- van Mulukom Valerie
- van Ravenzwaaij Don
- van Zyl Casper J. J.
- vanOyen-Witvliet Charlotte
- Vaughn Leigh Ann
- Verschuere Bruno
- Većkalov Bojana
- Vianello Michelangelo
- Vilanova Felipe
- Vishkin Allon
- Vogel Vera
- Vogelsmeier Leonie V. D. E.
- Wagenmakers Eric-Jan
- Watanabe Shoko
- White Cindel J. M.
- Wiebels Kristina
- Wiechert Sera
- Willett Zachary Z.
- Witkowiak Maciej
- Wiwad Dylan
- Wuyts Robin
- Xygalatas Dimitris
- Yang Xin
- Yeo Darren J.
- Yilmaz Onurcan
- Zarzeczna Natalia
- Zhao Yitong
- Zijlmans Josjan
- Łowicki Paweł
- Publication venue
- Hope College Digital Commons
- Publication date
- 06/07/2022
- Field of study
The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N = 10, 535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β = 0.120). For the second research question, this was the case for 65% of the teams (median reported β = 0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates
Community Structure and Market Outcomes: A Repeated Games in Networks Approach
- Author
- Alan P Kirman
- Alvin E Roth
- Andrea Galeotti
- Andrea Galeotti
- Antoni Calv�-Armengol
- Avner Greif
- Benjamin Golub
- Bramoull�
- Coralio Ballester
- Craig Mcintosh
- David A Miller
- David Dollar
- David Gamarnik
- Dean Karlan
- Dilip Abreu
- Duncan J Watts
- Francesco Nava
- George Akerlof
- Glenn Ellison
- Han N Ozsoylev
- Heski Bar-Isaac
- Iftekhar A Chaudhury
- Itay P Fainmesser
- Itay P Fainmesser
- Itay Perah Fainmesser
- James Dow
- Jim Engle-Warnick
- John Mcmillan
- Joshua Schwartzstein
- Marcel Fafchamps
- Margarida Corominas-Bosch
- Mark S Granovetter
- Markus Kinateder
- Markus M Mobius
- Matthew O Jackson
- Matthew O Jackson
- Matthew O Jackson
- Maximilian Mihm
- Michael S Chwe
- Michihiro Kandori
- Mihai Manea
- Rachel E Kranton
- Robert E Verrecchia
- Robin Lee
- Roland Pongou
- Ronald S Burt
- Sanjeev Goyal
- Sanjeev Goyal
- Simon Johnson
- Ste�en Lippert
- Truman F Bewley
- Venkatesh Bala
- Weisbuch Gerard
- Wolfgang Hardle
- Woodru� Christopher
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine
- Author
- Amaral Michelle
- Amendola Laura
- Amendola Laura M.
- Appelbaum Paul S.
- Appelbaum Paul S.
- Aronson Samuel J.
- Arora Shubhangi
- Azzariti Danielle R.
- Barsh Greg S.
- Bebin E.M.
- Berg Jonathan S.
- Bernhardt Barbara A.
- Biesecker Barbara B.
- Biesecker Leslie G.
- Biesecker Leslie G.
- Biswas Sawona
- Biswas Sawona
- Blout Carrie L.
- Blout Carrie L.
- Bowling Kevin M.
- Bowling Kevin M.
- Breitkopf Carmen Radecki
- Brothers Kyle B.
- Brothers Kyle B.
- Brown Brian L.
- Burke Wylie
- Burt Amber A.
- Byers Peter H.
- Caga-anan Charlisse F.
- Caga-anan Charlisse F.
- Calikoglu Muge G.
- Carlson Sara J.
- Chahin Nizar
- Chinnaiyan Arul M.
- Chinnaiyan Arul M.
- Christensen Kurt D.
- Chung Wendy
- Chung Wendy K.
- Cirino Allison L.
- Clayton Ellen
- Clayton Ellen W.
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- Lockhart Nicole
- Lonigro Bob
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- Lynch Frances
- Machini Kalotina
- MacRae Calum
- Manolio Teri A.
- Manolio Teri A.
- Marchuk Daniel S.
- Martinez Josue N.
- Masino Aaron
- McCullough Laurence
- McCullough Laurence
- McEwen Jean
- McEwen Jean
- McGuire Amy
- McGuire Amy
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- McMullen Carmit
- Mieczkowski Piotr A.
- Miller Jeff
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- Mody Rajen
- Mooney Sean D.
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- Murray Michael
- Muzny Donna
- Muzny Donna
- Myers Richard M.
- Myers Richard M.
- Ng David
- Nickerson Deborah A.
- Nickerson Deborah A.
- Oliver Nelly M.
- Ou Jeffrey
- Ou Jeffrey
- Parsons Donald W.
- Parsons Will
- Patrick Donald L.
- Pennington Jeffrey
- Perry Denise L.
- Petersen Gloria
- Petersen Gloria M.
- Plon Sharon
- Plon Sharon E.
- Porter Katie
- Powell Bradford C.
- Punj Sumit
- Raesz-Martinez Robin A.
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- Rich Carla A.
- Richards Carolyn Sue
- Rini Christine
- Rivera-Munoz Edgar A.
- Roberts J. Scott
- Roberts Scott
- Robertson Peggy D.
- Robinson Dan
- Robinson Dan
- Robinson Jill O.
- Robinson Marguerite E.
- Roche Myra I.
- Rodriguez Laura Lyman
- Romasko Edward J.
- Rosenthal Elisabeth A.
- Salama Joseph
- Salama Joseph S.
- Scarano Maria I.
- Schneider Jennifer
- Scollon Sarah
- Scollon Sarah
- Seidman Christine E.
- Seifert Bryce A.
- Sharp Richard R.
- Sharp Richard R.
- Shirts Brian
- Shirts Brian H.
- Sholl Lynette M.
- Siddiqui Javed
- Silverman Elian
- Simmons Shirley
- Simons Janae V.
- Skinner Debra
- Spinner Nancy B.
- Spinner Nancy B.
- Stoffel Elena
- Strande Natasha T.
- Sunyaev Shamil
- Sybert Virginia P.
- Taber Jennifer
- Tabor Holly K.
- Tabor Holly K.
- Tarczy-Hornoch Peter
- Tarczy-Hornoch Peter
- Taylor Deanne M.
- Tilley Christian R.
- Tomlinson Ashley
- Trinidad Susan
- Tsai Ellen
- Ubel Peter
- Van Allen Eliezer M.
- Vassy Jason L.
- Vats Pankaj
- Veenstra David L.
- Veenstra David L.
- Vetter Victoria L.
- Vries Raymond D.
- Wagle Nikhil
- Wagle Nikhil
- Walser Sarah A.
- Walsh Rebecca C.
- Weck Karen
- Weck Karen
- Werner-Lin Allison
- Whittle Jana
- Wilfond Ben
- Wilfond Benjamin S.
- Wilhelmsen Kirk
- Wilhelmsen Kirk C.
- Wolf Susan M.
- Wolf Susan M.
- Wynn Julia
- Wynn Julia
- Yang Yaping
- Young Carol
- Yu Joon-Ho
- Yu Joon-Ho
- Zikmund-Fisher Brian J.
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- Artía Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- Balaña-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- Bognár Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
- Bowman Gregory R.
- Bradley Robert K.
- Bradshaw William J.
- Brady-Kalnay Susann M.
- Breton Hairol E.
- Bruning John B.
- Bruning John Burt
- Bryant-Friedrich Amanda
- Buckner Frederick S.
- Buroni Silvia
- Butler Brittany
- Byrne Lee J.
- Byun Soo Young
- Caflisch Amedeo
- Cakir Isin
- Caliandro Ileana
- Caljon Guy
- Cann Andrew B.
- Caporali Andrea
- Capuzzi Stephen J.
- Caroleo Maria Cristina
- Cathcart Ann M.
- Celano Stephanie L.
- Cerna Mark Vincent C. dela
- Chadni Somaia Haque
- Champion Matthew M.
- Chan Nei-Li
- Chapman Carly J.
- Chaton Catherine T.
- Chatterjee Arnab K.
- Chaudhuri Dipayan
- Chauhan Shefali
- Chaytow Helena
- Chen Daniel
- Chen Lifeng
- Chen Yicheng
- Chern Ting-Rong
- Chini Andrea
- Chou Tristan
- Chou Tsui-Fen
- Christensen Emily M.
- Christodoulides Myron
- Chu Shaoyou
- Chua Benjamin Soon Kai
- Chuah Janelle
- Chung Zara
- Chuong Patrick
- Ciccia Alberto
- Cildir Gökhan
- Cione Erika
- Clayton W. Brent
- Coles John G.
- Colomba Audrey
- Colotti Gianni
- Conn Graeme L.
- Conticello Silvestro G.
- Contreras Stephanie
- Cools Julie
- Coombe Deirdre R.
- Corson Timothy W.
- Cortopassi Gino
- Corvo Ileana
- Costoya Jose A.
- Cowen Leah E.
- Cox Bryan D.
- Cuddihy Andrew R.
- Cullinane Ryan T.
- Cunningham Kathryn A.
- Dahal Gopal
- Dallman Sydney
- Dame Remus T.
- Davtyan Aram
- De Keulenaer Gilles
- De Luise Monica
- de Oliveira Aldo Sena
- de Oliveira Saulo
- de Sousa Alessandra Mara
- de Souza Guilherme Eduardo
- Debonsi Hosana Maria
- Degterev Alexei
- DeHaan Nicholas
- Del Rio Flores Antonio
- Dempsey Garrett
- Desai Umesh R.
- Diallo Bakary N’tji
- Dickhout Jeffrey
- Dickinson Bryan C.
- Dieck Chelsea L.
- Dirksen Dorian
- do Monte-Neto Rubens Lima
- Dolce Vincenza
- Donaldson William A.
- Douville Renée N.
- Dowling David J.
- Drewry David H.
- Duggan Brendan M.
- Duncan Dustin
- Dymock Brian W.
- Dzhumaev Sergei
- D’Antuono Anna
- Ebright Richard H.
- Eckert Sam
- Edelman Benjamin L.
- Eitzen Gary
- ElSheikh Assmaa
- Englinger Bernhard
- Escaffre Olivier
- Espinoza Stefano
- Evans Jay D.
- Faller Kiterie M. E.
- Fan Erkang
- Fan Hua-Ying
- Fathallah M. Dahmani
- Feng Hui
- Ferrando Adolfo A.
- Ferraris Davide Maria
- Ferreira Jacob
- Ferreira Rafaela Salgado
- Fiermonte Giuseppe
- Finkelstein Joshua M.
- Fiorillo Annarita
- Fish Paul V.
- Foong Wuen Ee
- Foote Andrea Talbot
- Francisco Karol R.
- Frangos Zachary J.
- Fraser Cameron
- Freiberg Alexander N.
- Freywald Andrew
- Friedland Greg
- Fries Jacob
- Gadar Kavita
- Gandhi Neha S.
- Garaeva Alisa A.
- Garavaglia Silvia
- Garcia George A.
- García-Cuesta Eva M.
- Garmendia Antonio E.
- Gasparre Giuseppe
- Gavathiotis Evripidis
- Gebauer Jan M.
- Geden Sandra E.
- Geisbrecht Brian V.
- Gelardi Edoardo Luigi Maria
- Gerwick William H.
- Ghilarducci Kim
- Ghosh Agnidipta
- Giardini Miriam A.
- Gierse Robin Matthias
- Giesler Kyle
- Gillingwater Thomas H.
- Gingras Alexandre R.
- Giorgis Marta
- Girolimetti Giulia
- Glubb Dylan M.
- Glukhov Evgenia
- Gniewek Pawel
- Goldenberg Joshua M.
- Gong Bin
- Gorgoglione Ruggiero
- Granneman James G.
- Greene Geoffrey L.
- Greig Iain R.
- Gruber Joshua J.
- Guido Rafael V. C.
- Gumede Njabulo Joyfull
- Gunasekharan Vignesh
- Gupta Tushita
- Gupta Yogesh K.
- Gustincich Stefano
- Haas Arthur L.
- Hahn William C.
- Haikarainen Teemu
- Hammock Bruce D.
- Hannink Mark
- Hansen Kasper B.
- Hare Stephanie
- Harijan Rajesh K.
- Haupt Larisa M.
- He Yuan
- Hedstrom Lizbeth
- Hedstrom Lizbeth
- Heifets Abraham
- Henriksen Niel
- Herdendorf Timothy J.
- Hermle Tobias
- Herr Andrew B.
- Hickey Robert J.
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- Hirsch Anna K. H.
- Ho Gregory
- Hopkins Kevin M.
- Hoppe Heinrich
- Horstmann Nicola
- Hosfield David J.
- Hossain Sakib
- Houry Walid A.
- Hsiao Edward C.
- Hu Di
- Hu Yanmei
- Huang Chang
- Huimei Chen
- Hussain Muhammad Saddam
- Iglesias Pablo
- Ikegami Tetsuro
- Ilari Andrea
- Inde Zintis
- Ingoglia Filippo
- Iommarini Luisa
- Ip Philbert
- Jackson Michael R.
- Jafar-Nejad Hamed
- Jayasinghe Thilina D.
- Jo Eunji
- Johannsen Sandra
- John Ashley L. St.
- Jones Peter L.
- Jossart Jennifer N.
- Jung Hoyoung
- Kahler Charlene M.
- Kampourakis Thomas
- Kandror Olga
- Karan Charles
- Katyal Sachin
- Kee Jung-Min
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- Keller Charles
- Kelm Robert J.
- Kemet Chinyere Maat
- Kenyon Victor
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- Khalaf Noureddine Ben
- Kilkenny Mairi Louise
- Kim Hyeong Jun
- Kim Kyu Kwang
- Kootstra Neeltje A.
- Koppisetti Rama K.
- Korotkov Konstantin V.
- Kotzé Timothy J.
- Kováts Benjámin
- Kratz Jadel Müller
- Krishnamurthy Durga
- Krist David T.
- Kroon Erna Geessien
- Kushnir Alexander
- Kwiatkowski Jacek
- Laggner Christian
- Lai Kent
- Lake Robert J.
- Lam Andrew
- Lama Eleonora
- Lan Tong
- Landfear Scott M.
- Lasarte Juan José
- Lawrence Daniel A.
- Lee Andreia H.
- Lee Donghan
- Lee Gyeongeun
- Lee Jiyoun
- Lee Kyung Hyeon
- Lee Pil H.
- Legare Scott
- Lehtiö Lari
- Lembo Gaia
- Lempicki Camille
- Lenci Elena
- Leng Fenfei
- Lescar Julien
- Leung Elisa
- Leuzzi Giuseppe
- Levin Michael
- Li Hai
- Li Shan
- Li Wei
- Li Yihe
- Li Yong
- Li Yunlong
- Liao Jiayu
- Liao Junzhuo
- Lieberman Howard B.
- Lin Jiabei
- Lin Jiusheng
- Liou Benjamin
- Lisabeth Erika Mathes
- Liu Chen
- Liu Koting
- Liu Pengda
- Liu Pengda
- Liu Zhongle
- Lobb Kevin A.
- Lolicato Marco
- Lolli Marco Lucio
- Longo Nicola
- Lotsaris Irina
- Lowther W. Todd
- Loy Cody A.
- Lu Xin
- Luh Frank
- Lukacs Gergely L.
- Luo Dahai
- Lussier Marc P.
- Lynn Edward G.
- Machaca Khaled
- Maciag Joseph J.
- Macias Maria J.
- MacKeigan Jeffrey P.
- Mahmoodi Niusha
- Maksimainen Mirko M.
- Malkas Linda H.
- Maltarollo Vinícius Gonçalves
- Mameli Eleonora
- Manor Danny
- Mantri Chinmay Kumar
- Maranda Vincent
- Martin Katie R.
- Martin-Malpartida Pau
- Maruta Shinsaku
- Marx Steven O.
- Mason Emily R.
- Matheeussen An
- Matovic Nick
- Mattevi Andrea
- Maurice Martin St.
- Mayer Gaétan
- Maynes Jason T.
- Mazitschek Ralph
- McCarthy Ronan R.
- McDowell Mary Ann
- McManus Kirk James
- Mehedi Masfique
- Mehlman Tamar
- Mellado Mario
- Mellor Paul
- Merrill Nathan M.
- Michlewski Gracjan
- Milosavljevic Julian
- Minakova Anna
- Miner Jaden
- Moharreri Ehsan
- Molyneaux Kathleen A.
- Montanaro Anna
- Moore Hannah P.
- Moore Richard G.
- Moreda Teresa Lozano
- Moreira David
- Moreira Paulo Otávio Lourenço
- Morisseau Christophe
- Morrison Adrian
- Morten Brianna C.
- Mostert Konrad J.
- Mota Bruno Eduardo Fernandes
- Motyl Anna A. L.
- Mousa Jarrod J.
- Mowat Michael
- Muli Christine S.
- Mungrue Imran N.
- Mushtaq Aisha
- Musta Kirsikka
- Müller Anna
- Müller Christa E.
- Myhr Courtney
- Mysinger Michael
- Mysore Venkatesh
- Nagai Maira Harume
- Nagamori Kiyo
- Namasivayam Vigneshwaran
- Nasburg Joshua Alexander
- Ng Ho Leung
- Ng James
- Ngo Lien
- Ngoi Peter
- Nguyen Kong
- Novina Carl D.
- null null
- Ogunwa Tomisin Happy
- Ojha Anil K.
- Ojo Kayode K.
- Olson Steven H.
- Ortiz Diana
- Oyarzabal Julen
- O’Brien Terrence E.
- O’Connell Patrick
- O’Dea Austin
- O’Donoghue Anthony J.
- O’Mara Megan L.
- O’Mara Tracy A.
- O’Meara Timothy R.
- O’Sullivan Ann Marie
- Pai Vaibhav P.
- Paige Mikell
- Palazzo Teresa
- Panganiban Antonito T.
- Paparella Ashleigh S.
- Parang Keykavous
- Parico Gian Carlo G.
- Park Soonju
- Partch Carrie L.
- Pascal John M.
- Pasquali Marzia
- Patel Amit K.
- Paulino Cristina
- Pederick Jordan L.
- Peltier Cheryl
- Pemberton Ryan P.
- Perry Benjamin
- Perry J. Jefferson P.
- Petretto Enrico
- Pérez-Pertejo Yolanda
- Phadke Sameer
- Pham Kien
- Pineda-Lucena Antonio
- Poirier Steve
- Popowicz Grzegorz Maria
- Porcelli Anna Maria
- PrasadPrasad Srimukh Veccham Krishna
- Presser Adam G.
- Pressly Brandon
- Prikler Gergely
- Prince Ashutosh
- Puchades-Carrasco Leonor
- Pusztai Lajos
- Qi Xin
- Qin Xingping
- Qureshi Insaf Ahmed
- Rabal Obdulia
- Radhakrishnan Senthil K.
- Ramachandran Rajesh
- Randall Lía M.
- Rangarajan Amith Vikram
- Rayman Joseph B.
- Reglero Clara
- Reguera Rosa Maria
- Reidenbach Andrew G.
- Reis Joana
- Ribeiro Beatriz Murta Rezende Moraes
- Richardson Timothy I.
- Riches David W. H.
- Rizzi Menico
- Robinson Victoria L.
- Rocha Rafael Eduardo Oliveira
- Rodriguez G. Marcela
- Rodríguez-Frade José Miguel
- Rohde Kyle H.
- Ronchi Virginia Paola
- Ronning Donald R.
- Rosnik Andreana
- Roti Giovanni
- Rouzbeh Nirvan
- Rowswell-Turner Rachael B.
- Rubin Eric J.
- Rucinski Gwennan
- Safo Martin K.
- Sainas Stefano
- Salas Brenda P. Medellin
- Samantha Ariela
- Samudio Ben
- Santiago César
- Sarangapani Krishna
- Sarilla Suryakala
- Sarosiek Kristopher
- Schneider Nicholas O.
- Schroedl Stefan
- Scoffone Viola Camilla
- Segers Vincent F. M.
- Seo Seung-Yong
- Serafim Mateus Sá Magalhães
- Shaqra Ala M.
- Shek Stefani
- Shelburne Samuel A.
- Shim Heesung
- Shorter James
- Shoue Douglas A.
- Shum David
- Shyng Show-Ling
- Siderovski David P.
- Sidorova Yulia A.
- Silva Elany Barbosa
- Silvennoinen Olli
- Singh Nathanael
- Singh Neeraj
- Singh Rakesh K.
- Siqueira-Neto Jair L.
- Sishtla Kamakshi
- Sistla Jyothi C.
- Skorodinsky Maxim
- Slotboom Dirk J.
- Smith David M.
- Smith Kristiana S.
- Smrcka Alan V.
- So Jonathan
- Sobrado Pablo
- Soellner Matthew B.
- Solano Roberto
- Sorenson Jon M.
- Stafford Kate
- Stahl Andreas
- Statsyuk Alexander V.
- Stec Natalia
- Stecula Adrian
- Stetefeld Joerg
- Strauss Erick
- Stuchbury Grant David
- Su Leila
- Su Tong
- Su Zhengchen
- Sugamori Kim S.
- Sun Ying
- Suterwala Shabbir
- Svensson Fredrik
- Sverzhinsky Aleksandr
- Swart Tarryn
- Taglialatela Angelo
- Tam Heng-Keat
- Tandon Vasudha
- Tang Weiping
- Tang Young
- Tanner John J.
- Taylor Richard E.
- Teixeira Thaiz Rodrigues
- Teramoto Tadahisa
- Thai Van Chi
- Thayer Desiree
- Thomas Bill
- Thompson Erik W.
- Tilford Hannah
- Tiwari Rakesh Kumar
- Toh Alan Kie Leong
- Tomilov Alexey
- Toogood Peter
- Torner Carles
- Trabocchi Andrea
- Trader Darci J.
- Trakhtenberg Ephraim F.
- Trinh Nguyen Mai
- Truong Ha
- Tse-Dinh Yuk-Ching
- Tsimbalyuk Sofiya
- Tumes Damon J.
- Tye Mark A.
- Uribe Ruben Vazquez
- Valli Marilia
- van den Akker Focco
- van den Bedem Henry
- Van Doren Steven R.
- Van Grack Tessa
- Van Hung Le Vuong
- Van Pelt Natascha
- Van Remmen Holly
- Van Voorhis Wesley C.
- Vandenberg Robert J.
- Veit Guido
- Verhamme Ingrid M.
- Verma Rajkumar
- Viola Ronald E.
- Virtanen Anniina
- Vizeacoumar Franco J.
- Vizeacoumar Frederick S.
- Vleminckx Margot
- von Hundelshausen Philipp
- Voss Jan Hendrik
- Vrielink Alice
- Waggoner Stephen N.
- Walensky Loren D.
- Wallach Izhar
- Wang Feng
- Wang Jianghai
- Wang Jun
- Wang Xingyou
- Wang Zhenghe
- Warrington Jeffrey M.
- Watkins Joshua
- Wazir Sarah
- Weber Christian
- Welsbie Derek S.
- Wentworth Kelly L.
- Wert-Lamas Leon
- White Andrew
- White Simon J.
- Whitesell Luke
- Williams Tiffany
- Wilson Cornelia M.
- Wilson Mark A.
- Windisch Marc P.
- Wong Keith S.
- Woods Virgil A.
- Worley Brad
- Wu Pengpeng
- Wu Xiaoyang
- Wulff Heike
- Xiang Fei
- Xu Hongyang
- Xu Jiake
- Xu Jingyi
- Xu Sophia Q.
- Xu Xin
- Yan Riqiang
- Yang Chao-Yie
- Yen Yun
- Young Matthew A.
- Yu Fang
- Yu Xinfang
- Yuan Haynes
- Yuan Xinrui
- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
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- S Mellor
- S Mepham
- S Metherell
- S Mitchard
- S Mohamed Ally
- S Monnery
- S Moore
- S Morrison
- S Moultrie
- S Mtuwa
- S Mulla
- S Munt
- S Murdoch
- S O'Sullivan
- S Packham
- S Patch
- S Pearson
- S Pitts
- S Preston
- S Purvis
- S Quaid
- S Ray
- S Roche
- S Rose
- S Rundell
- S Salmi
- S Sathe
- S Selvanayagam
- S Shelton
- S Shepardson
- S Siddiqui
- S Smuts
- S Sousa Arias
- S Spencer
- S Srikaran
- S Stone
- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
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- Breda David
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- Broiles Brian J.
- Bromenschenkel Asa
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- Bunker A. J.
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- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
- Cheezum Jeffrey I.
- Chen Bin
- Chen Christine H.
- Cherinka Brian
- Chichester Sarah C.
- Chilton Zachary S.
- Chittiraibalan Dharini
- Clampin Mark
- Clark Charles R.
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- Cleveland Keith A.
- Cohen Andrew L.
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- Cossou Christophe
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- Guyot Benjamin
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- Güdel Manuel
- Hack Warren J.
- Haderlein Peter
- Hagan James B.
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
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- Hami Maryam
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- Hammann Jeffrey
- Hammel Heidi B.
- Hanley Christopher J.
- Hansen Carl August
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- Jamieson William Brian
- Jandra Raymond D.
- Jayawardhana Ray
- Jedrzejewski Robert
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- Joanne Egges
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- Kammerer Jens
- Kan Samuel K.
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- Kao Shaw-Hong
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- Karl Hermann
- Kassin Susan A.
- Kauffman David D.
- Kavanagh Patrick
- Kelley Leigh L.
- Kelly Douglas M.
- Kendrew Sarah
- Kennedy Herbert V.
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- Kidwell Richard C.
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- Knollenberg Perry J.
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- Koehler Robert
- Koekemoer Anton M.
- Kofler Earl T.
- Kontson Vicki L.
- Kovacs Aiden Rose
- Kozhurina-Platais Vera
- Krause Oliver
- Kriss Gerard A.
- Krist John
- Kristoffersen Monica R.
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- Krueger Anthony P.
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- Labador Aurora Gadiano
- Labiano Álvaro
- Lafrenière David
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- Shanahan Clare Elizabeth
- Shaughnessy Bryan
- Shaw Richard A.
- Shay Christopher Michael
- Sheehan Even
- Sheth Kartik
- Shih Hsin-Yi
- Shivaei Irene
- Siegel Noah
- Sienkiewicz Matthew G.
- Simmons Debra D.
- Simon Bernard P.
- Sirianni Marco
- Sivaramakrishnan Anand
- Slade Jeffrey E.
- Sloan G. C.
- Slocum Christine E.
- Slowinski Steven E.
- Smith Corbett T.
- Smith Eric P.
- Smith Erin C.
- Smith Koby
- Smith Robert
- Smith Stephanie J.
- Smolik John L.
- Soderblom David R.
- Sohn Sangmo Tony
- Sokol Jeff
- Sonneborn George
- Sontag Christopher D.
- Sooy Peter R.
- Soummer Remi
- Southwood Dana M.
- Spain Kay
- Sparmo Joseph
- Speer David T.
- Spencer Richard
- Sprofera Joseph D.
- Stallcup Scott S.
- Stanley Marcia K.
- Stansberry John A.
- Stark Christopher C.
- Starr Carl W.
- Stassi Diane Y.
- Steck Jane A.
- Steeley Christine D.
- Stephens Matthew A.
- Stephenson Ralph J.
- Stewart Alphonso C.
- Stiavelli Massimo
- Stockman Jr. Hervey
- Strada Paolo
- Straughn Amber N.
- Streetman Scott
- Strickland David Kendal
- Strobele Jingping F.
- Stuhlinger Martin
- Stys Jeffrey Edward
- Such Miguel
- Sukhatme Kalyani
- Sullivan Joseph F.
- Sullivan Pamela C.
- Sumner Sandra M.
- Sun Fengwu
- Sunnquist Benjamin Dale
- Swade Daryl Allen
- Swam Michael S.
- Swenton Diane F.
- Swoish Robby A.
- Tamas Laszlo
- Tao Andrew
- Taylor David K.
- Taylor Joanna M.
- Teague Kelly K.
- Telfer Randal C.
- Temim Tea
- Texter Scott C.
- Thatte Deepashri G.
- Thompson Christopher Lee
- Thompson Linda M.
- Thomson Shaun R.
- Thronson Harley
- Tierney C. M.
- Tikkanen Tuomo
- Tinnin Lee
- Tippet William Thomas
- Todd Connor William
- Tran Hien D.
- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael A.
- Vaclavik Steven
- Valenduc Frida
- Valenti Jeff A.
- Van Campen Julie
- van de Wetering Inge
- Van Der Marel Roeland P.
- van Dishoeck Ewine F.
- van Haarlem Remy
- Van Tea Mason
- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbastabar Hedayat
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdollahi Arash
- Abdullahi Auwal
- Abegaz Kedir Hussein
- Abeldaño Zuñiga Roberto Ariel
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abreu Lucas Guimarães
- Abu-Gharbieh Eman
- Abu-Rmeileh Niveen ME
- Abualruz Hasan
- Ackerman Ilana N
- Addo Isaac Yeboah
- Addolorato Giovanni
- Adebiyi Akindele Olupelumi
- Adepoju Abiola Victor
- Adewuyi Habeeb Omoponle
- Afyouni Shadi
- Afzal Saira
- Afzal Sina
- Agodi Antonella
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Shahzaib
- Ahmed Ali
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ajami Marjan
- Akinosoglou Karolina
- Akkaif Mohammed Ahmed
- Al Hasan Syed Mahfuz
- Al-Aly Ziyad
- Al-Gheethi Adel Ali Saeed
- Al-Marwani Sabah
- Al-Omari Basem
- Al-Wardat Mohammad Sami
- Al-Worafi Yaser Mohammed
- Alalalmeh Samer O
- Albashtawy Mohammed
- Aldridge Robert W
- Alemu Meseret Desalegn
- Alemu Yihun Mulugeta
- Alene Kefyalew Addis
- Alharrasi Maryam
- Alhassan Robert Kaba
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Alif Sheikh Mohammad
- Aljunid Syed Mohamed
- Almazan Joseph Uy
- Alomari Mahmoud A
- Altaany Zaid
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J
- Alwafi Hassan
- Aly Safwat
- Alzoubi Karem H
- Amare Azmeraw T
- Amegbor Prince M
- Ameyaw Edward Kwabena
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Amiri Sohrab
- Amugsi Dickson A
- Ancuceanu Robert
- Anderlini Deanna
- Anderson David B
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Ansari Hossein
- Antony Catherine M
- Anwar Saleha
- Anwar Sumadi Lukman
- Anwer Razique
- Anyanwu Philip Emeka
- Arab Juan Pablo
- Arabloo Jalal
- Arafat Mosab
- Araki Daniel T
- Aravkin Aleksandr Y
- Arkew Mesay
- Armocida Benedetta
- Arndt Michael Benjamin
- Arooj Mahwish
- Artamonov Anton A
- Aruleba Raphael Taiwo
- Arumugam Ashokan
- Ashbaugh Charlie
- Ashemo Mubarek Yesse
- Ashraf Muhammad
- Asika Marvellous O
- Askari Elaheh
- Astell-Burt Thomas
- Athari Seyyed Shamsadin
- Atorkey Prince
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Aujayeb Avinash
- Ausloos Marcel
- Avan Abolfazl
- Awotidebe Adedapo Wasiu
- Awuviry-Newton Kofi
- Ayala Quintanilla Beatriz Paulina
- Ayuso-Mateos Jose L
- Azadnajafabad Sina
- Azevedo Rui M S
- Babu Abraham Samuel
- Badar Muhammad
- Badiye Ashish D
- Baghdadi Soroush
- Bagheri Nasser
- Bah Sulaiman
- Bai Ruhai
- Baker Jennifer L
- Bakkannavar Shankar M
- Bako Abdulaziz T
- Balakrishnan Senthilkumar
- Bam Kiran
- Banik Palash Chandra
- Barchitta Martina
- Bardhan Mainak
- Bardideh Erfan
- Barker-Collo Suzanne Lyn
- Barqawi Hiba Jawdat
- Barrow Amadou
- Barteit Sandra
- Barua Lingkan
- Bashiri Aliabadi Somaye
- Basiru Afisu
- Basu Sanjay
- Basu Saurav
- Bathini Prapthi Persis
- Batra Kavita
- Baune Bernhard T
- Bayileyegn Nebiyou Simegnew
- Behnam Babak
- Behnoush Amir Hossein
- Beiranvand Maryam
- Bejarano Ramirez Diana Fernanda
- Bell Michelle L
- Bello Olorunjuwon Omolaja
- Beloukas Apostolos
- Bensenor Isabela M
- Berezvai Zombor
- Bernabe Eduardo
- Bernstein Robert S
- Bettencourt Paulo J G
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhandari Dinesh
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhutta Zulfiqar A
- Bikbov Boris
- Bishai Jessica Devin
- Bisignano Catherine
- Bitra Veera R
- Bjørge Tone
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bogale Eyob Ketema
- Bonakdar Hashemi Milad
- Bonny Aime
- Bora Basara Berrak
- Borhany Hamed
- Boxe Christopher
- Brady Oliver J
- Bragazzi Nicola Luigi
- Braithwaite Dejana
- Brant Luisa C
- Brauer Michael
- Breitner Susanne
- Brenner Hermann
- Brown Julie
- Brugha Traolach
- Bulamu Norma B
- Buonsenso Danilo
- Burkart Katrin
- Burns Richard A
- Busse Reinhard
- Bustanji Yasser
- Butt Zahid A
- Byun Justin
- Caetano dos Santos Florentino Luciano
- Calina Daniela
- Campos-Nonato Ismael R
- Cao Chao
- Capodici Angelo
- Carr Sinclair
- Carreras Giulia
- Carugno Andrea
- Carvalho Márcia
- Castaldelli-Maia Joao Mauricio
- Castañeda-Orjuela Carlos A
- Castelpietra Giulio
- Catapano Alberico L
- Cattaruzza Maria Sofia
- Caye Arthur
- Cámera Luis Alberto
- Cegolon Luca
- Cembranel Francieli
- Cenderadewi Muthia
- Cerin Ester
- Chakraborty Promit Ananyo
- Chan Jeffrey Shi Kai
- Chan Raymond N C
- Chandika Rama Mohan
- Chandrasekar Eeshwar K
- Charalampous Periklis
- Chattu Vijay Kumar
- Chatzimavridou-Grigoriadou Victoria
- Chen An-Tian
- Chen Angela W
- Chen Catherine S
- Chen Haowei
- Chen Nathalie M
- Cheng Esther T W
- Chimed-Ochir Odgerel
- Chimoriya Ritesh
- Ching Patrick R
- Cho William C S
- Choi Sungchul
- Chong Bryan
- Chong Yuen Yu
- Choudhari Sonali Gajanan
- Chowdhury Rajiv
- Christensen Steffan Wittrup McPhee
- Chu Dinh-Toi
- Chukwu Isaac Sunday
- Chung Eric
- Chung Eunice
- Chutiyami Muhammad
- Claassens Mareli M
- Cogen Rebecca M
- Columbus Alyssa
- Conde Joao
- Cortesi Paolo Angelo
- Cousin Ewerton
- Criqui Michael H
- Cruz-Martins Natália
- D'Oria Mario
- Dadras Omid
- Dai Siyu
- Dai Xiaochen
- Dai Zhaoli
- Dalaba Maxwell Ayindenaba
- Damiani Giovanni
- Das Jai K
- Das Saswati
- Dashti Mohsen
- Davletov Kairat
- Dávila-Cervantes Claudio Alberto
- De Leo Diego
- Debele Aklilu Tamire
- Debopadhaya Shayom
- DeCleene Nicole K
- Deeba Farah
- Degenhardt Louisa
- Del Bo' Cristian
- Delgado-Enciso Ivan
- Demetriades Andreas K
- Denova-Gutiérrez Edgar
- Dervenis Nikolaos
- Desai Hardik Dineshbhai
- Desai Rupak
- Deuba Keshab
- Dhama Kuldeep
- Dharmaratne Samath Dhamminda
- Dhingra Sameer
- Dias da Silva Diana
- Diaz Daniel
- Diaz Luis Antonio
- Diaz Michael J
- Dima Adriana
- Ding Delaney D
- Dirac M Ashworth
- do Prado Camila Bruneli
- Do Thao Huynh Phuong
- Dohare Sushil
- Dominguez Regina-Mae Villanueva
- Dong Wanyue
- Dongarwar Deepa
- Dorsey E Ray
- Doshmangir Leila
- Dowou Robert Kokou
- Driscoll Tim Robert
- Dsouza Haneil Larson
- Dsouza Viola
- Dube John
- Dumith Samuel C
- Duncan Bruce B
- Duraes Andre Rodrigues
- Duraisamy Senbagam
- Durojaiye Oyewole Christopher
- Dzianach Paulina Agnieszka
- Dziedzic Arkadiusz Marian
- Eboreime Ejemai
- Ebrahimi Alireza
- Edinur Hisham Atan
- Edvardsson David
- Eikemo Terje Andreas
- Eini Ebrahim
- Ekholuenetale Michael
- Ekundayo Temitope Cyrus
- El Sayed Iman
- El Tantawi Maha
- Elbarazi Iffat
- Elemam Noha Mousaad
- ElGohary Ghada Metwally Tawfik
- Elhadi Muhammed
- Elmeligy Omar Abdelsadek Abdou
- ELNahas Gihan
- Elshaer Mohammed
- Elsohaby Ibrahim
- Engelbert Bain Luchuo
- Erkhembayar Ryenchindorj
- Eshrati Babak
- Estep Kara
- Fabin Natalia
- Fagbamigbe Adeniyi Francis
- Falzone Luca
- Fareed Mohammad
- Farinha Carla Sofia e Sá
- Faris MoezAlIslam Ezzat Mahmoud
- Faro Andre
- Farrokhi Pegah
- Fatehizadeh Ali
- Fauk Nelsensius Klau
- Feigin Valery L
- Feng Xiaoqi
- Fereshtehnejad Seyed-Mohammad
- Feroze Abdullah Hamid
- Ferrari Alize J
- Ferreira Nuno
- Ferreira Paulo H
- Fischer Florian
- Flavel Joanne
- Flood David
- Flor Luisa S
- Foigt Nataliya A
- Folayan Morenike Oluwatoyin
- Force Lisa M
- Fortuna Daniela
- Foschi Matteo
- Franklin Richard Charles
- Freitas Alberto
- Fukumoto Takeshi
- Furtado João M
- Gaal Peter Andras
- Gadanya Muktar A
- Gaidhane Abhay Motiramji
- Gaihre Santosh
- Galali Yaseen
- Ganbat Mandukhai
- Gandhi Aravind P
- Ganesan Balasankar
- Ganie Mohd Ashraf
- Ganiyani Mohammad Arfat
- Gardner William M
- Gebi Tilaye Gebru
- Gebregergis Miglas W
- Gebrehiwot Mesfin
- Gebremariam Tesfay B B
- Gebremeskel Teferi Gebru
- Gela Yibeltal Yismaw
- Georgescu Simona Roxana
- Getachew Obsa Abera
- Gething Peter W
- Getie Molla
- Ghadiri Keyghobad
- Ghadirian Fataneh
- Ghailan Khalid Yaser
- Ghajar Alireza
- Ghasemi MohammadReza
- Ghasempour Dabaghi Ghazal
- Ghasemzadeh Afsaneh
- Ghazy Ramy Mohamed
- Gholamrezanezhad Ali
- Ghorbani Mahsa
- Ghotbi Elena
- Gibson Ruth Margaret
- Gill Tiffany K
- Ginindza Themba G
- Girmay Alem
- Glasbey James C
- Godinho Myron Anthony
- Goharinezhad Salime
- Goldust Mohamad
- Golechha Mahaveer
- Goleij Pouya
- Gona Philimon N
- Gorini Giuseppe
- Goulart Alessandra C
- Göbölös Laszlo
- Grada Ayman
- Grivna Michal
- Guan Shi-Yang
- Guarducci Giovanni
- Gubari Mohammed Ibrahim Mohialdeen
- Gudeta Mesay Dechasa
- Guha Avirup
- Guicciardi Stefano
- Gulati Snigdha
- Gulisashvili David
- Gunawardane Damitha Asanga
- Guo Cui
- Gupta Anish Kumar
- Gupta Bhawna
- Gupta Ishita
- Gupta Mohak
- Gupta Rajeev
- Gupta Veer Bala
- Gupta Vijai Kumar
- Gupta Vivek Kumar
- Gutiérrez Reyna Alma
- Habibzadeh Farrokh
- Habibzadeh Parham
- Haddadi Rasool
- Hadi Najah R
- Haep Nils
- Hafezi-Nejad Nima
- Hafiz Abdul
- Hagins Hailey
- Halboub Esam S
- Halimi Aram
- Haller Sebastian
- Halwani Rabih
- Hamilton Erin B
- Hankey Graeme J
- Hannan Md Abdul
- Haque Md Nuruzzaman
- Harapan Harapan
- Haro Josep Maria
- Hartvigsen Jan
- Hasaballah Ahmed I
- Hasan Ikramul
- Hasanian Mohammad
- Hasnain Md Saquib
- Hassan Amr
- Haubold Johannes
- Havmoeller Rasmus J
- Hay Simon I
- Hayat Khezar
- Hebert Jeffrey J
- Hegazi Omar E
- Heidari Golnaz
- Helfer Bartosz
- Hemmati Mehdi
- Hendrie Delia
- Henson Claire A
- Hezam Kamal
- Hiraike Yuta
- Hoan Nguyen Quoc
- Holla Ramesh
- Hon Julia
- Hossain Md Mahbub
- Hosseinzadeh Hassan
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Hsu Johnathan M
- Huang Junjie
- Hugo Fernando N
- Hushmandi Kiavash
- Hussain Javid
- Hussein Nawfal R
- Huynh Chantal K
- Huynh Hong-Han
- Hwang Bing-Fang
- Iannucci Vincent C
- Ihler Audrey L
- Ikiroma Adalia I
- Ikuta Kevin S
- Ilesanmi Olayinka Stephen
- Ilic Irena M
- Ilic Milena D
- Imam Mohammad Tarique
- Immurana Mustapha
- Irham Lalu Muhammad
- Islam Md Rabiul
- Islam Sheikh Mohammed Shariful
- Islami Farhad
- Ismail Faisal
- Ismail Nahlah Elkudssiah
- Isola Gaetano
- Iwagami Masao
- Iwu Chidozie C D
- Iyer Mahalaxmi
- Jaafari Jalil
- Jacobsen Kathryn H
- Jadidi-Niaragh Farhad
- Jafarinia Morteza
- Jaggi Khushleen
- Jahankhani Kasra
- Jahanmehr Nader
- Jahrami Haitham
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- Jayapal Sathish Kumar
- Jayaram Shubha
- Jee Sun Ha
- Jeganathan Jayakumar
- Jeyakumar Angeline
- Jha Anil K
- Jiang Heng
- Jin Yinzi
- Jonas Jost B
- Joo Tamas
- Joseph Abel
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- Jozwiak Jacek Jerzy
- Jürisson Mikk
- K Vaishali
- Kaambwa Billingsley
- Kabir Ali
- Kabir Zubair
- Kadashetti Vidya
- Kalani Rizwan
- Kalankesh Leila R
- Kaliyadan Feroze
- Kalra Sanjay
- Kamenov Kaloyan
- Kamyari Naser
- Kanagasabai Thanigaivelan
- Kandel Himal
- Kanmanthareddy Arun R
- Kanmodi Kehinde Kazeem
- Kantar Rami S
- Karaye Ibraheem M
- Karim Asima
- Karimi Salah Eddin
- Karimi Yeganeh
- Kasraei Hengameh
- Kassel Molly B
- Kauppila Joonas H
- Kawakami Norito
- Kayode Gbenga A
- Kazemi Foad
- Kazemian Sina
- Keikavoosi-Arani Leila
- Keller Cathleen
- Kempen John H
- Kerr Jessica A
- Keshtkar Kamyab
- Kesse-Guyot Emmanuelle
- Keykhaei Mohammad
- Khajuria Himanshu
- Khalaji Amirmohammad
- Khalid Asaad
- Khalid Nauman
- Khalilian Alireza
- Khamesipour Faham
- Khan Asaduzzaman
- Khan Ikramullah
- Khan Maseer
- Khan Moien AB
- Khanmohammadi Shaghayegh
- Khatab Khaled
- Khatami Fatemeh
- Khatatbeh Moawiah Mohammad
- Khater Amir M
- Khayat Kashani Hamid Reza
- Khidri Feriha Fatima
- Khodadoust Elaheh
- Khormali Moein
- Khorrami Zahra
- Kifle Zemene Demelash
- Kim Min Seo
- Kimokoti Ruth W
- Kisa Adnan
- Kisa Sezer
- Knudsen Ann Kristin Skrindo
- Kocarnik Jonathan M
- Kochhar Sonali
- Koh Hyun Yong
- Kolahi Ali-Asghar
- Kompani Farzad
- Koren Gerbrand
- Korzh Oleksii
- Kosen Soewarta
- Koulmane Laxminarayana Sindhura Lakshmi
- Krishan Kewal
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- Krishnamoorthy Vijay
- Kuate Defo Barthelemy
- Kuddus Md Abdul
- Kuddus Mohammed
- Kuitunen Ilari
- Kulkarni Vishnutheertha
- Kumar Manasi
- Kumar Nithin
- Kumar Rakesh
- Kurmi Om P
- Kusuma Dian
- Kyu Hmwe Hmwe
- La Vecchia Carlo
- Lacey Ben
- Ladan Muhammad Awwal
- Laflamme Lucie
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- Lahariya Chandrakant
- Lai Daphne Teck Ching
- Lal Dharmesh Kumar
- Lalloo Ratilal
- Lallukka Tea
- Lan Qing
- Lan Tuo
- Landires Iván
- Lanfranchi Francesco
- Langguth Berthold
- Laplante-Lévesque Ariane
- Larijani Bagher
- Larsson Anders O
- Lasrado Savita
- Lauriola Paolo
- Lám Judit
- Le Huu-Hoai
- Le Long Khanh Dao
- Le Nhi Huu Hanh
- Le Trang Diep Thanh
- Leasher Janet L
- Ledda Caterina
- Lee Munjae
- Lee Paul H
- Lee Sang-woong
- Lee Seung Won
- Lee Wei-Chen
- Lee Yo Han
- LeGrand Kate E
- Lenzi Jacopo
- Leong Elvynna
- Leung Janni
- Li Ming-Chieh
- Li Wei
- Li Xiaopan
- Li Yichong
- Li Yongze
- Lim Lee-Ling
- Lim Stephen S
- Lindstrom Megan
- Linn Shai
- Liu Gang
- Liu Runben
- Liu Shiwei
- Liu Wei
- Liu Xiaofeng
- Liu Xuefeng
- Llanaj Erand
- Lo Chun-Han
- Loreche Arianna Maever
- Lorenzovici László
- Lozano Rafael
- López-Bueno Rubén
- Lubinda Jailos
- Lucchetti Giancarlo
- Lunevicius Raimundas
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- Machairas Nikolaos
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- Magaña Gómez Javier A
- Maghazachi Azzam A
- Maharjan Preeti
- Mahasha Phetole Walter
- Maheri Mina
- Mahjoub Soleiman
- Mahmoud Mansour Adam
- Mahmoudi Elham
- Majeed Azeem
- Makris Konstantinos Christos
- Malakan Rad Elaheh
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- Malik Ahmad Azam
- Malik Iram
- Malta Deborah Carvalho
- Manla Yosef
- Mansour Ali
- Mansouri Pejman
- Mansournia Mohammad Ali
- Mantilla Herrera Ana M
- Mantovani Lorenzo Giovanni
- Manu Emmanuel
- Marateb Hamid Reza
- Mardi Parham
- Martinez Gabriel
- Martinez-Piedra Ramon
- Martini Daniela
- Martins-Melo Francisco Rogerlândio
- Martorell Miquel
- Marx Wolfgang
- Maryam Sharmeen
- Marzo Roy Rillera
- Mathangasinghe Yasith
- Mathieson Stephanie
- Mathioudakis Alexander G
- Mattumpuram Jishanth
- Maugeri Andrea
- Mayeli Mahsa
- Mazidi Mohsen
- Mazzotti Antonio
- McGrath John J
- McKee Martin
- McKowen Anna Laura W
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- Mehrabani-Zeinabad Kamran
- Mehrabi Nasab Entezar
- Mekene Meto Tesfahun
- Mendoza Walter
- Menezes Ritesh G
- Mensah George A
- Mentis Alexios-Fotios A
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- Yadav Lalit
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- Yesuf Subah Abderehim
- Yezli Saber
- Yigzaw Zeamanuel Anteneh
- Yiğit Arzu
- Yiğit Vahit
- Yismaw Yazachew
- Yon Dong Keon
- Yonemoto Naohiro
- Younis Mustafa Z
- Yu Chuanhua
- Yu Yong
- Yusuf Hadiza
- Zahid Mondal Hasan
- Zakham Fathiah
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- Zamora Nelson
- Zand Ramin
- Zandieh Ghazal G Z
- Zar Heather J
- Zarrintan Armin
- Zastrozhin Mikhail Sergeevich
- Zhang Haijun
- Zhang Ning
- Zhang Yunquan
- Zhao Hanqing
- Zhong Chenwen
- Zhong Panliang
- Zhou Juexiao
- Zhu Zhaohua
- Ziafati Makan
- Zielińska Magdalena
- Zimsen Stephanie R M
- Zoladl Mohammad
- Zumla Alimuddin
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate more rigorous monitoring of progress towards national and international health targets, such as the Sustainable Development Goals. For three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has filled that need. A global network of collaborators contributed to the production of GBD 2021 by providing, reviewing, and analysing all available data. GBD estimates are updated routinely with additional data and refined analytical methods. GBD 2021 presents, for the first time, estimates of health loss due to the COVID-19 pandemic. Methods: The GBD 2021 disease and injury burden analysis estimated years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries using 100 983 data sources. Data were extracted from vital registration systems, verbal autopsies, censuses, household surveys, disease-specific registries, health service contact data, and other sources. YLDs were calculated by multiplying cause-age-sex-location-year-specific prevalence of sequelae by their respective disability weights, for each disease and injury. YLLs were calculated by multiplying cause-age-sex-location-year-specific deaths by the standard life expectancy at the age that death occurred. DALYs were calculated by summing YLDs and YLLs. HALE estimates were produced using YLDs per capita and age-specific mortality rates by location, age, sex, year, and cause. 95% uncertainty intervals (UIs) were generated for all final estimates as the 2·5th and 97·5th percentiles values of 500 draws. Uncertainty was propagated at each step of the estimation process. Counts and age-standardised rates were calculated globally, for seven super-regions, 21 regions, 204 countries and territories (including 21 countries with subnational locations), and 811 subnational locations, from 1990 to 2021. Here we report data for 2010 to 2021 to highlight trends in disease burden over the past decade and through the first 2 years of the COVID-19 pandemic. Findings: Global DALYs increased from 2·63 billion (95% UI 2·44–2·85) in 2010 to 2·88 billion (2·64–3·15) in 2021 for all causes combined. Much of this increase in the number of DALYs was due to population growth and ageing, as indicated by a decrease in global age-standardised all-cause DALY rates of 14·2% (95% UI 10·7–17·3) between 2010 and 2019. Notably, however, this decrease in rates reversed during the first 2 years of the COVID-19 pandemic, with increases in global age-standardised all-cause DALY rates since 2019 of 4·1% (1·8–6·3) in 2020 and 7·2% (4·7–10·0) in 2021. In 2021, COVID-19 was the leading cause of DALYs globally (212·0 million [198·0–234·5] DALYs), followed by ischaemic heart disease (188·3 million [176·7–198·3]), neonatal disorders (186·3 million [162·3–214·9]), and stroke (160·4 million [148·0–171·7]). However, notable health gains were seen among other leading communicable, maternal, neonatal, and nutritional (CMNN) diseases. Globally between 2010 and 2021, the age-standardised DALY rates for HIV/AIDS decreased by 47·8% (43·3–51·7) and for diarrhoeal diseases decreased by 47·0% (39·9–52·9). Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). Between 2010 and 2021, among the 25 leading Level 3 causes, age-standardised DALY rates increased most substantially for anxiety disorders (16·7% [14·0–19·8]), depressive disorders (16·4% [11·9–21·3]), and diabetes (14·0% [10·0–17·4]). Age-standardised DALY rates due to injuries decreased globally by 24·0% (20·7–27·2) between 2010 and 2021, although improvements were not uniform across locations, ages, and sexes. Globally, HALE at birth improved slightly, from 61·3 years (58·6–63·6) in 2010 to 62·2 years (59·4–64·7) in 2021. However, despite this overall increase, HALE decreased by 2·2% (1·6–2·9) between 2019 and 2021. Interpretation: Putting the COVID-19 pandemic in the context of a mutually exclusive and collectively exhaustive list of causes of health loss is crucial to understanding its impact and ensuring that health funding and policy address needs at both local and global levels through cost-effective and evidence-based interventions. A global epidemiological transition remains underway. Our findings suggest that prioritising non-communicable disease prevention and treatment policies, as well as strengthening health systems, continues to be crucially important. The progress on reducing the burden of CMNN diseases must not stall; although global trends are improving, the burden of CMNN diseases remains unacceptably high. Evidence-based interventions will help save the lives of young children and mothers and improve the overall health and economic conditions of societies across the world. Governments and multilateral organisations should prioritise pandemic preparedness planning alongside efforts to reduce the burden of diseases and injuries that will strain resources in the coming decades. Funding: Bill & Melinda Gates Foundation
Finishing the euchromatic sequence of the human genome
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- Brandriff Brigitte F.
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- Brimhall Angela K.
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- Hitchens Matthew Edward
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- Lowry Stephen
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- Machrus Migdad
- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
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- Major John
- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
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- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
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- McLean James
- McLellan Michael D.
- McLeod Michael P.
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- McMurray Amanda
- McMurray Des
- McMurray Kimberly
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- Meidi Patrick
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- Mungall Andy
- Munidasa Mala
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- Murayama Yuji
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- Omotosho Bamidele
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- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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