Debris about asteroids: Where and how much?

We summarize several recent findings on the size and shape of the region within which material can stably orbit an asteroid. If the asteroid (with assumed density 2.38 g/cu cm) circles the Sun at 2.55 AU, co-planar prograde material will remain trapped whenever started on unperturbed circular orbits at less than about 220 R(sub A) (asteroid radii); co-planar retrograde particles are stable out twice as far. Our 3-D stability surface, which encloses several hundred numerically calculated orbits that start with various inclinations, is shaped like a sphere with its top and bottom sliced off; its dimensions scale like the Hill radius =(mu/3)(exp 1/3)R, where mu is the asteroid-to-solar mass ratio and R is the asteroid's orbital radius. If the asteroid moves along an elliptical orbit, a fairly reliable indicator of the dimensions of the hazard zone is the size of its Hill sphere at the orbit's pericenter. Grains with radii less than a few mm will be lost through the action of radiation forces which can induce escape or cause collisions with the asteroid on times scales of a few years; interplanetary micrometeoroids produce collisional break-up of these particles in approximately 10(exp 4) yrs. The effects of Jupiter and of asteroids that pass close to the target asteroid allow particles to diffuse from the system, again shrinking the hazard zone. None of the considered sources-primordial formation, debris spalled off the asteroid during micrometeoroid impact, captured interplanetary particles, feeder satellites, etc., seem capable of densely populating distant orbits from the asteroid. No certain detections of debris clouds or of binary asteroids have been made. Thus, it seems highly unlikely that a spacecraft fly-by targeted at 100 R(sub A) from the asteroid over its orbital pole would encounter any material

Finding the trigger to Iapetus' odd global albedo pattern: Dynamics of dust from Saturn's irregular satellites

The leading face of Saturn's moon Iapetus, Cassini Regio, has an albedo only one tenth that on its trailing side. The origin of this enigmatic dichotomy has been debated for over forty years, but with new data, a clearer picture is emerging. Motivated by Cassini radar and imaging observations, we investigate Soter's model of dark exogenous dust striking an originally brighter Iapetus by modeling the dynamics of the dark dust from the ring of the exterior retrograde satellite Phoebe under the relevant perturbations. In particular, we study the particles' probabilities of striking Iapetus, as well as their expected spatial distribution on the Iapetian surface. We find that, of the long-lived particles (greater than about 5 microns), most particle sizes (greater than about 10 microns) are virtually certain to strike Iapetus, and their calculated distribution on the surface matches up well with Cassini Regio's extent in its longitudinal span. The satellite's polar regions are observed to be bright, presumably because ice is deposited there. Thus, in the latitudinal direction we estimate polar dust deposition rates to help constrain models of thermal migration invoked to explain the bright poles (Spencer & Denk 2010). We also analyze dust originating from other irregular outer moons, determining that a significant fraction of that material will eventually coat Iapetus--perhaps explaining why the spectrum of Iapetus' dark material differs somewhat from that of Phoebe. Finally we track the dust particles that do not strike Iapetus, and find that most land on Titan, with a smaller fraction hitting Hyperion. As has been previously conjectured, such exogenous dust, coupled with Hyperion's chaotic rotation, could produce Hyperion's roughly isotropic, moderate-albedo surface.Comment: Accepted for publication in Icaru

A Second Generation 2-Methoxyestradiol Prodrug Is Effective Against Barrett's Adenocarcinoma in a Mouse Xenograft Model

This is the author's accepted manuscript. The original is available at http://mct.aacrjournals.org/content/12/3/2552-Methoxyestradiol (2-ME2) is an endogenous metabolite of estradiol. In preclinical models, 2-ME2 is effective against different types of tumors. Unfortunately, only low systemic concentrations of 2-ME2 can be achieved following oral administration, even after very high doses are administered to patients. In an effort to solve this problem we have now synthesized and tested a new prodrug of 2-ME2 that is water soluble due to a bio-reversible hydrophilic group added at the 3-position and more effectively resists metabolic inactivation due to an ester moiety added to mask the 17-position alcohol. We are reporting here for the first time that this double prodrug of 2-ME2 is effective as an antiproliferative and anti-cancer agent for both in vitro and in vivo studies against Barrett's esophageal adenocarcinoma (BEAC), and provided greater potency than 2-ME2 in inhibiting the growth of BEAC xenografts. Finally, studies indicate that, like 2-ME2, the 2-ME2-PD1 exhibits anticancer effect through possible disruption of microtubule-network

Bring a plate: facilitating experimentation in the Welcome Dinner Project

Drawing on in-depth empirical research, we explore a project called The Welcome Dinner (WDP). The WDP aims to bring together ‘newly arrived’ people and ‘established Australians’ to meet and ‘share stories’ over a potluck meal in ‘the comfort of their own home’. The purpose is to create meaningful connections, new friendships and social solidarities. In this paper, we focus on the micro-contexts of the dinners and the minute activities and techniques that facilitators use in hosting. Our aim is not to analyse the effects of the project but rather the design and meaning of the activities. As a form of ‘designed everyday multiculturalism’, focused on welcoming new arrivals to Australia, it takes effort, skill and labour to manage the contact between different cultural groups over organised meals. Thus, facilitators take over the hosting of the lunches and dinners to run activities, which are imagined to lubricate social dynamics and relations, and produce convivial commensal affects and behaviours. Drawing on theories of training activities as embodied and cognitive experimentations, which enable new knowledge practices and social relations, we analyse field notes and interviews about the facilitation, structure and activities at the WDP home dinners

Open string instantons and superpotentials

We study the F-terms in N=1 supersymmetric, d=4 gauge theories arising from D(p+3)-branes wrapping supersymmetric p-cycles in a Calabi-Yau threefold. If p is even the spectrum and superpotential for a single brane are determined by purely classical ($\alpha^\prime \to 0$) considerations. If p=3, superpotentials for massless modes are forbidden to all orders in $\alpha^\prime$ and may only be generated by open string instantons. For this latter case we find that such instanton effects are generically present. Mirror symmetry relates even and odd p and thus perturbative and nonperturbative superpotentials; we provide a preliminary discussion of a class of examples of such mirror pairs.Comment: 22 pages, harvmac big; v2, corrected some typo

Appetite and gut hormone responses to moderate-intensity continuous exercise versus high-intensity interval exercise, in normoxic and hypoxic conditions.

This study investigated the effects of continuous moderate-intensity exercise (MIE) and high-intensity interval exercise (HIIE) in combination with short exposure to hypoxia on appetite and plasma concentrations of acylated ghrelin, peptide YY (PYY), and glucagon-like peptide-1 (GLP-1). Twelve healthy males completed four, 2.6 h trials in a random order: 1) MIE-normoxia, 2) MIE-hypoxia, 3) HIIE-normoxia, and 4) HIIE-hypoxia. Exercise took place in an environmental chamber. During MIE, participants ran for 50 min at 70% of altitude-specific maximal oxygen uptake ( 2max) and during HIIE performed 6 x 3 min running at 90% 2max interspersed with 6 x 3 min active recovery at 50% 2max with a 7 min warm-up and cool-down at 70% 2max (50 min total). In hypoxic trials, exercise was performed at a simulated altitude of 2,980 m (14.5% O2). Exercise was completed after a standardised breakfast. A second meal standardised to 30% of participants’ daily energy requirements was provided 45 min after exercise. Appetite was suppressed more in hypoxia than normoxia during exercise, post-exercise, and for the full 2.6 h trial period (linear mixed modelling, p 0.05). These findings demonstrate that short exposure to hypoxia causes suppressions in appetite and plasma acylated ghrelin concentrations. Furthermore, appetite responses to exercise do not appear to be influenced by exercise modality