427 research outputs found
On the nature of the hard X-ray sources SWIFTJ1907.3-2050, IGRJ12123-5802 and IGRJ19552+0044
The INTEGRAL and Swift hard X-ray surveys have identified a large number of
new sources, among which many are proposed as Cataclysmic Variables (CVs). Here
we present the first detailed study of three X-ray selected CVs, Swift
J1907.3-2050, IGRJ12123-5802, and IGRJ19552+0044 based on XMM-Newton, Suzaku,
Swift observations and ground based optical and archival nIR/IR data. Swift
J1907.3-2050 is highly variable from hours to months-years at all wavelengths.
No coherent X-ray pulses are detected but rather transient features. The X-ray
spectrum reveals a multi-temperature optically thin plasma absorbed by complex
neutral material and a soft black body component arising from a small area.
These characteristics are remarkably similar to those observed in magnetic CVs.
A supra-solar abundance of nitrogen could arise from nuclear processed material
from the donor star. Swift J1907.3-2050 could be a peculiar magnetic CV with
the second longest (20.82 h) binary period. IGRJ12123-5802 is variable in the
X-rays on a timescale of ~7.6 h. No coherent pulsations are detected, but its
spectral characteristics suggest that it could be a magnetic CV of the
Intermediate Polar (IP) type. IGRJ19552+0044 shows two X-ray periods, 1.38 h
and 1.69 h and a X-ray spectrum characterized by a multi-temperature plasma
with little absorption.We derive a low accretion rate, consistent with a CV
below the orbital period gap. Its peculiar nIR/IR spectrum suggests a
contribution from cyclotron emission. It could either be a pre-polar or an IP
with the lowest degree of asynchronism.Comment: Accepted for publication in MNRAS. 14 pages, 11 figures, 5 table
Galactomannan Does Not Precede Major Signs on a Pulmonary Computerized Tomographic Scan Suggestive of Invasive Aspergillosis in Patients with Hematological Malignancies
Background. Detection of serum galactomannan (GM) antigen and presence of the halo sign on a pulmonary computerized tomographic (CT) scan have a high specificity but a low sensitivity to diagnose invasive aspergillosis (IA) in patients at risk for this disease. To our knowledge, the relationship between the time at which pulmonary infiltrates are detected by CT and the time at which GM antigens are detected by enzyme immunoassay (EIA) has not been studied. Methods. In a prospective study, tests for detection of GM were performed twice weekly for patients with hematological malignancies who had undergone hematopoetic stem cell transplantation (HSCT) or had received induction and/or consolidation chemotherapy. A pulmonary CT scan was performed once weekly. Infiltrates were defined as either major or minor signs. IA was classified as proven, probable, or possible, in accordance with the definition stated by the European Organization for Research and Treatment of Cancer-Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group. Results. We analyzed 161 episodes of infection in 107 patients (65 allogeneic HSCT recipients, 30 autologous HSCT recipients, and 66 induction and/or consolidation chemotherapy recipients). A total of 109 episodes with no IA, 32 episodes with possible IA, and 20 episodes with probable or proven IA were identified. Minor pulmonary signs were detected by CT in 70 episodes (43%), and major pulmonary signs were detected by CT in 11 episodes (7%). Univariate and multivariate analyses revealed no significant association between detection of GM by EIA and detection of abnormal pulmonary signs by CT. A significant association was found between GM levels and receipt of piperacillin-tazobactam. GM test results were not positive before major signs were seen on CT images. Only 7 (10%) of 70 patients with minor pulmonary signs had positive GM test results before detection of the greatest pathologic change by CT. Conclusions. We show that detection of GM by EIA does not precede detection of major lesions by pulmonary CT. In the clinical setting, the decision to administer mold-active treatment should based on detection of new pulmonary infiltrates on CT performed early during infection, rather than on results of EIA for detection of G
PENSAMIENTO COMPUTACIONAL Y EDUCACIÓN STEM: REFLEXIONES PARA UNA EDUCACIÓN INCLUSIVA DESDE LAS PRÁCTICAS PEDAGÓGICAS
This pedagogical reflection, which arises from a significant experience in an official institution in the city of Manizales (Colombia) on the use and appropriation of computational thinking in regular classrooms characterized by having a high percentage of students with disabilities, has the purpose of demonstrating how inclusive education is not a limitation to develop this thinking. To this end, a dialogue was held between the teachers about their classroom practices, disconnected activities were carried out and technological tools were used. The above made them aware of the importance of its use and allowed them to include in the curriculum some strategies of education in Science, Technology, Engineering and Mathematics (STEM) and computational thinking to be part of the institutional culture, taking into account the diversity present in the classroom. The results of the reflection show that: a. in addition to computational thinking, STEM strategies allow the development of 21st century skills, b. students with disabilities respond in an assertive and motivated way, c. Peer work enriches own and collective learning, d. the greater the number of teachers linked, the more coverage the project reaches. This article contributes to the field of knowledge as a motivating and guiding reference for those who wish to incorporate new practices and use of technologies in educational contexts with a diverse population, also contributing to the reduction of imaginary established by fear or misinformation about working with a population that has a disability.Esta reflexión pedagógica, que nace de una experiencia significativa en una institución oficial de la ciudad de Manizales (Colombia) sobre el uso y apropiación del pensamiento computacional en aulas regulares caracterizadas por tener un porcentaje alto de estudiantes con discapacidad, tiene el propósito de demostrar cómo la educación inclusiva no es una limitante para desarrollar este pensamiento. Para tal fin se sostuvo un diálogo entre los docentes acerca de sus prácticas de aula, se realizaron actividades desconectadas y se usaron herramientas tecnológicas. Lo anterior los concientizó acerca de la importancia de su utilización y les permitió incluir en el currículo algunas estrategias de la educación en Ciencia, Tecnología, Ingeniería y Matemáticas (STEM) y del pensamiento computacional para ser parte de la cultura institucional, teniendo en cuenta la diversidad presente en el aula. Los resultados de la reflexión demuestran que: a. además del pensamiento computacional, las estrategias STEM permiten desarrollar competencias propias del siglo XXI, b. los estudiantes con discapacidad responden de forma asertiva y motivada, c. el trabajo entre pares enriquece los aprendizajes propios y colectivos, d. a mayor número de docentes vinculados, más cobertura alcanza el proyecto. Este artículo contribuye al campo de conocimiento como referente motivador y orientador para quienes deseen efectuar incorporación de nuevas prácticas y empleo de tecnologías en contextos educativos con población diversa, aportando también a la disminución de imaginarios instaurados por el miedo o la desinformación sobre el trabajo con población que presenta discapacidad
Broad-band gravitational-wave pulses from binary neutron stars in eccentric orbits
Maximum gravitational wave emission from binary stars in eccentric orbits
occurs near the periastron passage. We show that for a stationary distribution
of binary neutron stars in the Galaxy, several high-eccentricity systems with
orbital periods in the range from tens of minutes to several days should exist
that emit broad gravitational-wave pulses in the frequency range 1-100 mHz. The
space interferometer LISA could register the pulsed signal from these system at
a signal-to-noise ratio level in the frequency range Hz during one-year observational time. Some detection
algorithms for such a signal are discussed.Comment: 17 pages, LATEX, 3 figures, Astronomy Letters, 2002, in press; typos
corrected, refference adde
Discovery of an 86 AU Radius Debris Ring Around HD 181327
HST/NICMOS PSF-subtracted coronagraphic observations of HD 181327 have
revealed the presence of a ring-like disk of circumstellar debris seen in 1.1
micron light scattered by the disk grains, surrounded by a di use outer region
of lower surface brightness. The annular disk appears to be inclined by 31.7
+/- 1.6 deg from face on with the disk major axis PA at 107 +/-2 deg . The
total 1.1 micron flux density of the light scattered by the disk (at 1.2" < r <
5.0") of 9.6 mJy +/- 0.8 mJy is 0.17% +/- 0.015% of the starlight. Seventy
percent of the light from the scattering grains appears to be confined in a 36
AU wide annulus centered on the peak of the radial surface brightness (SB)
profile 86.3 +/- 3.9 AU from the star, well beyond the characteristic radius of
thermal emission estimated from IRAS and Spitzer flux densities assuming
blackbody grains (~ 22 AU). The light scattered by the ring appears bilaterally
symmetric, exhibits directionally preferential scattering well represented by a
Henyey-Greenstein scattering phase function with g = 0.30 +/- 0.03, and has an
azimuthally medianed SB at the 86.3 AU radius of peak SB of 1.00 +/- 0.07 mJy
arcsec^-2. No photocentric offset is seen in the ring relative to the position
of the central star. A low surface brightness diffuse halo is seen in the
NICMOS image to a distance of ~ 4" Deeper 0.6 micron HST/ACS PSF-subtracted
coronagraphic observations reveal a faint outer nebulosity, asymmetrically
brighter to the North of the star. We discuss models of the disk and properties
of its grains, from which we infer a maximum vertical scale height of 4 - 8 AU
at the 87.6 AU radius of maximum surface density, and a total maximum dust mass
of collisionally replenished grains with minimum grain sizes of ~ 1 micron of ~
4 M(moon).Comment: 45 pages, 15 figures, accepted for publication in Ap
Measuring star formation in high-z massive galaxies: A mid-infrared to submillimeter study of the GOODS NICMOS Survey sample
We present measurements of the mean mid-infrared-to-submillimeter flux
densities of massive (M\ast \approx 2 \times 10^11 Msun) galaxies at redshifts
1.7 < z < 2.9, obtained by stacking positions of known objects taken from the
GOODS NICMOS Survey (GNS) catalog on maps: at 24 {\mu}m (Spitzer/MIPS); 70,
100, and 160{\mu}m (Herschel/PACS); 250, 350, 500{\mu}m (BLAST); and 870{\mu}m
(LABOCA). A modified blackbody spectrum fit to the stacked flux densities
indicates a median [interquartile] star-formation rate of SFR = 63 [48, 81]
Msun yr^-1 . We note that not properly accounting for correlations between
bands when fitting stacked data can significantly bias the result. The galaxies
are divided into two groups, disk-like and spheroid-like, according to their
Sersic indices, n. We find evidence that most of the star formation is
occurring in n \leq 2 (disk-like) galaxies, with median [interquartile] SFR =
122 [100,150] Msun yr^-1, while there are indications that the n > 2
(spheroid-like) population may be forming stars at a median [interquartile] SFR
= 14 [9,20] Msun yr^-1, if at all. Finally, we show that star formation is a
plausible mechanism for size evolution in this population as a whole, but find
only marginal evidence that it is what drives the expansion of the
spheroid-like galaxies.Comment: Accepted by MNRAS. 10 pages, 3 figures, 3 table
The Size Evolution of Passive Galaxies: Observations from the Wide Field Camera 3 Early Release Science Program
We present results on the size evolution of passively evolving galaxies at
1<z<2 drawn from the Wide Field Camera 3 Early Release Science program. Our
sample was constructed using an analog to the passive BzK selection criterion,
which isolates galaxies with little or no on-going star formation at z>1.5. We
identify 30 galaxies in ~40 square arcmin to H<25 mag. We supplement
spectroscopic redshifts from the literature with photometric redshifts
determined from the 15-band photometry from 0.22-8 micron. We determine
effective radii from Sersic profile fits to the H-band image using an empirical
PSF. We find that size evolution is a strong function of stellar mass, with the
most massive (M* ~ 10^11 Msol) galaxies undergoing the most rapid evolution
from z~2 to the present. Parameterizing the size evolution as (1+z)^{-alpha},
we find a tentative scaling between alpha and stellar mass of alpha ~ -1.8+1.4
log(M*/10^9 Msol). We briefly discuss the implications of this result for our
understanding of the dynamical evolution of the red galaxies.Comment: 11 pages, 7 figures, 4 tables. Submitted to Ap
Identification of tidal features in deep optical galaxy images with Convolutional Neural Networks
Interactions between galaxies leave distinguishable imprints in the form of
tidal features which hold important clues about their mass assembly.
Unfortunately, these structures are difficult to detect because they are low
surface brightness features so deep observations are needed. Upcoming surveys
promise several orders of magnitude increase in depth and sky coverage, for
which automated methods for tidal feature detection will become mandatory. We
test the ability of a convolutional neural network to reproduce human visual
classifications for tidal detections. We use as training 6000 simulated
images classified by professional astronomers. The mock Hyper Suprime Cam
Subaru (HSC) images include variations with redshift, projection angle and
surface brightness ( =26-35 mag arcsec). We obtain
satisfactory results with accuracy, precision and recall values of Acc=0.84,
P=0.72 and R=0.85, respectively, for the test sample. While the accuracy and
precision values are roughly constant for all surface brightness, the recall
(completeness) is significantly affected by image depth. The recovery rate
shows strong dependence on the type of tidal features: we recover all the
images showing shell features and 87% of the tidal streams; these fractions are
below 75% for mergers, tidal tails and bridges. When applied to real HSC
images, the performance of the model worsens significantly. We speculate that
this is due to the lack of realism of the simulations and take it as a warning
on applying deep learning models to different data domains without prior
testing on the actual data.Comment: 13 pages, 10 figures, accepted for publication in MNRA
wallace 2: a shiny app for modeling species niches and distributions redesigned to facilitate expansion via module contributions
Released 4 years ago, the Wallace EcoMod application (R package wallace) provided an open-source and interactive platform for modeling species niches and distributions that served as a reproducible toolbox and educational resource. wallace harnesses R package tools documented in the literature and makes them available via a graphical user interface that runs analyses and returns code to document and reproduce them. Since its release, feedback from users and partners helped identify key areas for advancement, leading to the development of wallace 2. Following the vision of growth by community expansion, the core development team engaged with collaborators and undertook a major restructuring of the application to enable: simplified addition of custom modules to expand methodological options, analyses for multiple species in the same session, improved metadata features, new database connections, and saving/loading sessions. wallace 2 features nine new modules and added functionalities that facilitate data acquisition from climate-simulation, botanical and paleontological databases; custom data inputs; model metadata tracking; and citations for R packages used (to promote documentation and give credit to developers). Three of these modules compose a new component for environmental space analyses (e.g., niche overlap). This expansion was paired with outreach to the biogeography and biodiversity communities, including international presentations and workshops that take advantage of the software's extensive guidance text. Additionally, the advances extend accessibility with a cloud-computing implementation and include a suite of comprehensive unit tests. The features in wallace 2 greatly improve its expandability, breadth of analyses, and reproducibility options, including the use of emerging metadata standards. The new architecture serves as an example for other modular software, especially those developed using the rapidly proliferating R package shiny, by showcasing straightforward module ingestion and unit testing. Importantly, wallace 2 sets the stage for future expansions, including those enabling biodiversity estimation and threat assessments for conservation.journal articl
Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application
Background
The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus. In this work we have developed a complete and original process for the production and recovery of the properly folded intracellular domain of IA-2 fused to thioredoxin (TrxIA-2ic) in Escherichia coli GI698 and GI724 strains. We have also carried out the biochemical and immunochemical characterization of TrxIA-2icand design variants of non-radiometric immunoassays for the efficient detection of IA-2 autoantibodies (IA-2A).
Results
The main findings can be summarized in the following statements: i) TrxIA-2ic expression after 3 h of induction on GI724 strain yielded ≈ 10 mg of highly pure TrxIA-2ic/L of culture medium by a single step purification by affinity chromatography, ii) the molecular weight of TrxIA-2ic (55,358 Da) could be estimated by SDS-PAGE, size exclusion chromatography and mass spectrometry, iii) TrxIA-2ic was properly identified by western blot and mass spectrometric analysis of proteolytic digestions (63.25 % total coverage), iv) excellent immunochemical behavior of properly folded full TrxIA-2ic was legitimized by inhibition or displacement of [35S]IA-2 binding from IA-2A present in Argentinian Type 1 Diabetic patients, v) great stability over time was found under proper storage conditions and vi) low cost and environmentally harmless ELISA methods for IA-2A assessment were developed, with colorimetric or chemiluminescent detection.
Conclusions
E. coli GI724 strain emerged as a handy source of recombinant IA-2ic, achieving high levels of expression as a thioredoxin fusion protein, adequately validated and applicable to the development of innovative and cost-effective immunoassays for IA-2A detection in most laboratories.Fil: Guerra, Luciano Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Faccinetti, Natalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Trabucchi, Aldana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Rovitto, Bruno David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Sabljic, Adriana Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Poskus, Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Iacono, Ruben Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Valdez, Silvina Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentin
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