348 research outputs found
New Territories in Adult Education: Game-based Learning for Adult Learners
The purpose of this paper is to address the different approaches to game-based learning by focusing on applied examples and implications for adult education
The Grizzly, September 10, 2015
Campus Adapts to Canvas Roll Out • Blomberg Spends Summer Traveling, Meeting with Alumni • New Greek Organizations Look to Form Chapters on Campus • Student Government Launches Free Textbook Pilot Program • Ursinus Songwriter Explores Human Nature Through Music • Mentors in Academics and Life: Ursinus Remembers Dr. Cameron and Dr. Hemphill • Theater Community Welcomes Performing Arts Scholar • Opinions: New Tips for a New Year at UC; Straight Outta Compton Rates 7 / 10 • Globetrotters: Men\u27s Basketball Competes in Europe • Bears Upset Millersville in Record Five Overtimeshttps://digitalcommons.ursinus.edu/grizzlynews/1669/thumbnail.jp
Targeting DNA repair in Metastatic Castration-Resistant Prostate Cancer (mCRPC): Genomic Screening for a Clinical Trial of Rucaparib
Objectives: The high prevalence of men with mCRPC carrying pathogenic mutations in DNA damage repair (DDR) genes may have implications for clinical treatment, as poly(ADP-ribose) polymerase (PARP) inhibitors, such as rucaparib, have shown preliminary evidence of activity in these patients. The ongoing phase 2 TRITON2 study (NCT02952534) is evaluating rucaparib in mCRPC patients harboring a deleterious germline or somatic mutation in BRCA1, BRCA2, ATM, or other DDR gene. Here we present results from genomic screening of tissue and plasma samples from mCRPC patients.
Methods: Comprehensive genomic profiling was performed by Foundation Medicine, Inc., using FFPE tumor tissue and plasma circulating cell-free DNA (cfDNA) samples. These next-generation sequencing (NGS) assays detect germline and somatic genomic alterations (GAs), but do not distinguish between them.
Results: By Jan 15, 2019, prostate or metastatic tumor tissue samples from 1050 mCRPC patients were processed. Sequencing was successful for 68% of prostate samples, 82% of soft-tissue metastatic samples, and 57% of bone metastatic samples. In total, tissue sequencing results were obtained for 774 (74%) patients. GAs in BRCA1, BRCA2, or ATM were observed in 16.7% of patients’ tissue. In parallel, plasma from 654 mCRPC patients was collected and sequenced: 96% of plasma samples had sufficient cfDNA to obtain sequencing results, and sequencing success was independent of the location of metastases (visceral, nodal, or bone). GAs in BRCA1, BRCA2, or ATM were observed in 21.4% of patients’ plasma. There was high concordance between the alterations detected by the tissue and plasma assays. For example, in 86% of patients the plasma assay detected the same BRCA2 alteration present in tissue.
Conclusions: Genomic profiling may help guide clinical decision-making for mCRPC patients. Tumor and plasma testing successfully identified patients with eligible somatic or germline GAs for enrollment into TRITON2. These data continue to support the utilization of plasma genomic testing, particularly in patients without a lesion that can be biopsied.
Source of Funding: Clovis Oncology, Inc
An up-conversion luminophore with high quantum yield and brightness based on BaF:Yb,Er single crystals
Up-conversion (UC) of near-infrared radiation to visible light has received much attention because of its use in the conversion of solar radiation, luminescence thermometry, biosensing, and anti-counterfeiting applications. However, the main issue hindering the successful utilization of UC is the relatively low quantum efficiency of the process. In order to design new UC systems with high quantum yield (ϕ) values, we synthesized two series of co-doped BaF single crystals with nominal concentrations of Yb (2–15 mol%)/Er (2 mol%) as well as Yb (3 mol%)/Er (2–15 mol%). The highest ϕ value of 10.0% was demonstrated for the BaF:Er (2 mol%) and Yb (3 mol%) sample under 490 W cm of 976 nm excitation. To study the natural limit of UC efficiency, quantum yield values upon direct excitation (ϕ) of the S (ϕ ≤ 26%) levels were measured. Comparison of experimental values of quantum yields to the ones obtained using Judd–Ofelt theory reveals strong quenching of the S state for all investigated compositions. In addition, we observed an unusually strong contribution of the Er:4I excited state to both UC and down-shifting luminescent processes. This contribution becomes possible due to the very low maximum phonon energy of BaF crystals (240 cm)
The Grizzly, November 19, 2015
On the Way to the Final Four • Watson Finalists Prepare for Next Steps • U-Imagine Center Offers First Course • Committee Searches for Violence Prevention Educator • International Perspective: Dealing With Graduation Concerns Abroad • Warming Up to the Challenge • Podcast Roars to Life • Preparing for Professional Life • Opinions: It\u27s On Us is Insufficient; Wellness Critics are Ill-Informed • New Era Begins for Women\u27s Basketball • Two Wrestlers Named Preseason All-Americans • Final Four Boundhttps://digitalcommons.ursinus.edu/grizzlynews/1678/thumbnail.jp
The contributions of molecular vibrations and higher triplet levels to the intersystem crossing mechanism in metal-free organic emitters.
Intense, simultaneous, room temperature phosphorescence (RTP) and thermally activated delayed fluorescence (TADF) is observed in a series of donor-acceptor-donor (D–A–D) molecules. This dual-luminescence is stronger in the “angular” isomers, compared to their “linear” regioisomers, which is consistent with an enhanced intersystem crossing (ISC) in the former. Herein, we demonstrate that the small energy gap between the triplet levels, T1-Tn, below the lowest singlet state, S1, in the “angular” regioisomers, enhances the coupling between S1 and T1 states and favors ISC and reverse ISC (rISC). This is consistent with a spin-vibronic mechanism. In the absence of this “triplet ladder”, due to the larger energy difference between T1 and Tn in the “linear” regioisomers, the ISC and rISC are not efficient. Remarkably the enhancement on the ISC rate in the “angular” regioisomers is accompanied by an increase on the rate of internal conversion (IC). These results highlight the contributions of higher triplet excited states and molecular vibronic coupling to harvest triplet states in organic compounds, and casts the TADF and RTP mechanisms into a common conceptual framework
Radio source calibration for the VSA and other CMB instruments at around 30 GHz
Accurate calibration of data is essential for the current generation of CMB
experiments. Using data from the Very Small Array (VSA), we describe procedures
which will lead to an accuracy of 1 percent or better for experiments such as
the VSA and CBI. Particular attention is paid to the stability of the receiver
systems, the quality of the site and frequent observations of reference
sources. At 30 GHz the careful correction for atmospheric emission and
absorption is shown to be essential for achieving 1 percent precision. The
sources for which a 1 percent relative flux density calibration was achieved
included Cas A, Cyg A, Tau A and NGC7027 and the planets Venus, Jupiter and
Saturn. A flux density, or brightness temperature in the case of the planets,
was derived at 33 GHz relative to Jupiter which was adopted as the fundamental
calibrator. A spectral index at ~30 GHz is given for each. Cas A,Tau A, NGC7027
and Venus were examined for variability. Cas A was found to be decreasing at
percent per year over the period March 2001 to August 2004.
In the same period Tau A was decreasing at percent per year. A
survey of the published data showed that the planetary nebula NGC7027 decreased
at percent per year over the period 1967 to 2003. Venus showed
an insignificant ( percent) variation with Venusian illumination.
The integrated polarization of Tau A at 33 GHz was found to be
percent at pa .}Comment: 13 pages, 15 figures, submitted to MNRA
The Atacama Cosmology Telescope: Extragalactic Sources at 148 GHz in the 2008 Survey
We report on extragalactic sources detected in a 455 square-degree map of the
southern sky made with data at a frequency of 148 GHz from the Atacama
Cosmology Telescope 2008 observing season. We provide a catalog of 157 sources
with flux densities spanning two orders of magnitude: from 15 to 1500 mJy.
Comparison to other catalogs shows that 98% of the ACT detections correspond to
sources detected at lower radio frequencies. Three of the sources appear to be
associated with the brightest cluster galaxies of low redshift X-ray selected
galaxy clusters. Estimates of the radio to mm-wave spectral indices and
differential counts of the sources further bolster the hypothesis that they are
nearly all radio sources, and that their emission is not dominated by
re-emission from warm dust. In a bright (>50 mJy) 148 GHz-selected sample with
complete cross-identifications from the Australia Telescope 20 GHz survey, we
observe an average steepening of the spectra between 5, 20, and 148 GHz with
median spectral indices of , , and . When the
measured spectral indices are taken into account, the 148 GHz differential
source counts are consistent with previous measurements at 30 GHz in the
context of a source count model dominated by radio sources. Extrapolating with
an appropriately rescaled model for the radio source counts, the Poisson
contribution to the spatial power spectrum from synchrotron-dominated sources
with flux density less than 20 mJy is C^{\rm Sync} = (2.8 \pm 0.3) \times
10^{-6} \micro\kelvin^2.Comment: Accepted to Ap
IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection
Funding: This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC). IS was supported by The University of Queensland Centennial and IPRS Scholarships. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
The Atacama Cosmology Telescope: A Measurement of the Cosmic Microwave Background Power Spectrum at 148 and 218 GHz from the 2008 Southern Survey
We present measurements of the cosmic microwave background (CMB) power
spectrum made by the Atacama Cosmology Telescope at 148 GHz and 218 GHz, as
well as the cross-frequency spectrum between the two channels. Our results
clearly show the second through the seventh acoustic peaks in the CMB power
spectrum. The measurements of these higher-order peaks provide an additional
test of the {\Lambda}CDM cosmological model. At l > 3000, we detect power in
excess of the primary anisotropy spectrum of the CMB. At lower multipoles 500 <
l < 3000, we find evidence for gravitational lensing of the CMB in the power
spectrum at the 2.8{\sigma} level. We also detect a low level of Galactic dust
in our maps, which demonstrates that we can recover known faint, diffuse
signals.Comment: 19 pages, 13 figures. Submitted to ApJ. This paper is a companion to
Hajian et al. (2010) and Dunkley et al. (2010
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