The influence of creative industry definitions on subsector typologies

In this conceptual article we explore the influence of creative industry definitions on subsector typologies. Based on a systematic literature review of the Creative Industries Journal, we examine alternative creative industry definitions, criteria, subsector typologies, and streams of thought. As a corollary of such a literature review, we suggest a theoretical framework – the Value/Scale matrix – which distinguishes four types of creative industries. In particular, we distinguish between creative and cultural activities as well as between creative and cultural industries. Our distinction is based on the degree of value added and the scale of operations. We conclude with a discussion of the theoretical and practical implications of such a framework.info:eu-repo/semantics/publishedVersio

A perspectiva comunicacional da oralidade e a utilização das mídias digitais (redes sociais online) para a produção e a reprodução do conhecimento tradicional: estudo da comunidade tradicional quilombola de Lajeado (Dianópolis/TO)

Orality and online social networks are means by which knowledge is produced and reproduced in traditional communities. This master's thesis is the result of interdisciplinary scientific research in the humanities area, especially in the convergence between the fields of communication and cultural anthropology. The participation of orality and digital media (specifically online social networks) on the processes of knowledge production and reproduction within the Traditional Quilombola Community of Lajeado (Dianópolis / TO) was investigated. We used the qualitative approach and the typology of exploratory-descriptive research, according to its objectives. The techniques started from socio-historical studies and from dense theories of communication and anthropology to the application of a semi-structured questionnaire of guidelines, using the google forms tool, given the pandemic condition and the interests of obtaining quick answers to the questionnaire. The main conclusions point to the greater importance, in terms of acceptance and legitimacy, of orality for the maintenance of memory and community dialogues, but that the dialogue and the demarcation of identity with society, in general, pass through the use new information and communication technologies. Thus, it can be concluded that, in the Lajeado Community, the production and reproduction of knowledge do go through generational issues, but have orality and new information and communication technologies as means of communication, which have contributed with preservation of traditional culture, specifically through the use of online social networks.A oralidade e as redes sociais on-line são meios pelos quais há produção e reprodução de conhecimento nas comunidades tradicionais. A presente dissertação de mestrado é fruto de pesquisa científica interdisciplinar na área de humanidades, especialmente na convergência entre os campos da comunicação e da antropologia cultural. Investigou-se a participação da oralidade e das mídias digitais (especificamente as redes sociais on-line) sobre os processos de produção e de reprodução do conhecimento junto à Comunidade Tradicional Quilombola de Lajeado (Dianópolis/TO). Utilizou-se da abordagem qualitativa e a tipologia de pesquisa exploratória-descritiva, segundo seus objetivos. As técnicas partiram de estudos socio históricos e das densas teorias da comunicação e da antropologia para a aplicação de um questionário semiestruturado de pautas, sendo utilizada a ferramenta google forms, dada a condição pandêmica e os interesses de se obter rápidas respostas ao questionário, inclusive com caráter censitário. As principais conclusões apontam para a maior importância, em termos de aceitação e de legitimidade, da oralidade para a manutenção da memória e dos diálogos comunitários, mas que o diálogo e a demarcação da identidade para com a sociedade, de modo geral, passam pela utilização das novas tecnologias da informação e da comunicação. Assim, conclui-se que, na Comunidade Lajeado, a produção e a reprodução do conhecimento passam sim pelas questões de ordem geracional, mas que possuem como vias de comunicação a oralidade e as novas tecnologias da informação e da comunicação, as quais vêm contribuindo com preservação da cultura tradicional, especificamente pela utilização das redes sociais on line

AS REDES SOCIAIS ON-LINE E A ORALIDADE COMO TRILHAS DE COMUNICAÇÃO PARA A PRODUÇÃO E REPRODUÇÃO DO CONHECIMENTO

This article theoretically contextualizes orality and online social networks together with the production and reproduction of traditional knowledge from traditional communities. Fundamentally, historical approaches were explored by the anthropological and sociological areas to describe the communicational aspects in question, which allows horizontally to present a discussion on the relevance of preserving the culture of traditional communities. In this sense, considerations are made about the level of importance of orality and social networks online in the community reality. The content presented here was extracted from the results of research at the master's level of the Communication and Society Course (PPGCOM / UFT) in the year 2020.Este artículo contextualiza teóricamente la oralidad y las redes sociales online junto con la producción y reproducción de conocimientos tradicionales de las comunidades tradicionales. Fundamentalmente, los enfoques históricos fueron explorados por las áreas antropológica y sociológica para describir los aspectos comunicacionales en cuestión, lo que permite presentar de manera horizontal una discusión sobre la relevancia de preservar la cultura de las comunidades tradicionales. En este sentido, se hacen consideraciones sobre el nivel de importancia de la oralidad y las redes sociales online en la realidad comunitaria. El contenido aquí presentado fue extraído de los resultados de la investigación a nivel de maestría del Curso de Comunicación y Sociedad (PPGCOM / UFT) en el año 2020.O presente artigo contextualiza teoricamente a oralidade e as redes sociais on-line junto à produção e reprodução de conhecimento tradicional de comunidades tradicionais. Permeou-se fundamentalmente, abordagens históricas pelas áreas antropológica e sociológica para descrever os aspectos comunicacionais em questão, o que permite horizontalmente apresentar uma  discussão sobre a relevância da preservação da cultura das comunidades tradicionais.   Neste sentido, faz-se considerações sobre o nivel de importância da oralidade e das redes sociais on-line na realidade comunitária. O conteúdo ora apresentado foi extraído dos resultadas de pesquisa de nível de mestrado do Curso de Comunicação e Sociedade (PPGCOM/UFT) do ano 2020

ON-LINE SOCIAL NETWORKS AND ORALITY AS COMMUNICATION TRAILS FOR THE PRODUCTION AND REPRODUCTION OF KNOWLEDGE

This article theoretically contextualizes orality and online social networks together with the production and reproduction of traditional knowledge from traditional communities. Fundamentally, historical approaches were explored by the anthropological and sociological areas to describe the communicational aspects in question, which allows horizontally to present a discussion on the relevance of preserving the culture of traditional communities. In this sense, considerations are made about the level of importance of orality and social networks online in the community reality. The content presented here was extracted from the results of research at the master's level of the Communication and Society Course (PPGCOM / UFT) in the year 2020

The influence of the surgical approach concerning dislocation in total hip arthroplasty

OBJETIVO: Avaliar a ocorrência de luxação nas artroplastias totais do quadril não cimentadas, comparando-se os acessos posterior e lateral direto. Métodos: Estudo retrospectivo comparativo com 232 pacientes submetidos à artroplastia total do quadril não cimentada, por diagnóstico de osteoartrose primária e secundária, sendo 105 submetidos ao acesso posterior e 127 ao acesso lateral. O modelo protético utilizado foi único, assim como o protocolo de reabilitação e cuidados pós-operatórios. Foram verificados ocorrência de luxação, posicionamento acetabular e componentes utilizados. RESULTADOS: Ocorreu um caso isolado de luxação no grupo do acesso lateral direto (0,8%) contra 0% no grupo de pacientes submetidos ao acesso posterior, sem diferença significativa (p = 1). A luxação ocorreu em uma paciente de 47 anos de idade, que foi tratada com redução incruenta sem recidiva da luxação após três anos e um mês de seguimento. O tempo de seguimento dos dois grupos variou entre seis e 42 meses, com média de 23,7 meses. CONCLUSÃO: Os autores concluem que a prevalência de luxação nas artroplastias totais do quadril é similar nos dois acessos estudados e que medidas educativas, técnica cirúrgica adequada e utilização de próteses com offsets maiores podem diminuir o risco dessa complicação.OBJECTIVES: Our primary aim was to evaluate the occurrence of dislocation of non-cemented total hip arthroplasty, when using the posterior and the direct lateral approaches. METHODS: We performed a comparative retrospective study with 232 patients submitted to non-cemented total hip arthroplasty, due to the diagnosis of primary or secondary osteoarthritis. The posterior approach was used in 105 patients while direct lateral approach was used in 127 patients. There was only one prosthesis model and the same rehabilitation program and post-operative care was used for all patients. We checked the occurrence of dislocation, the acetabular positioning and also the size of the components. RESULTS: There was only one case of dislocation, treated with closed reduction successfully. This was a 47 year-old female, submitted to direct lateral approach. The mean follow-up time for both groups was 23.7 months, ranging from six to 42 months. Conclusion: The authors conclude that the prevalence of total hip arthroplasty dislocation is similar for both approaches, and educational measures besides the use of a higher femoral offset seem to reduce the risk of this complication

Cofilin-1 is a mechanosensitive regulator of transcription

The mechanical properties of the extracellular environment are interrogated by cells and integrated through mechanotransduction. Many cellular processes depend on actomyosin-dependent contractility, which is influenced by the microenvironment's stiffness. Here, we explored the influence of substrate stiffness on the proteome of proliferating undifferentiated human umbilical cord-matrix mesenchymal stem/stromal cells. The relative abundance of several proteins changed significantly by expanding cells on soft (∼3 kPa) or stiff substrates (GPa). Many such proteins are associated with the regulation of the actin cytoskeleton, a major player of mechanotransduction and cell physiology in response to mechanical cues. Specifically, Cofilin-1 levels were elevated in cells cultured on soft comparing with stiff substrates. Furthermore, Cofilin-1 was de-phosphorylated (active) and present in the nuclei of cells kept on soft substrates, in contrast with phosphorylated (inactive) and widespread distribution in cells on stiff. Soft substrates promoted Cofilin-1-dependent increased RNA transcription and faster RNA polymerase II-mediated transcription elongation. Cofilin-1 is part of a novel mechanism linking mechanotransduction and transcription.publishe

Uso de materiales reciclabes en la construcción de equipos de irrigación

A agricultura irrigada proporciona empregos, aumento da produção, produtividade e rentabilidade agrícola das culturas. Entretanto, os sistemas de irrigação, em especial os pressurizados, demandam energia elétrica e componentes que apresentam um determinado custo, dificultando sua utilização em áreas cultivadas de menor escala ou em condições de escassez de recursos. Assim, dentre as alternativas atuais para minimizar as despesas com os sistemas de irrigação, destaca-se o uso de equipamentos sustentáveis feitos com material mais acessível e reciclável. Esses dispositivos, por serem de elaboração mais simples, podem ser utilizados em hortas comunitárias e escolares, melhorando a produtividade de pequenos cultivos. Desta forma, este trabalho visa apresentar irrigadores sustentáveis construídos a partir de um projeto de extensão e apresentados em um curso de extensão ministrado na VI Semana do Livro e da Biblioteca da Universidade Estadual Paulista (UNESP), Campus de Tupã.  Irrigated agriculture provides jobs, increases production, productivity and crop yields. However, irrigation systems, especially the pressurized ones, demand electric power and expensive components, that hinders their use in small-scale cultivated areas or in situations of resources scarcity. Thus, the use of sustainable equipment made of accessible and recyclable material is one of the current alternatives to minimize expenses with irrigation systems. These devices are simple to make and can be used in community and school gardens, improving the productivity of small crops. In this way, this work aims to present sustainable irrigators developed by students of the extension project denominated “Equipment made with recyclable materials” and presented in an extension course taught at the VI Book and Library Week of the Universidade Estadual Paulista (UNESP), Campus of Tupã, with the participation of students, employees and the community of the same institution. La agricultura de regadío proporciona empleos, aumento de la producción, productividad e rentabilidad agrícola. Sin embargo, los sistemas de irrigación, en especial los presurizados, necesitan de energía eléctrica y componentes costosos, dificultando su uso en áreas cultivadas de pequeña escala o en situaciones de escasez de recursos. Así, entre las alternativas actuales para minimizar los gastos con los sistemas de irrigación, se destaca el uso de equipamientos sustentables hechos con material más accesible y reciclable. Estos dispositivos, por ser de elaboración más simple, pueden ser utilizados en jardines de vegetales comunitarios y escolares, mejorando la productividad de pequeños cultivos. De esta forma, este trabajo tiene por objetivo presentar irrigadores sustentables desarrollados a partir de un proyecto de extensión denominado “Equipos hechos con materiales reciclables” y presentados en un curso de extensión impartido en la VI Semana del Libro y de la Biblioteca de la Universidad Paulista (UNESP) Campus de Tupã, con la participación de estudiantes, empleados y la comunidad local de esta misma institución.

Uso de materiales reciclabes en la construcción de equipos de irrigación

A agricultura irrigada proporciona empregos, aumento da produção, produtividade e rentabilidade agrícola das culturas. Entretanto, os sistemas de irrigação, em especial os pressurizados, demandam energia elétrica e componentes que apresentam um determinado custo, dificultando sua utilização em áreas cultivadas de menor escala ou em condições de escassez de recursos. Assim, dentre as alternativas atuais para minimizar as despesas com os sistemas de irrigação, destaca-se o uso de equipamentos sustentáveis feitos com material mais acessível e reciclável. Esses dispositivos, por serem de elaboração mais simples, podem ser utilizados em hortas comunitárias e escolares, melhorando a produtividade de pequenos cultivos. Desta forma, este trabalho visa apresentar irrigadores sustentáveis construídos a partir de um projeto de extensão e apresentados em um curso de extensão ministrado na VI Semana do Livro e da Biblioteca da Universidade Estadual Paulista (UNESP), Campus de Tupã.  Irrigated agriculture provides jobs, increases production, productivity and crop yields. However, irrigation systems, especially the pressurized ones, demand electric power and expensive components, that hinders their use in small-scale cultivated areas or in situations of resources scarcity. Thus, the use of sustainable equipment made of accessible and recyclable material is one of the current alternatives to minimize expenses with irrigation systems. These devices are simple to make and can be used in community and school gardens, improving the productivity of small crops. In this way, this work aims to present sustainable irrigators developed by students of the extension project denominated “Equipment made with recyclable materials” and presented in an extension course taught at the VI Book and Library Week of the Universidade Estadual Paulista (UNESP), Campus of Tupã, with the participation of students, employees and the community of the same institution. La agricultura de regadío proporciona empleos, aumento de la producción, productividad e rentabilidad agrícola. Sin embargo, los sistemas de irrigación, en especial los presurizados, necesitan de energía eléctrica y componentes costosos, dificultando su uso en áreas cultivadas de pequeña escala o en situaciones de escasez de recursos. Así, entre las alternativas actuales para minimizar los gastos con los sistemas de irrigación, se destaca el uso de equipamientos sustentables hechos con material más accesible y reciclable. Estos dispositivos, por ser de elaboración más simple, pueden ser utilizados en jardines de vegetales comunitarios y escolares, mejorando la productividad de pequeños cultivos. De esta forma, este trabajo tiene por objetivo presentar irrigadores sustentables desarrollados a partir de un proyecto de extensión denominado “Equipos hechos con materiales reciclables” y presentados en un curso de extensión impartido en la VI Semana del Libro y de la Biblioteca de la Universidad Paulista (UNESP) Campus de Tupã, con la participación de estudiantes, empleados y la comunidad local de esta misma institución.

WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma

Glioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT6, an activator of this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated in GBM. WNT6 levels were silenced or overexpressed in GBM cells to assess functional effects in vitro and in vivo. Phospho-kinase arrays and TCF/LEF reporter assays were used to identify WNT6-signaling pathways, and significant associations with stem cell features and cancer-related pathways were validated in patients. Survival analyses were performed with Cox regression and Log-rank tests. Meta-analyses were used to calculate the estimated pooled effect. Results: We show that WNT6 is significantly overexpressed in GBMs, as compared to lower-grade gliomas and normal brain, at mRNA and protein levels. Functionally, WNT6 increases typical oncogenic activities in GBM cells, including viability, proliferation, glioma stem cell capacity, invasion, migration, and resistance to temozolomide chemotherapy. Concordantly, in in vivo orthotopic GBM mice models, using both overexpressing and silencing models, WNT6 expression was associated with shorter overall survival, and increased features of tumor aggressiveness. Mechanistically, WNT6 contributes to activate typical oncogenic pathways, including Src and STAT, which intertwined with the WNT pathway may be critical effectors of WNT6-associated aggressiveness in GBM. Clinically, we establish WNT6 as an independent prognostic biomarker of shorter survival in GBM patients from several independent cohorts. Conclusion: Our findings establish WNT6 as a novel oncogene in GBM, opening opportunities to develop more rational therapies to treat this highly aggressive tumor.FCT - Foundation for Science and Technology (PTDC/SAU-GMG/113795/2009 and IF/00601/2012 to B.M.C.; SFRH/BD/92786/2013 to C.S.G.; SFRH/BD/88121/2012 to J.V.C.; SFRH/BD/81042/2011 to M.P.; SFRH/BD/93443/2013 to S.Q.) and Fundação Calouste Gulbenkian (B.M.C.), by FEDER funds through the Operational Programme Competitiveness Factors - COMPETE and National Funds through FCT under the project POCI-01-0145-FEDER-007038; by the project NORTE-01-0145-FEDER-000013 and NORTE-01-0246-FEDER-000012, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); and by the project NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER)info:eu-repo/semantics/publishedVersio

Impact of EGFR genetic variants on glioma risk and patient outcome

B.M. Costa and M. Viana-Pereira contributed equally to this work; The authors thank the Immunochemotherapy Department of Hospital S. Marcos, and Clinica Laboratorial Dr. Edgar Botelho Moniz, S. Tirso, Portugal, for their helpful assistance in the management of controlsBACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide polymorphisms in the essential promoter region, -216G/T and -191C/A, and a polymorphic (CA)(n) microsatellite sequence in intron 1. We aimed to elucidate the roles of these EGFR polymorphisms in glioma susceptibility and prognosis. METHODS: We conducted a case-control study with 196 patients with glioma and 168 cancer-free controls. Unconditional multivariate logistic regression models were used to calculate ORs and 95% confidence intervals. A Cox regression model was used to evaluate associations with patient survival. False-positive report probabilities were also assessed. RESULTS: None of the EGFR -216G/T variants was significantly associated with glioma risk. The -191C/A genotype was associated with higher risk for glioma when the (CA)(n) alleles were classified as short for ≤16 or ≤17 repeats. Independently of the (CA)(n) repeat cutoff point used, shorter (CA)(n) repeat variants were significantly associated with increased risk for glioma, particularly glioblastoma and oligodendroglioma. In all tested models with different (CA)(n) cutoff points, only -191C/A genotype was consistently associated with improved survival of patients with glioblastoma. CONCLUSIONS: Our findings implicate EGFR -191C/A and the (CA)(n) repeat polymorphisms as risk factors for gliomas, and suggest -191C/A as a prognostic marker in glioblastoma. Impact: Our data support a role of these EGFR polymorphisms in determining glioma susceptibility, with potential relevance for molecularly based stratification of patients with glioblastoma for individualized therapies.Schering-Plough Farma, PortugalFundação para a Ciência e a Tecnologia (FCT) - SFRH/BPD/33612/2009; SFRH/BD/29145/200