379 research outputs found
AKARI observations of ice absorption bands towards edge-on young stellar objects
To investigate the composition and evolution of circumstellar ice around low-mass young stellar objects (YSOs), we observed ice absorption bands in the near infrared (NIR) towards eight YSOs ranging from class 0 to class II, among which seven are associated with edge-on disks. We performed slit-less spectroscopic observations using the grism mode of the InfraRed Camera (IRC) on board AKARI, which enables us to obtain full NIR spectra from 2.5 mu m to 5 mu m, including the CO2 band and the blue wing of the H2O band, which are inaccessible from the ground. We developed procedures to carefully process the spectra of targets with nebulosity. The spectra were fitted with polynomial baselines to derive the absorption spectra. The molecular absorption bands were then fitted with the laboratory database of ice absorption bands, considering the instrumental line profile and the spectral resolution of the grism dispersion element. Towards the class 0-I sources (L1527, IRC-L1041-2, and IRAS 04302), absorption bands of H2O, CO2, CO, and XCN are clearly detected. Column density ratios of CO2 ice and CO ice relative to H2O ice are 21-28% and 13-46%, respectively. If XCN is OCN-, its column density is as high as 2-6% relative to H2O ice. The HDO ice feature at 4.1 mu m is tentatively detected towards the class 0-I sources and HV Tau. Non-detections of the CH-stretching mode features around 3.5 mu m provide upper limits to the CH3OH abundance of 26% (L1527) and 42% (IRAS 04302) relative to H2O. We tentatively detect OCS ice absorption towards IRC-L1041-2. Towards class 0-I sources, the detected features should mostly originate in the cold envelope, while CO gas and OCN-could originate in the region close to the protostar, where there are warm temperatures and UV radiation. We detect H2O ice band towards ASR41 and 2MASSJ 1628137-243139, which are edge-on class II disks. We also detect H2O ice and CO2 ice towards HV Tau, HK Tau, and UY Aur, and tentatively detect CO gas features towards HK Tau and UY Aur
Parental perspectives on ECEC settings that foster child well-being: A comparison across nine European countries
Parents play a vital role in identifying childrenâs needs for support and Early Childhood Education and Care
(ECEC ) features that support childrenâs well -being.This study examined parental perspectives on features of ECEC that foster young childrenâs well -being under and above the age of 3 years by interviewing 359 parents across nine European countries (England, Finland, Germany, Greece, Italy, the Netherlands, Norway, Poland, and Portugal).
Results revealed that parental perspectives largely converged with quality features discussed in ECEC research. Process quality features were mentioned more frequently than structural features for all children 0- to 6-years-old in almost all countries. However, care -oriented features were mentioned more frequently for under 3 years, and educational-oriented features were mentioned more frequently for the older group. Regarding structural features, patterns of responses across the two age groups were similar in most countries. Age differences were not more pronounced in countries with a split governance system.info:eu-repo/semantics/publishedVersio
Effectiveness and cost-effectiveness of a nurse-delivered intervention to improve adherence to treatment for HIV : a pragmatic, multicentre, open-label, randomised clinical trial
This trial was funded from public money by the Netherlands Organisation for Health Research and Development (ZonMW; grant number 171002208). Aardex provided support on the development of the study website. We thank all the HIV nurses and physicians from the seven HIV clinics involved in the AIMS study for their input and collaboration (Academic Medical Centre, Slotervaart hospital, and St. Lucas-Andreas hospital, all in Amsterdam; the Leiden University Medical Centre, Leiden; HAGA hospital, The Hague; Erasmus Medical Centre, Rotterdam; and Isala clinic, Zwolle), the study participants, and the Stichting HIV Monitoring (SHM) for their support in accessing the SHM database for identifying patient inclusion criteria and developing the Markov model. Finally, we thank and remember Herman Schaalma (deceased) for his contribution to the study design and grant application.Peer reviewedPostprin
Parental perspectives on ECEC settings that foster child well-being: a comparison across nine European countries
Parents play a vital role in identifying childrenâs needs for support and Early Childhood Education and Care (ECEC) features that support childrenâs well-being. This study examined parental perspectives on features of ECEC that foster young childrenâs well-being under and above the age of 3 years by interviewing 359 parents across nine European countries (England, Finland, Germany, Greece, Italy, the Netherlands, Norway, Poland, and Portugal). Results revealed that parental perspectives largely converged with quality features discussed in ECEC research. Process quality features were mentioned more frequently than structural features for all children 0- to 6-years-old in almost all countries. However, care-oriented features were mentioned more frequently for under 3 years, and educational-oriented features were mentioned more frequently for the older group. Regarding structural features, patterns of responses across the two age groups were similar in most countries. Age differences were not more pronounced in countries with a split governance system.publishedVersio
Ice chemistry in massive Young Stellar Objects: the role of metallicity
We present the comparison of the three most important ice constituents
(water, CO and CO2) in the envelopes of massive Young Stellar Objects (YSOs),
in environments of different metallicities: the Galaxy, the Large Magellanic
Cloud (LMC) and, for the first time, the Small Magellanic Cloud (SMC). We
present observations of water, CO and CO2 ice in 4 SMC and 3 LMC YSOs (obtained
with Spitzer-IRS and VLT/ISAAC). While water and CO2 ice are detected in all
Magellanic YSOs, CO ice is not detected in the SMC objects. Both CO and CO2 ice
abundances are enhanced in the LMC when compared to high-luminosity Galactic
YSOs. Based on the fact that both species appear to be enhanced in a consistent
way, this effect is unlikely to be the result of enhanced CO2 production in
hotter YSO envelopes as previously thought. Instead we propose that this
results from a reduced water column density in the envelopes of LMC YSOs, a
direct consequence of both the stronger UV radiation field and the reduced
dust-to-gas ratio at lower metallicity. In the SMC the environmental conditions
are harsher, and we observe a reduction in CO2 column density. Furthermore, the
low gas-phase CO density and higher dust temperature in YSO envelopes in the
SMC seem to inhibit CO freeze-out. The scenario we propose can be tested with
further observations.Comment: accepted by MNRAS Letters; 5 pages, 3 figures, 1 tabl
Infrared spectroscopy of solid CO-CO2 mixtures and layers
The spectra of pure, mixed and layered CO and CO2 ices have been studied
systematically under laboratory conditions using infrared spectroscopy. This
work provides improved resolution spectra (0.5 cm-1) of the CO2 bending and
asymmetric stretching mode, as well as the CO stretching mode, extending the
existing Leiden database of laboratory spectra to match the spectral resolution
reached by modern telescopes and to support the interpretation of the most
recent data from Spitzer. It is shown that mixed and layered CO and CO2 ices
exhibit very different spectral characteristics, which depend critically on
thermal annealing and can be used to distinguish between mixed, layered and
thermally annealed CO-CO2 ices. CO only affects the CO2 bending mode spectra in
mixed ices below 50K under the current experimental conditions, where it
exhibits a single asymmetric band profile in intimate mixtures. In all other
ice morphologies the CO2 bending mode shows a double peaked profile, similar to
that observed for pure solid CO2. Conversely, CO2 induces a blue-shift in the
peak-position of the CO stretching vibration, to a maximum of 2142 cm-1 in
mixed ices, and 2140-2146 cm-1 in layered ices. As such, the CO2 bending mode
puts clear constraints on the ice morphology below 50K, whereas beyond this
temperature the CO2 stretching vibration can distinguish between initially
mixed and layered ices. This is illustrated for the low-mass YSO HH46, where
the laboratory spectra are used to analyse the observed CO and CO2 band
profiles and try to constrain the formation scenarios of CO2.Comment: Accepted in A&
Cost-effectiveness of healthy eating and/or physical activity promotion in pregnant women at increased risk of gestational diabetes mellitus: Economic evaluation alongside the DALI study, a European multicenter randomized controlled trial
Background: Gestational diabetes mellitus (GDM) is associated with perinatal health risks to both mother and offspring, and represents a large economic burden. The DALI study is a multicenter randomized controlled trial, undertaken to add to the knowledge base on the effectiveness of interventions for pregnant women at increased risk for GDM. The purpose of this study was to evaluate the cost-effectiveness of the healthy eating and/or physical activity promotion intervention compared to usual care among pregnant women at increased risk of GDM from a societal perspective. Methods: An economic evaluation was performed alongside a European multicenter-randomized controlled trial. A total of 435 pregnant women at increased risk of GDM in primary and secondary care settings in nine European countries, were recruited and randomly allocated to a healthy eating and physical activity promotion intervention (HE + PA intervention), a healthy eating promotion intervention (HE intervention), or a physical activity promotion intervention (PA intervention). Main outcome measures were gestational weight gain, fasting glucose, insulin resistance (HOMA-IR), quality adjusted life years (QALYs), and societal costs. Results: Between-group total cost and effect differences were not significant, besides significantly less gestational weight gain in the HE + PA group compared with the usual care group at 35-37 weeks ( 2.3;95%CI:-3.7;-0.9). Cost-effectiveness acceptability curves indicated that the HE + PA intervention was the preferred intervention strategy. At 35-37 weeks, it depends on the decision-makers\u27 willingness to pay per kilogram reduction in gestational weight gain whether the HE + PA intervention is cost-effective for gestational weight gain, whereas it was not cost-effective for fasting glucose and HOMA-IR. After delivery, the HE + PA intervention was cost-effective for QALYs, which was predominantly caused by a large reduction in delivery-related costs. Conclusions: Healthy eating and physical activity promotion was found to be the preferred strategy for limiting gestational weight gain. As this intervention was cost-effective for QALYs after delivery, this study lends support for broad implementation
Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein e-deficient mice
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