Approche pour l'identification des causes de la mauvaise décantation des solides biologiques

Les procédés d'épuration biologique à culture libre (boues activées) comprennent habituellement un décanteur qui permet de concentrer les solides biologiques en vue de leur recirculation en tête du réacteur biologique. Lorsque ce décanteur fonctionne mal on observe une perte de solides biologiques (SB), ce qui se traduit par une augmentation de la concentration des matières en suspension (MES) dans l'effluent du décanteur secondaire et par une baisse des performances du procédé d'épuration. Lorsque la concentration de MES dans l'effluent du décanteur secondaire est trop élevée on mesure l'indice de volume des boues (IVB). Un IVB faible indique que les solides biologiques ont de bonnes caractéristiques de décantation de sorte que la cause de la mauvaise efficacité du décanteur est d'ordre physique et peut être identifiée facilement. Lorsque l'IVB est élevé, la mauvaise décantation est alors causée par un désordre de l'écosystème qui se traduit le plus souvent par une croissance excessive d'organismes filamenteux. Les causes et les solutions d'un tel problème sont alors difficiles à identifier. Pour ce travail, les auteurs ont réalisé une importante revue bibliographique dont les résultats sont présentés sous la forme d'un cheminement critique (fig. 1). Dans cette figure, les cases numérotées de 1 à 48 sont liées par des énoncés logiques. Ainsi, en répondant à des questions simples, il est possible de cheminer dans la figure 1 et d'identifier les causes les plus probables du déséquilibre microbiologique ainsi que les solutions qui ont déjà été apportées avec succès. De plus les auteurs ont associé à chaque case une fiche technique (portant le même numéro que la case) sur laquelle sont présentées des explications et la liste des références consultées.Activated sludge is a microbiological aerated sewage treatment process which includes a secondary clarifier to separate the treated effluent from the biological solids. Part of the concentrated solids is recirculated to maintain an adequate concentration of mixed liquor suspended solids (MLSS) In the aerated basin. When the secondary clarifier malfunctions, some biological solids are lost to the effluent : the process efficiency drops and the concentration of suspended solids (SS) increases. When the SS in the effluent is too high the sludge volume index (SVI) must be measured. A low SVI means that the biological solids have good sedimentation characteristics : the problem is thon physical in nature and is easily identified. When the SVI is high, the problem is due to a disturbance of the microbiological ecosystem, which is at the origin of excessive filamentous organism growth. The origins and solutions of such a problem are much harder to find. To this end the authors proceeded with an important review of the literature, the results of which are summarized through a critical path, in figure 1. Files from 1 to 48 are linked by logical statements in such a way that by answering simple questions, one can proceed through the files and identify the must probable cause of the biological disturbance as well as the solution which has already proven successful. Furthermore, the authors have linked each file to a technical file which bears the same number and on which an explanation and references are found.Before proceeding with figure 1 to identify a problem in real life, one must obtain information, resulting from an analysis and observations, with regard to plant effluent, primary clarifier effluent and activated sludge characteristics, including the MLSS concentration. One must also know the chemical oxygen demand (COD), the soluble and total biochemical oxygen demand (BOD5), as well as the nitrogen and phosphorus concentrations in the plant influent. Furthermore, one must also be told of the presence of toxic material or industrial wastes in the sewage and of the fraction of pollution load which is in the form of particulates. Whether sudden changes in the quality of the plant influent have occurred is worth knowing. The concentration of oxygen or hydrogen sulfide in the primary clarifier is also important. One must also gather data related to the activated sludge treatment itself : type of reactor (completely mixed or plug flow), mixed liquor volatile suspended solids (MLVSS) concentration, dissolved oxygen concentration, rate of oxygen uptake and pH. Finally, the results of a microbiological analysis of the sludge are very useful.To illustrate the use of figure 1, let us say that we have the following data :a) Many filamentous microorganisms are present in the MLSS, in particular Microthrix parvicella, type 0092, and Thiothrix sp;b) The rate of dissolved oxygen uptake is 12 mg O2/g of SS - h;c) The rate of COD removal is 0,48 Kg/Kg of SS -d;d) There are no toxic substances in the plant influent;e) There are no abrupt changes in plant influent quality;f) The pHs of the plant influent and of the MLSS are 7,0 and 6,8 respectively;g) The ammonia nitrogen concentration of the plant influent is 1,2 mg/L (N);h) The phosphorus concentration of the plant influent is 4,4 mg/L (P);i) The total and soluble BOD5 concentrations of the plant influent are 400 and 80 mg/L respectively.With this information, we are ready to proceed through figure 1. From file one, one goes to file 2, since the rate of oxygen uptake is sufficient. Otherwise, we would have proceeded to file 32. The reactor being completely mixed, the next step is file 3, where it is said that, because of the low soluble BOD5 concentration one must go to file 9, where we find a fast of filamentous microarganisms which may be responsible for the disturbance. Since two of these microorganisms are effectively present in the mixed liquor suspended solids (MLSS), Microthrox parvicella and type 0092, we are invited to go to file 35, where it is stated that someone has already solved a similar problem by creating a modified contact zone to increase the substrats (organic matter) concentration around the microbiological flocs. The third filamentous microorganism is not identified in file 9. As a second possibility one may assume, in file 2. That the mixing is not complete, which is often the case. With the help of information and results of analyses already available, we proceed, through file 4, 14, 15 and 16, to file 20 where Thiothrixsp is included in the microorganisms listed. File 20 is linked to file 41, where it is said that the controlled addition of nitrogen in the plant influent has already been used to solve this type of problem.The critical path presented in this article is the result of an elaborate study. It may be used as a tool to identify the causes of bad biological flocs sedimentation in the secondary clarifier and select solutions that have already been used successfully

Results of the BiPo-1 prototype for radiopurity measurements for the SuperNEMO double beta decay source foils

The development of BiPo detectors is dedicated to the measurement of extremely high radiopurity in $^{208}$Tl and $^{214}$Bi for the SuperNEMO double beta decay source foils. A modular prototype, called BiPo-1, with 0.8 $m^2$ of sensitive surface area, has been running in the Modane Underground Laboratory since February, 2008. The goal of BiPo-1 is to measure the different components of the background and in particular the surface radiopurity of the plastic scintillators that make up the detector. The first phase of data collection has been dedicated to the measurement of the radiopurity in $^{208}$Tl. After more than one year of background measurement, a surface activity of the scintillators of $\mathcal{A}$($^{208}$Tl) $=$ 1.5 $\mu$Bq/m$^2$ is reported here. Given this level of background, a larger BiPo detector having 12 m$^2$ of active surface area, is able to qualify the radiopurity of the SuperNEMO selenium double beta decay foils with the required sensitivity of $\mathcal{A}$($^{208}$Tl) $<$ 2 $\mu$Bq/kg (90% C.L.) with a six month measurement.Comment: 24 pages, submitted to N.I.M.

A conceptual framework for interprofessional shared decision making in home care: Protocol for a feasibility study

<p>Abstract</p> <p>Background</p> <p>Shared decision making (SDM) is fundamental to informed consent and client-centered care. So far, SDM frameworks have been limited to the client-physician dyad, even though care is increasingly delivered by interprofessional (IP) teams. IP collaboration is especially essential in home care, one of health care's most rapidly growing areas. This study will assess whether it is possible to practice SDM in IP home care.</p> <p>Methods/Design</p> <p>We will use a qualitative case study and a quantitative survey to capture the macro, meso and micro levels of stakeholders in home care. The case study will follow the knowledge-to-action process framework to evaluate the work of an IP home care team at a Quebec City health center. Sources of data will include one-on-one interviews with patients, family caregivers or surrogates and significant others, and administrators; a focus group of home care health professionals; organizational documents; and government policies and standards. The interview guide for the interviews and the focus group will explore current practices and clinical problems addressed in home care; factors that could influence the implementation of the proposed IP approach to SDM; the face and content validity of the approach; and interventions to facilitate the implementation and evaluation of the approach. The survey will ask 300 health professionals working in home care at the health center to complete a questionnaire based on the Theory of Planned Behaviour that measures their intentions to engage in an IP approach to SDM. We will use our analysis of the individual interviews, the focus group and the survey to elaborate a toolkit for implementing an IP approach to SDM in home care. Finally, we will conduct a pilot study in Alberta to assess the transferability of our findings.</p> <p>Discussion</p> <p>We believe that developing tools to implement IP SDM in home care is essential to strengthening Canada's healthcare system and furthering patient-centered care. This study will contribute to the evaluation of IP SDM delivery models in home care. It will also generate practical, policy-oriented knowledge regarding the barriers and facilitators likely to influence the practice of IP SDM in home care.</p

New Trends in Beverage Packaging Systems: A Review

New trends in beverage packaging are focusing on the structure modification of packaging materials and the development of new active and/or intelligent systems, which can interact with the product or its environment, improving the conservation of beverages, such as wine, juice or beer, customer acceptability, and food security. In this paper, the main nutritional and organoleptic degradation processes of beverages, such as oxidative degradation or changes in the aromatic profiles, which influence their color and volatile composition are summarized. Finally, the description of the current situation of beverage packaging materials and new possible, emerging strategies to overcome some of the pending issues are discussed

NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels

Short-chain quinones are described as potent antioxidants and in the case of idebenone have already been under clinical investigation for the treatment of neuromuscular disorders. Due to their analogy to coenzyme Q10 (CoQ10), a long-chain quinone, they are widely regarded as a substitute for CoQ10. However, apart from their antioxidant function, this provides no clear rationale for their use in disorders with normal CoQ10 levels. Using recombinant NAD(P)H:quinone oxidoreductase (NQO) enzymes, we observed that contrary to CoQ10 short-chain quinones such as idebenone are good substrates for both NQO1 and NQO2. Furthermore, the reduction of short-chain quinones by NQOs enabled an antimycin A-sensitive transfer of electrons from cytosolic NAD(P)H to the mitochondrial respiratory chain in both human hepatoma cells (HepG2) and freshly isolated mouse hepatocytes. Consistent with the substrate selectivity of NQOs, both idebenone and CoQ1, but not CoQ10, partially restored cellular ATP levels under conditions of impaired complex I function. The observed cytosolic-mitochondrial shuttling of idebenone and CoQ1 was also associated with reduced lactate production by cybrid cells from mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) patients. Thus, the observed activities separate the effectiveness of short-chain quinones from the related long-chain CoQ10 and provide the rationale for the use of short-chain quinones such as idebenone for the treatment of mitochondrial disorders

Obinutuzumab versus Rituximab in young patients with advanced DLBCL, a PET-guided and randomized phase 3 study by LYSA.

Rituximab plus polychemotherapy is standard of care in diffuse large B-cell lymphoma (DLBCL). GAINED trial compares obinutuzumab to rituximab. GAINED (NCT01659099) is an open-label, randomized phase 3 trial. Transplant-eligible patients (18-60yrs) with untreated aged-adjusted international prognostic index (aaIPI) ≥1 DLBCL were randomized (1:1) between obinutuzumab or rituximab. Patients were stratified by aaIPI (1; 2-3) and chemotherapy regimen (ACVBP; CHOP). Consolidation treatment was determined according to response assessed by centrally reviewed interim semi-quantitative PET. Responders after cycle 2 and 4 (PET2-/PET4-) received planned immuno-chemotherapy consolidation. Responders only after cycle 4 (PET2+/4-) received highdose methotrexate plus transplantation. The primary objective was an 8% improvement (HR=0.73; 80% power; alpha risk 2.5%; one-sided) in 2-year event-free survival (EFS) in the obinutuzumab arm. Events included death, progression, PET 2 or 4 positivity, modification of planned treatment. From September 20, 2012, 670 patients were enrolled (obinutuzumab n=336; rituximab n=334). 383 (57.2%) were aaIPI 2-3, 339 (50.6%) received CHOP and 324 (48.4%) received ACVBP. Median follow-up was 38.7 months. The 2-year EFS were similar in obinutuzumab and rituximab groups (59.8% vs 56.6%; p=0.123; HR=0.88). The 2-year PFS in the whole cohort was 83.1% (95%CI 80–85.8). PET2-/4- and PET2+/4- had similar 2-year PFS and OS (89.9% vs 83.9%) and 94.8% vs 92.8%). The 2-year PFS and OS for PET4+ patients were 62% and 83.1%. Grade 3-5 infections were more frequent in the obinutuzumab arm (21% vs 12%). Obinutuzumab is not superior to rituximab in untreated aaIPI≥1 DLBCL transplant-eligible patients

Essential thrombocythemia

Essential thrombocythemia (ET) is an acquired myeloproliferative disorder (MPD) characterized by a sustained elevation of platelet number with a tendency for thrombosis and hemorrhage. The prevalence in the general population is approximately 30/100,000. The median age at diagnosis is 65 to 70 years, but the disease may occur at any age. The female to male ratio is about 2:1. The clinical picture is dominated by a predisposition to vascular occlusive events (involving the cerebrovascular, coronary and peripheral circulation) and hemorrhages. Some patients with ET are asymptomatic, others may experience vasomotor (headaches, visual disturbances, lightheadedness, atypical chest pain, distal paresthesias, erythromelalgia), thrombotic, or hemorrhagic disturbances. Arterial and venous thromboses, as well as platelet-mediated transient occlusions of the microcirculation and bleeding, represent the main risks for ET patients. Thromboses of large arteries represent a major cause of mortality associated with ET or can induce severe neurological, cardiac or peripheral artery manifestations. Acute leukemia or myelodysplasia represent only rare and frequently later-onset events. The molecular pathogenesis of ET, which leads to the overproduction of mature blood cells, is similar to that found in other clonal MPDs such as chronic myeloid leukemia, polycythemia vera and myelofibrosis with myeloid metaplasia of the spleen. Polycythemia vera, myelofibrosis with myeloid metaplasia of the spleen and ET are generally associated under the common denomination of Philadelphia (Ph)-negative MPDs. Despite the recent identification of the JAK2 V617F mutation in a subset of patients with Ph-negative MPDs, the detailed pathogenetic mechanism is still a matter of discussion. Therapeutic interventions in ET are limited to decisions concerning the introduction of anti-aggregation therapy and/or starting platelet cytoreduction. The therapeutic value of hydroxycarbamide and aspirin in high risk patients has been supported by controlled studies. Avoiding thromboreduction or opting for anagrelide to postpone the long-term side effects of hydrocarbamide in young or low risk patients represent alternative options. Life expectancy is almost normal and similar to that of a healthy population matched by age and sex

Sandy coastlines under threat of erosion

Sandy beaches occupy more than one-third of the global coastline(1) and have high socioeconomic value related to recreation, tourism and ecosystem services(2). Beaches are the interface between land and ocean, providing coastal protection from marine storms and cyclones(3). However the presence of sandy beaches cannot be taken for granted, as they are under constant change, driven by meteorological(4,5), geological(6) and anthropogenic factors(1,7). A substantial proportion of the world's sandy coastline is already eroding(1,7), a situation that could be exacerbated by climate change(8,9). Here, we show that ambient trends in shoreline dynamics, combined with coastal recession driven by sea level rise, could result in the near extinction of almost half of the world's sandy beaches by the end of the century. Moderate GHG emission mitigation could prevent 40% of shoreline retreat. Projected shoreline dynamics are dominated by sea level rise for the majority of sandy beaches, but in certain regions the erosive trend is counteracted by accretive ambient shoreline changes; for example, in the Amazon, East and Southeast Asia and the north tropical Pacific. A substantial proportion of the threatened sandy shorelines are in densely populated areas, underlining the need for the design and implementation of effective adaptive measures. Erosion is a major problem facing sandy beaches that will probably worsen with climate change and sea-level rise. Half the world's beaches, many of which are in densely populated areas, could disappear by the end of the century under current trends; mitigation could lessen retreat by 40%.info:eu-repo/semantics/publishedVersio