9 research outputs found
Métastases cutanées révélant un adénocarcinome bronchique
Nous rapportons le cas dâun cancer bronchique rĂ©vĂ©lĂ© par des nodules cutanĂ©s mĂ©tastatiques du cuir chevelu. Ce mode de dĂ©couverte assez frĂ©quent est souvent associĂ© Ă un mauvais pronostic. Cette observation souligne lâintĂ©rĂȘt de rechercher un cancer primitif pulmonaire en cas de localisation secondaire cutanĂ©e.English abstractWe report the case of bronchial carcinoma revealed by metastatic skin nodules on the scalp. This fairly common mode of discovery is often associated with poor prognosis. This study aims to underline the importance of directing the search for a primary lung cancer in cases of secondary skin involvement.Key words: Cutaneous metastases, bronchial adenocarcinoma, excisional biops
Textilome abdominal: Ă propos d'un cas
Le textilome est une complication postopĂ©ratoire trĂšs rare mais bien connue. Il peut s'agir d'un corps Ă©tranger composĂ© de compresse(s) ou champ(s) chirurgicaux laissĂ©s au niveau d'un foyer opĂ©ratoire. La dĂ©couverte du textilome abdominale est gĂ©nĂ©ralement tardive. L'anamnĂšse est donc essentielle pour diagnostic vu que la clinique n'est pas concluante. La clinique associe des troubles chroniques du transit Ă des syndromes sub-occlusifs, le clichĂ© d'abdomen sans prĂ©paration est peu contributif. LâĂ©chographie est fiable. La tomodensitomĂ©trie permet un diagnostic topographique prĂ©cis. Certaines Ă©quipes proposent des explorations par IRM. Nous rapportons un cas de textilome intra abdominale, chez une patiente opĂ©rĂ©e 6 mois auparavant d'un fibrome utĂ©rin
Bee venom: a case of effectiveness on skin varicosities veins with review of its dermatological benefits
Bee venom is a very rich and varied biochemical complex, which explains the multitude of its physiological effects as well as its medical indications. In dermatology, apart from psoriasis, few studies have been conducted concerning its interest and effectiveness; however the preliminary results remain so promising and encouraging. We present a clinical case illustrating the efficacy of bee venom in cutaneous varicosities, with a review of the literature of its main dermatological indications
Hepatic Metastasis Revealing a Melanoma of the Penis: Case Report
Melanoma of the penis is a rare tumor with a poor prognosis. We report the case of a 73-year-old patient with no significant medical history, admitted for deterioration of the general condition and bilateral inguinal lymph nodes. An abdominal ultrasound and thoraco-abdomino-pelvic CT (computed tomography) scan revealed metastatic liver nodules, the tumoral nature of which was confirmed by an anatomopathological examination. Further clinical examination revealed papular and ulcerated lesions of the penis located at the urethral meatus and glans penis. These lesions were biopsied and histologically assessed as melanoma. The contribution of imaging in penile tumors is generally not useful for diagnosis as clinical examination is key. However, it has its place in the assessment of locoregional and distant extension. In our case, it was the distant lesions that helped orient the diagnosis. The patient underwent immunotherapical treatment and is still alive 19 months after the diagnosis
Le condylome acuminĂ© isolĂ© de la cavitĂ© buccale : Ă propos dâun cas clinique
Introduction : Le condylome acuminĂ© est une tumeur Ă©pithĂ©liale bĂ©nigne classĂ©e parmi les infections sexuellement transmissibles. Les virus responsables des condylomes sont Ă 90 % les papillomavirus muqueux de type 6 et 11 rĂ©putĂ©s Ă bas risque de cancĂ©risation. Le but de ce travail est de rappeler les aspects cliniques, histologiques et thĂ©rapeutiques du condylome acuminĂ© de la cavitĂ© buccale et de mettre la lumiĂšre sur ses voies de transmission non sexuelle. Observation : Il sâagissait dâun patient ĂągĂ© de trente ans, sans notion de pratique sexuelle bucco-gĂ©nitale, qui prĂ©sentait des lĂ©sions blanchĂątres millimĂ©triques au niveau du palais et de la commissure labiale gauche Ă©voluant depuis un an. LâexĂ©rĂšse des deux lĂ©sions palatines avait Ă©tĂ© rĂ©alisĂ©e ainsi quâune biopsie des lĂ©sions de la commissure labiale gauche complĂ©tĂ©e par une Ă©lectrocoagulation. Lâexamen histologique confirmait le diagnostic de condylome. Le suivi postopĂ©ratoire ne montrait aucune rĂ©cidive aprĂšs dix mois de surveillance. Discussion : Les condylomes buccaux sont exceptionnels et sont souvent secondaires Ă une contamination par contact sexuel direct. Cependant dâautres voies de transmission non liĂ©es aux relations sexuelles sont dĂ©crites. Le diagnostic est suspectĂ© cliniquement et confirmĂ© par lâĂ©tude histologique. Un traitement radical basĂ© sur lâexĂ©rĂšse chirurgicale avec excision ou Ă©lectrocoagulation sâimpose vu le caractĂšre hautement contagieux des lĂ©sions. Conclusion : Le condylome acuminĂ© est rarement de localisation buccale. Son diagnostic procĂšde conjointement dâun entretien mĂ©dical soigneux et de lâexamen histologique
Mucocele apendicular: a propĂłsito de un caso
Resumen: El mucocele apendicular es una entidad patolĂłgica rara, pero potencialmente peligrosa, se presenta en diferentes formas clĂnicas. Presentamos el caso de un paciente de 47 años, sin antecedentes particulares, que consulta por dolor crĂłnico en fosa ilĂaca derecha y cuya tomografĂa computarizada abdomino-pĂ©lvica muestra una masa quĂstica del apĂ©ndice que evoca un mucocele apendicular. El paciente se sometiĂł a una apendicectomĂa. El anĂĄlisis histolĂłgico de este confirmĂł el diagnĂłstico de mucocele apendicular sin cĂ©lulas malignas. El seguimiento postoperatorio fue sencillo. Abstract: Appendiceal mucocele is a rare pathological entity, but potentially dangerous, it presents in different clinical forms. We present the case of a 47-year-old patient, with no particular history, who consulted for chronic pain in the right iliac fossa and whose abdominal-pelvic computed tomography showed a cystic mass in the appendix that evokes an appendiceal mucocele. The patient underwent an appendectomy. Histological analysis of this confirmed the diagnosis of appendiceal mucocele without malignant cells. Postoperative follow-up was easy
Prevalence of resistance to integrase strand-transfer inhibitors (INSTIs) among untreated HIV-1 infected patients in Morocco
Abstract Objective The integrase strand-transfer inhibitors (INSTIs) are an important class in the arsenal of antiretroviral drugs designed to block the integration of HIV-1 cDNA into the host DNA through the inhibition of DNA strand transfer. In this study for the first time in Morocco, the complete HIV-1 integrase gene was analysed from newly diagnosed patients to evaluate the prevalence of natural polymorphisms and INSTIs resistance-associated mutations in the integrase gene. Results The 864pb IN coding region was successfully sequenced from plasma sample for 77 among 80 antiretroviral naĂŻve patients. The sequences were interpreted for drug resistance according to the Stanford algorithm. Sixty samples were HIV-1 subtype B (78%), fourteen CRF02_AG (18%), two subtype C and one subtype A. Overall 81 of 288 (28%) amino acid IN positions presented at least one polymorphism each. We found 18 (36.73%), 42 (25.76%) and 21 (27.27%) of polymorphic residues assigned to the N-Terminal Domain, Catalytic Core Domaine and the C-Terminal Domain positions respectively. Primary INSTIs resistance mutation were absent, however secondary mutations L74IM, T97A were detected in four samples (5.2%). These results demonstrate that untreated HIV-1 infected Moroccans will be susceptible to INSTIs
MOESM1 of Prevalence of resistance to integrase strand-transfer inhibitors (INSTIs) among untreated HIV-1 infected patients in Morocco
Additional file 1. Distribution of IN mutations in subtypes B and non-B in therapy-naÄĆ»ve patients. Secondary and additional mutations screened in 17 positions (V72I, T112I, S119PRTG, T124A, T125K, A128T, Q146K, M154I, K156N, V165I, V201I, I203M, T206S, S230N, D232N, V249I and C280Y) using the Stanford HIV Drug Resistance Program (Version September 23, 2016), all mutations identified in this study are likely natural polymorphisms