Víctor zuluaga gómez. territorio, religión y guerra: cauca y antioquia, 1850-1870

El maestro Víctor Zuluaga ofrece a los lectores colombianos una obra que abre fronteras en el conocimiento de la historia regional del Antiguo Caldas. Con anterioridad, sus escritos sobre la nueva historia de Pereira habían dado lugar al derrumbe de los mitos tejidos sobre la fundación de la ciudad; lo cual ha motivado incluso un revisionismo histórico en el área para tratar de escribir la historia real de los procesos de poblamiento de la zona cafetera de Occidente. En este libro, con base en pesquisas profundas en los archivos regionales, el autor consolida sus textos anteriores y dilucida de una vez por todas las polémica

“Viceversos Socio-arquitectónicos”. Tentativas metodológicas para ampliar márgenes disciplinares en Arquitectura y Sociología

El Trabajo de la Red reflexiona acerca de modos de retro-alimentar las prácticas docentes arquitectónicas y sociológicas con metodologías aparentemente exclusivas de cada una de ellas. La Red está formada por investigadores docentes y estudiantes de ambas ramas de conocimiento y acaba cristalizando en una serie de acciones para los cuales los miembros de la red son ponentes u observadores-narradores. Tras una serie de reuniones introductorias llevadas a cabo desde finales de 2013, la escenificación de los acuerdos se realizó el 6 de marzo de 2014 entorno a una mesa tapizada con la cartografía de Alicante y Murcia en el aula 4 del Politécnico IV de la UA. En ella, los ponentes fueron explicando sus propuestas mientras colocaban unos indicadores en el mapa de la región de Murcia y Alicante a la espera de adhesiones para formar grupos. Coincidiendo con el final del curso académico, las propuestas de análisis tuvieron lugar y son expuestas, resumidamente, en esta memoria de Red

Anti-Spike antibodies 3 months after SARS-CoV-2 mRNA vaccine booster dose in patients on hemodialysis: the prospective SENCOVAC study

Background: Patients on hemodialysis are at high-risk for complications derived from coronavirus disease 2019 (COVID-19). The present analysis evaluated the impact of a booster vaccine dose and breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on humoral immunity 3 months after the booster dose. Methods: This is a multicentric and prospective study assessing immunoglobulin G anti-Spike antibodies 6 and 9 months after initial SARS-CoV-2 vaccination in patients on hemodialysis that had also received a booster dose before the 6-month assessment (early booster) or between the 6- and 9-month assessments (late booster). The impact of breakthrough infections, type of vaccine, time from the booster and clinical variables were assessed. Results: A total of 711 patients [67% male, median age (range) 67 (20-89) years] were included. Of these, 545 (77%) received an early booster and the rest a late booster. At 6 months, 64 (9%) patients had negative anti-Spike antibody titers (3% of early booster and 29% of late booster patients, P =. 001). At 9 months, 91% of patients with 6-month negative response had seroconverted and there were no differences in residual prevalence of negative humoral response between early and late booster patients (0.9% vs 0.6%, P =. 693). During follow-up, 35 patients (5%) developed breakthrough SARS-CoV-2 infection. Antibody titers at 9 months were independently associated with mRNA-1273 booster (P =. 001), lower time from booster (P =. 043) and past breakthrough SARS-CoV-2 infection (P <. 001). Conclusions: In hemodialysis patients, higher titers of anti-Spike antibodies at 9 months were associated with mRNA-1273 booster, lower time from booster and past breakthrough SARS-CoV-2 infectionThe present project has been supported by Fresenius Medical Care, Diaverum, Vifor Pharma, Vircell, Fundación Renal Iñigo Álvarez de Toledo and ISCIII FEDER funds RICORS2040 (RD21/0005

Violencia, democracia y globalización

IP 1101-10-11194Incluye anexos.violence in the colombian war / Francisco Gutierrez S. --En:Seminario Peacefull Setllements in Civil Wars;(2003 : Bogotá). -- Bogotá : [s.n.], 2000. -- p. ; 28 cm.'-- organizado por Santafe Institute y la Pontificia;Universidad Javeriana -- ARTICULO(S) EN REVISTA: Institutionalizing globalwars : state transformations in;Colombia, 1978-2002 / Francisco Gutierrez. -- En: Journalof internationalaffairs. -- (Fall 2003); p. 135-152; La seguridad : dificil de abordar con democracia / FranciscoLeal Buitrago. -- En: Analisis politico. --;LIBRO(S): Nuestra guerra sin nombre : transformaciones delconflicto en Colombia / Francisco Gutierrez,;Maria Emma Wills y Gonzalo Sanchez Gomez. -- Bogotá : Grupo Editorial Norma, 2006. -- 610 p. ; 23 cm. --;(Coleccion vitral). -- ISBN 9580490570 -- DOCUMENTO(S): Criminalrebels? adiscussion of war and criminality;from the colombian experience / Francisco Gutierrez Sanin.--London : Development Research Centre, 2003. --;24 h. ; 28 cm. -- (Working paper ; no. 27). -- PONENCIA(S)ENCONGRESO: Clausewitz vindicated? : economics and;politics in the colombian war / Francisco Gutierrez Sanin.--En: Seminario Orden y Violencia (2004 :;Universidad de Yale). -- [s.l.] : Universidad de Yale, 2004. --p. ; 28 cm. -- Recruitment in a civil war : a;preliminary discussion of the colombian case / Francisco Gutierrez Sanin.'-- en: seminario Patterns of;Violence in Civil Wars (2004 : New Mexico). -- Santafe NewMexico : [s.n.], 2004. -- p. ; 28 cm. -- Organizado;No. 46 (mayo-ago. 2002); p. 58-77. -- ISSN 01214705. -- La posguerra colombiana : divagaciones sobre la;por Santafe Institute -- Heating up and cooling down : armed agencies, civilians, an the oligoloply, of;venganza, la justicia y la reconciliacion / Ivan Orozco Abad.--En: Analisis politico. -- Vol. 46 (mayo-ago.;2002); p. 78-99. -- ISSN 01214705 -- La politica internacionaldel gobierno Pastrana en tres actos / Diana;Marcela Rojas Rivas. -- En: Analisis politico. -- No. 46 (mayo'-ago. 2002);p. 100-115. -- ISSN 01214705. --;Credo, necesidad y codicia : los alimentos de la guerra /AlvaroCamacho Guizado. -- En: Analisis politico. --;No. 46 (mayo-ago. 2002); p. 137-150. -- ISSN 01214705 -- ?Guerracivil enColombia? / William Ramirez Tobon.; En: Analisis politico. -- No. 46 (mayo-ago. 2002); p. 151-163. -- ISSN01214705 -- Colombia : ?guerra;civil, guerra contra la sociedad, guerra antiterrorista oguerraambigua?/ Eduardo Pizarro Leongomez. -- En:;Analisis politico. -- No. 46 (mayo-ago. 2002); p. 164-180.--ISSN 01214705 -- La violencia en Colombia :;estudio de un proceso social, de German Guzman, Orlando Fals Borda y Eduardo Umaña Luna / Gonzalo Sanchez;Gomez. -- En: Analisis politico. -- No. 46 (mayo-ago. 2002); p.198-199. -- ISSN 01214705 -- La seguridad;nacional a la deriva : del Frente Nacional a la PosguerraFria,de Francisco Leal Buitrago / Lair Eric. -- En:;01214705

Poesías varias del siglo XVII [Manuscrito]

Ms. misceláneoTít. tomado del lomoRestos de foliación a tinta de la época en h. 1-12 (1-12), 37-45 (188-196) y 125-129 (400-409); h. 19-20, 29, 36, 52, 70-79, 84-86, 104, 112-116, 123-124 y 135 en bl.Según an. ms. de Antonio Rodríguez-Moñino, compró el ms. al librero Cayo de Miguel el 19-11-1955Contiene obras, entre otras, de Luis Vélez de Guevara, Juan Bautista de Dávila, Gabriel Bocángel, Gabriel de Bolaños, Francisco de Borja, Francisco de Calatayud y Sandoval, Valentín Antonio de Céspedes, Juan de Espinosa Medrano, Diego de Frías, Góngora, Fernando de Guzmán Mexía, Hurtado de Mendoza, Juan de Jáuregui, fray Luis de León, los Argensola, Francisco López de Zárate, Miguel Moreno, Hortensio Félix Paravicino, Juan Pérez de Montalbán, José Perez de Montoro, Francisco de Quevedo, Pedro de Robles, el comendador Román, Juan Ruiz de Alarcón, Alonso Jerónimo de Salas de Barbadillo, Diego Silva y Mendoza, Juan de Salinas, Miguel Sánchez, el conde de Villamediana, Pedro de Toledo, Francisco de la Torre y Sebil, Lópe de Veg

Novel genes and sex differences in COVID-19 severity.

Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (p = 1.3x10-22 and p = 8.1x10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (p = 4.4x10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (p = 2.7x10-8) and ARHGAP33 (p = 1.3x10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, p = 4.1x10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥ 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population