The most common causes of endodontic failure

Endodontic treatment continues to focus on chemomechanical preparation and the removal of diseased tissues in order to eradicate bacteria and avoid subsequent pathologies.In addition to creating space for obturation, mechanical preparation of the canals also makes it easier to sanitize the root canal system using irrigation solutions.The presence of iatrogenic errors occurring during treatment, such as missed diagnosis, poor access cavity shape, coronal leakage, improper mechanical debridement or irrigation, untreated canals, perforations, separated instruments, poor canal obturation, and persistence of bacteria, are all linked to less effective endodontic outcome and clinical failure.Even though endodontic treatment has a high success rate, failures do happen frequently and are typically caused by the aforementioned factors

The Hertzsprung-gap giant 31 Comae in 2013: Magnetic field and activity indicators

We have observed the giant star 31 Comae in April and May 2013 with the spectropolarimeter Narval at Pic du Midi Observatory, France. 31 Comae is a single, rapidly rotating giant with rotational period ~6.8 d and vsini ~ 67 km/s. We present measurements and discuss variability of the longitudinal magnetic field (Bl), spectral activity indicators Hα, CaII H&K, Ca II IR triplet and evolutionary status. Our future aim is to perform a Zeeman-Doppler imaging study for the sta

Congenital muscular hypotonia

IMSP Institutul Mamei şi Copilului, Departamentul Pediatrie, USMF „ Nicolae Testemiţanu”Congenital muscular hypotonia is a state of low muscle tone, often involving reduced muscle strength. Hypotonia is not a specific medical disorder, but a potential manifestation of many different diseases and disorders that affect motor nerves control by the brain or muscle strength. Recognizing hypotonia, even in early infancy, is usually relatively straightforward, but diagnosing the underlying cause can be difficult and often unsuccessful [1, 2]. The long-term effects of hypotonia on child development and later life depend primarily on the severity of the muscle weakness and the nature of the cause [4]

Monitoring of the magnetic field topology and activity of the core helium-burning giant beta Ceti in the period 2010-2013

Beta Ceti is a slowly rotating (v sin i = 3.5 kms−1) single giant. In our previous study (Tsvetkova et al. (2013)) we showed that it is in the core He-burning phase and we reconstructed two Zeeman Doppler imaging (ZDI) maps (using data from 2010 and 2011) revealing a simple large-scale magnetic field structure. We concluded that the magnetic field of beta Ceti could have a fossil field origin. In addition, the study of Aurière et al. (2015) about the properties and origin of the magnetism of late-type giants, where beta Ceti was a member of that sample, revealed that this star did not follow the general trends for dynamo-generated magnetic fields. Now, we present a new ZDI map of beta Ceti and compare the new results with our previous study. This monitoring for several years of the magnetic field topology and line activity indicators variability supports our previous conclusion about the fossil field origin of the magnetic field of beta Ceti

The History of the Mysterious Eclipses of KH 15D II. Asiago, Kiso, Kitt Peak, Mt. Wilson, Palomar, Tautenburg and Rozhen Observatories, 1954-97

The unusual pre-main-sequence binary star named KH 15D undergoes remarkably deep and long-lasting periodic eclipses. Some clues about the reason for these eclipses have come from the observed evolution of the system's light curve over the last century. Here we present UBVRI photometry of KH 15D based on photographic plates from various observatories, ranging in time from 1954 to 1997. The system has been variable at the ~1 mag level since at least 1965. There is no evidence for color variations, with a typical limit of Delta(B-V) < 0.2 mag. We confirm some previously published results that were based on a smaller sample of plates: from approximately 1965 to 1990, the total flux was modulated with the 48-day orbital period of the binary, but the maximum flux was larger, the fractional variations were smaller, and the phase of minimum flux was shifted by almost a half-cycle relative to the modern light curve. All these results are consistent with the recently proposed theory that KH 15D is being occulted by an inclined, precessing, circumbinary ring.Comment: 10 pages, 3 figures, 3 tables, accepted for publication in Astronomical Journa

Ecosystem services mapping and assessment for policy- and decision-making: Lessons learned from a comparative analysis of European case studies

This paper analyses and compares a set of case studies on ecosystem services (ES) mapping and assessment with the purpose of formulating lessons learned and recommendations. Fourteen case studies were selected during the EU Horizon 2020 “Coordination and Support Action” ESMERALDA to represent different policy- and decision-making processes throughout the European Union, across a wide range of themes, biomes and scales. The analysis is based on a framework that addresses the key steps of an ES mapping and assessment process, namely policy questions, stakeholder identification and involvement, application of mapping and assessment methods, dissemination and communication and implementation. The analysis revealed that most case studies were policy-orientated or gave explicit suggestions for policy implementation in different contexts, including urban, rural and natural areas. Amongst the findings, the importance of starting stakeholder engagement early in the process was confirmed in order to generate interest and confidence in the project and to increase their willingness to cooperate. Concerning mapping and assessment methods, it was found that the integration of methods and results is essential for providing a comprehensive overview from different perspectives (e.g. social, economic). Finally, lessons learned for effective implementation of ES mapping and assessment results are presented and discussed

Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a double blind, phase III randomized clinical trial in healthy Serbian adults

This study was a phase III, multicenter, double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a seasonal trivalent split, inactivated influenza vaccine (TIV) in healthy Serbian adults between the ages of 18 and 65 years. This egg-based vaccine was manufactured by the Institute of Virology, Vaccines and Sera, Torlak, Belgrade, Serbia. A total of 480 participants were assigned randomly in a ratio of 2:1 to receive a single intramuscular dose (0.5 ml) of the vaccine (15 µg of hemagglutinin per strain) or placebo (phosphate-buffered saline). Participants were monitored for safety, including solicited and unsolicited adverse events (AEs) and serious adverse events (SAEs). No SAEs related to vaccination were reported. Injection site pain (51.3%), injection site tenderness (40.4%), tiredness (17.0%), and headache (15.1%) were the most commonly reported solicited events in the vaccine group. Incidence of related unsolicited AEs was low (1.3%) among vaccinees. Hemagglutinin inhibition (HAI) titers were measured before and 21 days after vaccination in 151 participants. Overall, HAI seroconversion rates to H1 and H3 were observed in 90.1% and 76.2% of vaccinees, respectively. For B antigen, it was 51.5%, likely due to high pre-vaccination titers. Post-vaccination seroprotection rates were in the range of 78.2–95.0% for the three antigens. Post-vaccination geometric mean titers (GMT) were at least 3.8 times higher than baseline levels for all the three strains among vaccinees. Overall, the study showed that the vaccine was safe and well tolerated, and induced a robust immune response against all three vaccine strains., ClinicalTrials.gov identifier: NCT02935192, October 17, 201

Magnetic field variability in RZ Ari - an evolved M giant

International audienceRZ Ari is a fast rotating apparently single M giant of 2.2 Msun. It is fairly evolved to tip RGB or early AGB stage. In addition, the star is known as semi-regular variable. We have studied its longitudinal magnetic field variability using spectropolarimetric data obtained with Narval at Telescope Bernard Lyot, Pic du Midi Observatory, France in the period 2008 - 2018. Two periods were identified using the Lomb - Scargle method: 1310 days and 498 days. The second one is very close to the Long Secondary Period of RZ Ari (480 days) and maybe we observe for first time an interplay of the magnetic field and pulsations for a M giant. Taking into account literature data we determined the radius of the star (117.2 Rsun) that is consistent with the AGB phase. Our work hypothesis is that RZ Ari with its fast rotation is an intermediate case of dynamo generated magnetic field and shock wave compression generated fields as we observe in Miras. These stars are the next evolutionary stage, after early-AGB stars. Further study is required to confirm or reject the hypothesis and to understand better the interplay of the magnetic field and pulsation in this fairly evolved giant