287 research outputs found

    Differential Transfer Ionization Cross Sections for 50175-keV Proton-Helium Collisions

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    We have measured coincidences between neutralized projectiles and He recoil ions for 50175-keV proton-helium collisions. From the data we obtained transfer ionization (TI) cross sections differential in the projectile scattering angle. Laboratory scattering angles range from 0 to 2.0 mrad. The experimental method allowed separation of the postcollision charge states of the target atoms. The ratio of the cross sections for TI to the sum of TI and single capture, F, is presented as a function of projectile scattering angle. Comparison is made to previous measurements of this ratio where data is available. The differential cross sections are compared to dynamical classical trajectory Monte Carlo (dCTMC) calculations. Agreement in the shape of the differential cross sections is good between the theory and measurement over the entire energy range

    Effect of polymer-entwined reduced graphene oxide laminates on the performance and stability of forward osmosis membranes for water desalination

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    Layered graphene oxide (GO) membranes have been widely employed for water desalination in forward osmosis (FO) systems, however, the balance between performance and long-term stability of membranes is still a trade-off in the practical application. A newly developed laminar GO-based FO membrane was prepared by a two-step protocol, including acid treatment of GO before crosslinking and reduction of GO by hyperbranched polyethylenimine (HPEI), and followed by coating HPEI-reduced graphene oxide (HPEI:rGO) laminates by polyethylene glycol (PEG). It is suggested that the long-chain and amino-enrichment HPEI polymer can be covalently bonded with the acid-treated GO at elevated temperatures. This chemical process partially removed oxygen-containing functional groups of GO and formed a nanocomposite structure with tuned interlaminar spacing for better selectivity of NaCl ions. Subsequently, the infiltration of PEG molecules through the HPEI-rGO structure improved the hydrophilicity, and hence the water permeability across the PEI60k:rGO/PEG membrane. In this study, the resultant membrane exhibited water flux of 7.7 LMH, salt rejection efficiency of 97.9 %, and low reverse solute flux of 0.56 gMH in an FO filtration process. Also, synergistic effects of the double-polymer modification reinforced enhancement of dimensional integrity and durability of the membrane structure in both ionic and harsh conditions

    Transitory electrochemical masking for precision jet processing techniques

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    Electrochemical jet processing techniques provide an efficient method for large area surface structuring and micro-milling, where the metallurgy of the near-surface is assured and not adversely affected by thermal loading. Here, doped electrolytes are specifically developed for jet techniques to exploit the Gaussian energy distribution as found in energy beam processes. This allows up to 26% reduction in dissolution kerf and enhancements of the defined precision metric of up to 284% when compared to standard electrolytes. This is achieved through the filtering of low energy at discrete points within the energy distribution curve. Two fundamental mechanisms of current filtering and refresh rate are proposed and investigated in order to underpin the performance enhancements found using this methodology. This study aims to demonstrate that a step change in process fidelity and flexibility can be achieved through optimisation of the electrochemistry specific to jet processes

    Effects of selective serotonin reuptake inhibitor treatment on plasma oxytocin and cortisol in major depressive disorder

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    Background: Oxytocin is known for its capacity to facilitate social bonding, reduce anxiety and for its actions on the stress hypothalamopituitary adrenal (HPA) axis. Since oxytocin can physiologically suppress activity of the HPA axis, clinical applications of this neuropeptide have been proposed in conditions where the function of the HPA axis is dysregulated. One such condition is major depressive disorder (MDD). Dysregulation of the HPA system is the most prominent endocrine change seen with MDD, and normalizing the HPA axis is one of the major targets of recent treatments. The potential clinical application of oxytocin in MDD requires improved understanding of its relationship to the symptoms and underlying pathophysiology of MDD. Previous research has investigated potential correlations between oxytocin and symptoms of MDD, including a link between oxytocin and treatment related symptom reduction. The outcomes of studies investigating whether antidepressive treatment (pharmacological and non-pharmacological) influences oxytocin concentrations in MDD, have produced conflicting outcomes. These outcomes suggest the need for an investigation of the influence of a single treatment class on oxytocin concentrations, to determine whether there is a relationship between oxytocin, the HPA axis (e.g., oxytocin and cortisol) and MDD. Our objective was to measure oxytocin and cortisol in patients with MDD before and following treatment with selective serotonin reuptake inhibitors, SSRI. Method: We sampled blood from arterial plasma. Patients with MDD were studied at the same time twice; pre- and post- 12 weeks treatment, in an unblinded sequential design (clinicaltrials.govNCT00168493). Results: Results did not reveal differences in oxytocin or cortisol concentrations before relative to following SSRI treatment, and there were no significant relationships between oxytocin and cortisol, or these two physiological variables and psychological symptom scores, before or after treatment. Conclusions: These outcomes demonstrate that symptoms of MDD were reduced following effective treatment with an SSRI, and further, stress physiology was unlikely to be a key factor in this outcome. Further research is required to discriminate potential differences in underlying stress physiology for individuals with MDD who respond to antidepressant treatment, relative to those who experience treatment resistance.Charlotte Keating, Tye Dawood, David A Barton, Gavin W Lambert and Alan J Tilbroo
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