Nitrate Respiration in Thermus thermophilus NAR1: from Horizontal Gene Transfer to Internal Evolution.

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Prevalencia de los trastornos musculoesqueléticos más frecuentes en los odontólogos. Revisión bibliográfica

Introducción: Los trastornos musculoesqueléticos (TME) constituyen uno de los problemas de salud ocupacional más prevalentes en nuestra sociedad, siendo la causa más importante de discapacidad global. La odontología es una profesión que no se encuentra exenta de este riesgo ergonómico, y de acuerdo con lo establecido en la Ley 31/1995 de 8 de noviembre de Prevención de Riesgos Laborales (LPRL), será fundamental la protección y prevención de estos riesgos para garantizar la salud y seguridad de estos profesionales. Objetivos: Determinar los principales problemas musculoesqueléticos en los odontólogos y proponer determinadas intervenciones de fisioterapia para disminuirlos. Material y métodos: Se realizó una búsqueda bibliográfica en los motores de búsqueda PubMed, Scopus, Web of Science, Cochrane Library, PEDro, de aquellos artículos descriptivos trasversales publicados en los últimos 11 años. Resultados: Los trastornos musculoesqueléticos relacionados con la zona lumbar fueron los más prevalentes, seguido de los relacionados con la región del cuello, hombro, dorsal, cadera y glúteo, muñeca y mano y por último el síndrome del túnel carpiano (STC). Conclusiones: El dolor lumbar es el principal factor que contribuye a la carga general de trastornos musculoesqueléticos. La evidencia científica demuestra que el ejercicio terapéutico es efectivo para disminuir o prevenir los efectos sobre la salud de los odontólogos, sin embargo, serán necesarios más estudios que investiguen este tipo de trastornos en estos profesionales y se establezcan programas de intervención que permitan a este colectivo mantener su salud durante el ejercicio de su profesión.Introduction: Musculoskeletal disorders (MSDs) are one of the most prevalent occupational health problems in our society, being the most important cause of global disability. Odontology is a profession that isn´t exempt from these ergonomic risk factors, and according with the provisions of Law 31/1995 of 8 November on the Prevention of Occupational Risks (LPRL), the protection and prevention of these risks will be essential to guarantee the health and safety of these professionals. Objectives: Determine the main musculoskeletal problems in odontologists and proposing certain physiotherapy interventions to reduce them. Material and methods: A bibliographic search was carried out in the search engines PubMed, Scopus, Web of Science, Cochrane Library, PEDro, for descriptive cross-sectional articles published in the last 11 years. Results: Musculoskeletal disorders related to the lower back were the most prevalent, followed by those related to the neck, shoulder, dorsal, hip and gluteus región, wrist and hand and finally carpal tunnel syndrome (CTS). Conclusions: Low back pain is the main factor contributing to the overall burden of musculoskeletal disorders. The scientific evidence shows that therapeutic exercise is effective in reducing or preventing the effects on the health of odontologists, however, more studies are needed to investigate this type of disorders in odontologists and the establishment of intervention programmes that allow this group to maintain their health during the performance of their profession

Complete Genome Sequence of Mycolicibacterium hassiacum DSM 44199

Mycolicibacterium hassiacum is the most thermophilic of all the mycobacteria. A partial sequence based on Illumina technology of around 5 Mbp was published in 2012. Here, we report the 5,269,097-bp complete genome sequence assembled into a single circular chromosome.post-print117 K

Análisis de los golpes ganadores y errores en pádel profesional

The objective of the study was to analyze the winning shots and the errors in professional padel. A total of 1.927 hits were recorded in the Madrid Master Finals tournament of the official circuit of the World Pádel Tour 2021, both for men and women. Variables such as the effectiveness of the hit, the area of the court, the type of hit, the type of point and the result of the match were taken into account. The 8 best couples of the male and female professional padel ranking (N=32) were evaluated. The results according to the type of shot showed that spikes and volleys are the shots with the highest percentage of winning points, while groundstrokes and lobs obtained the highest percentage of errors. Also, the net zone is where a higher number of winners occur, with the winning pair getting 20% more winners than errors. Finally, the type of point does not seem to influence the effectiveness of the hit. These data can serve as a reference for coaches and players in the design of exercises and preparation of strategies and tactics in competition. El objetivo de estudio fue analizar los golpes ganadores y los errores en pádel profesional. Se registraron 1.927 golpes correspondientes al Master Final de Madrid del circuito oficial World Pádel Tour 2021, tanto en categoría masculina como femenina. Se tuvieron en cuenta las siguientes variables: eficacia del golpe, la zona de pista, el tipo de golpe, el tipo de punto y el resultado del partido. Se evaluaron las 8 mejores parejas del ranking de pádel profesional masculino y femenino (N=32). Los resultados mostraron que, los remates y las voleas son los golpes con mayor porcentaje de puntos ganadores, mientras que los golpes de fondo y los globos obtuvieron mayor porcentaje de errores. Además, la zona de red es donde se produce un número mayor de golpes ganadores, mientras que la pareja ganadora obtiene un 20 % más de golpes ganadores que de errores. Finalmente, el tipo de punto no parece influir en la eficacia del golpe. Estos datos pueden servir de referencia a entrenadores y jugadores en el diseño de ejercicios y preparación de estrategias y tácticas en la competición

Into the Thermus Mobilome: Presence, Diversity and Recent Activities of Insertion Sequences Across Thermus spp.

: A high level of transposon-mediated genome rearrangement is a common trait among microorganisms isolated from thermal environments, probably contributing to the extraordinary genomic plasticity and horizontal gene transfer (HGT) observed in these habitats. In this work, active and inactive insertion sequences (ISs) spanning the sequenced members of the genus Thermus were characterized, with special emphasis on three T. thermophilus strains: HB27, HB8, and NAR1. A large number of full ISs and fragments derived from different IS families were found, concentrating within megaplasmids present in most isolates. Potentially active ISs were identified through analysis of transposase integrity, and domestication-related transposition events of ISTth7 were identified in laboratory-adapted HB27 derivatives. Many partial copies of ISs appeared throughout the genome, which may serve as specific targets for homologous recombination contributing to genome rearrangement. Moreover, recruitment of IS1000 32 bp segments as spacers for CRISPR sequence was identified, pointing to the adaptability of these elements in the biology of these thermophiles. Further knowledge about the activity and functional diversity of ISs in this genus may contribute to the generation of engineered transposons as new genetic tools, and enrich our understanding of the outstanding plasticity shown by these thermophiles.post-print2.276 K

PSA Response to Lenalidomide Therapy in a Pre-Treated Patient with Metastatic Prostate Cancer Refractory to Hormones and Chemotherapy: A Case Report

Hormone-resistant prostate cancer (HRPC) occurs when prostate cancer is no longer responsive to hormone therapy. Treatment options are limited, and there is a clear necessity for therapies that improve outcome. Preclinical and clinical evidence supports the role of the immunomodulatory agent lenalidomide in HRPC. In this paper, we report that lenalidomide showed antitumoral activity in a patient with HRPC and bone metastases pre-treated with chemotherapy, decreased the PSA level and improved the patient's health status for the first 5 months. It is important to emphasize that it was not associated with hematologic toxicity

Una competición de algoritmos y estructuras de datos

La asignatura “Algoritmos y estructuras de datos III” se imparte en segundo curso de la Escuela y Facultad de Informática de la Universidad Politécnica de Valencia. La asignatura tiene una carga lectiva de seis créditos, que se dividen en cuatro de teoría y problemas y dos de prácticas en el laboratorio. Las prácticas de la asignatura son fundamentales para la consecución de los objetivos de la asignatura. En esta línea, adicionalmente a la propuesta de prácticas de la asignatura (estrechamente relacionadas con los contenidos teóricos), se ha puesto en marcha este curso académico un Concurso de algoritmos con el fin de incentivar al alumnado en la realización de las prácticas. En esta comunicación se describirá la aplicación que se planteó en el concurso, las herramientas implementadas para el seguimiento, el contraste de resultados y las medidas de tiempos puestas a disposición de los alumnos, así como los resultados conseguidos

Differences in breast cancer risk after benign breast disease by type of screening diagnosis

Neoplàsies de mama; Detecció precoç del càncer; Factors de riscNeoplasias de mama; Detección precoz del cáncer; Factores de riesgoBreast neoplasms; Early cancer detection; Risk factorsIntroduction: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. Materials and methods: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or roliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer. Results: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value ¼ 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24e3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57e2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09e9.08, and 3.35; 95%CI: 1.51e7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95e2.93, and 1.63; 95%CI: 1.32e2.02 for those diagnosed at incident and prevalent screens, respectively). Conclusion: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosisThis study was supported by grants from Instituto de Salud Carlos III FEDER (grant numbers: PI15/00098 and PI17/00047), and by the Research Network on Health Services in Chronic Diseases (RD12/0001/0015

Control biológico en árboles ornamentales y cítricos

[ES] En este documento se detallan algunas de las plagas más importantes presentes en árboles ornamentales y en el cultivo de los cítricos en diferentes localidades de España. Las especies que se analizan son pulgones, psila, trips y pseudocóccidos en Ficus nitida, pulgones en Jacaranda mimosifolia y piojo rojo de California en Citrus sinensis. Se han detallado también los principales enemigos naturales encontrados en estas plagas, tanto parasitoides como depredadores, tratando de establecer con detalle las cadenas tróficas que se establecen entre la planta y los insectos.Laborda Cenjor, R.; Rodrigo Santamalia, ME.; Xamani Monserrat, P.; Galan Blesa, J.; Sanchez Domingo, A. (2013). Control biológico en árboles ornamentales y cítricos. Rafael Laborda Cenjor. http://hdl.handle.net/10251/54936

APP-derived peptides reflect neurodegeneration in frontotemporal dementia

Altres ajuts: The Catalan frontotemporal initiative (CATFI) is funded by the Health Department of the Government of Catalonia (grant PERIS SLT002/16/00408 to Alberto Lleó and Raquel Sánchez-Valle). This work was also supported by research grants from the CIBERNED Program (Program 1, Alzheimer Disease to Alberto Lleó and SIGNAL study, file://www.signalstudy.es), partly funded by Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, "Una manera de hacer Europa." This work has also been supported by a "Marató TV3" grant (20141210 to Juan Fortea, 044412 to Rafael Blesa, 20143710 to Ricard Rojas-García and 20143810 to Raquel Sánchez-Valle) and Fundación BBVA (grant to A. Lleó) and a grant from the Fundació Bancaria La Caixa to Rafael Blesa. Ignacio Illán-Gala and Sergi Borrego-Écija are supported by the Rio Hortega grant from "Acción estratégica en Salud 2013-2016" and the European Social Fund. Ignacio Illán-Gala is supported by the Global Brain Health Institute (Atlantic Fellow for Equity in Brain Health). We acknowledge all the participants in this study and all the collaborators of the SPIN cohort. We also acknowledge Soraya Torres and Laia Muñoz for technical assistance. We thank EUROIMMUN for providing Aβ1-38 and Aβ1-40 ELISA assays for this study.Objective: We aimed to investigate the relationship between cerebrospinal fluid levels (CSF) of amyloid precursor protein (APP)-derived peptides related to the amyloidogenic pathway, cortical thickness, neuropsychological performance, and cortical gene expression profiles in frontotemporal lobar degeneration (FTLD)-related syndromes, Alzheimer's disease (AD), and healthy controls. Methods: We included 214 participants with CSF available recruited at two centers: 93 with FTLD-related syndromes, 57 patients with AD, and 64 healthy controls. CSF levels of amyloid β (Aβ)1-42, Aβ1-40, Aβ1-38, and soluble β fragment of APP (sAPPβ) were centrally analyzed. We compared CSF levels of APP-derived peptides between groups and, we studied the correlation between CSF biomarkers, cortical thickness, and domain-specific cognitive composites in each group. Then, we explored the relationship between cortical thickness, CSF levels of APP-derived peptides, and regional gene expression profile using a brain-wide regional gene expression data in combination with gene set enrichment analysis. Results: The CSF levels of Aβ1-40, Aβ1-38, and sAPPβ were lower in the FTLD-related syndromes group than in the AD and healthy controls group. CSF levels of all APP-derived peptides showed a positive correlation with cortical thickness and the executive cognitive composite in the FTLD-related syndromes group but not in the healthy control or AD groups. In the cortical regions where we observed a significant association between cortical thickness and CSF levels of APP-derived peptides, we found a reduced expression of genes related to synaptic function. Interpretation: APP-derived peptides in CSF may reflect FTLD-related neurodegeneration. This observation has important implications as Aβ1-42 levels are considered an indirect biomarker of cerebral amyloidosis