Plenary Session II – Mobility Track: When the Wheels Fall Off

This session captures the consumer experience throughout the transition process, their struggle to maintain control and solutions to help them preserve independence and identity

Examining Louisiana state university college of agriculture students’ perceived motivators and barriers to participation in international experiences

© 2015, Assoc. Int. Agricultural and Extension Education. All rights reserved. In an effort to internationalize higher education and produce globally competent professionals, many universities have increased the time and financial assets put toward promoting an international experience (IE). Research supports using an IE to supplement international education efforts and help students develop the global perspective and experience needed to succeed in the workplace. The purpose of this study was to determine College of Agriculture (CoA) students’ perceptions of IE participation, and identify factors that CoA students perceived as barriers and motivators to participation in an IE. CoA students were interested in an IE. Overall life experience was identified as the most agreed motivator, and financial cost was identified as the most agreed barrier. No differences were found in perceived motivators or barriers of CoA students based on academic status. University faculty should encourage students who have participated in an IE to provide presentations and workshops to other CoA students. Further, presentations should focus on overall life experiences students gained from their IE participation, and should be informal in nature to allow for peer-to-peer discussion. This study should be replicated at other peer and regional universities for comparison, and a longitudinal study could be conducted to identify trends over time. Differences in gender and major regarding barriers and motivators should also be examined

Long-term geomorphic adjustments following the recoupling of a tributary to its main-stem river

River restoration and rehabilitation projects are widespread, but rarely include the data needed to fully evaluate if they are successful in achieving their goals or how long the process of readjustment takes before a new ‘recovered’ regime state is reached. Here we present a seven-year post-project dataset detailing the morpho-sedimentary responses of a river to the reconnection of a formerly diverted tributary, and relate observed changes to conditions in the river prior to the reconnection. We describe changes in the tributary and main-stem channels, including changes in channel planform, morphology, and the export of coarse and fine sediment from the tributary to the main-stem river. We use the data to develop a conceptual model of the system's response to the reconnection. Marked geomorphic changes occurred within the first two years after the reconnection. Changes during this ‘shock phase’ included dramatic erosion and subsequent deepening and widening of the tributary channel, rapid development of a confluence bar and an increase in fine sediment delivered to the main-stem. After this shock phase, and despite the continued occurrence of high magnitude flow events, the rate of geomorphic change in the tributary began to decrease, and the rate of growth of the confluence bar slowed. Fine sediment volumes in the main-stem also decreased steadily. After an adjustment phase lasting a total of approximately 4.5 yr (including the initial 2-yr shock phase), the tributary to mainstem system appeared to reach a new dynamic equilibrium that we consider the adjusted regime state. This new regime state was characterised by, among other things, an increase in geomorphic heterogeneity in the tributary and main-stem channels. Changes in both fluvial processes and forms indicate that within 4.5 yr the project was successful in achieving its goal of augmenting sediment and increasing geomorphic heterogeneity. Our conceptual model of adjustment mirrors that developed by Petts and Gurnell (2005), with the river passing through a complex and dynamic adjustment phase before reaching a new regime state. However, unlike the responses to impoundment represented by Petts and Gurnell, our model of river response to rehabilitation charts increases in dynamism and heterogeneity.The research presented in this paper has been supported by a number of organisations. We thank United Utilities (UU) and the Environment Agency (EA) for funding and support. In particular, we thank Kat Liney and Alice Senior from UU, and Gez Foster and Jane Atkins from EA. Part of this research benefited from the methods and outcomes of the MorphHab (PID2019-104979RB-I00/AEI/10.13039/501100011033) research project. B. Marteau's contribution was in part supported by a postdoctoral fellowship from the EUR H2O'Lyon (ANR-17-EURE-0018). D. Vericat is a Serra Húnter Fellow at the University of Lleida. We are also grateful to the reviewers and editor for their comments that improved the manuscript

Adipose tissue attenuation and adipocyte size

Objective: To assess the ability of CT-derived measurements including adipose tissue attenuation and area to predict fat cell hypertrophy and related cardiometabolic risk. Methods: Abdominal adipose tissue areas and radiologic attenuation were assessed using 4 CT images in 241 women (age: 47 years, BMI: 26.5 kg/m2). Fat cell weight was measured in paired VAT and SAT samples. Fasting plasma lipids, glucose and insulin levels were measured. Results: Adipose tissue attenuation was negatively correlated with SAT (r=-0.46) and VAT (r=-0.67) fat cell weight in the corresponding depot (p<0.0001 for both). Women with visceral adipocyte hypertrophy had higher total-, VLDL-, LDL- and HDL-triglyceride and apoB levels as well as a higher cholesterol/HDL-cholesterol ratio, fasting glucose and insulin levels compared to women with smaller visceral adipocytes. Adjustment for VAT area minimized these differences while subsequent adjustment for attenuation eliminated all differences, with the exception of fasting glycaemia. In SAT, adjustment for VAT area and attenuation eliminated all adipocyte hypertrophy-related alterations except for fasting hyperglycaemia. Conclusion: CT-derived adipose tissue attenuation and area both contribute to explain variation in the cardiometabolic risk profile associated with the same biological parameter: visceral fat cell hypertrophy

Quantum plasticity and dislocation-induced supersolidity

We suggest that below a certain temperature T_k, the free energy for the creation of kinks-antikinks pairs in the dislocation network of solid He4 becomes negative. The underlying physical mechanism is the related liberation of vacancies which initiate Feynman's permutation cycles in the bulk. Consequently, dislocations should wander and sweep an increasingly larger volume at low temperatures. This phenomenon should lead both to a stiffening of the solid below T_k and to the appearance of a non zero superfluid fraction at a second temperature T_c < T_k.Comment: Longer revised version with more detailed discussion, submitted to EPJ

Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria

CDKN2A is a proven and validated biomarker of ageing which acts as an off switch for cell proliferation. We have demonstrated previously that CDKN2A is the most robust and the strongest pre-transplant predictor of post- transplant serum creatinine when compared to “Gold Standard” clinical factors, such as cold ischaemic time and donor chronological age. This report shows that CDKN2A is better than telomere length, the most celebrated biomarker of ageing, as a predictor of post-transplant renal function. It also shows that CDKN2A is as strong a determinant of post-transplant organ function when compared to extended criteria (ECD) kidneys. A multivariate analysis model was able to predict up to 27.1% of eGFR at one year post-transplant (p = 0.008). Significantly, CDKN2A was also able to strongly predict delayed graft function. A pre-transplant donor risk classification system based on CDKN2A and ECD criteria is shown to be feasible and commendable for implementation in the near future

Comparison of community-wide, integrated mass drug administration strategies for schistosomiasis and soil-transmitted helminthiasis: a cost-eff ectiveness modelling study

Background More than 1·5 billion people are aff ected by schistosomiasis or soil-transmitted helminthiasis. WHO’s recommendations for mass drug administration (MDA) against these parasitic infections emphasise treatment of school-aged children, using separate treatment guidelines for these two helminthiases groups. We aimed to evaluate the cost-eff ectiveness of expanding integrated MDA to the entire community in four settings in Côte d’Ivoire. Methods We extended previously published, dynamic, age-structured models of helminthiases transmission to simulate costs and disability averted with integrated MDA (of praziquantel and albendazole) for schistosomiasis and soil-transmitted helminthiasis. We calibrated the model to data for prevalence and intensity of species-specifi c helminth infection from surveys undertaken in four communities in Côte d’Ivoire between March, 1997, and September, 2010. We simulated a 15-year treatment programme with 75% coverage in only school-aged children; school-aged children and preschool-aged children; adults; and the entire community. Treatment costs were estimated at US$0·74 for school-aged children and$1·74 for preschool-aged children and adults. The incremental costeff ectiveness ratio (ICER) was calculated in 2014 US dollars per disability-adjusted life-year (DALY) averted. Findings Expanded community-wide treatment was highly cost eff ective compared with treatment of only school-aged children (ICER $167 per DALY averted) and WHO guidelines (ICER$127 per DALY averted), and remained highly cost eff ective even if treatment costs for preschool-aged children and adults were ten times greater than those for school-aged children. Community-wide treatment remained highly cost eff ective even when elimination of helminth infections was not achieved. These fi ndings were robust across the four diverse communities in Côte d’Ivoire, only one of which would have received annual MDA for both schistosomiasis and soil-transmitted helminthiasis under the latest WHO guidelines. Treatment every 6 months was also highly cost eff ective in three out of four communities. Interpretation Integrated, community-wide MDA programmes for schistosomiasis and soil-transmitted helminthiasis can be highly cost eff ective, even in communities with low disease burden in any helminth group. These results support an urgent need to re-evaluate current global guidelines for helminthiases control programmes to include community-wide treatment, increased treatment frequency, and consideration for lowered prevalence thresholds for integrated treatment

Publishing and sharing multi-dimensional image data with OMERO

Imaging data are used in the life and biomedical sciences to measure the molecular and structural composition and dynamics of cells, tissues, and organisms. Datasets range in size from megabytes to terabytes and usually contain a combination of binary pixel data and metadata that describe the acquisition process and any derived results. The OMERO image data management platform allows users to securely share image datasets according to specific permissions levels: data can be held privately, shared with a set of colleagues, or made available via a public URL. Users control access by assigning data to specific Groups with defined membership and access rights. OMERO’s Permission system supports simple data sharing in a lab, collaborative data analysis, and even teaching environments. OMERO software is open source and released by the OME Consortium at www.openmicroscopy.org