826 research outputs found
T-cell activation without proliferation in juvenile idiopathic arthritis
A study was done to determine if the differentiation and activation phenotype of T cells in synovial fluid (SF) from patients with juvenile idiopathic arthritis (JIA) is associated with T-cell proliferation in situ. Mononuclear cells were isolated from 44 paired samples of peripheral blood and SF. Differentiation and activation markers were determined on CD4 and CD8 T cells by flow cytometry. Cell-cycle analysis was performed by propidium iodide staining, and surface-marker expression was also assessed after culture of the T cells under conditions similar to those found in the synovial compartment. The majority of the T cells in the SF were CD45RO+CD45RBdull. There was greater expression of the activation markers CD69, HLA-DR, CD25 and CD71 on T cells from SF than on those from peripheral blood. Actively dividing cells accounted for less than 1% of the total T-cell population in SF. The presence or absence of IL-16 in T-cell cultures with SF or in a hypoxic environment did not affect the expression of markers of T-cell activation. T cells from the SF of patients with JIA were highly differentiated and expressed early and late markers of activation with little evidence of in situ proliferation. This observation refines and extends previous reports of the SF T-cell phenotype in JIA and may have important implications for our understanding of chronic inflammation
Patterns of domestication in the Ethiopian oil-seed crop noug (Guizotia abyssinica)
Noug (Guizotia abyssinica) is a semidomesticated oil-seed crop, which is primarily cultivated in Ethiopia. Unlike its closest crop relative, sunflower, noug has small seeds, small flowering heads, many branches, many flowering heads, and indeterminate flowering, and it shatters in the field. Here, we conducted common garden studies and microsatellite analyses of genetic variation to test whether high levels of cropâwild gene flow and/or unfavorable phenotypic correlations have hindered noug domestication. With the exception of one population, analyses of microsatellite variation failed to detect substantial recent admixture between noug and its wild progenitor. Likewise, only very weak correlations were found between seed mass and the number or size of flowering heads. Thus, noug's âatypicalâ domestication syndrome does not seem to be a consequence of recent introgression or unfavorable phenotypic correlations. Nonetheless, our data do reveal evidence of local adaptation of noug cultivars to different precipitation regimes, as well as high levels of phenotypic plasticity, which may permit reasonable yields under diverse environmental conditions. Why noug has not been fully domesticated remains a mystery, but perhaps early farmers selected for resilience to episodic drought or untended environments rather than larger seeds. Domestication may also have been slowed by noug's outcrossing mating syste
Mesoscopic interplay of superconductivity and ferromagnetism in ultra-small metallic grains
We review the effects of electron-electron interactions on the ground-state
spin and the transport properties of ultra-small chaotic metallic grains. Our
studies are based on an effective Hamiltonian that combines a superconducting
BCS-like term and a ferromagnetic Stoner-like term. Such terms originate in
pairing and spin exchange correlations, respectively. This description is valid
in the limit of a large dimensionless Thouless conductance. We present the
ground-state phase diagram in the fluctuation-dominated regime where the
single-particle mean level spacing is comparable to the bulk BCS pairing gap.
This phase diagram contains a regime in which pairing and spin exchange
correlations coexist in the ground-state wave function. We discuss the
calculation of the tunneling conductance for an almost-isolated grain in the
Coulomb-blockade regime, and present measurable signatures of the competition
between superconductivity and ferromagnetism in the mesoscopic fluctuations of
the conductance.Comment: 6 pages, 3 figures, To be published in the proceedings of the NATO
Advance Research Workshop "Recent Advances in Nonlinear Dynamics and Complex
System Physics.
Effect of Nuclear Quadrupole Interaction on the Relaxation in Amorphous Solids
Recently it has been experimentally demonstrated that certain glasses display
an unexpected magnetic field dependence of the dielectric constant. In
particular, the echo technique experiments have shown that the echo amplitude
depends on the magnetic field. The analysis of these experiments results in the
conclusion that the effect seems to be related to the nuclear degrees of
freedom of tunneling systems. The interactions of a nuclear quadrupole
electrical moment with the crystal field and of a nuclear magnetic moment with
magnetic field transform the two-level tunneling systems inherent in amorphous
dielectrics into many-level tunneling systems. The fact that these features
show up at temperatures , where the properties of amorphous materials
are governed by the long-range interaction between tunneling systems,
suggests that this interaction is responsible for the magnetic field dependent
relaxation. We have developed a theory of many-body relaxation in an ensemble
of interacting many-level tunneling systems and show that the relaxation rate
is controlled by the magnetic field. The results obtained correlate with the
available experimental data. Our approach strongly supports the idea that the
nuclear quadrupole interaction is just the key for understanding the unusual
behavior of glasses in a magnetic field.Comment: 18 pages, 9 figure
A radium assay technique using hydrous titanium oxide adsorbent for the Sudbury Neutrino Observatory
As photodisintegration of deuterons mimics the disintegration of deuterons by
neutrinos, the accurate measurement of the radioactivity from thorium and
uranium decay chains in the heavy water in the Sudbury Neutrino Observatory
(SNO) is essential for the determination of the total solar neutrino flux. A
radium assay technique of the required sensitivity is described that uses
hydrous titanium oxide adsorbent on a filtration membrane together with a
beta-alpha delayed coincidence counting system. For a 200 tonne assay the
detection limit for 232Th is a concentration of 3 x 10^(-16) g Th/g water and
for 238U of 3 x 10^(-16) g U/g water. Results of assays of both the heavy and
light water carried out during the first two years of data collection of SNO
are presented.Comment: 12 pages, 4 figure
Detector Description and Performance for the First Coincidence Observations between LIGO and GEO
For 17 days in August and September 2002, the LIGO and GEO interferometer
gravitational wave detectors were operated in coincidence to produce their
first data for scientific analysis. Although the detectors were still far from
their design sensitivity levels, the data can be used to place better upper
limits on the flux of gravitational waves incident on the earth than previous
direct measurements. This paper describes the instruments and the data in some
detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial
change
Search for Gravitational Waves from Primordial Black Hole Binary Coalescences in the Galactic Halo
We use data from the second science run of the LIGO gravitational-wave
detectors to search for the gravitational waves from primordial black hole
(PBH) binary coalescence with component masses in the range 0.2--.
The analysis requires a signal to be found in the data from both LIGO
observatories, according to a set of coincidence criteria. No inspiral signals
were found. Assuming a spherical halo with core radius 5 kpc extending to 50
kpc containing non-spinning black holes with masses in the range 0.2--, we place an observational upper limit on the rate of PBH coalescence
of 63 per year per Milky Way halo (MWH) with 90% confidence.Comment: 7 pages, 4 figures, to be submitted to Phys. Rev.
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt{s} = 1.96 TeV using Kinematic Characteristics of Lepton + Jets Events
We present a measurement of the top quark pair ttbar production cross section
in ppbar collisions at a center-of-mass energy of 1.96 TeV using 230 pb**{-1}
of data collected by the DO detector at the Fermilab Tevatron Collider. We
select events with one charged lepton (electron or muon), large missing
transverse energy, and at least four jets, and extract the ttbar content of the
sample based on the kinematic characteristics of the events. For a top quark
mass of 175 GeV, we measure sigma(ttbar) = 6.7 {+1.4-1.3} (stat) {+1.6- 1.1}
(syst) +/-0.4 (lumi) pb, in good agreement with the standard model prediction.Comment: submitted to Phys.Rev.Let
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt(s)=1.96 TeV using Lepton + Jets Events with Lifetime b-tagging
We present a measurement of the top quark pair () production cross
section () in collisions at TeV
using 230 pb of data collected by the D0 experiment at the Fermilab
Tevatron Collider. We select events with one charged lepton (electron or muon),
missing transverse energy, and jets in the final state. We employ
lifetime-based b-jet identification techniques to further enhance the
purity of the selected sample. For a top quark mass of 175 GeV, we
measure pb, in
agreement with the standard model expectation.Comment: 7 pages, 2 figures, 3 tables Submitted to Phys.Rev.Let
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