Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.

EBV-induced gene 3 (EBI-3) codes for a soluble type I receptor homologous to the p40 subunit of IL-12 that is expressed by APCs following activation. In this study, we assessed the role of EBI-3 in a model of lung melanoma metastasis. Intravenous injection of the B16-F10 cell line resulted in a significant reduction of lung tumor metastasis in EBI-3(-/-) recipient mice compared with wild-type mice. The immunological finding accompanying this effect was the expansion of a newly described cell subset called IFN-gamma producing killer dendritic cells associated with CD8(+) T cell responses in the lung of EBI-3(-/-) mice including IFN-gamma release and TNF-alpha-induced programmed tumor cell death. Depletion of CD8(+) T cells as well as targeting T-bet abrogated the protective effects of EBI-3 deficiency on lung melanoma metastases. Finally, adoptive transfer of EBI-3(-/-) CD8(+) T cells into tumor bearing wild-type mice inhibited lung metastasis in recipient mice. Taken together, these data demonstrate that targeting EBI-3 leads to a T-bet-mediated antitumor CD8(+) T cell responses in the lung

Impacts of Covid-19 on Norwegian salmon exports: A firm-level analysis

A rapidly growing literature investigates how the recent Covid-19 pandemic has affected international seafood trade along multiple dimensions, creating opportunities as well as challenges. This suggests that many of the impacts of the Covid measures are subtle and require disaggregated data to allow the impacts in different supply chains to be teased out. In aggregate, Norwegian salmon exports have not been significantly impacted by Covid-related measures. Using firm-level data to all export destinations to examine the effects of lockdowns in different destination countries in 2020, we show that the Covid-related lockdown measures significantly impacted trade patterns for four product forms of salmon. The results also illustrate how the Covid measures create opportunities, as increased stringency of the measures increased trade for two of the product forms. We also find significant differences among firms' responses, with large firms with larger trade networks reacting more strongly to the Covid measures. The limited overall impacts and the significant dynamics at the firm level clearly show the resiliency of the salmon supply chains.publishedVersio

High-spin structure of Xe 134

A. Vogt et al. ; 12 págs.; 9 figs.; 1 tab.Detailed spectroscopic information on the N∼82 nuclei is necessary to benchmark shell-model calculations in the region. The nuclear structure above long-lived isomers in Xe134 is investigated after multinucleon transfer (MNT) and actinide fission. Xenon-134 was populated as (i) a transfer product in Xe136+U238 and Xe136+Pb208 MNT reactions and (ii) as a fission product in the Xe136+U238 reaction employing the high-resolution Advanced Gamma Tracking Array (AGATA). Trajectory reconstruction has been applied for the complete identification of beamlike transfer products with the magnetic spectrometer PRISMA. The Xe136+Pt198 MNT reaction was studied with the γ-ray spectrometer GAMMASPHERE in combination with the gas detector array Compact Heavy Ion Counter (CHICO). Several high-spin states in Xe134 on top of the two long-lived isomers are discovered based on γγ-coincidence relationships and information on the γ-ray angular distributions as well as excitation energies from the total kinetic energy loss and fission fragments. The revised level scheme of Xe134 is extended up to an excitation energy of 5.832 MeV with tentative spin-parity assignments up to 16+. Previous assignments of states above the 7- isomer are revised. Latest shell-model calculations employing two different effective interactions reproduce the experimental findings and support the new spin and parity assignments.The research leading to these results has received funding from the German BMBF under Contract No. 05P12PKFNE TP4, from the European Union Seventh Framework Programme FP7/2007–2013 under Grant Agreement No. 262010 - ENSAR, from the Spanish Ministerio de Ciencia e Innovación under Contract No. FPA2011-29854-C04, from the Spanish Ministerio de Economía y Competitividad under Contract No. FPA2014-57196-C5, from the Bonn-Cologne Graduate School of Physics and Astronomy (BCGS), from the UK Science and Technology Facilities Council (STFC), and from the US National Science Foundation (NSF). One of the authors (A. Gadea) has been supported by the Generalitat Valenciana, Spain, under Grant No. PROMETEOII/2014/019 and EU under the FEDER program.Peer Reviewe

Isospin dependence of electromagnetic transition strengths among an isobaric triplet

Electric quadrupole matrix elements, M, for the J=2→0, ΔT=0, T=1 transitions across the A=46 isobaric multiplet Cr-V-Ti have been measured at GSI with the FRS-LYCCA-AGATA setup. This allows direct insight into the isospin purity of the states of interest by testing the linearity of M with respect to T. Pairs of nuclei in the T=1 triplet were studied using identical reaction mechanisms in order to control systematic errors. The M values were obtained with two different methodologies: (i) a relativistic Coulomb excitation experiment was performed for Cr and Ti; (ii) a “stretched target” technique was adopted here, for the first time, for lifetime measurements in V and Ti. A constant value of M across the triplet has been observed. Shell-model calculations performed within the fp shell fail to reproduce this unexpected trend, pointing towards the need of a wider valence space. This result is confirmed by the good agreement with experimental data achieved with an interaction which allows excitations from the underlying sd shell. A test of the linearity rule for all published data on complete T=1 isospin triplets is presented.Peer Reviewe

Study of Isomeric States in ^{198,200,202,206}Pb and ²⁰⁶Hg Populated in Fragmentation Reactions

Isomeric states in isotopes in the vicinity of doubly-magic 208Pb were populated following reactions of a relativistic 208Pb primary beam impinging on a 9Be fragmentation target. Secondary beams of 198;200;202;206Pb and 206Hg were isotopically separated and implanted in a passive stopper positioned in the focal plane of the GSI Fragment Separator. Delayed γ rays were detected with the Advanced GAmma Tracking Array (AGATA). Decay schemes were re-evaluated and interpreted with shell-model calculations. The momentum-dependent population of isomeric states in the two-nucleon hole nuclei 206Pb/206Hg was found to differ from the population of multi neutron-hole isomeric states in 198;200;202Pb

Quadrupole collectivity in Ca 42 from low-energy Coulomb excitation with AGATA

A Coulomb-excitation experiment to study electromagnetic properties of Ca42 was performed using a 170-MeV calcium beam from the TANDEM XPU facility at INFN Laboratori Nazionali di Legnaro. γ rays from excited states in Ca42 were measured with the AGATA spectrometer. The magnitudes and relative signs of ten E2 matrix elements coupling six low-lying states in Ca42, including the diagonal E2 matrix elements of 21+ and 22+ states, were determined using the least-squares code gosia. The obtained set of reduced E2 matrix elements was analyzed using the quadrupole sum rule method and yielded overall quadrupole deformation for 01,2+ and 21,2+ states, as well as triaxiality for 01,2+ states, establishing the coexistence of a weakly deformed ground-state band and highly deformed slightly triaxial sideband in Ca42. The experimental results were compared with the state-of-the-art large-scale shell-model and beyond-mean-field calculations, which reproduce well the general picture of shape coexistence in Ca42

Superdeformed and Triaxial States in Ca 42

Shape parameters of a weakly deformed ground-state band and highly deformed slightly triaxial sideband in ^{42}Ca were determined from E2 matrix elements measured in the first low-energy Coulomb excitation experiment performed with AGATA. The picture of two coexisting structures is well reproduced by new state-of-the-art large-scale shell model and beyond-mean-field calculations. Experimental evidence for superdeformation of the band built on 0_{2}^{+} has been obtained and the role of triaxiality in the A∼40 mass region is discussed. Furthermore, the potential of Coulomb excitation as a tool to study superdeformation has been demonstrated for the first time

Identification of high-spin proton configurations in Ba 136 and Ba 137

19 pags., 11 figs., 3 tabs.The high-spin structures of Ba136 and Ba137 are investigated after multinucleon-transfer (MNT) and fusion-evaporation reactions. Ba136 is populated in a Xe136+U238 MNT reaction employing the high-resolution Advanced GAmma Tracking Array (AGATA) coupled to the magnetic spectrometer PRISMA at the Laboratori Nazionali di Legnaro, Italy, and in two Be9+Te130 fusion-evaporation reactions using the High-efficiency Observatory for γ-Ray Unique Spectroscopy (HORUS) at the FN tandem accelerator of the University of Cologne, Germany. Furthermore, both isotopes are populated in an elusive reaction channel in the B11+Te130 fusion-evaporation reaction utilizing the HORUS γ-ray array. The level scheme above the Jπ=10+ isomer in Ba136 is revised and extended up to an excitation energy of approximately 5.5 MeV. From the results of angular-correlation measurements, the Ex=3707- and Ex=4920-keV states are identified as the bandheads of positive- and negative-parity cascades. While the high-spin regimes of both Te132 and Xe134 are characterized by high-energy 12+→10+ transitions, the Ba136E2 ground-state band is interrupted by negative-parity states only a few hundred keV above the Jπ=10+ isomer. Furthermore, spins are established for several hitherto unassigned high-spin states in Ba137. The new results close a gap along the high-spin structure of N<82 Ba isotopes. Experimental results are compared to large-scale shell-model calculations employing the GCN50:82, Realistic SM, PQM130, and SN100PN interactions. The calculations suggest that the bandheads of the positive-parity bands in both isotopes are predominantly of proton character.Furthermore, we express our thanks to Dr. E. Teruya and Dr. N. Yoshinaga from Saitama University, Japan, for providing the results of their shellmodel calculation with the PQM130 interaction. The research leading to these results has received funding from the German BMBF under Contracts No. 05P15PKFN9 TP1 and No. 05P18PKFN9 TP1, from the European Union Seventh Framework Programme FP7/2007-2013 under Grant Agreement No. 262010 - ENSAR, from the Spanish Ministerio de Ciencia e Innovación under Contract No. FPA2011-29854- C04, from the Spanish Ministerio de Economía y Competitividad under Contract No. FPA2014-57196-C5, and from the UK Science and Technology Facilities Council (STFC). L.K. and A.V. thank the Bonn-Cologne Graduate School of Physics and Astronomy (BCGS) for financial support. One of the authors (A. Gadea) has been supported by the Generalitat Valenciana, Spain, under Grant No. PROMETEOII/2014/019, and EU under the FEDER program