Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

African Agriculture and The World Bank : Development or Impoverishment?

African smallholder family farming, the backbone of the continental economy throughout the colonial and early post-colonial period, has been destabilized and eroded over the past thirty years. Despite the World Bank’s poverty alleviation concerns, agrarian livelihoods continue to unravel under the impact of economic liberalization and global value chains. Can African smallholders bounce back and compete? The World Development Report 2008 argues they can and must. How realistic is this given the history of World Bank conditionality in Africa? This essay explores the productivity and welfare concerns of Africa’s smallholder farming population in the shadow of the World Bank.CONTENTS -- World Bank Policy and the WDR 2008 -- African Development Policies over the Last 25 Years Land Rights, Markets and Capital -- Institutional Supports for African Smallholder Agriculture -- African Rural Agency in Response to Global Market Pressures -- Reading Between the Lines of the WDR 2008: African Smallholders’ Rural Future</p