Flat-spectrum radio sources as likely counterparts of unidentified INTEGRAL sources (Research Note)

Many sources in the fourth INTEGRAL/IBIS catalogue are still unidentified, since they lack an optical counterpart. An important tool that can help in identifying/classifying these sources is the cross-correlation with radio catalogues, which are very sensitive and positionally accurate. Moreover, the radio properties of a source, such as the spectrum or morphology, could provide further insight into its nature. Flat-spectrum radio sources at high Galactic latitudes are likely to be AGN, possibly associated to a blazar or to the compact core of a radio galaxy. Here we present a small sample of 6 sources extracted from the fourth INTEGRAL/IBIS catalogue that are still unidentified/unclassified, but which are very likely associated with a bright, flat-spectrum radio object. To confirm the association and to study the source X-ray spectral parameters, we performed X-ray follow-up observations with Swift/XRT. We report the results obtained from this search and discuss the nature of each source. 5 of the 6 radio associations are also detected in X-rays; in 3 cases they are the only counterpart found. IGR J06073--0024 is a flat-spectrum radio quasar at z=1.08, IGR J14488--4008 is a newly discovered radio galaxy, while IGR J18129--0649 is an AGN of a still unknown type. The nature of IGR J07225--3810 and IGR J19386--4653 is less well defined, since in both cases we find another X-ray source in the INTEGRAL error circle; nevertheless, the flat-spectrum radio source, likely to be a radio loud AGN, remains a viable and more convincing association in both cases. Only for IGR J11544--7618 could we not find any convincing counterpart since the radio association is not an X-ray emitter.Comment: 7 pages, 7 figures, accepted for publication on Astronomy and Astrophysic

IGR J14488-4008: an X-ray peculiar giant radio galaxy discovered by INTEGRAL

In this paper we report the discovery and detailed radio/X-ray analysis of a peculiar giant radio galaxy (GRG) detected by INTEGRAL, IGR J14488-4008. The source has been recently classified as a Seyfert 1.2 galaxy at redshift 0.123; the radio data denote the source to be a type II Fanaroff-Riley radio galaxy, with a linear projected size exceeding 1.5 Mpc, clearly assigning IGR J14488-4008 to the class of GRG. In the X-rays, the source shows a remarkable spectrum, characterised by absorption by ionised elements, a characteristic so far found in only other four broad line radio galaxies.Comment: 7 pages, 3 tables, 5 figures. Accepted for publication on MNRA

Inverse correlation between quasiparticle mass and Tc in a cuprate high-Tc superconductor

Close to a zero-temperature transition between ordered and disordered electronic phases, quantum fluctuations can lead to a strong enhancement of electron mass and to the emergence of competing phases such as superconductivity. A correlation between the existence of such a quantum phase transition and superconductivity is quite well established in some heavy fermion and iron-based superconductors, and there have been suggestions that high-temperature superconductivity in copper-oxide materials (cuprates) may also be driven by the same mechanism. Close to optimal doping, where the superconducting transition temperature Tc is maximal in cuprates, two different phases are known to compete with superconductivity: a poorly understood pseudogap phase and a charge-ordered phase. Recent experiments have shown a strong increase in quasiparticle mass m* in the cuprate YBa2Cu3O7-δ as optimal doping is approached, suggesting that quantum fluctuations of the charge-ordered phase may be responsible for the high-Tc superconductivity. We have tested the robustness of this correlation between m* and Tc by performing quantum oscillation studies on the stoichiometric compound YBa2Cu4O8 under hydrostatic pressure. In contrast to the results for YBa2Cu3O7-δ, we find that in YBa2Cu4O8, the mass decreases as Tc increases under pressure. This inverse correlation between m* and Tc suggests that quantum fluctuations of the charge order enhance m* but do not enhance Tc

Confirmation of six Be X-ray binaries in the Small Magellanic Cloud

The X-ray binary population of the Small Magellanic Cloud (SMC) contains a large number of massive X-ray binaries, and the recent survey of the SMC by XMM–Newton has resulted in almost 50 more tentative high-mass X-ray binary (HMXB) candidates. Using probability parameters from Haberl and Sturm together with the optical spectra and timing in this work, we confirm six new massive X-ray binaries in the SMC. We also report two very probable binary periods of 36.4 d in XMM 1859 and of 72.2 d in XMM 2300. These Be X-ray binaries are likely part of the general SMC population, which rarely undergoes an X-ray outburst.This paper is based on ESO data from 079.D−0371 and 088.D−0352. The AAT observations have been supported by the OPTICON project (observing proposals 2011A/014 and 2012/A015), which is funded by the European Commission under the Seventh Framework Programme (FP7). VAM acknowledges financial support from the National Research Foundation of South Africa (Grant 93405) and the World Universities Network. RD, AM and IN from the University of Alicante acknowledge support from the Spanish Government Ministerio de Economía y Competitividad under grant AYA2015-68012-C2-2-P (MINECO/FEDER). ESB acknowledges support from a Claude Leon Foundation fellowship and from the Marie Curie Actions of the European Commission (FP7-COFUND). The OGLE project has received funding from the National Science Centre, Poland, grant MAESTRO 2014/14/A/ST9/00121 to AU

"Did the trial kill the intervention?" experiences from the development, implementation and evaluation of a complex intervention

Background: The development, implementation and evaluation of any new health intervention is complex. This paper uses experiences from the design, implementation and evaluation of a rehabilitation programme to shed light on, and prompt discussion around, some of the complexities involved in such an undertaking. Methods: Semi-structured interviews were conducted with 15 trial participants and five members of staff at the conclusion of a trial evaluating a rehabilitation programme aimed at promoting recovery after stem cell transplantation. Results: This study identified a number of challenges relating to the development and evaluation of complex interventions. The difficulty of providing a standardised intervention that was acceptable to patients was highlighted in the participant interviews. Trial participants and some members of staff found the concept of equipoise and randomisation challenging and there was discord between the psychosocial nature of the intervention and the predominant bio-medical culture in which the research took place. Conclusions: A lack of scientific evidence as to the efficacy of an intervention does not preclude staff and patients holding strong views about the benefits of an intervention. The evaluation of complex interventions should, where possible, facilitate not restrict that complexity. Within the local environment where the trial is conducted, acquiescence from those in positions of authority is insufficient; commitment to the trial is required

The Early Royal Society and Visual Culture

Recent studies have fruitfully examined the intersection between early modern science and visual culture by elucidating the functions of images in shaping and disseminating scientific knowledge. Given its rich archival sources, it is possible to extend this line of research in the case of the Royal Society to an examination of attitudes towards images as artefacts –manufactured objects worth commissioning, collecting and studying. Drawing on existing scholarship and material from the Royal Society Archives, I discuss Fellows’ interests in prints, drawings, varnishes, colorants, images made out of unusual materials, and methods of identifying the painter from a painting. Knowledge of production processes of images was important to members of the Royal Society, not only as connoisseurs and collectors, but also as those interested in a Baconian mastery of material processes, including a “history of trades”. Their antiquarian interests led to discussion of painters’ styles, and they gradually developed a visual memorial to an institution through portraits and other visual records.AH/M001938/1 (AHRC

cAMP Response Element Binding Protein Is Required for Differentiation of Respiratory Epithelium during Murine Development

The cAMP response element binding protein 1 (Creb1) transcription factor regulates cellular gene expression in response to elevated levels of intracellular cAMP. Creb1−/− fetal mice are phenotypically smaller than wildtype littermates, predominantly die in utero and do not survive after birth due to respiratory failure. We have further investigated the respiratory defect of Creb1−/− fetal mice during development. Lungs of Creb1−/− fetal mice were pale in colour and smaller than wildtype controls in proportion to their reduced body size. Creb1−/− lungs also did not mature morphologically beyond E16.5 with little or no expansion of airway luminal spaces, a phenotype also observed with the Creb1−/− lung on a Crem−/− genetic background. Creb1 was highly expressed throughout the lung at all stages examined, however activation of Creb1 was detected primarily in distal lung epithelium. Cell differentiation of E17.5 Creb1−/− lung distal epithelium was analysed by electron microscopy and showed markedly reduced numbers of type-I and type-II alveolar epithelial cells. Furthermore, immunomarkers for specific lineages of proximal epithelium including ciliated, non-ciliated (Clara), and neuroendocrine cells showed delayed onset of expression in the Creb1−/− lung. Finally, gene expression analyses of the E17.5 Creb1−/− lung using whole genome microarray and qPCR collectively identified respiratory marker gene profiles and provide potential novel Creb1-regulated genes. Together, these results demonstrate a crucial role for Creb1 activity for the development and differentiation of the conducting and distal lung epithelium

Advances in Understanding High-Mass X-ray Binaries with INTEGRAL and Future Directions

High mass X-ray binaries are among the brightest X-ray sources in the Milky Way, as well as in nearby Galaxies. Thanks to their highly variable emissions and complex phenomenology, they have attracted the interest of the high energy astrophysical community since the dawn of X-ray Astronomy. In more recent years, they have challenged our comprehension of physical processes in many more energy bands, ranging from the infrared to very high energies. In this review, we provide a broad but concise summary of the physical processes dominating the emission from high mass X-ray binaries across virtually the whole electromagnetic spectrum. These comprise the interaction of stellar winds with the high gravitational and magnetic fields of compact objects, the behaviour of matter under extreme magnetic and gravity conditions, and the perturbation of the massive star evolutionary processes by presence in a binary system. We highlight the role of the INTEGRAL mission in the discovery of many of the most interesting objects in the high mass X-ray binary class and its contribution in reviving the interest for these sources over the past two decades. We show how the INTEGRAL discoveries have not only contributed to significantly increase the number of high mass X-ray binaries known, thus advancing our understanding of the population as a whole, but also have opened new windows of investigation that stimulated the multi-wavelength approach nowadays common in most astrophysical research fields. We conclude the review by providing an overview of future facilities being planned from the X-ray to the very high energy domain that will hopefully help us in finding an answer to the many questions left open after more than 18 years of INTEGRAL scientific observations.The INTEGRALteams in the participating countries acknowledge the continuous support from their space agencies and funding organizations: the Italian Space Agency ASI (via different agreements including the latest one, 2019-35HH, and the ASIINAF agreement 2017-14-H.0), the French Centre national d’études spatiales (CNES), the Russian Foundation for Basic Research (KP, 19-02-00790), the Russian Science Foundation (ST, VD, AL; 19-12-00423), the Spanish State Research Agency (via different grants including ESP2017-85691-P, ESP2017-87676-C5-1-R and Unidad de Excelencia María de Maeztu – CAB MDM-2017-0737). IN is partially supported by the Spanish Government under grant PGC2018-093741-B-C21/C22 (MICIU/AEI/FEDER, UE). LD acknowledges grant 50 OG 1902

Maternal depressive symptoms, and not anxiety symptoms, are associated with positive mother–child reporting discrepancies of internalizing problems in children: a report on the TRAILS Study

Maternal internalizing problems affect reporting of child’s problem behavior. This study addresses the relative effects of maternal depressive symptoms versus anxiety symptoms and the association with differential reporting of mother and child on child’s internalizing problems. The study sample comprised a cohort of 1,986 10- to 12-year-old children and their mothers from the Dutch general population in a cross sectional setup. Children’s internalizing problems were assessed with the DSM-IV anxiety and affective problem scales of the Child Behavior Checklist (CBCL) and the Youth Self-Report (YSR). Current maternal internalizing problems were assessed with the depressive and anxiety symptom scales of the Depression Anxiety Stress Scale (DASS), while the TRAILS Family History Interview (FHI) measured lifetime maternal depression and anxiety. Results show that current and lifetime maternal depressive symptoms were associated with positive mother–child reporting discrepancies (i.e. mothers reporting more problems than their child). Considering the small amount of variance explained, we conclude that maternal depressive symptoms do not bias maternal reporting on child’s internalizing problems to a serious degree. Studies concerning long term consequences of mother–child reporting discrepancies on child’s internalizing problems are few, but show a risk for adverse outcome. More prognostic research is needed