Noise Sensitivity and Diminished Health: Testing Moderators and Mediators of the Relationship

The concept of noise sensitivity emerged in public health and psychoacoustic research to help explain individual differences in reactions to noise. Noise sensitivity has been associated with health problems, but the mechanisms underlying this relationship have yet to be fully examined. Participants (n = 1102) were residents of Auckland, New Zealand, who completed questionnaires and returned them through the post. Models of noise sensitivity and health were tested in the analyses using bootstrapping methods to examine indirect effects. Results indicated that gender and noise exposure were not significant moderators in the model. Perceived stress and sleep problems were significant mediators of the relationship between noise sensitivity and subjective health complaints, even after controlling for the influence of neuroticism. However, the relationship between noise sensitivity and mental health complaints (anxiety and depression) was accounted for by the variance explained by neuroticism. Overall, this study provides considerable understanding of the relationship between noise sensitivity and health problems and identifies areas for further research in the field

Evaluating the Effectiveness of a ‘Real‐World’ Shared Reading Intervention for Preschool Children and Their Families: A Randomised Controlled Trial

Background Shared reading interventions can impact positively on preschool children's language development and on their caregiver's attitudes/behaviours towards reading. However, a number of barriers may discourage families from engaging with these interventions, particularly families from lower socio‐economic status (SES) backgrounds. We investigated how families from such backgrounds responded to an intervention designed explicitly to overcome these barriers. Methods In a preregistered cluster randomised controlled trial, 85 lower SES families and their 3‐year‐old to 4‐year‐old children from 10 different preschools were randomly allocated to take part in The Reader's Shared Reading programme (intervention) or an existing ‘Story Time’ group at a library (control) once a week for 8 weeks. Three outcome measures were assessed at baseline and post intervention: (1) attendance, (2) enjoyment of the reading groups and (3) caregivers' knowledge of, attitudes and behaviours towards reading. A fourth − children's vocabulary – was assessed at baseline and 4 weeks post intervention. Results Families were significantly more likely to attend the intervention group and rated it more favourably, compared with the control group. However, there were no significant effects on caregivers' knowledge, attitudes and behaviours or on children's language. Conclusion The intervention was only successful in engaging families from disadvantaged backgrounds in shared reading. Implications for the use, duration and intensity of shared reading interventions are discussed

Frequency of Natural Hybridization between Saugers and Walleyes in the Peoria Pool of the Illinois River, as Determined by Morphological and Electrophoretic Criteria

External morphological characteristics and protein electrophoresis at two diagnostic loci were used to determine the proportion of 704 Stizostedion samples collected from the Peoria Pool of the Illinois River during March 1995 that were saugers S. canadense, walleyes S. vitreum, or their hybrids. Morphological analyses indicated that 616 (87.5%) fish were saugers, 58 (8.2%) were walleyes, and 30 (4.3%) were hybrids; electrophoretic analyses indicated that 625 (88.8%) fish were saugers, 50 (7.1%) were walleyes, and 29 (4.1%) were hybrids. Clear discrepancies between the morphological and electrophoretic analyses affected at least 43 (6.1%) fish. Only 2% of saugers were hybrids, but at least 14% of walleyes possessed sauger alleles. Polymorphism at the PGM-1* locus in Peoria Pool saugers was also identified. We recommend electrophoretic screening for hybrids if saugers or walleyes are collected for use as broodstock from waters where they co-occur

The origins of Atlantic salmon (Salmo salar L.) recolonizing the River Mersey in northwest England.

notes: PMCID: PMC3492779types: Journal Article© 2012 The Authors. Ecology and Evolution published by Blackwell Publishing Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.By the 1950s, pollution had extirpated Atlantic salmon in the river Mersey in northwest England. During the 1970s, an extensive restoration program began and in 2001, an adult salmon was caught ascending the river. Subsequently, a fish trap was installed and additional adults are now routinely sampled. In this study, we have genotyped 138 adults and one juvenile salmon at 14 microsatellite loci from across this time period (2001-2011). We have used assignment analysis with a recently compiled pan-European microsatellite baseline to identify their most probable region of origin. Fish entering the Mersey appear to originate from multiple sources, with the greatest proportion (45-60%, dependent on methodology) assigning to rivers in the geographical region just north of the Mersey, which includes Northwest England and the Solway Firth. Substantial numbers also appear to originate from rivers in western Scotland, and from rivers in Wales and Southwest England; nonetheless, the number of fish originating from proximal rivers to the west of the Mersey was lower than expected. Our results suggest that the majority of salmon sampled in the Mersey are straying in a southerly direction, in accordance with the predominantly clockwise gyre present in the eastern Irish Sea. Our findings highlight the complementary roles of improving water quality and in-river navigability in restoring salmon to a river and underlines further the potential benefits of restoration over stocking as a long-term solution to declining fish stocks.The Environment Agency (England & Wales)The Game and Wildlife Conservation TrustThe Westcountry Rivers TrustThe University of Exete

A versatile high resolution objective for imaging quantum gases

We present a high resolution objective lens made entirely from catalog singlets that has a numerical aperture of 0.36. It corrects for aberrations introduced by a glass window and has a long working distance of 35mm, making it suitable for imaging objects within a vacuum system. This offers simple high resolution imaging for many in the quantum gas community. The objective achieves a resolution of 1.3{\mu}m at the design wavelength of 780nm, and a diffraction-limited field of view of 360{\mu}m when imaging through a 5mm window. Images of a resolution target and a pinhole show quantitative agreement with the simulated lens performance. The objective is suitable for diffraction-limited imaging on the D2 line of all the alkalis by changing only the aperture diameter, retaining numerical apertures above 0.32. The design corrects for window thicknesses of up to 15mm if the singlet spacings are modified

Children’s engagement and caregivers’ use of language-boosting strategies during shared book reading: A mixed methods approach

For shared book reading to be effective for language development, the adult and child need to be highly engaged. The current paper adopted a mixed-methods approach to investigate caregiver’s language-boosting behaviours and children’s engagement during shared book reading. The results revealed there were more instances of joint attention and caregiver’s use of prompts during moments of higher engagement. However, instances of most language-boosting behaviours were similar across episodes of higher and lower engagement. Qualitative analysis assessing the link between children’s engagement and caregiver’s use of speech acts, revealed that speech acts do seem to contribute to high engagement, in combination with other aspects of the interaction

HTR4 gene structure and altered expression in the developing lung

Background: Meta-analyses of genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) spanning the 5-hydroxytryptamine receptor 4 (5-HT4R) gene (HTR4) associated with lung function. The aims of this study were to i) investigate the expression profile of HTR4 in adult and fetal lung tissue and cultured airway cells, ii) further define HTR4 gene structure and iii) explore the potential functional implications of key SNPs using a bioinformatic approach

Drosophila non-muscle myosin II motor activity determines the rate of tissue folding

Non-muscle cell contractility is critical for tissues to adopt shape changes. Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. Here, combining the biochemical analysis of enzymatic and motile properties for purified myosin mutants with in vivo measurements of apical constriction for the same mutants, we show that in vivo constriction rate scales with myosin motor activity. We show that so-called phosphomimetic mutants of the Drosophila regulatory light chain (RLC) do not mimic the phosphorylated RLC state in vitro. The defect in the myosin motor activity in these mutants is evident in developing Drosophila embryos where tissue recoil following laser ablation is decreased compared to wild-type tissue. Overall, our data highlights that myosin activity is required for rapid cell contraction and tissue folding in developing Drosophila embryos