The Effects of Note-taking Strategies and Gender on Word Recognition

Technological advancements have changed the way notes are taken. This study will examine gender and note-taking style on the student\u27s ability to recognize words. Participants were instructed to either write, type or read a set of randomly generated words. After a word search buffer, participants were instructed to complete a post-test. Lastly,participants completed a questionnaire. Past studies have supported that handwriting notes is the most effective way for students to retain information and score higher on tests

Hilbert schemes of 8 points

The Hilbert scheme H^d_n of n points in A^d contains an irreducible component R^d_n which generically represents n distinct points in A^d. We show that when n is at most 8, the Hilbert scheme H^d_n is reducible if and only if n = 8 and d >= 4. In the simplest case of reducibility, the component R^4_8 \subset H^4_8 is defined by a single explicit equation which serves as a criterion for deciding whether a given ideal is a limit of distinct points. To understand the components of the Hilbert scheme, we study the closed subschemes of H_n^d which parametrize those ideals which are homogeneous and have a fixed Hilbert function. These subschemes are a special case of multigraded Hilbert schemes, and we describe their components when the colength is at most 8. In particular, we show that the scheme corresponding to the Hilbert function (1,3,2,1) is the minimal reducible example.Comment: 28 pages; Rewrote introduction and reorganized parts of the paper, some minor errors have been fixe

Exploring Race: The Collaborative Inquiry Experience of a Group of Black Social Work Faculty

Through a partnership presentation, presenters discussed the co-inquiry group process through which they explored their experiences as Black faculty who teach race based content in social work programs. They shared insights into what it means, what it takes, and what it costs to teach such content, and the benefits of the group process

miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

ObjectiveOnset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding RNAs that affect gene expression by binding target gene mRNAs. Few studies have specifically examined miRNAs in ped-MS, but individuals developing MS at an early age may carry a relatively high burden of genetic risk factors, and miRNA dysregulation may therefore play a larger role in the development of ped-MS than in adult-onset MS. This study aimed to look for evidence of miRNA involvement in ped-MS pathogenesis.MethodsGWAS results from 486 ped-MS cases and 1362 controls from the U.S. Pediatric MS Network and Kaiser Permanente Northern California membership were investigated for miRNA-specific signals. First, enrichment of miRNA-target gene network signals was evaluated using MIGWAS software. Second, SNPs in miRNA genes and in target gene binding sites (miR-SNPs) were tested for association with ped-MS, and pathway analysis was performed on associated target genes.ResultsMIGWAS analysis showed that miRNA-target gene signals were enriched in GWAS (P = 0.038) and identified 39 candidate biomarker miRNA-target gene pairs, including immune and neuronal signaling genes. The miR-SNP analysis implicated dysregulation of miRNA binding to target genes in five pathways, mainly involved in immune signaling.InterpretationEvidence from GWAS suggests that miRNAs play a role in ped-MS pathogenesis by affecting immune signaling and other pathways. Candidate biomarker miRNA-target gene pairs should be further studied for diagnostic, prognostic, and/or therapeutic utility

Analysis of a Landscape Intensely Modified by Agriculture in the Tietê–Jacaré Watershed, Brazil

From MDPI via Jisc Publications RouterHistory: accepted 2021-08-04, pub-electronic 2021-08-19Publication status: PublishedFunder: São Paulo Research Support Foundation; Grant(s): 2015/19918-3, 2018/00162-4, 660020, PR140015Anthropogenic actions influence landscapes, and the resulting mosaic is a mix of natural and anthropogenic elements that vary in size, shape, and pattern. Considering this, our study aimed to analyse the land use and land cover changes in the Tietê–Jacaré watershed (São Paulo state, Brazil), using the random forest (RF) algorithm and Sentinel-2 satellite data from 2016 to 2018 to detect landscape changes. By overlapping the environmental data and the proposed model evaluation, it was possible to observe the landscape structure, produce information about the state of this region, and assess the environmental responses to anthropic impacts. The land use and land cover analysis identified eight classes: exposed soil, citriculture, pasture, silviculture, sugar cane, urban area, vegetation, and water. The RF classification for the three years reached high accuracy with a kappa index of 0.87 in 2016, 0.85 in 2017, and 0.85 in 2018. The model developed was essential for the temporal analysis since it allowed us to comprehend the driving forces that act in this landscape and contribute to the discussions about their impacts over time. The results showed a predominance of agricultural activities over the three years, with approximately 900.000 ha (76% of the area), mainly covered by sugarcane cultivation

Interferon Gamma Activated Macrophages Kill Mycobacteria by Nitric Oxide Induced Apoptosis

Mycobacterium tuberculosis is an intracellular pathogen of macrophages and escapes the macrophages' bactericidal effectors by interfering with phagosome-lysosome fusion. IFN-γ activation renders the macrophages capable of killing intracellular mycobacteria by overcoming the phagosome maturation block, nutrient deprivation and exposure to microbicidal effectors including nitric oxide (NO). While the importance about NO for the control of mycobacterial infection in murine macrophages is well documented, the underlying mechanism has not been revealed yet. In this study we show that IFN-γ induced apoptosis in mycobacteria-infected macrophages, which was strictly dependent on NO. Subsequently, NO-mediated apoptosis resulted in the killing of intracellular mycobacteria independent of autophagy. In fact, killing of mycobacteria was susceptible to the autophagy inhibitor 3-methyladenine (3-MA). However, 3-MA also suppressed NO production, which is an important off-target effect to be considered in autophagy studies using 3-MA. Inhibition of caspase 3/7 activation, as well as NO production, abolished apoptosis and elimination of mycobacteria by IFN-γ activated macrophages. In line with the finding that drug-induced apoptosis kills intracellular mycobacteria in the absence of NO, we identified NO-mediated apoptosis as a new defense mechanism of activated macrophages against M. tuberculosis

A stochastic individual-based model to explore the role of spatial interactions and antigen recognition in the immune response against solid tumours

FRM is funded by the Engineering and Physical Sciences Research Council (EPSRC).Spatial interactions between cancer and immune cells, as well as the recognition of tumour antigens by cells of the immune system, play a key role in the immune response against solid tumours. The existing mathematical models generally focus only on one of these key aspects. We present here a spatial stochastic individual-based model that explicitly captures antigen expression and recognition. In our model, each cancer cell is characterised by an antigen profile which can change over time due to either epimutations or mutations. The immune response against the cancer cells is initiated by the dendritic cells that recognise the tumour antigens and present them to the cytotoxic T cells. Consequently, T cells become activated against the tumour cells expressing such antigens. Moreover, the differences in movement between inactive and active immune cells are explicitly taken into account by the model. Computational simulations of our model clarify the conditions for the emergence of tumour clearance, dormancy or escape, and allow us to assess the impact of antigenic heterogeneity of cancer cells on the efficacy of immune action. Ultimately, our results highlight the complex interplay between spatial interactions and adaptive mechanisms that underpins the immune response against solid tumours, and suggest how this may be exploited to further develop cancer immunotherapies.PostprintPeer reviewe

The wide-field, multiplexed, spectroscopic facility WEAVE: Survey design, overview, and simulated implementation

© 2023 The Author(s) . Published by Oxford University Press on behalf of Royal Astronomical Society. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/WEAVE, the new wide-field, massively multiplexed spectroscopic survey facility for the William Herschel Telescope, will see first light in late 2022. WEAVE comprises a new 2-degree field-of-view prime-focus corrector system, a nearly 1000-multiplex fibre positioner, 20 individually deployable 'mini' integral field units (IFUs), and a single large IFU. These fibre systems feed a dual-beam spectrograph covering the wavelength range 366$-$959\,nm at $R\sim5000$, or two shorter ranges at $R\sim20\,000$. After summarising the design and implementation of WEAVE and its data systems, we present the organisation, science drivers and design of a five- to seven-year programme of eight individual surveys to: (i) study our Galaxy's origins by completing Gaia's phase-space information, providing metallicities to its limiting magnitude for $\sim$3 million stars and detailed abundances for $\sim1.5$ million brighter field and open-cluster stars; (ii) survey $\sim0.4$ million Galactic-plane OBA stars, young stellar objects and nearby gas to understand the evolution of young stars and their environments; (iii) perform an extensive spectral survey of white dwarfs; (iv) survey $\sim400$ neutral-hydrogen-selected galaxies with the IFUs; (v) study properties and kinematics of stellar populations and ionised gas in $z1$ million spectra of LOFAR-selected radio sources; (viii) trace structures using intergalactic/circumgalactic gas at $z>2$. Finally, we describe the WEAVE Operational Rehearsals using the WEAVE Simulator.Peer reviewe

The Association of Systemic Microvascular Changes with Lung Function and Lung Density: A Cross-Sectional Study

10.1371/journal.pone.0050224PLoS ONE712