A Di Stefano

A Pesci

A Soltani

A Zanini

AH Chester

AM Miniño

BA Forey

Barbara E. K. Klein

BG Ferris

Bianca Harris

C Calabrese

C Casanova

C Gordon

CD Stehouwer

D Chandra

David R. Jacobs

DB Hancock

DE Bild

EA Hoffman

Eric A. Hoffman

ES Mendes

Firas S. Ahmed

H Kramer

HC Gerstein

HL Hillege

HO Coxson

J Hankinson

J Rodriguez

J Sharma

JJ Carr

JJ Wang

JL Hankinson

Joao A. C. Lima

JR Panting

JR Williamson

K McGeechan

KJ Rothman

KM Gooding

KS Schweitzer

L Wang

M Hashimoto

M Jerosch-Herold

M Polatli

M Seimetz

Mary Frances Cotch

MF O'Rourke

Michael Jerosch-Herold

MR Miller

P Eickhoff

PP Mehrotra

PS Bakke

R Damico

R. Graham Barr

RG Barr

RJ Giordano

Ronald Klein

Rory Edward Morty

S Hallan

S Hu

S Reddy

SE Michaud

SI Rennard

SK Alford

SK Nana-Sinkam

T Ozer

T Takahashi

T Yoshida

Tien Y. Wong

TT Nguyen

TY Wong

PLoS ONE

PubMed

Crossref

The Association of Systemic Microvascular Changes with Lung Function and Lung Density: A Cross-Sectional Study

Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45-84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second (FEV(1)) (P<0.001) and FEV(1)/forced vital capacity (FVC) ratio (P = 0.04). Albumin-to-creatinine ratio was inversely associated with FEV(1) (P = 0.002) but not FEV(1)/FVC. Myocardial blood flow (n = 126) was associated with lower FEV(1) (P = 0.02), lower FEV(1)/FVC (P = 0.001) and greater percentage LAA (P = 0.04). Associations were of greater magnitude among smokers. Low lung function was associated with microvascular changes in the retina, kidneys and heart, and low lung density was associated with impaired myocardial microvascular perfusion. These cross-sectional results suggest that microvascular damage with end-organ dysfunction in all circulations may pertain to the lung, that lung dysfunction may contribute to systemic microvascular disease, or that there may be a shared predisposition

Harris, B

Klein, R

Jerosch-Herold, M

Hoffman, EA

Ahmed, FS

Jacobs, DR

Klein, BEK

Wong, TY

Lima, JAC

Cotch, MF

Barr, RG

University of Melbourne Institutional Repository

Eric A Hoffman

Firas S Ahmed

David R Jacobs

Barbara E K Klein

Tien Y Wong

Joao A C Lima

R Graham Barr

Directory of Open Access Journals

The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.

<div>Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45–84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second (FEV1) (P<0.001) and FEV1/forced vital capacity (FVC) ratio (P = 0.04). Albumin-to-creatinine ratio was inversely associated with FEV1 (P = 0.002) but not FEV1/FVC. Myocardial blood flow (n = 126) was associated with lower FEV1 (P = 0.02), lower FEV1/FVC (P = 0.001) and greater percentage LAA (P = 0.04). Associations were of greater magnitude among smokers. Low lung function was associated with microvascular changes in the retina, kidneys and heart, and low lung density was associated with impaired myocardial microvascular perfusion. These cross-sectional results suggest that microvascular damage with end-organ dysfunction in all circulations may pertain to the lung, that lung dysfunction may contribute to systemic microvascular disease, or that there may be a shared predisposition. </div

Bianca Harris (109948)

Ronald Klein (103769)

Michael Jerosch-Herold (109951)

Eric A. Hoffman (109953)

Firas S. Ahmed (109955)

David R. Jacobs Jr (109956)

Barbara E. K. Klein (103701)

Tien Y. Wong (103774)

Joao A. C. Lima (109957)

Mary Frances Cotch (103771)

R. Graham Barr (109958)

The Francis Crick Institute

Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45–84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second \((FEV_1) (P<0.001)\) and \(FEV_1\)/forced vital capacity (FVC) ratio (P = 0.04). Albumin-to-creatinine ratio was inversely associated with \(FEV_1 (P = 0.002)\) but not \(FEV_1\)/FVC. Myocardial blood flow (n = 126) was associated with lower \(FEV_1 (P = 0.02)\), lower \(FEV_1/FVC (P = 0.001)\) and greater percentage LAA (P = 0.04). Associations were of greater magnitude among smokers. Low lung function was associated with microvascular changes in the retina, kidneys and heart, and low lung density was associated with impaired myocardial microvascular perfusion. These cross-sectional results suggest that microvascular damage with end-organ dysfunction in all circulations may pertain to the lung, that lung dysfunction may contribute to systemic microvascular disease, or that there may be a shared predisposition.Version of Recor

Harris, Bianca

Klein, Ronald

Jerosch-Herold, Michael

Hoffman, Eric A.

Ahmed, Firas S.

Klein, Barbara E. K.

Wong, Tien Y.

Lima, Joao A. C.

Cotch, Mary Frances

Barr, R. Graham

Jacobs, David R., Jr.

Harvard University - DASH

https://figshare.com/articles/The_Association_of_Systemic_Microvascular_Changes_with_Lung_Function_and_Lung_Density_A_Cross_Sectional_Study__/115484

The Association of Systemic Microvascular Changes with Lung Function and Lung Density: A Cross-Sectional Study

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Crossref

University of Melbourne Institutional Repository

Directory of Open Access Journals

The Francis Crick Institute

Harvard University - DASH