Mantle Xenoliths from Huanul Volcano (Central-West Argentina): A Poorly Depleted Mantle Source under Southern Payenia

Huanul is a shield volcano with several lava flows hosting mantle xenoliths erupted during the Pleistocene (0.84 ± 0.05 Ma). It is located in the southern part of the Payenia Volcanic Province, which is among the largest Neogene-Quaternary volcanic provinces of South America. The vol-canism here has been ascribed as the northernmost expression of the back-arc volcanism of the Andean Southern Volcanic Zone. We present the first petrographic and mineral chemistry study of mantle xenoliths collected from Huanul lavas with the aim of reconstructing directly the mantle source of the Payenia Volcanic Province. Xenoliths are commonly small (<5 cm in radius) but scarcely crossed by basaltic veins. All xenoliths have a fertile lherzolitic modal composition and are equilibrated in the spinel-facies. Most of them exhibit an almost primitive-mantle geochemical affinity, characterized by slightly depleted clinopyroxene REE patterns reproducible by partial melting degrees between 0 and 4% of a PM source. Geothermobarometric P-T estimates of cli-nopyroxene-orthopyroxene couples form a linear trend between 10 and 24 kbar with constant increase of T from 814 to 1170 °C along a 50–60 mW/m2 geotherm. Evidences of interaction with the host basalts occur as spongy textures in clinopyroxene and reacted spinel, which tend to became more restitic in composition and show chromatographic or complete overprinting of the trace element compositions. The presence of plagioclase and calculated P-T values constrain this melt/rock reaction process between 6 and 14 kbar, during magma ascent, and fit the mantle ad-iabat model. Calculated melts in equilibrium with the primary clinopyroxenes do not fit the composition of the host basalt and, together with the geothermobarometric estimations, point to an asthenospheric mantle source for the magmatism in southern Payenia. The PM geochemical affinity of the xenoliths of Huanul is an extremely rare finding in the South America lithospheric mantle, which is commonly extensively refertilized by subduction-derived melts

Across-arc geochemical variations in the Southern Volcanic Zone, Chile (34.5- 38.0°S): Constraints on Mantle Wedge and Input Compositions

Crustal assimilation (e.g. Hildreth and Moorbath, 1988) and/or subduction erosion (e.g. Stern, 1991; Kay et al., 2005) are believed to control the geochemical variations along the northern portion of the Chilean Southern Volcanic Zone. In order to evaluate these hypotheses, we present a comprehensive geochemical data set (major and trace elements and O-Sr-Nd-Hf-Pb isotopes) from Holocene primarily olivine-bearing volcanic rocks across the arc between 34.5-38.0°S, including volcanic front centers from Tinguiririca to Callaqui, the rear arc centers of Infernillo Volcanic Field, Laguna del Maule and Copahue, and extending 300 km into the backarc. We also present an equivalent data set for Chile Trench sediments outboard of this profile. The volcanic arc (including volcanic front and rear arc) samples primarily range from basalt to andesite/trachyandesite, whereas the backarc rocks are low-silica alkali basalts and trachybasalts. All samples show some characteristic subduction zone trace element enrichments and depletions, but the backarc samples show the least. Backarc basalts have higher Ce/Pb, Nb/U, Nb/Zr, and Ta/Hf, and lower Ba/Nb and Ba/La, consistent with less of a slab-derived component in the backarc and, consequently, lower degrees of mantle melting. The mantle-like δ18O in olivine and plagioclase phenocrysts (volcanic arc = 4.9-5.6 and backarc = 5.0-5.4 per mil) and lack of correlation between δ18O and indices of differentiation and other isotope ratios, argue against significant crustal assimilation. Volcanic arc and backarc samples almost completely overlap in Sr and Nd isotopic composition. High precision (double-spike) Pb isotope ratios are tightly correlated, precluding significant assimilation of older sialic crust but indicating mixing between a South Atlantic Mid Ocean-Ridge Basalt (MORB) source and a slab component derived from subducted sediments and altered oceanic crust. Hf-Nd isotope ratios define separate linear arrays for the volcanic arc and backarc, neither of which trend toward subducting sediment, possibly reflecting a primarily asthenospheric mantle array for the volcanic arc and involvement of enriched Proterozoic lithospheric mantle in the backarc. We propose a quantitative mixing model between a mixed-source, slab-derived melt and a heterogeneous mantle beneath the volcanic arc. The model is consistent with local geodynamic parameters, assuming water-saturated conditions within the slab

Retroarc Neogene volcanism at Payenia: A review

The Payenia basaltic province is a typical retroarc association developed along the foothills of the Andes between 33°40 ́S and 38°00'S. It records two main events, an older, mostly Miocene one (26 to 8 Ma) and a younger Pliocene to Holocene one (younger than 5 Ma). It covers an N-S lowland belt named here the central depression. To the North of 36°20'S, the region was described as Los Huarpes depression, a partially deformed sedimentary basin characterized by a 1000 m-thick, undifferentiated Cenozoic sequence. To the south, Upper Cretaceous to Lower Paleogene layers, instead of the undifferentiated Cenozoic deposits, are covered by basalts. The volcanism additionally covers the western side of the San Rafael Block as well as the fold and thrust belt of the Andean foothills. The Payenia province consists of more than 800 monogenetic basaltic cones, and scarce polygenetic volcanos fed by shallow magmatic chambers. Among the latter, the following examples can be mentioned: Miocene Chachahuén volcano (7 to 5 Ma), composed of andesites, rhyodacites and basalts with high-K and amphibole; Pliocene El Nevado volcano, with calc-alkaline, basaltic trachyandesites, trachytes, dacites and rhyolites; and Upper Pleistocene to Holocene Payún Matrú volcano, composed of trachytes, trachyandesites and trachybasalts. The southernmost area of the central depression is covered by the Pleistocene, Auca Mahuida basaltic shield (1.7 to 0.88 Ma), consisting of trachybasalts, basaltic trachyandesites and trachyandesites. This shield is aligned with Tromen and Domuyo volcanos, defining an NW-SE volcanic belt, oblique to the Andes, whose southern tip corresponds to the Cortaderas lineament. Some of the monogenetic cones are of hydromagmatic origin, whereas a few others exhibit small mantle inclusions. The Payenia retroarc province develops to the south of the Pampean flat slab segment, where the heights of the Andes are smaller. This height difference might have been caused by a higher thermal gradient that softened the crust in the steeper subduction segment, while the colder lithosphere in the flat slab segment allowed greater crustal thickening and height. From the tectonic point of view the height difference has been attributed to a smaller orogenic contraction in the southern segment. Holocene volcanism appears exclusively at Payun Matru volcano. The associated thermal anomaly may explain the segmentation of the central depression, separating the Cenozoic Los Huarpes basin in the north and the section without coeval sedimentation in the south. The only surface evidence of this segmentation is the E-W, La Carbonilla fault, running both sides of the Payun Matru volcano. Other authors have explained this thermal anomaly as a process of crustal thinning and stretching associated with hot injection from the asthenosphere.Fil:Llambías, E.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Risso, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina

Variation of breast vascular maps at dynamic contrast-enhanced MR imaging after primary chemotherapy of locally advanced breast cancer

OBJECTIVE. The purpose of this article is to assess changes in breast vascular maps on dynamic contrast-enhanced MRI (DCE-MRI) after primary chemotherapy in patients with locally advanced breast cancer (LABC). SUBJECTS AND METHODS. Thirty-four patients with unilateral LABC underwent DCE-MRI before and after anthracycline- and taxane-based primary chemotherapy. The number of vessels 30 mm or longer in length and 2 mm or larger in maximum transverse diameter were counted on maximum intensity projections of the first subtracted phase for each of the two breasts. Patients achieving pathologic response or small clusters of residual cancer cells after primary chemotherapy were considered as responders, and those with an inferior pathologic response were considered as nonresponders. RESULTS. The mean (\ub1 SD) number of vessels in the breast harboring the cancer and in the contralateral breast was 2.7 \ub1 1.3 and 1.1 \ub1 1.0 (p < 0.001), respectively, before primary chemotherapy and 1.3 \ub1 1.1 and 1.1 \ub1 1.1 (p = 0.147), respectively, after primary chemotherapy. Overall, primary chemotherapy was associated with a significant reduction in DCE-MRI vascular maps in the breast harboring the cancer only (p < 0.001). Of the 34 patients, 10 were considered responders and 24 were nonresponders. The mean number of vessels in the breast harboring the cancer changed from 2.7 \ub1 1.1 to 0.6 \ub1 0.8 for the 10 responders and from 2.7 \ub1 1.4 to only 1.6 \ub1 0.9 for the 24 nonresponders. The mean reduction of vascular map in the breast harboring the cancer was significantly higher in responders compared with nonresponders (p = 0.017). CONCLUSION. Before primary chemotherapy, DCE-MRI vascular maps were asymmetrically increased ipsilaterally to the LABC. After primary chemotherapy, vascular maps significantly changed only in the breast harboring the cancer, with significant differences between responders and nonresponders

A new algorithm for automatic vascular mapping of DCE-MRI of the breast: Clinical application of a potential new biomarker

Background and objective: Vascularity evaluation on breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has a potential diagnostic value, but it represents a time consuming procedure, affected by intra- and inter-observer variability. This study tests the application of a recently published method to reproducibly quantify breast vascularity, and evaluates if the vascular volume of cancer-bearing breast, calculated from automatic vascular maps (AVMs), may correlate with pathologic tumor response after neoadjuvant chemotherapy (NAC). Methods: Twenty-four patients with unilateral locally advanced breast cancer underwent DCE-MRI before and after NAC, 8 responders and 16 non-responders. A validated algorithm, based on multiscale 3D Hessian matrix analysis, provided AVMs and allowed the calculation of vessel volume before the initiation and after the last NAC cycle for each breast. For cancer bearing breast, the difference in vascular volume before and after NAC was compared in responders and non-responders using the Wilcoxon two-sample test. A radiologist evaluated the vascularity on the subtracted images (first enhanced minus unenhanced), before and after treatment, assigning a vascular score for each breast, according to the number of vessels with length ≥30. mm and maximal transverse diameter ≥2. mm. The same evaluation was repeated with the support of the simultaneous visualization of the AVMs. The two evaluations were compared in terms of mean number of vessels and mean vascular score per breast, in responders and non-responders, by use of Wilcoxon two sample test. For all the analysis, the statistical significance level was set at 0.05. Results: For breasts harboring the cancer, evidence of a difference in vascular volume before and after NAC for responders (median. =. 1.71. cc) and non-responders (median. =. 0.41. cc) was found (. p=. 0.003). A significant difference was also found in the number of vessels (. p=. 0.03) and vascular score (. p=. 0.02) before or after NAC, according to the evaluation supported by the AVMs. Conclusions: The encouraging, although preliminary, results of this study suggest the use of AVMs as new biomarker to evaluate the pathologic response after NAC, but also support their application in other breast DCE-MRI vessel analysis that are waiting for a reliable quantification method