On a nilpotent lie superalgebra which generalizes Qn

In [6] and [7] the author introduces the notion of filiform Lie superalgebras, generalizing the filiform Lie algebras studied by Vergne in the sixties. In these appers, the superalgebras whose even part is isomorphic to the model filiform Lie algebra Ln are studied and classified in low dimensions. Here we consider a class of superalgebras whose even part is the filiform, naturally graded Lie algebra Qn, which only exists in even dimension as a consequence of the centralizer property. Certain central extensions of Qn which preserve both the nilindex and the cited property are also generalized to obtain nonfiliform Lie superalgebras.In [6] and [7] the author introduces the notion of filiform Lie superalgebras, generalizing the filiform Lie algebras studied by Vergne in the sixties. In these appers, the superalgebras whose even part is isomorphic to the model filiform Lie algebra Ln are studied and classified in low dimensions. Here we consider a class of superalgebras whose even part is the filiform, naturally graded Lie algebra Qn, which only exists in even dimension as a consequence of the centralizer property. Certain central extensions of Qn which preserve both the nilindex and the cited property are also generalized to obtain nonfiliform Lie superalgebras

Análisis para predicción de ventas utilizando minería de datos en almacenes de ventas de grandes superficies

desde hace algunas décadas, el hombre se ha visto en la necesidad de administrar sus actividades la mayoría de éstas comerciales, como lo es el uso que le da al dinero tanto en el hogar como a nivel empresarial, por lo tanto le es necesario almacenar un historial de algunos o la mayoría de sus actividades comerciales, lo que lo obliga a llevar de manera ordenada el cómo y en qué ha gastado su dinero, hasta el punto de ser necesario contar con una persona que se dedique a administrar, almacenar y vigilar dichas actividades a nivel empresarial. Con el paso del tiempo se ha visto que para dar una adecuada administración de todas esas actividades y con el fin de evitar muchos conflictos, en la mayoría de los lugares como por ejemplo los hospitales se realizan historial de visitas, entradas y salidas de pacientes; en las estaciones de policía se registran con hora y fecha exactas de los hechos sucedidos; en almacenes grandes se registran las transacciones en facturas con fecha de compra y en algunos casos con nombre del cajero, entre otros ejemplos; por lo que se comienza a formar una generación masiva de datos los cuales llevan a la creación de almacenes o bodegas de datos, algunos con un crecimiento tan exagerado que hasta para las consultas realizadas por lenguajes como SQL es imposible lograr resultados eficientes. A nivel comercial se puede observar que las empresas logran la recolección de grandes volúmenes de información acerca de su actividad, tales como compras, ventas, inventarios, entre otros, de los cuales algunos de estos datos serán usados y otros se acumularán hasta inclusive llegar a perderse por falta de actualidad o cambio en las políticas de manejo de datos. para darle un poco de utilidad a esta información se han aplicado diversos modelos y técnicas especialmente desarrollados en el campo de la Minería de Datos por medio de los cuales es posible describir el movimiento de los inventarios así como encontrar posibles relaciones que se puedan dar entre determinados productos

Rapid Differential Diagnosis between Extrapulmonary Tuberculosis and Focal Complications of Brucellosis Using a Multiplex Real-Time PCR Assay

BACKGROUND: Arduous to differ clinically, extrapulmonary tuberculosis and focal complications of brucellosis remain important causes of morbidity and mortality in many countries. We developed and applied a multiplex real-time PCR assay (M RT-PCR) for the simultaneous detection of Mycobacterium tuberculosis complex and Brucella spp. METHODOLOGY: Conventional microbiological techniques and M RT-PCR for M. tuberculosis complex and Brucella spp were performed on 45 clinical specimens from patients with focal complications of brucellosis or extrapulmonary tuberculosis and 26 control samples. Fragments of 207 bp and 164 bp from the conserved region of the genes coding for an immunogenic membrane protein of 31 kDa of B. abortus (BCSP31) and the intergenic region SenX3-RegX3 were used for the identification of Brucella and M. tuberculosis complex, respectively. CONCLUSIONS: The detection limit of the M RT-PCR was 2 genomes per reaction for both pathogens and the intra- and inter-assay coefficients of variation were 0.44% and 0.93% for Brucella and 0.58% and 1.12% for Mycobacterium. M RT-PCR correctly identified 42 of the 45 samples from patients with tuberculosis or brucellosis and was negative in all the controls. Thus, the overall sensitivity, specificity, PPV and NPV values of the M RT PCR assay were 93.3%, 100%, 100% and 89.7%, respectively, with an accuracy of 95.8% (95% CI, 91.1%-100%). Since M RT-PCR is highly reproducible and more rapid and sensitive than conventional microbiological tests, this technique could be a promising and practical approach for the differential diagnosis between extrapulmonary tuberculosis and focal complications of brucellosis

Normalized sombor indices as complexity measures of random networks

We perform a detailed computational study of the recently introduced Sombor indices on random networks. Specifically, we apply Sombor indices on three models of random networks: Erdös-Rényi networks, random geometric graphs, and bipartite random networks. Within a statistical random matrix theory approach, we show that the average values of Sombor indices, normalized to the order of the network, scale with the average degree. Moreover, we discuss the application of average Sombor indices as complexity measures of random networks and, as a consequence, we show that selected normalized Sombor indices are highly correlated with the Shannon entropy of the eigenvectors of the adjacency matrix.The research of J.M.R. and J.M.S. was supported by a grant from Agencia Estatal de Investigación (PID2019-106433GBI00/AEI/10.13039/501100011033), Spain. J.M.R. was supported by the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with UC3M in the line of Excellence of University Professors (EPUC3M23), and in the context of the V PRICIT (Regional Programme of Research and Technological Innovation)

Albendazole solid dispersions against alveolar echinococcosis: a pharmacotechnical strategy to improve the efficacy of the drug

Alveolar echinococcosis is a neglected parasitic zoonosis caused by Echinococcus multilocularis. The pharmacological treatment is based on albendazole (ABZ). However, the low water solubility of the drug produces a limited dissolution rate, with the consequent failure in the treatment of the disease. Solid dispersions are a successful pharmacotechnical strategy to improve the dissolution profile of poorly water-soluble drugs. The aim of this work was to determine the in vivo efficacy of ABZ solid dispersions using poloxamer 407 as a carrier (ABZ:P407 solid dispersions (SDs)) in the murine intraperitoneal infection model for secondary alveolar echinococcosis. In the chemoprophylactic efficacy study, the ABZ suspension, the ABZ:P407 SDs and the physical mixture of ABZ and poloxamer 407 showed a tendency to decrease the development of murine cysts, causing damage to the germinal layer. In the clinical efficacy study, the ABZ:P407 SDs produced a significant decrease in the weight of murine cysts. In addition, the SDs produced extensive damage to the germinal layer. The increase in the efficacy of ABZ could be due to the improvement of water solubility and wettability of the drug due to the surfactant nature of poloxamer 407. In conclusion, this study is the basis for further research. This pharmacotechnical strategy might in the future offer novel treatment alternatives for human alveolar echinococcosis.Fil: Fabbri, Julia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pensel, Patricia Eugenia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Albani, Clara Maria. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lopez, Lurdes Milagros. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; ArgentinaFil: Simonazzi, Analía. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bermudez, José María. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Elissondo, María Celina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentin

Analysis of psychic imbalance, caused by screening of a video of surgical extraction of a lower third molar in a sample of mental patients as compared to the general population

The goal of this study is to validate the psychometric properties of the Hamilton Rating Scales for anxiety and depression. These two scales will be used to analyze anxiety and depression, seven days before, after and seven days after screening of a vide

Validação aparente de um instrumento de notificação de eventos adversos aos cuidados de saúde

The objective of this study was to validate the appearance of an adverse event notification (EA) instrument based on the “System of Notification and Learning for Patient Safety” proposed by the Spanish Ministry of Health, from the perception of nurses of the Medicine and Surgery Areas of the Rafael Ángel Calderón Guardia Hospital during the first semester of 2017. Based on a qualitative design, 15 nurses participated in the apparent validation of the instrument. No contributions were recorded regarding the writing and logical sequence of the information. Three items were added. The foregoing, considering that the ideas expressed were in accordance with the principles of voluntary reporting, non-punishability, confidentiality, systemic orientation, promotion of analysis for learning and implementation of improvements. It is concluded that the instrument is considered adequate for the notification of adverse events associated with health care in that hospital center.El objetivo de este estudio fue validar la apariencia de un instrumento de notificación de eventos adversos (EA) basado en el “Sistema de Notificación y Aprendizaje para la Seguridad del Paciente” propuesto por el Ministerio de Sanidad Español, desde la percepción de enfermeras y enfermeros de las Áreas de Medicinas y Cirugías del Hospital Rafael Ángel Calderón Guardia durante el I semestre del año 2017. A partir de un diseño cualitativo, participaron en la validación aparente del instrumento 15 enfermeros(as). No se registraron aportes en cuanto a la redacción y la secuencia lógica de la información. Se agregaron tresítemes. Lo anterior, al considerar que las ideas expresadas estuvieran en concordancia con los principios de voluntariedad de la notificación, la no punibilidad, la confidencialidad, la orientación sistémica, la promoción del análisis para el aprendizaje y la implementación de mejoras. Se concluye que el instrumento es considerado adecuado para la notificación de eventos adversos asociados a la atención de la salud en dicho centro hospitalario.  O objetivo deste estudo foi validar o aparecimento de um instrumento de notificação de eventos adversos (EA) baseado no “Sistema de Notificação e Aprendizado para Segurança do Paciente” proposto pelo Ministério da Saúde da Espanha, a partir da percepção dos enfermeiros. das Áreas de Medicina e Cirurgia do Hospital Rafael Ángel Calderón Guardia durante o primeiro semestre de 2017. Com base em um desenho qualitativo, 15 enfermeiros participaram da aparente validação do instrumento. Não foram registradas contribuições quanto à escrita e sequência lógica das informações. Três itens foram adicionados. O exposto, considerando que as idéias expressas estavam de acordo com os princípios de denúncia voluntária, não punibilidade, confidencialidade, orientação sistêmica, promoção de análises para aprendizado e implementação de melhorias. Conclui-se que o instrumento é considerado adequado para a notificação de eventos adversos associados aos cuidados de saúde naquele centro hospitalar

Thyroid Pathology Findings in Cowden Syndrome: A Clue for the Diagnosis of the PTEN Hamartoma Tumor Syndrome

OBJECTIVES: PTEN hamartoma tumor syndrome (PHTS) is a hereditary disorder caused by germline inactivating mutations of the PTEN gene. PHTS includes Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. We describe how the peculiar pathologic and immunohistochemical thyroid features lead pathologists to suggest PHTS. METHODS: A 28-year-old white Spanish woman had a multinodular goiter. Total thyroidectomy was performed after fine-needle aspiration biopsy. Microscopic, immunohistochemical, and molecular analyses of the thyroid lesions were realized. RESULTS: The thyroid was multinodular, showing one papillary microcarcinoma, five follicular adenomas, three adenolipomas, 46 tiny adenomatous nodules (microadenomas), scattered foci of adipose tissue, and lymphocytic thyroiditis. Tumors were positive for thyroglobulin, thyroperoxidase, pendrin, cyclin D1, and p27 but negative for calcitonin and PTEN. A germline heterozygous deletion of one adenine at nucleotide 827 in exon 8 of the PTEN gene was confirmed. No BRAF, NRAS, or KRAS somatic mutations were detected in the papillary microcarcinoma, follicular adenoma, adenolipomas, or microadenomas. Negativity for PTEN was also found in the colonic tubulovillous adenoma and the storiform collagenoma. CONCLUSIONS: Pathologists play a crucial role in recognizing pathologic thyroid findings associated with PHTS for selecting patients for genetic testing

Ionic and conformational mobility in poly(vinylidene fluoride)/ionic liquid blends: Dielectric and electrical conductivity behavior

[EN] The glass transition dynamics and the charge transport for blends composed of poly(vinylidene fluoride) (PVDF) and the ionic liquid (IL) 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide, [Emim] [TESI] have been investigated as a function of different IL content (0, 10, 25 and 40 % wt) by differential scanning calorimetry (DSC), dynamic-mechanical analysis (DMA) and broadband dielectric relaxation spectroscopy (BDS) in wide frequency and temperature ranges (0.1 Hz-1 MHz and -120 to 150 degrees C, respectively). The inclusion of the IL in the polymer matrix affected the main relaxation process (beta-relaxation) of the amorphous phase of the polymer matrix detected with all the techniques employed. It is demonstrated, that the chain segments of PVDF and the IL are mixed at the nanometer range. The blends were homogeneous regardless of the amount of IL and the glass transition temperature (Tg) shifted to lower temperatures as the IL content was increased. A good agreement between the Tg measured by BDS and DSC was observed for all PVDF/IL samples. The conductivity formalism revealed significant contributions of the IL concentration to the conductivity behavior of the blends in that is described by charge motion and electrode polarization effects. The activation energy of all the PVDF/IL samples, calculated by Dyre model, decreased with IL addition with respect to that of neat PVDF. (C) 2018 Elsevier Ltd. All rights reserved.This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013. The authors thank FEDER funds through the COMPETE 2020 Programme and National Funds through FCT under the projects PTDC/CTM-ENE/5387/2014, PTDC/EEI-SII/5582/2014 and UID/CTM/50025/2013 and Grants SFRH/BPD/121526/2016 (D.M.C.), SFRH/BPD/112547/2015 (C.M.C.). Financial support from the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) (including the FEDER financial support) and from the Basque Government Industry Department under the ELKARTEK and HAZITEK programs is also acknowledged. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER Actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund.Correia, D.; Sabater I Serra, R.; Gómez-Tejedor, JA.; De Zea Bermudez, V.; Andrio Balado, A.; Meseguer Dueñas, JM.; Gómez Ribelles, JL.... (2018). Ionic and conformational mobility in poly(vinylidene fluoride)/ionic liquid blends: Dielectric and electrical conductivity behavior. Polymer. 143:164-172. https://doi.org/10.1016/j.polymer.2018.04.019S16417214